213 research outputs found
Local and global Fokker-Planck neoclassical calculations showing flow and bootstrap current modification in a pedestal
In transport barriers, particularly H-mode edge pedestals, radial scale
lengths can become comparable to the ion orbit width, causing neoclassical
physics to become radially nonlocal. In this work, the resulting changes to
neoclassical flow and current are examined both analytically and numerically.
Steep density gradients are considered, with scale lengths comparable to the
poloidal ion gyroradius, together with strong radial electric fields sufficient
to electrostatically confine the ions. Attention is restricted to relatively
weak ion temperature gradients (but permitting arbitrary electron temperature
gradients), since in this limit a delta-f (small departures from a Maxwellian
distribution) rather than full-f approach is justified. This assumption is in
fact consistent with measured inter-ELM H-Mode edge pedestal density and ion
temperature profiles in many present experiments, and is expected to be
increasingly valid in future lower collisionality experiments. In the numerical
analysis, the distribution function and Rosenbluth potentials are solved for
simultaneously, allowing use of the exact field term in the linearized
Fokker-Planck collision operator. In the pedestal, the parallel and poloidal
flows are found to deviate strongly from the best available conventional
neoclassical prediction, with large poloidal variation of a different form than
in the local theory. These predicted effects may be observable experimentally.
In the local limit, the Sauter bootstrap current formulae appear accurate at
low collisionality, but they can overestimate the bootstrap current near the
plateau regime. In the pedestal ordering, ion contributions to the bootstrap
and Pfirsch-Schluter currents are also modified
Evidence of seismic slip on a large splay fault in the Hikurangi subduction zone
The Hikurangi subduction zone is capable of producing moderate to large earthquakes as well as regularly repeating slow slip events. However, it is unclear what structures host these different slip styles along the margin. Here we address whether splay faults can host seismic slip at shallow (1 m as observed in the 1947 Poverty and Tolaga Bay earthquakes
Introducing BASE: the Biomes of Australian Soil Environments soil microbial diversity database
Microbial inhabitants of soils are important to ecosystem and planetary functions, yet there are large gaps in our knowledge of their diversity and ecology. The ‘Biomes of Australian Soil Environments’ (BASE) project has generated a database of microbial diversity with associated metadata across extensive environmental gradients at continental scale. As the characterisation of microbes rapidly expands, the BASE database provides an evolving platform for interrogating and integrating microbial diversity and function
Combined Effects of Rotation and Age Spreads on Extended Main-Sequence Turn Offs
The extended main-sequence turn offs (eMSTOs) of several young to intermediate age clusters are examined in the Magellanic Clouds and the Milky Way. We explore the effects of extended star formation (eSF) and a range of stellar rotation rates on the behavior of the color–magnitude diagram, paying particular attention to the MSTO. We create synthetic stellar populations based on MESA stellar models to simulate observed Hubble Space Telescope and Gaia star cluster data. We model the effect of rotation as a nonparametric distribution, allowing for maximum flexibility. In our models the slow rotators comprise the blueward, and fast rotators the redward portion of the eMSTO. We simulate data under three scenarios: nonrotating eSF, a range of rotation rates with a single age, and a combination of age and rotation effects. We find that two of the five clusters (the youngest and oldest) favor an age spread, but these also achieve the overall worst fits of all clusters. The other three clusters show comparable statistical evidence between rotation and an age spread. In all five cases, a rotation-rate distribution alone is capable of qualitatively matching the observed eMSTO structure. In future work, we aim to compare our predicted with observations in order to better constrain the physics related to stellar rotation
LSST Science Book, Version 2.0
A survey that can cover the sky in optical bands over wide fields to faint
magnitudes with a fast cadence will enable many of the exciting science
opportunities of the next decade. The Large Synoptic Survey Telescope (LSST)
will have an effective aperture of 6.7 meters and an imaging camera with field
