Factors associated with the intention to participate in COVID-19 vaccine clinical trials: A cross-sectional study in Peru

Objective: To evaluate the factors associated with the intention to participate in COVID-19 vaccine clinical trials in the Peruvian population. Methods: Cross-sectional study and secondary analysis of a database that involved Peruvian population during September 2020. The Poisson regression model was used to estimate the associated factors. Results: Data from 3231 individuals were analyzed, 44.1% of whom intended to participate in COVID-19 vaccine clinical trials. Factors associated with the outcome were being male (RPa: 1.25; 95% CI: 1.15–1.35), being from the highlands region (RPa: 1.18; 95% CI: 1.09–1.28) or jungle (RPa: 1.30; 95% CI: 1.15–1.47), having a relative that is a healthcare professional (PRa: 1.16; 95% CI: 1.06–1.28), using a medical source of information (PRa: 1.28; 95% CI: 1.17–1.41), and trusting in the possible effectiveness of vaccines (PRa: 1.40; 95% CI: 1.29–1.51). The main reason for not participating in the trial was the possibility of developing side effects (69.80%). Conclusion: There is an urgent need to generate a perception of safety in COVID-19 vaccine clinical trials, to increase the population's intention to participate in these studies, and to provide evidence-based information about the vaccine.Revisión por pare

Echoes of the pandemic: Contrasting COVID-19 outbreaks in northern Peru

Peru reported the second-highest COVID-19 cases in Latin America, after Brazil. The first COVID-19 wave occurred between March– December 2020, and the second occurred between January–September 2021. The differences between these waves remain largely unknown, and there is no comparison between them in Peru. We evaluated the variation in the clinical and epidemiological components of COVID-19-affected patients in both waves in northern Peru by a retrospective study using the clinical follow-up database of Lambayeque and the epidemiological notification form database of NotiWeb. The COVID-19-associated factors during the two waves were determined using simple and multiple regression analysis, and the prevalence ratio (PR) was estimated. During the second wave of COVID-19, there was an increase in cough symptoms in 12.1%, odynophagia in 5.0%, and chills in 16.0% compared with the first wave. The second wave was marked by a higher proportion of affected adolescents and children and a greater percentage of respiratory symptoms than the first wave. © Failoc-Rojas VE et al. This is an open access article distributed under the terms of the Creative Commons Attribution License (CC-BY 4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.Revisión por pare

Percepciones e intención de los padres de vacunar a sus hijos menores de 12 años contra la COVID-19: Estudio transversal en Perú

Objectives: To evaluate the perceptions and intention of parents to vaccinate their children under 12 years of age. Methodology: Analytical cross-sectional study based on an online survey that collected the parents’ perception on the risk of their children getting COVID-19, on the need of vaccination and on the development of adverse events related to the vaccine. We evaluated the factors associated with the intention to vaccinate through crude (cPR) and adjusted prevalence rates (aPR), with confidence interval of 95% (CI 95%) Results: 83.5% of respondents had the intention of vaccinating their children under 12 years of age. In the multivariate analysis, the factors associated with an decrease in the intention to vaccinate were to think that the vaccine is not necessary (aPR 0.65; 95% CI 0.44 – 0.94), that it would not protect (aPR: 0.14; 95% CI 0.03 – 0.63) , that it would not be safe (aPR: 0.80; 95% CI 0.70 – 0.92) and that it would cause long-term side effects (aPR: 0.92; 95% CI 0.85 – 1.00). On the other hand, living on the highlands or jungle was associated with an increase on the intention. Conclusions: In Peru, 16.5% of parents would not vaccinate their children under 12 years of age, because they perceive that the vaccine is not necessary and would not protect against COVID-19. In addition, they expressed concerns about the development of possible adverse events.Objetivos: Evaluar las percepciones e intención de los padres de vacunar a sus hijos menores de 12 años en Perú. Metodología: Estudio transversal analítico a partir de una encuesta en línea (25 de noviembre al 6 de diciembre del 2021) para padres de niños menores de 12 años que recopiló la percepción sobre el riesgo de contagio por COVID-19 en sus hijos, sobre la necesidad de vacunación y sobre los eventos adversos relacionados con la vacuna. Evaluamos los factores asociados a la intención de vacunación mediante razones de prevalencia crudas (RPc) y ajustadas (RPa) con intervalos de confianza al 95% (IC 95%). Resultados: El 83.5% de los padres tenían la intención de vacunar a sus hijos menores de 12 años. En el análisis multivariado, los factores asociados a una disminución de la intención de vacunación fueron pensar que la vacuna no es necesaria (RPa: 0.65; IC 95% 0.44 – 0,94), que no protegería (RPa: 0.14; IC 95% 0.03 – 0.63), que no sería segura (RPa: 0.80; IC 95% 0.70 – 0.92) y que ocasionaría efectos negativos a largo plazo (RPa: 0.92; IC 95% 0.85 – 1.00). Por otro lado, residir en la Selva (RPa: 1.09; IC 95%: 1.03 – 1.15) o en la Sierra (RPa: 1.06; IC 95%: 1.00 – 1.11) se asoció a una mayor prevalencia de intención. Conclusiones: En Perú, un 16.5% de padres no vacunaría a sus hijos menores de 12 años, ya que perciben que la vacuna no es necesaria y no protegería contra la COVID-19, además de tener la preocupación de posibles eventos adversos

