Evaluation of the results of arthroscopic repair of rotator cuff tears

Rotatorenmanschettenruprturen gehören zu den häufigsten Beschwerdebildern der Schulter. Seit kurzem werden nun arthroskopische Rekonstruktionsmethoden angewandt, die viel versprechende Ergebnisse zeigen. Ziel dieser Studie war die Ergebnisse der arthroskopischen Rotatorenmanschettenrekonstruktion zu bewerten und ihre Einflußfaktoren zu ermitteln. Die Studiengruppe besteht aus 40 Patienten( 19m, 21f) zwischen 37-78Jr. ( Median 61,15 Jr.). Spezielle Ein- und Ausschlusskriterien wurden angewandt. Die Symptome bestanden im Median seit 0,83Jr. ( 0,25-5Jr.). Arthoskopische Rotatorenmanschettenrekonstruktion wurde mittels Knochenankertechnik in Kombination mit einer subacromialen Dekompression durchgeführt. Arthroskopische Rekonstruktionen haben somit ein gutes Ergebnis und ermöglichen die Rekonstruktion der Rotatorenmanschette ähnlich der offenen Operationstechniken mit Vermeidung deren Komplikationen

Arabic open information extraction system using dependency parsing

Arabic is a Semitic language and one of the most natural languages distinguished by the richness in morphological enunciation and derivation. This special and complex nature makes extracting information from the Arabic language difficult and always needs improvement. Open information extraction systems (OIE) have been emerged and used in different languages, especially in English. However, it has almost not been used for the Arabic language. Accordingly, this paper aims to introduce an OIE system that extracts the relation tuple from Arabic web text, exploiting Arabic dependency parsing and thinking carefully about all possible text relations. Based on clause types' propositions as extractable relations and constituents' grammatical functions, the identities of corresponding clause types are established. The proposed system named Arabic open information extraction(AOIE) can extract highly scalable Arabic text relations while being domain independent. Implementing the proposed system handles the problem using supervised strategies while the system relies on unsupervised extraction strategies. Also, the system has been implemented in several domains to avoid information extraction in a specific field. The results prove that the system achieves high efficiency in extracting clauses from large amounts of text

Some Chemical Aspects of Tetrahydro-1-thiopyran-4-one Derivatives

3,5-Diarylmethylene-2,6-diphenyltetrahydrothiopyran-4-thiones, 2, reacted with two or four moles of bromine to form 3-aryimethylene 5-bromoarylmethylene- 2,6-dipheny1tetrahydrothiopyran- -4-thione, 3, and 3-arylmethylene-5-bromoarylmethylene-2,6-dibromo- 2,6-diphenyltetrahydrothiopyran-4-thione, 5, respectively. Compound 2a reacted with amines giving 2,6-diphenyl-5-iminophenylmethyl- 3-phenylmethylenetetrahydrothiopyran-4-thiones, 6. Diphenydiazomethane and 9-diazofluorene converted 2a into 4-diphenylethylene- 2,6-dipheny1-3,5 diphenylmethylenetetrahydrothiopyran, 7, and 2,6-diphenyl-3,5-diphenylmethylene-4-(9-fluorenylidene) tetrahydrothiopyran, 8, respectively. Compounds 2 with copper-bronze afforded 3,3\u27,5,5\u27-tetraarylmethylene-2,2\u27 ,6,6\u27-tetraphenyl-Lr-thio- 4,4\u27 dipyranylidenes

The correlation between increasing Body Mass Index and the incidence of local recurrence and distant metastasis in breast cancer patients

