Mortarboard Review: Montessori-Related Dissertations 2022 – 2023

This article is the first in a series of planned reviews to be published annually that highlight a selection of dissertations. Some aspects of the selection and review methodology may be adjusted in coming issues as the process is refined to maximize the value to the field. Twenty-three Montessori-related dissertations completed during 2021 and 2022 were identified that represented five broad categories based on topic or subject matter. Two dissertations were selected for inclusion in this review because they represent high-quality research in areas that are of particular relevance and value to the field at this time: (a) public Montessori education and issues of equity and intercultural competence and (b) teacher perspectives and technology

1 Thessalonians 4.13–18 in Rabbinic Perspective

1 Thessalonians 4.13-18 has occasioned much scholarly speculation regarding Paul’s conception of the resurrected body, the character of those caught up in Christ, the ultimate fate of those who are caught up in the air, and Pauline eschatology in general. The interpretation of the passage may be illuminated by comparison with rabbinic traditions in which the righteous escape judgment and destruction in Sheol by flying and being borne aloft by clouds, traditions that, given Paul’s Jewish heritage, could well stand in the background of 1 Thess 4.13-18

Therapeutic options for lymphangioleiomyomatosis (LAM): where we are and where we are going

Lymphangioleiomyomatosis (LAM), a multisystem disease affecting predominantly premenopausal and middle-aged women, causes progressive respiratory failure due to cystic lung destruction and is associated with lymphatic and kidney tumors. In the past, the treatment of LAM comprised exclusively anti-estrogen and related hormonal therapies. These treatments, however, have not been proven effective. In this article, we discuss new findings regarding the molecular mechanisms involved in the regulation of LAM cell growth, which may offer opportunities to develop effective and targeted therapeutic agents

Mass Loss From Evolved Stars in Elliptical Galaxies

Most of the X-ray emitting gas in early-type galaxies probably originates from red giant mass loss and here we model the interaction between this stellar mass loss and the hot ambient medium. Using two-dimensional hydrodynamic simulations, we adopt a temperature for the ambient medium of 3E6 K along with a range of ambient densities and stellar velocities. When the stellar velocity is supersonic relative to the ambient medium, a bow shock occurs, along with a shock driven into the stellar ejecta, which heats only a fraction of the gas. Behind the bow shock, a cool wake develops but the fast flow of the hot medium causes Kelvin-Helmholtz instabilities to grow and these fingers are shocked and heated (without radiative cooling). Along with the mixing of this wake material with the hot medium, most of the stellar ejecta is heated to approximately the temperature of the hot ambient medium within 2 pc of the star. With the addition of radiative cooling, some wake material remains cool (< 1E5 K), accounting for up to 25% of the stellar mass loss. Less cooled gas survives when the ambient density is lower or when the stellar velocity is higher than in our reference case. These results suggest that some cooled gas should be present in the inner part of early-type galaxies that have a hot ambient medium. These calculations may explain the observed distributed optical emission line gas as well as the presence of dust in early-type galaxies.Comment: 57 pages, which includes 27 figures; ApJ, in press. A version with full-resolution figures can be found at http://www.astro.lsa.umich.edu/~jbregman/public/ms.ps.g

Mortarboard Review

This is the second article in an ongoing series, published annually, highlighting a selection of English-language dissertations from the previous calendar year related to Montessori philosophy and education. Thirteen doctoral dissertations completed and approved during the 2023 calendar year were identified. The authors selected three dissertations to spotlight because they represent high-quality research in an area that is relevant to the current educational landscape: antibias and anti-racist (ABAR) educational practices

MCP-1 overexpressed in tuberous sclerosis lesions acts as a paracrine factor for tumor development