Association of vision impairment and blindness with socioeconomic status in adults 50 years and older from Alto Amazonas, Peru.

OBJECTIVE: To determine the relationship between socioeconomic status (SES) and visual impairment (VI) or blindness in the rural Peruvian Amazon, hypothesizing that higher SES would have a protective effect on the odds of VI or blindness. METHODS: In this cross-sectional study of 16 rural communities in the Peruvian Amazon, consenting adults aged ≥ 50 years were recruited from ~30 randomly selected households per village. Each household was administered a questionnaire and had a SES score constructed using principal components analysis. Blindness and VI were determined using a ministry of health 3-meter visual acuity card. RESULTS: Overall, 207 adults aged ≥ 50 were eligible; 146 (70.5%) completed visual acuity screening and answered the questionnaire. Of those 146 participants who completed presenting visual acuity screening, 57 (39.0%, 95% CI 30.2-47.1) were classified as visually impaired and 6 (4.1%, 95% CI 0.9-7.3) as blind. Belonging to the highest SES tercile had a protective effect on VI or blindness (OR 0.29, 95% CI 0.09 to 0.91, p = 0.034), with a linear trend across decreasing levels of SES (p = 0.019). This observed effect remained significant regardless of how SES groups were assigned. CONCLUSION: Belonging to a higher SES group resulted in a lower odds of VI or blindness compared to those in the lowest SES group. The observation of a dose response provides confidence in the observed association, but causality remains unclear. Blindness prevention programs could maximize impact by designing activities that specifically target people with lower SES

Self-medication in hospitalized patients with COVID-19: A cross-sectional study in northern Peru

Introduction This study aimed to identify factors associated with self-medication in patients with COVID-19. Methods A cross-sectional study was conducted using medical records of patients with COVID-19 who self-medicated before admission to a hospital in Piura, Peru. Prevalence ratios and 95% confidence intervals were estimated using generalized linear models with Poisson distribution family, log link function, and robust variance. Results Out of 301 patients, 165 (54.8%) self-medicated before hospital admission, being more frequent self-medication with ivermectin (85.5%) and azithromycin (71.5%). The frequency of self-medication in those aged between 30-59 years was 2.53-fold higher than in those between 18-29 years. Male patients, dyslipidemia, smoking, and hepatic steatosis were associated with self-medication. Clinical characteristics associated with self-medication were fever, cough, headache, anosmia, dysgeusia, nausea/vomiting, and gastroesophageal reflux. Conclusions A high frequency of self-medication before hospital admission was observed in Peruvian patients with COVID-19, mainly of drugs without proven efficacy

Asociación entre tipo de terapia y erradicación de Helicobacter pylori en pacientes del Hospital Cayetano Heredia, Piura, Perú