OBJECTIVE: Patients with breast cancer (BC) who are obese or overweight at the time of diagnosis have a low survival rate and a high death rate. We aimed to investigate if having a higher body mass index (BMI) at diagnosis raised the risk of local recurrence (LR) and distant metastasis. PATIENTS AND METHODS: Patients were divided into three categories based on their BMI. The patient's BMI was determined by dividing his weight in kilograms by his height in square meters (kg/m2). The WHO defines normal weight as 18.5 ≤ BMI < 25 kg/m2, overweight as 25 ≤ BMI < 30 kg/m2, and obesity as BMI ≥ 30 kg/m2. RESULTS: The mean BMI was 30.27±6.06 kg/m2. Out of 250 patients, 60 (24.0%), 73 (29.2%) and 117 (46.8%) patients had normal, overweight and obese BMI respectively. No significant difference between BMI and estrogen receptor (ER), progesterone receptor (PR), and human epidermal growth factor receptor (HER2) was found, but there was an association between tumor (T) stage and lymph vascular invasion (LVI) (p<0.05). Obese patients had poorer disease-free survival (DFS) and overall survival (OS) than normal and overweight categories (35.38 ±1.72 vs. 42.38 ± 2.79 and 37.82 ± 2.27 months) (39.65±1.65 vs.45.70 ± 2.53 and 44.31 ± 2.04 months) (p<0.001). LR occurs more prevalent in over-weight and obese patients than normal (p<0.03) but there is no significant difference for distant metastasis. CONCLUSIONS: There is a strong negative association between increased BMI and BC prognosis and patient survival; controlling of this phenomenon may improve the response to treatment and survival, therefore health awareness programs should be implemented

Practical Needs in Assessing Response to Therapy in Operated Brain High Grade Glioma According to Response Assessment in Neuro-Oncology Criteria

Background: Tumors known as gliomas begin in the brain or spine's glial cells and might spread throughout the body.&nbsp; An effort was made to improve tumor response evaluation and end point selection through the Response Assessment in Neuro-Oncology (RANO) working group. Objective: To standardize the assessment method and results reporting by applying MRI-RANO criteria in detecting glioma response to surgical treatment. Patients and Methods: This was a prospective cohort study included 12 patients (4 males and 8 females) whose mean age was 53.6 ± 15.1years. Included patients are those who were operated and pathologically proved as brain glioma grade IV (GBM). They underwent post-operative MRI within 48 hours and are available for follow up MRI after 3 months. Imaging modalities applied in both MRI exams were conventional magnetic resonance imaging, MRI diffusion weighted images, and contrast imaging. RANO criteria were applied. Results: According to RANO criteria, none of the lesions had pseudo response or pseudo progression. However, two thirds (66.7%) had progressive disease and one third (33.3%) had complete response. There was statistically significant association between MRI findings 3 months postoperative and RANO criteria as patients with compete response had statistically significant decrease on measurable solid components, diffusion restriction, post contrast enhancement and all lesions had grade I edema with no mass effect or midline shift compared to patients with progressive disease. 4 cases that showed complete response category had fulfilled all the RANO criteria, while 8 cases with category progressive disease had fulfilled more than one of the described RANO criteria. Conclusion: RANO criteria are an effective tool to be used in interpretation of MRI for follow-up of surgically operated glioma patients to detect their response

Dynamic Modeling of Inland Flooding and Storm Surge on Coastal Cities Under Climate Change Scenarios: Transportation Infrastructure Impacts in Norfolk, Virginia USA as a Case Study

Low-lying coastal cities across the world are vulnerable to the combined impact of rainfall and storm tide. However, existing approaches lack the ability to model the combined effect of these flood mechanisms, especially under climate change and sea level rise (SLR). Thus, to increase flood resilience of coastal cities, modeling techniques to improve the understanding and prediction of the combined effect of these flood hazards are critical. To address this need, this study presents a modeling system for assessing the combined flood impact on coastal cities under selected future climate scenarios that leverages ocean modeling with land surface modeling capable of resolving urban drainage infrastructure within the city. The modeling approach is demonstrated in quantifying the impact of possible future climate scenarios on transportation infrastructure within Norfolk, Virginia, USA. A series of combined storm events are modeled for current (2020) and projected future (2070) climate scenarios. The results show that pluvial flooding causes a larger interruption to the transportation network compared to tidal flooding under current climate conditions. By 2070, however, tidal flooding will be the dominant flooding mechanism with even nuisance flooding expected to happen daily due to SLR. In 2070, nuisance flooding is expected to cause a 4.6% total link close time (TLC), which is more than two times that of a 50-year storm surge (1.8% TLC) in 2020. The coupled flood model was compared with a widely used but physically simplistic bathtub method to assess the difference resulting from the more complex modeling presented in this study. The results show that the bathtub method overestimated the flooded area near the shoreline by 9.5% and 3.1% for a 10-year storm surge event in 2020 and 2070, respectively, but underestimated the flooded area in the inland region by 9.0% and 4.0% for the same events. The findings demonstrate the benefit of sophisticated modeling methods compared to more simplistic bathtub approaches, in climate adaptive planning and policy in coastal communities

