652 research outputs found
Behaviour of the Blazar CTA 102 during two giant outbursts
Blazar CTA 102 underwent exceptional optical and high-energy outbursts in 2012 and 2016-2017. We analyze its behaviour during these events, focusing on polarimetry as a tool that allows us to trace changes in the physical conditions and geometric configuration of the emission source close to the central black hole. We also use Fermi gamma-ray data in conjunction with optical photometry in an effort to localize the origin of the outbursts.AST-1615796 - Boston Universit
ERGR: An ethanol-related gene resource
Over the last decade rapid progress has been made in the study of ethanol-related traits including alcohol abuse and dependence, and behavioral responses to ethanol in both humans and animal models. To collect, curate, integrate these results so as to make them easily accessible and interpretable for researchers, we developed ERGR, a comprehensive ethanol-related gene resource. We collected and curated more than 30 large-scale data sets including linkage, association and microarray gene expression from the literature and 21 mouse QTLs from public databases. At present, the ERGR deposits ethanol-related information of ∼7000 genes from five organisms: human (3311), mouse (2129), rat (679), fly (614) and worm (228). ERGR provides gene annotations and orthologs, detailed gene study information (e.g. fold changes of gene expression, P-values), and both the text and BLAST searches. Moreover, ERGR has data integration tools such as for data union and intersection, and candidate gene selection based on evidence in multiple datasets or organisms. The ERGR database is evolving with new data releases. More functions will also be added. ERGR has a user-friendly web interface with browse and search functions at multiple levels. It is freely available at http://bioinfo.vipbg.vcu.edu/ERGR/
Isolation of two strains of West Nile virus during an outbreak in southern Russia, 1999.
From July to September 1999, a widespread outbreak of meningoencephalitis associated with West Nile virus (Flavivirus, Flaviviridae) occurred in southern Russia, with hundreds of cases and dozens of deaths. Two strains of West Nile virus isolated from patient serum and brain-tissue samples reacted in hemagglutination-inhibition and neutralization tests with patients' convalescent-phase sera and immune ascites fluid from other strains of West Nile virus
Bures volume of the set of mixed quantum states
We compute the volume of the N^2-1 dimensional set M_N of density matrices of
size N with respect to the Bures measure and show that it is equal to that of a
N^2-1 dimensional hyper-halfsphere of radius 1/2. For N=2 we obtain the volume
of the Uhlmann 3-D hemisphere, embedded in R^4. We find also the area of the
boundary of the set M_N and obtain analogous results for the smaller set of all
real density matrices. An explicit formula for the Bures-Hall normalization
constants is derived for an arbitrary N.Comment: 15 revtex pages, 2 figures in .eps; ver. 3, Eq. (4.19) correcte
Исследование кросс-реактивности терапевтических препаратов на основе моноклональных антител на тканях человека: основные подходы и методические приемы
Tissue cross-reactivity (TCR) studies are screening immunohistochemical (IHC) assays, usually conducted on frozen human and animal tissues. This study is obligatory for getting the permission for clinical trials in Russia for all innovative therapeutic products based on monoclonal antibodies or antibody-like molecules that contain complementarity-determining region (CDR). In this article are represented approaches and methodical features for successful conduction of tissue cross-reactivity studies with examples from own authors’ experience.Исследование тканевой перекрестной реактивности (кросс-реактивности, TCR, Tissue cross-reactivity) представляет собой скрининговое иммуногистохимическое исследование, которое обычно проводят на замороженных тканях человека и животных. Данное исследование обязательно для получения разрешения на клинические исследования в Российской Федерации любого инновационного терапевтического препарата на основе моноклональных антител или антителоподобных молекул, содержащих участок, определяющий комплементарность (complementarity-determining region, CDR). В данной статье представлены подходы для изучения и методические приемы для успешного проведения исследования тканевой перекрестной реактивности с примерами из собственного опыта авторов
