Towards e-health literacy on depression for adolescents: Information sought versus information gained

Half of all mental health disorders start occurring by the age of 14, with depression being the fourth most common disorder among adolescents worldwide. The prevalence of depression among German adolescents has nearly doubled in recent years. When it comes to mental health information sources, the internet has become a common medium for adolescents. Hence, to raise awareness of depression among this group, their specific expectations for online information and services must be met. Due to a lack of mixed-methods studies, this study therefore compares adolescents' expectations of online information and support services about depression (Study I), and information provided on the internet (Study II). Based on a literature review, qualitative interviews with adolescents were conducted (N=34). Moreover, the multi-platform online communication of nine German non-profit organizations (NPOs) that aim to improve information and care for people suffering from depression was analyzed using quantitative content analysis (N=1,435). Comparing the information gained from both studies, results indicate that expectations for fact-based communication were met by the NPOs frequently providing information on depression and requested experience reports were often communicated. However, discrepancies are apparent in the use of communication channels and videos, and the particular importance of personalization is evident

A non-diploid DNA status is linked to poor prognosis in renal cell cancer

Purpose!#!DNA ploidy measurement has earlier been suggested as a potentially powerful prognostic tool in many cancer types, but the role in renal tumors is still unclear.!##!Methods!#!To clarify its prognostic impact, we analyzed the DNA content of 1320 kidney tumors, including clear cell, papillary and chromophobe renal cell carcinoma (RCC) as well as renal oncocytoma and compared these data with clinico-pathological parameters and patient prognosis.!##!Results!#!A non-diploid DNA content was seen in 37% of 1276 analyzable renal tumors with a striking predominance in chromophobe carcinoma (74.3% of 70 cases). In clear cell carcinoma, a non-diploid DNA content was significantly linked to high-grade (ISUP, Fuhrman, Thoenes; p < 0.0001 each), advanced tumor stage (p = 0.0011), distant metastasis (p < 0.0001), shortened overall survival (p = 0.0010), and earlier recurrence (p < 0.0001). In papillary carcinoma, an aberrant DNA content was significantly linked to high Fuhrman grade (p = 0.0063), distant metastasis (p = 0.0138), shortened overall survival (p = 0.0010), and earlier recurrence (p = 0.0003).!##!Conclusion!#!In summary, the results of our study identify a non-diploid DNA content as a predictor of an unfavorable prognosis in clear cell and papillary carcinoma