of view of 9.6 deg^2, and will be devoted to a ten-year imaging survey over
20,000 deg^2 south of +15 deg. Each pointing will be imaged 2000 times with
fifteen second exposures in six broad bands from 0.35 to 1.1 microns, to a
total point-source depth of r~27.5. The LSST Science Book describes the basic
parameters of the LSST hardware, software, and observing plans. The book
discusses educational and outreach opportunities, then goes on to describe a
broad range of science that LSST will revolutionize: mapping the inner and
outer Solar System, stellar populations in the Milky Way and nearby galaxies,
the structure of the Milky Way disk and halo and other objects in the Local
Volume, transient and variable objects both at low and high redshift, and the
properties of normal and active galaxies at low and high redshift. It then
turns to far-field cosmological topics, exploring properties of supernovae to
z~1, strong and weak lensing, the large-scale distribution of galaxies and
baryon oscillations, and how these different probes may be combined to
constrain cosmological models and the physics of dark energy.Comment: 596 pages. Also available at full resolution at
http://www.lsst.org/lsst/sciboo
The Long-Baseline Neutrino Experiment: Exploring Fundamental Symmetries of the Universe
The preponderance of matter over antimatter in the early Universe, the
dynamics of the supernova bursts that produced the heavy elements necessary for
life and whether protons eventually decay --- these mysteries at the forefront
of particle physics and astrophysics are key to understanding the early
evolution of our Universe, its current state and its eventual fate. The
Long-Baseline Neutrino Experiment (LBNE) represents an extensively developed
plan for a world-class experiment dedicated to addressing these questions. LBNE
is conceived around three central components: (1) a new, high-intensity
neutrino source generated from a megawatt-class proton accelerator at Fermi
National Accelerator Laboratory, (2) a near neutrino detector just downstream
of the source, and (3) a massive liquid argon time-projection chamber deployed
as a far detector deep underground at the Sanford Underground Research
Facility. This facility, located at the site of the former Homestake Mine in
Lead, South Dakota, is approximately 1,300 km from the neutrino source at
Fermilab -- a distance (baseline) that delivers optimal sensitivity to neutrino
charge-parity symmetry violation and mass ordering effects. This ambitious yet
cost-effective design incorporates scalability and flexibility and can
accommodate a variety of upgrades and contributions. With its exceptional
combination of experimental configuration, technical capabilities, and
potential for transformative discoveries, LBNE promises to be a vital facility
for the field of particle physics worldwide, providing physicists from around
the globe with opportunities to collaborate in a twenty to thirty year program
of exciting science. In this document we provide a comprehensive overview of
LBNE's scientific objectives, its place in the landscape of neutrino physics
worldwide, the technologies it will incorporate and the capabilities it will
possess.Comment: Major update of previous version. This is the reference document for
LBNE science program and current status. Chapters 1, 3, and 9 provide a
comprehensive overview of LBNE's scientific objectives, its place in the
landscape of neutrino physics worldwide, the technologies it will incorporate
and the capabilities it will possess. 288 pages, 116 figure
Reovirus exerts potent oncolytic effects in head and neck cancer cell lines that are independent of signalling in the EGFR pathway
Background: reovirus exploits aberrant signalling downstream of Ras to mediate tumor-specific oncolysis. Since ~90% squamous cell carcinomas of the head and neck (SCCHN) over-express EGFR and SCCHN cell lines are sensitive to oncolytic reovirus, we conducted a detailed analysis of the effects of reovirus in 15 head and neck cancer cell lines. Both pre- and post-entry events were studied in an attempt to define biomarkers predictive of sensitivity/resistance to reovirus. In particular, we analysed the role of EGFR/Ras signalling in determining virus-mediated cytotoxicity in SCCHN. Methods: to test whether EGFR pathway activity was predictive of increased sensitivity to reovirus, correlative analyses between reoviral IC50 by MTT assay and EGFR levels by western blot and FACS were conducted. Inhibition or stimulation of EGFR signalling were analysed for their effect on reoviral oncolysis by MTT assay, and viral growth by TCID50 assay. We next analysed the effects of inhibiting signalling downstream of Ras, by specific inhibitors of