Music Therapy: Music Sharing Intervention with Acute Adolescents

This thesis explores a music therapy song sharing group method with acute adolescents in community-based acute treatment and partial hospitalization. While there is research on music therapy and acute adolescents, there is a gap in the literature surrounding the topic of acute adolescents participating in music therapy group sessions. Research on music therapy and adolescents focuses on interventions for an outpatient setting and/or a variety of different interventions. There was limited research on inpatient music therapy with adolescents and more research on adult inpatients working with music therapy. The method presented here incorporates sharing personal songs that clients have a connection with, describing the connection through lyric analysis and/or sound descriptions, identifying when they listen to the song (as a coping skill), and opening conversations with the group about the song. Results indicated that adolescents enjoy sharing personal music, feel comfortable expressing themselves and discussing their history, and as a coping skill music reduces their symptoms. As a group, sharing the songs sparked a variety of conversations based on the different themes of each song, such as: loss, trauma, drugs, suicide, society’s labels, mental health, resilience, and so forth. From this method, the participants felt comfortable processing intense feelings and were able to join together as a community

Mindfulness-based approaches for Young People with Autism Spectrum Disorder and their Caregivers: Do these Approaches Hold Benefits for Teachers?

Parents and teachers who care for and educate young people with Autism Spectrum Disorder (ASD) face unique challenges associated with their roles. In this review we investigated the efficacy of mindfulness-based interventions in reducing stress and increasing positive behaviours in young people with ASD and their caregivers: parents and teachers. Nine studies on the topic were located, showing that the research base in this field is in the infancy stage. Each study illuminated the transformational change caregivers and young people experience after practicing mindfulness training (MT). The results also highlighted the interdependent relationship between the caregivers’ level of mindfulness and their child’s pro-social behaviours. We recommend that future researchers focus on understanding mindfulness as a relational practice as well as how the practice can support teachers who care for and educate students with ASD

Student Recital (December 11, 2012)

Choro No. 1 / Heitor Villa-Lobos Praeludium, BWV 999 / Johann Sebastian Bach Thomas Prosser, guitar Fugue in C minor, BWV 847 / J. S. Bach Carl Hollant, piano Sonata in G minor, Op. 1, No. 2, HWV 360 / Georg Friedrich Handel Adagio Andante Nicole Mount, flute Minuet in C, Op. 22 / Fernando Sor Mark Gavin, guitar Where’re Your Walk, from Semele, HWV 58 / G. F. Handel Thomas Manning, tenor Romance / anon. Un Dia De Noviembre / Leo Brower Christopher Bosch, guitar Etude No. 57 / Mitchell Peters Nicole Desmarais, timpani Suite for Cello No. 1, BWV 1007 / Johann Sebastian Bach Courante Mackenzie Leahy, alto saxophone Prelude No. 4 in E minor / Heitor Villa-Lobos Ian Timpany, guitar Sonata / Kent Kennan James Sheehan, trumpet Sonate pour Flute et Piano / Francis Poulenc Allegretto Malincolico Jennifer Drake, flutehttps://vc.bridgew.edu/student_concerts/1033/thumbnail.jp

Student Recital (March 6, 2015)

Reverie / André Caplet Nicole Mount, flute “La fleur que tu m’avais jetée” from Carmen / Georges Bizet Richard Moran, tenor Care Selve from Atlanta, HWV 35 / George Frederic Handel Brooke Speigel, soprano Sonata Romantica / Manuel Ponce Andante Expressivo Thomas Prosser, guitar Meditation from “Thais” / Jules Massenet Gail Colombo, violin Libra Sonatine / Roland Dyens (b. 1955) Fouco Bryan Picher, guitar Sonatine for Flute and Piano / Walter Gieseking Moderato Marie Doyon, flute Variation on a theme by Robert Schumann, Op. 20 / Clara Schumann Theme Variation I Variation II Variation III Jiaying Zhu, pianohttps://vc.bridgew.edu/student_concerts/1077/thumbnail.jp

Outcomes in patients with gunshot wounds to the brain.

Introduction:Gunshot wounds to the brain (GSWB) confer high lethality and uncertain recovery. It is unclear which patients benefit from aggressive resuscitation, and furthermore whether patients with GSWB undergoing cardiopulmonary resuscitation (CPR) have potential for survival or organ donation. Therefore, we sought to determine the rates of survival and organ donation, as well as identify factors associated with both outcomes in patients with GSWB undergoing CPR. Methods:We performed a retrospective, multicenter study at 25 US trauma centers including dates between June 1, 2011 and December 31, 2017. Patients were included if they suffered isolated GSWB and required CPR at a referring hospital, in the field, or in the trauma resuscitation room. Patients were excluded for significant torso or extremity injuries, or if pregnant. Binomial regression models were used to determine predictors of survival/organ donation. Results:825 patients met study criteria; the majority were male (87.6%) with a mean age of 36.5 years. Most (67%) underwent CPR in the field and 2.1% (n=17) survived to discharge. Of the non-survivors, 17.5% (n=141) were considered eligible donors, with a donation rate of 58.9% (n=83) in this group. Regression models found several predictors of survival. Hormone replacement was predictive of both survival and organ donation. Conclusion:We found that GSWB requiring CPR during trauma resuscitation was associated with a 2.1% survival rate and overall organ donation rate of 10.3%. Several factors appear to be favorably associated with survival, although predictions are uncertain due to the low number of survivors in this patient population. Hormone replacement was predictive of both survival and organ donation. These results are a starting point for determining appropriate treatment algorithms for this devastating clinical condition. Level of evidence:Level II

