3,350 research outputs found
Elastic cavitation, tube hollowing, and differential growth in plants and biological tissues
Elastic cavitation is a well-known physical process by which elastic materials under stress can open cavities. Usually, cavitation is induced by applied loads on the elastic body. However, growing materials may generate stresses in the absence of applied loads and could induce cavity opening. Here, we demonstrate the possibility of spontaneous growth-induced cavitation in elastic materials and consider the implications of this phenomenon to biological tissues and in particular to the problem of schizogenous aerenchyma formation
Generation of directional, coherent matter beams through dynamical instabilities in Bose-Einstein condensates
We present a theoretical analysis of a coupled, two-state Bose-Einstein
condensate with non-equal scattering lengths, and show that dynamical
instabilities can be excited. We demonstrate that these instabilities are
exponentially amplified resulting in highly-directional,
oppositely-propagating, coherent matter beams at specific momenta. To
accomplish this we prove that the mean field of our system is periodic, and
extend the standard Bogoliubov approach to consider a time-dependent, but
cyclic, background. This allows us to use Floquet's theorem to gain analytic
insight into such systems, rather than employing the usual Bogoliubov-de Gennes
approach, which is usually limited to numerical solutions. We apply our theory
to the metastable Helium atom laser experiment of Dall et al. [Phys. Rev. A 79,
011601(R) (2009)] and show it explains the anomalous beam profiles they
observed. Finally we demonstrate the paired particle beams will be
EPR-entangled on formation.Comment: Corrected reference
Dynamical derivation of Bode's law
In a planetary or satellite system, idealized as n small bodies in initially
coplanar, concentric orbits around a large central body, obeying Newtonian
point-particle mechanics, resonant perturbations will cause dynamical evolution
of the orbital radii except under highly specific mutual relationships, here
derived analytically apparently for the first time. In particular, the most
stable situation is achieved (in this idealized model) only when each planetary
orbit is roughly twice as far from the Sun as the preceding one, as observed
empirically already by Titius (1766) and Bode (1778) and used in both the
discoveries of Uranus (1781) and the Asteroid Belt (1801). ETC.Comment: 27 page
Damaging Cardiac and Cancer Genetic Variants in the LVAD Population
Background: Next generation sequencing technology, coupled with population genetic databases, have made broad genetic evaluation relatively inexpensive and widely available. Our objective was to assess the prevalence of potentially damaging cancer and cardiac gene variants in advanced non-ischemic cardiomyopathy patients.
Methods: Explanted human heart tissue procured at LVAD placement was obtained from the University of Nebraska Medical Center Heart Tissue Bank. Genomic DNA was isolated from tissues and amplified by PCR using targeted ampliseq primer pools from an inherited disease panel. Individual libraries were amplified by emulsion PCR on Ion Sphere particles and sequencing was performed on a PGM sequencer (Ion torrent) using the Ion 316 chip. The Ion Torrent browser suite was used to map the reads and call the variants. The identified single nucleotide polymorphisms, insertions, and deletions were then annotated and characterized with ANNOVAR. Non-synonymous mutations with a population frequency of less than or equal to 1% were identified and analyzed utilizing an open source integrative genomics viewer. Amino acid substitution effects on protein function were determined by a bioinformatics algorithm. Myocardial recovery was defined as an improvement in EF to greater than 45% at three months post implant.
Results: Our sample population included 12 males and 2 females with an average age of 49 and an average EF at presentation of 17%. Damaging cardiac gene variants were present in 11/14 patients. Only 1 of the 11 patients with damaging cardiac gene variants improved their ejection fraction to greater than 45% post LVAD. Two of the 2 patients without mutations improved their ejection fraction to greater than 45%, p-value=.04. Nine of the 14 patients in this population had damaging oncogene mutations.