Another look at the BL Lacertae flux and spectral variability
The GLAST-AGILE Support Program (GASP) of the Whole Earth Blazar Telescope
(WEBT) monitored BL Lacertae in 2008-2009 at radio, near-IR, and optical
frequencies. During this period, high-energy observations were performed by
XMM-Newton, Swift, and Fermi. We analyse these data with particular attention
to the calibration of Swift UV data, and apply a helical jet model to interpret
the source broad-band variability. The GASP-WEBT observations show an optical
flare in 2008 February-March, and oscillations of several tenths of mag on a
few-day time scale afterwards. The radio flux is only mildly variable. The UV
data from both XMM-Newton and Swift seem to confirm a UV excess that is likely
caused by thermal emission from the accretion disc. The X-ray data from
XMM-Newton indicate a strongly concave spectrum, as well as moderate flux
variability on an hour time scale. The Swift X-ray data reveal fast (interday)
flux changes, not correlated with those observed at lower energies. We compare
the spectral energy distribution (SED) corresponding to the 2008 low-brightness
state, which was characterised by a synchrotron dominance, to the 1997 outburst
state, where the inverse-Compton emission was prevailing. A fit with an
inhomogeneous helical jet model suggests that two synchrotron components are at
work with their self inverse-Compton emission. Most likely, they represent the
radiation from two distinct emitting regions in the jet. We show that the
difference between the source SEDs in 2008 and 1997 can be explained in terms
of pure geometrical variations. The outburst state occurred when the
jet-emitting regions were better aligned with the line of sight, producing an
increase of the Doppler beaming factor. Our analysis demonstrates that the jet
geometry can play an extremely important role in the BL Lacertae flux and
spectral variability.Comment: 12 pages, 10 figures, accepted for publication in A&
The structure and emission model of the relativistic jet in the quasar 3C 279 inferred from radio to high-energy gamma-ray observations in 2008-2010
We present time-resolved broad-band observations of the quasar 3C 279
obtained from multi-wavelength campaigns conducted during the first two years
of the Fermi Gamma-ray Space Telescope mission. While investigating the
previously reported gamma-ray/optical flare accompanied by a change in optical
polarization, we found that the optical emission appears delayed with respect
to the gamma-ray emission by about 10 days. X-ray observations reveal a pair of
`isolated' flares separated by ~90 days, with only weak gamma-ray/optical
counterparts. The spectral structure measured by Spitzer reveals a synchrotron
component peaking in the mid-infrared band with a sharp break at the
far-infrared band during the gamma-ray flare, while the peak appears in the
mm/sub-mm band in the low state. Selected spectral energy distributions are
fitted with leptonic models including Comptonization of external radiation
produced in a dusty torus or the broad-line region. Adopting the interpretation
of the polarization swing involving propagation of the emitting region along a
curved trajectory, we can explain the evolution of the broad-band spectra
during the gamma-ray flaring event by a shift of its location from ~ 1 pc to ~
4 pc from the central black hole. On the other hand, if the gamma-ray flare is
generated instead at sub-pc distance from the central black hole, the
far-infrared break can be explained by synchrotron self-absorption. We also
model the low spectral state, dominated by the mm/sub-mm peaking synchrotron
component, and suggest that the corresponding inverse-Compton component
explains the steady X-ray emission.Comment: 23 pages, 18 figures 5 tables, Accepted for publication in The
Astrophysical Journa
The brightest gamma-ray flaring blazar in the sky: AGILE and multi-wavelength observations of 3C 454.3 during November 2010
Since 2005, the blazar 3C 454.3 has shown remarkable flaring activity at all
frequencies, and during the last four years it has exhibited more than one
gamma-ray flare per year, becoming the most active gamma-ray blazar in the sky.