p38MAPK, PI3-K or MEK, on reoviral killing examined by MTT assay. The role of PKR in reoviral killing was also determined by blockade of PKR using 2-aminopurine and assaying for cell survival by MTT assay. The apoptotic response of SCCHN to reovirus was examined by western blot analysis of caspase 3 cleavage. Results: correlative analyses between reoviral sensitivity and EGFR levels revealed no association. Intermediate sub-viral and core particles showed the same infectivity/cytotoxicity as intact reovirus. Therefore, sensitivity was not determined by cell entry. In 4 cell lines, oncolysis and viral growth were both unaffected by inhibition or stimulation of EGFR signalling. Inhibition of signalling downstream of Ras did not abrogate reoviral oncolysis and, in addition, modulation of PKR using 2-aminopurine did not alter reovirus sensitivity in resistant cell lines. Caspase 3 cleavage was not detected in infected cells and oncolysis was observed in pan-caspase inhibited cells. Conclusions: in summary, reovirus is potently oncolytic in a broad panel of SCCHN cell lines. Attempts to define sensitivity/resistance by analysis of the EGFR/Ras/MAPK pathway have failed to provide a clear predictive biomarker of response. Further analysis of material from in vitro and clinical studies is ongoing in an attempt to shed further light on this issue
Role of genetic testing for inherited prostate cancer risk: Philadelphia prostate cancer consensus conference 2017
Purpose: Guidelines are limited for genetic testing for prostate cancer (PCA). The goal of this conference was to develop an expert consensus-dri
Black hole spin: theory and observation
In the standard paradigm, astrophysical black holes can be described solely
by their mass and angular momentum - commonly referred to as `spin' - resulting
from the process of their birth and subsequent growth via accretion. Whilst the
mass has a standard Newtonian interpretation, the spin does not, with the
effect of non-zero spin leaving an indelible imprint on the space-time closest
to the black hole. As a consequence of relativistic frame-dragging, particle
orbits are affected both in terms of stability and precession, which impacts on
the emission characteristics of accreting black holes both stellar mass in
black hole binaries (BHBs) and supermassive in active galactic nuclei (AGN).
Over the last 30 years, techniques have been developed that take into account
these changes to estimate the spin which can then be used to understand the
birth and growth of black holes and potentially the powering of powerful jets.
In this chapter we provide a broad overview of both the theoretical effects of
spin, the means by which it can be estimated and the results of ongoing
campaigns.Comment: 55 pages, 5 figures. Published in: "Astrophysics of Black Holes -
From fundamental aspects to latest developments", Ed. Cosimo Bambi, Springer:
Astrophysics and Space Science Library. Additional corrections mad
A Pre-Landing Assessment of Regolith Properties at the InSight Landing Site
This article discusses relevant physical properties of the regolith at the Mars InSight landing site as understood prior to landing of the spacecraft. InSight will land in the northern lowland plains of Mars, close to the equator, where the regolith is estimated to be ≥3--5 m thick. These investigations of physical properties have relied on data collected from Mars orbital measurements, previously collected lander and rover data, results of studies of data and samples from Apollo lunar missions, laboratory measurements on regolith simulants, and theoretical studies. The investigations include changes in properties with depth and temperature. Mechanical properties investigated include density, grain-size distribution, cohesion, and angle of internal friction. Thermophysical properties include thermal inertia, surface emissivity and albedo, thermal conductivity and diffusivity, and specific heat. Regolith elastic properties not only include parameters that control seismic wave velocities in the immediate vicinity of the Insight lander but also coupling of the lander and other potential noise sources to the InSight broadband seismometer. The related properties include Poisson’s ratio, P- and S-wave velocities, Young’s modulus, and seismic attenuation. Finally, mass diffusivity was investigated to estimate gas movements in the regolith driven by atmospheric pressure changes. Physical properties presented here are all to some degree speculative. However, they form a basis for interpretation of the early data to be returned from the InSight mission.Additional co-authors: Nick Teanby and Sharon Keda
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