Conclusions: Damaging variants in cancer and cardiac genes are common in end-stage non-ischemic cardiomyopathy patients undergoing LVAD placement. Genetic variation likely contributes to disease progression and cancer risk
Low thrust propulsion in a coplanar circular restricted four body problem
This paper formulates a circular restricted four body problem (CRFBP), where the three primaries are set in the stable Lagrangian equilateral triangle configuration and the fourth body is massless. The analysis of this autonomous coplanar CRFBP is undertaken, which identies eight natural equilibria; four of which are close to the smaller body, two stable and two unstable, when considering the primaries to be the Sun and two smaller bodies of the solar system. Following this, the model incorporates `near term' low-thrust propulsion capabilities to generate surfaces of articial equilibrium points close to the smaller primary, both in and out of the plane containing the celestial bodies. A stability analysis of these points is carried out and a stable subset of them is identied. Throughout the analysis the Sun-Jupiter-Asteroid-Spacecraft system is used, for conceivable masses of a hypothetical asteroid set at the libration point L4. It is shown that eight bounded orbits exist, which can be maintained with a constant thrust less than 1:5 10􀀀4N for a 1000kg spacecraft. This illustrates that, by exploiting low-thrust technologies, it would be possible to maintain an observation point more than 66% closer to the asteroid than that of a stable natural equilibrium point. The analysis then focusses on a major Jupiter Trojan: the 624-Hektor asteroid. The thrust required to enable close asteroid observation is determined in the simplied CRFBP model. Finally, a numerical simulation of the real Sun-Jupiter-624 Hektor-Spacecraft is undertaken, which tests the validity of the stability analysis of the simplied model
Regression Discontinuity Designs with Clustered Data
Regression discontinuity designs have become popular in empirical studies due to their attractive properties for estimating causal effects under transparent assumptions. Nonetheless, most popular procedures assume i.i.d. data, which is unreasonable in many common applications. To fill this gap, we derive the properties of traditional local polynomial estimators in a fixed- setting that allows for cluster dependence in the error term. Simulation results demonstrate that accounting for clustering in the data while selecting bandwidths may lead to lower MSE while maintaining proper coverage. We then apply our cluster-robust procedure to an application examining the impact of Low-Income Housing Tax Credits on neighborhood characteristics and low-income housing supply
High potential for weathering and climate effects of non-vascular vegetation in the Late Ordovician
It has been hypothesized that predecessors of today’s bryophytes significantly increased global chemical weathering in the Late Ordovician, thus reducing atmospheric CO2 concentration and contributing to climate cooling and an interval of glaciations. Studies that try to quantify the enhancement of weathering by non-vascular vegetation, however, are usually limited to small areas and low numbers of species, which hampers extrapolating to the global scale and to past climatic conditions. Here we present a spatially explicit modelling approach to simulate global weathering by non-vascular vegetation in the Late Ordovician. We estimate a potential global weathering flux of 2.8 (km3 rock) yr−1, defined here as volume of primary minerals affected by chemical transformation. This is around three times larger than today’s global chemical weathering flux. Moreover, we find that simulated weathering is highly sensitive to atmospheric CO2 concentration. This implies a strong negative feedback between weathering by non-vascular vegetation and Ordovician climate
Bridge distress caused by approach embankment settlement
Surtees Bridge, which carries the A66(T) over the River
Tees near Thornaby-on-Tees in the UK, has been
showing signs of distress that predate its opening in
1981. Subsequent investigations have shown that the
bridge distress is related to unexpectedly large
settlement of the eastern approach embankment.
Recent ground investigations prompted by a proposed
widening of the river crossing have produced many new
data on the alluvial deposits underlying the site, and
explain why embankment settlement was so much larger
than originally anticipated. Comparison of the
geotechnical parameters obtained from the original and
more recent ground investigations suggests that the
original investigation significantly underestimated the
thickness of an alluvial clay layer underlying the site, and
that its coefficient of consolidation was overestimated.
Settlement analyses using geotechnical data from the
original ground investigations predict moderate
embankment settlements occurring principally during
construction. Settlement analyses based on all the
available data predict far larger embankment
settlements occurring over extended time periods. The
latter analyses predict an embankment settlement
similar to that observed and of sufficient magnitude to
cause the observed lateral displacement of the bridge
due to lateral loading of its piled foundation
Magnetic field independence of the spin gap in YBa_2Cu_3O_{7-delta}
We report, for magnetic fields of 0, 8.8, and 14.8 Tesla, measurements of the
temperature dependent ^{63}Cu NMR spin lattice relaxation rate for near
optimally doped YBa_2Cu_3O_{7-delta}, near and above T_c. In sharp contrast
with previous work we find no magnetic field dependence. We discuss
experimental issues arising in measurements of this required precision, and
implications of the experiment regarding issues including the spin or pseudo
gap.Comment: 4 pages, 3 figures, as accepted for publication in Physical Review
Letter
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