Student Recital (May 2, 2014)

Etude No. 62 / Mitchell Peters Nicole Desmarais, timpani Malagueña from Spanish Dances, Op. 21 / Pablo de Sarasate Carla Mason, violin Valse Venezolano No. 2 / Antonio Lauro Michael Cirino, guitar Ballade / Albert Périlhou Nicole Mount, flute Etude No. 8 / Heitor Villa-Lobos Dylan Mowry, guitar Sicilienne and Rigaudon / Fritz Kreisler Tempo di Allegretto and Allegro Megan Polk, violin Cavatine, Op. 144 / Camile Saint-Saëns Cody O’Toole, trombone Concerto No. 1 in A minor / Jean Baptiste Accolaÿ Gail Colombo, violin Das Wohltemperierte Klavier II, BWV 886 / Johann Sebastian Bach Prelude and Fugue in Ab Major Jiaying Zhu, piano Cello Suite No. 1, BWV 1007 / J. S. Bach Prelude Killian Kerrigan, guitar El Colibri / Julio S. Sagreras Brian Picher, guitar Maria Wiegenlied / Max Reger Se Tu M’ami / Giovanni Battista Pergolesi Brooke Speigel, soprano Nocturnal After John Dowland / Benjamin Britten Passacaglia and Theme Jim Davidson, guitar Spring / Ivor Gurney Lied Der Mignon, D. 877, No. 3 / Franz Schubert Mackenzie Leahy, soprano Ma Mère L’oye (Mother Goose Suite) / Maurice Ravel Pavane de la Belle au bois dormant (Lent) Petit Poucet. (Très modéré) Laideronnette, Impératrice des pagodes ( Mouvement de marche) Jiaying Zhu, piano Alexander Heinrich, piano Waltz in Db Major, Op. 64, No. 1 / Frederic Chopin Brenner Campos, piano Three Songs Without Words / Paul Ben-Haim Arioso Ballad Shepardic Melody Colby DeWitt, alto saxophone For You There is No Song / Leslie Adams Deborah / Gene Bone Justine Smigel, sopranohttps://vc.bridgew.edu/student_concerts/1065/thumbnail.jp

GDNF Selectively Induces Microglial Activation and Neuronal Survival in CA1/CA3 Hippocampal Regions Exposed to NMDA Insult through Ret/ERK Signalling

The glial cell line-derived neurotrophic factor (GDNF) is a potent survival factor for several neuronal populations in different brain regions, including the hippocampus. However, no information is available on the: (1) hippocampal subregions involved in the GDNF-neuroprotective actions upon excitotoxicity, (2) identity of GDNF-responsive hippocampal cells, (3) transduction pathways involved in the GDNF-mediated neuroprotection in the hippocampus. We addressed these questions in organotypic hippocampal slices exposed to GDNF in presence of N-methyl-D-aspartate (NMDA) by immunoblotting, immunohistochemistry, and confocal analysis. In hippocampal slices GDNF acts through the activation of the tyrosine kinase receptor, Ret, without involving the NCAM-mediated pathway. Both Ret and ERK phosphorylation mainly occurred in the CA3 region where the two activated proteins co-localized. GDNF protected in a greater extent CA3 rather than CA1 following NMDA exposure. This neuroprotective effect targeted preferentially neurons, as assessed by NeuN staining. GDNF neuroprotection was associated with a significant increase of Ret phosphorylation in both CA3 and CA1. Interestingly, confocal images revealed that upon NMDA exposure, Ret activation occurred in microglial cells in the CA3 and CA1 following GDNF exposure. Collectively, this study shows that CA3 and CA1 hippocampal regions are highly responsive to GDNF-induced Ret activation and neuroprotection, and suggest that, upon excitotoxicity, such neuroprotection involves a GDNF modulation of microglial cell activity

Exome-wide association study to identify rare variants influencing COVID-19 outcomes : Results from the Host Genetics Initiative

Publisher Copyright: Copyright: © 2022 Butler-Laporte et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.Host genetics is a key determinant of COVID-19 outcomes. Previously, the COVID-19 Host Genetics Initiative genome-wide association study used common variants to identify multiple loci associated with COVID-19 outcomes. However, variants with the largest impact on COVID-19 outcomes are expected to be rare in the population. Hence, studying rare variants may provide additional insights into disease susceptibility and pathogenesis, thereby informing therapeutics development. Here, we combined whole-exome and whole-genome sequencing from 21 cohorts across 12 countries and performed rare variant exome-wide burden analyses for COVID-19 outcomes. In an analysis of 5,085 severe disease cases and 571,737 controls, we observed that carrying a rare deleterious variant in the SARS-CoV-2 sensor toll-like receptor TLR7 (on chromosome X) was associated with a 5.3-fold increase in severe disease (95% CI: 2.75–10.05, p = 5.41x10-7). This association was consistent across sexes. These results further support TLR7 as a genetic determinant of severe disease and suggest that larger studies on rare variants influencing COVID-19 outcomes could provide additional insights.Peer reviewe