We present for the first time the multi-wavelength AGILE, SWIFT, INTEGRAL, and
GASP-WEBT data collected in order to explain the extraordinary gamma-ray flare
of 3C 454.3 which occurred in November 2010. On 2010 November 20 (MJD 55520),
3C 454.3 reached a peak flux (E>100 MeV) of F_gamma(p) = (6.8+-1.0)E-5 ph/cm2/s
on a time scale of about 12 hours, more than a factor of 6 higher than the flux
of the brightest steady gamma-ray source, the Vela pulsar, and more than a
factor of 3 brighter than its previous super-flare on 2009 December 2-3. The
multi-wavelength data make a thorough study of the present event possible: the
comparison with the previous outbursts indicates a close similarity to the one
that occurred in 2009. By comparing the broadband emission before, during, and
after the gamma-ray flare, we find that the radio, optical and X-ray emission
varies within a factor 2-3, whereas the gamma-ray flux by a factor of 10. This
remarkable behavior is modeled by an external Compton component driven by a
substantial local enhancement of soft seed photons.Comment: Accepted for publication in ApJ Letters. 18 Pages, 4 Figures, 1 Tabl
Electromagnetic Fields of Slowly Rotating Compact Magnetized Stars in Braneworld
We study the structure of electromagnetic field of slowly rotating magnetized
star in a Randall-Sundrum II type braneworld. The star is modeled as a sphere
consisting of perfect highly magnetized fluid with infinite conductivity and
frozen-in dipolar magnetic field. Maxwell's equations for the external magnetic
field of the star in the braneworld are analytically solved in approximation of
small distance from the surface of the star. We have also found numerical
solution for the electric field outside the rotating magnetized neutron star in
the braneworld in dependence on brane tension. The influence of brane tension
on the electromagnetic energy losses of the rotating magnetized star is
underlined. Obtained "brane" corrections are shown to be relevant and have
non-negligible values. In comparison with astrophysical observations on pulsars
spindown data they may provide an evidence for the brane tension and, thus,
serve as a test for the braneworld model of the Universe.Comment: 11 pages, 5 figure
Long-term multi-wavelength variability and correlation study of Markarian 421 from 2007 to 2009
We study the multi-band variability and correlations of the TeV blazar Mrk
421 on year time scales, which can bring additional insight on the processes
responsible for its broadband emission. We observed Mrk 421 in the very high
energy (VHE) gamma-ray range with the Cherenkov telescope MAGIC-I from March
2007 to June 2009 for a total of 96 hours of effective time after quality cuts.
The VHE flux variability is quantified with several methods, including the
Bayesian Block algorithm, which is applied to data from Cherenkov telescopes
for the first time. The 2.3 year long MAGIC light curve is complemented with
data from the Swift/BAT and RXTE/ASM satellites and the KVA, GASP-WEBT, OVRO,
and Mets\"ahovi telescopes from February 2007 to July 2009, allowing for an
excellent characterisation of the multi-band variability and correlations over
year time scales. Mrk 421 was found in different gamma-ray emission states
during the 2.3 year long observation period. Flares and different levels of
variability in the gamma-ray light curve could be identified with the Bayesian
Block algorithm. The same behaviour of a quiet and active emission was found in
the X-ray light curves measured by Swift/BAT and the RXTE/ASM, with a direct
correlation in time. The behaviour of the optical light curve of GASP-WEBT and
the radio light curves by OVRO and Mets\"ahovi are different as they show no
coincident features with the higher energetic light curves and a less variable
emission. The fractional variability is overall increasing with energy. The
comparable variability in the X-ray and VHE bands and their direct correlation
during both high- and low-activity periods spanning many months show that the
electron populations radiating the X-ray and gamma-ray photons are either the
same, as expected in the Synchrotron-Self-Compton mechanism, or at least
strongly correlated, as expected in electromagnetic cascades.Comment: Corresponding authors: Ann-Kristin Overkemping
([email protected]), Marina Manganaro
([email protected]), Diego Tescaro ([email protected]), To be published
in Astronomy&Astrophysics (A&A), 12 pages, 9 figure
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