Patients with tuberous sclerosis complex (TSC) develop hamartomatous tumors showing loss of function of the tumor suppressor TSC1 (hamartin) or TSC2 (tuberin) and increased angiogenesis, fibrosis, and abundant mononuclear phagocytes. To identify soluble factors with potential roles in TSC tumorigenesis, we screened TSC skin tumor–derived cells for altered gene and protein expression. Fibroblast-like cells from 10 angiofibromas and five periungual fibromas produced higher levels of monocyte chemoattractant protein-1 (MCP-1) mRNA and protein than did fibroblasts from the same patient's normal skin. Conditioned medium from angiofibroma cells stimulated chemotaxis of a human monocytic cell line to a greater extent than conditioned medium from TSC fibroblasts, an effect blocked by neutralizing MCP-1–specific antibody. Overexpression of MCP-1 seems to be caused by loss of tuberin function because Eker rat embryonic fibroblasts null for Tsc2 (EEF Tsc2 (−/−)) produced 28 times as much MCP-1 protein as did EEF Tsc2 (+/+) cells; transient expression of WT but not mutant human TSC2 by EEF Tsc2 (−/−) cells inhibited MCP-1 production; and pharmacological inhibition of the Rheb-mTOR pathway, which is hyperactivated after loss of TSC2, decreased MCP-1 production by EEF Tsc2 (−/−) cells. Together these findings suggest that MCP-1 is an important paracrine factor for TSC tumorigenesis and may be a new therapeutic target

Osteoprotegerin Contributes to the Metastatic Potential of Cells with a Dysfunctional TSC2 Tumor-Suppressor Gene

In addition to its effects on bone metabolism, osteoprotegerin (OPG), a soluble member of the tumor necrosis factor family of receptors, promotes smooth muscle cell proliferation and migration and may act as a survival factor for tumor cells. We hypothesized that these cellular mechanisms of OPG may be involved in the growth and proliferation of lymphangioleiomyomatosis (LAM) cells, abnormal smooth muscle-like cells with mutations in one of the tuberous sclerosis complex tumor-suppressor genes (TSC1/TSC2) that cause LAM, a multisystem disease characterized by cystic lung destruction, lymphatic infiltration, and abdominal tumors. Herein, we show that OPG stimulated proliferation of cells cultured from explanted LAM lungs, and selectively induced migration of LAM cells identified by the loss of heterozygosity for TSC2. Consistent with these observations, cells with TSC2 loss of heterozygosity expressed the OPG receptors, receptor activator of NF-κB ligand, syndecan-1, and syndecan-2. LAM lung nodules showed reactivities to antibodies to tumor necrosis factor–related apoptosis-inducing ligand, receptor activator of NF-κB ligand, syndecan-1, and syndecan-2. LAM lung nodules also produced OPG, as shown by expression of OPG mRNA and colocalization of reactivities to anti-OPG and anti-gp100 (HMB45) antibodies in LAM lung nodules. Serum OPG was significantly higher in LAM patients than in normal volunteers. Based on these data, it appears that OPG may have tumor-promoting roles in the pathogenesis of lymphangioleiomyomatosis, perhaps acting as both autocrine and paracrine factors

Partial pressure of oxygen in adipose tissue and its relationship with fatness in a natural animal model of extreme fat deposition, the grey seal

Excessive adiposity is associated with altered oxygen tension and comorbidities in humans. In contrast, marine mammals have high adiposity with no apparent detrimental effects. However, partial pressure of oxygen (Po2) in their subcutaneous adipose tissue (blubber) and its relationship with fatness have not been reported. We measured Po2 and temperature at different blubber depths in 12 healthy juvenile grey seals. Fatness was estimated from blubber thickness and morphometric parameters. Simultaneously, we monitored breathing pattern; heart rate and arterial blood saturation with a pulse oximeter; and relative changes in total hemoglobin, deoxyhemoglobin, and oxyhemoglobin in blubber capillaries using near-infrared spectroscopy (NIRS) as proxies for local oxygenation changes. Blubber Po2 ranged from 14.5 to 71.4 mmHg (39.2 ± 14.1 mmHg), which is similar to values reported in other species. Blubber Po2 was strongly and negatively associated with fatness (LME: p &lt; 0.0001, R2marginal = 0.53, R2conditional = 0.64, n = 10), but not with blubber depth. No other parameters explained variability in Po2, suggesting arterial blood and local oxygen delivery did not vary within and between measurements. The fall in blubber Po2 with increased fatness in seals is consistent with other animal models of rapid fat deposition. However, the Po2 levels at which blubber becomes hypoxic and consequences of low blubber Po2 for its health and function, particularly in very fat individuals, remain unknown. How seals avoid detrimental effects of low oxygen tension in adipose tissue, despite their high and fluctuating adiposity, is a fruitful avenue to explore