Amenability of heap leaching technology on uranium extraction from Gattar and El Missikat area, Eastern Desert, Egypt: A kinetic approach

Studies of uranium heap leaching from different uranium mineralization situated in Eastern Desert of Egypt was investigated via batch experiments, followed by its optimum condition applicationon column percolationtests.The optimum process operating parameters were implemented on large column scale in order to make more condition control and evaluate the time and reagents needed in the large scale. The results show thatleaching efficiency of GIIattained about 78.3% with 34kg/ton acid consumption in a 44 days period, while leaching efficiency of El-Missikat attained about 86.6% with 28kg/ton acid consumption in a 40 days period.Kinetics reaction models of column tests have been investigated to optimize the column leaching behavior. Based on the leaching results of two mineralized samples, the rate of the uranium metal dissolution is controlled by the chemical reaction and the diffusion reaction but diffusion reaction control was more predominate than a chemical reaction control

Design of a Metadata Framework for the Environmental Models with an Example Hydrologic Application in HydroShare

Environmental modelers rely on a variety of computational models to make predictions, test hypotheses, and address specific problems related to environmental science and natural resource management. Scientists and engineers must devote significant effort to preparing these computational models. While significant attention has been devoted to sharing and reusing environmental data, less attention has been devoted to sharing and reusing environmental models. A first step toward increasing environmental model sharing and reuse is to define a general metadata framework for models that is flexible and, therefore, applicable across the wide variety of models used by environmental modelers. This paper proposes a general approach for representing environmental model metadata that extends the Dublin Core metadata framework. The framework is implemented within the HydroShare system and applied for a hydrologic model sharing use case. This example application demonstrates how the metadata framework implemented within HydroShare can assist in model sharing, publication, reuse, and reproducibility

New Paracyclophanylthiazoles with Anti-Leukemia Activity: Design, Synthesis, Molecular Docking, and Mechanistic Studies

A new series of methyl 2-(2-(4′-[2.2]paracyclophanyl)-hydrazinylidene)-3-substituted-4-oxothiazolidin-5-ylidene)acetates 3a–f were synthesized from the reaction of paracyclophanyl-acylthiosemicarbazides 2a–f with dimethyl acetylenedicarboxylate. Based upon nuclear magnetic resonance (NMR), infrared (IR), and mass spectra (HRMS), the structure of the obtained products was elucidated. X-ray structure analysis was also used as unambiguous tool to elucidate the structure of the products. The target compounds 3a–f were screened against 60 cancer cell lines. They displayed anticancer activity against a leukemia subpanel, namely, RPMI-8226 and SR cell lines. The activity of compound 3a was found as the most cytotoxic potency against 60 cancer cell lines. Consequently, it was selected for further five doses analysis according to National Cancer Institute (NCI) protocol. The cytotoxic effect showed selectivity ratios ranging between 0.63 and 1.28 and between 0.58 and 5.89 at the GI50 and total growth inhibition (TGI) levels, respectively. Accordingly, compound 3a underwent further mechanistic study against the most sensitive leukemia RPMI-8226 and SR cell lines. It showed antiproliferation with IC50 = 1.61 ± 0.04 and 1.11 ± 0.03 µM against RPMI-8226 and SR cell lines, respectively. It also revealed a remarkable tubulin inhibitory activity, compared to colchicine with IC50 = 4.97 µM/mL. Caspase-3, BAX, and Bcl-2 assays for 3a using annexin V-FITC staining revealed significant pro-apoptotic activity. Furthermore, multidrug-resistant leukemia SR cells were used to show better resistance indices (1.285 ng/mL, 1.15-fold) than the reference. Docking studies with β-tubulin indicate that most of the tested compounds illustrated good binding at the colchicine binding site of the enzyme, especially for compound 3a, which made several interactions better than that of the reference colchicine