4 research outputs found
Genetic analysis of over one million people identifies 535 novel loci for blood pressure
High blood pressure is the foremost heritable global risk factor for cardiovascular disease.
We report the largest genetic association study of blood pressure traits to date (systolic,
diastolic, pulse pressure) in over one million people of European ancestry. We identify 535
novel blood pressure loci that not only offer new biological insights into blood pressure
regulation but also reveal shared loci influencing lifestyle exposures. Our findings offer the
potential for a precision medicine strategy for future cardiovascular disease prevention
Genetic analysis of over 1 million people identifies 535 new loci associated with blood pressure traits
High blood pressure is a highly heritable and modifiable risk factor for cardiovascular disease. We report the largest genetic
association study of blood pressure traits (systolic, diastolic and pulse pressure) to date in over 1 million people of European
ancestry. We identify 535 novel blood pressure loci that not only offer new biological insights into blood pressure regulation but
also highlight shared genetic architecture between blood pressure and lifestyle exposures. Our findings identify new biological
pathways for blood pressure regulation with potential for improved cardiovascular disease prevention in the future
Erratum to: Genetic analysis of over 1 million people identifies 535 new loci associated with blood pressure traits
In the version of this article originally published, the name of author Martin H. de Borst was coded incorrectly in the XML.
The error has now been corrected in the HTML version of the paper