Introducción: Estudios recientes han identificado reducción de eficacia de terapia triple para la erradicación del H. pylori. En Perú, no existe suficiente evidencia sobre la eficacia de este tipo de terapia. El objetivo fue identificar la asociación entre tipo de terapia y erradicación de H. pylori. Materiales y métodos: Estudio retrospectivo analítico en un hospital privado de Piura, Perú 2017. Se recolectó información de historias clínicas de pacientes con biopsia positiva para H. pylori. Se evaluó la asociación entre tipo de terapia recibida (triple estándar, MOCA y BOTF) y la erradicación de infección por H. pylori. También, se exploró la presencia de comorbilidad, diagnóstico endoscópico antes y después de la terapia recibida,presencia de metaplasia y displasia. Se utilizó la prueba exacta de Fisher y un nivel de significancia al 5 %. Resultados: De 80 pacientes, la mayoría era mujer (65 %) y la media de edad fue 52,4 años. El 76,3 % recibió terapia triple estándar y la mayoría obtuvo erradicación de H. pylori (75 %). Se observa que los pacientes que recibieron terapia triple tenían 62 % y 17,7 % mayor frecuencia de erradicación de H. pylori, en comparación con quienes recibieron terapia BOTF y MOCA, respectivamente (82 % vs 20 % vs 64,3 %). Se observó asociación entre presencia de metaplasia y erradicación de H. pylori (89,3 % vs. 67,3 %). Conclusión: La mayoría de los pacientes erradicaron el H. pylori, particularmente con el uso de terapia triple estándar. El tipo de terapia implementada y la presencia de metaplasia resultaron asociados a la erradicación de la bacteria

Asociación entre tipo de terapia y erradicación de Helicobacter pylori en pacientes del Hospital Cayetano Heredia, Piura, Perú

Estudios recientes han identificado reducción de eficacia de terapia triple para la erradicación del H. pylori. En Perú, no existe suficiente evidencia sobre la eficacia de este tipo de terapia. El objetivo fue identificar la asociación entre tipo de terapia y erradicación de H. pylori.Recent studies have identified a reduction in the effectiveness of triple therapy for H. pylori eradication. In Peru, there is not enough evidence on the efficacy of this type of therapy. The objective was to identify the association between the type of therapy and the eradication of H. pylori

Prevalence and Factors Associated with Anxiety and Depression in Peruvian Medical Students

During medical training, students are exposed to stressors that deteriorate mental health. This study determined depression and anxiety prevalence and their associated factors in students from four medical schools in northern Peru. A cross-sectional study was conducted among medical students from Lambayeque, Peru. The Goldberg Anxiety and Zung Depression tests were applied. The dependent variables were depression and anxiety, and their association with covariates (age, sex, type of university, socioeconomic level, experience, family problem, and physical activity) was evaluated. Prevalence ratios were calculated using generalized linear models. Of 482 students, the prevalence of anxiety was 61.8% and depression was 22.0%. A severe level of anxiety was observed in 6.2% in the group between 16 and 20 years old. It was observed that private university students had higher frequencies of having depression (PR = 2.01) and anxiety (PR = 1.35); males had a lower risk of anxiety (PR = 0.82), but higher risk of depression compared to females (PR = 1.45). Performing physical activity decreased the prevalence of depression (PR = 0.53); however, it increased the frequency of anxiety (PR = 1.26). Having family problems increased the prevalence of anxiety (PR = 1.26). Medical students from private universities experienced higher rates of depression and anxiety. Depression and anxiety were associated with gender and physical activity. These findings highlight the importance of mental health promotion due to its link with quality of life and academic performance

Factors Associated with Drug Consumption Without Scientific Evidence in Patients with Mild COVID-19 in Peru

Objective This study aimed to evaluate the factors associated with the consumption of drugs without scientific evidence in patients with mild COVID-19 infection in Peru. Methods An analytical cross-sectional study was carried out including 372 adult patients with a history of mild COVID-19 disease. Factors associated with drug consumption were evaluated by Poisson regressions with robust variance adjustment using the bootstrapping resampling method. Results Seventy-two percent consumed some medication without scientific evidence, with antibiotics (71%) and ivermectin for human use (68%) being the most commonly used. Factors associated with the consumption of drugs to treat mild COVID-19 infection were thinking that the drugs are not effective (adjusted prevalence ratio, 0.55; 95% confidence interval, 0.41-0.74) and not being informed about the efficacy of the drugs (adjusted prevalence ratio, 0.48; 95% confidence interval, 0.36-0.65). Conclusions Education of the population seems to be the main factor that increases the consumption of drugs without scientific evidence in the Peruvian population to treat mild COVID-19.Revisión por pare