Empowering Christian Witness at Sixth Avenue United Church of Christ through the Stories of Jesus

The purpose of this ministry focus paper is to offer a culturally appropriate, theologically formed strategy to empower lay people from Denver Colorado’s Sixth Avenue UCC for a way-of-life approach to evangelism, informed by both the biblical narrative and personal stories. Sixth Avenue United Church of Christ is a small, vibrant, growing congregation guided by a biblical, progressive, inclusive, liberal theology. The church leadership embrace a moderate to low Christology within an open and affirming environment. The congregation has had limited practices of evangelism, and this paper offers a plan for expanding Christian witness through Sixth Avenue. The paper contains three major sections. The first outlines mission challenges embedded in the local context, beginning with a general overview and history of the national denomination and a description of the local congregation and surrounding community. Additionally, it explores the church’s fears, hesitancies, values, successes, failures, and celebrations around evangelistic efforts, past and present. The second section describes the biblical and theological foundations—the platform for empowering lay Christian witness—guided by the stories and relational style of Jesus. The section begins with a review of nine books, then folds in theological reflection of six personal encounters Jesus had in his ministry, and proposes a theology of ministry for the church’s future. The third section provides a practical strategy for empowering lay Christians to engage actively and naturally in evangelism in their workplaces, families, communities, neighborhoods, and friendship circles. The strategy is delivered through small groups, and the essence of the strategy is developing skills for listening, storytelling, conversing, welcoming, and abiding in Christ. A plan for implementation, evaluation, and adaptation is also offered. Content Reader: Richard Peace, Ph

Introduction: The Sexual Body

Introduction to the special issue, The Sexual Body, edited by Shelly Eversley and Jennifer L. Morgan

Between the Literary and the Visual: Inter-Artistic Approaches to African-American Art History

A stubborn truism vexes African-American art history: the canon of black American literature is viewed as more established and robust than that of black American visual arts. This misconception has more to do with conventional disciplinary divisions, than it does with either the quantity or quality of black visual expression. Segregating the literary from the visual --and assigning these to English and Art History departments, respectively--has obscured the originally inter-artistic nature of much black cultural expression as well as the terms of its early reception and critique. African-American artists have repeatedly worked in black literary contexts--from Aaron Douglas\u27s illustrations for Alain Locke\u27s The New Negro to Glenn Ligon\u27s painted excerpts from Ralph Ellison and Richard Pryor. At the same time, many (nonblack) literary critics have been enthusiastic interpreters of black visual arts. Theater critic and novelist Carl Van Vechten promoted the painters of the Harlem Renaissance; Sidney Hirsch, one of Vanderbilt University\u27s influential literary modernists, discovered black folk sculptor William Edmondson; and French poststructuralist Roland Barthes famously used a photograph by James Van Der Zee to explain his concept of the photographic punctum. This panel seeks papers that take stock of this prodigious overlap between the literary and the visual arts. Participants are invited to address how literature and literary criticism may productively inform African-American art history, to recount the specific historical circumstances that compel this approach, and to consider broadly how attention to inter-artistic histories might helpfully reform both approaches to and canons of black cultural expression

Conservation of Sharp-Tailed Grouse (\u3cem\u3eTympanuchus phasianellus columbianus\u3c/em\u3e) Through Fecal DNA Extraction

Columbian Sharp-tailed Grouse (Tympanuchus phasianellus columbianus) are the rarest of the six extant Sharp-tailed Grouse subspecies. This subspecies experienced a 90% range contraction over the last century and have been extirpated from several states (Figure 1). In Washington alone, populations that once numbered hundreds of thousands of individuals now consist of fewer than 1,000 birds. Conservation efforts—including conservation translocations and habitat management—are underway to help bolster this imperiled subspecies across their range. However, little is known about the ecology of this charismatic species and the factors that may be contributing towards higher rates of decline. The collection of fecal pellets presents an opportunity to better understand Columbian Sharp-tailed Grouse across their range, by providing information on their diet and host ID. As a HERC Fellow in the Conservation Genetics Lab at Boise State University, I have been exploring the potential to use non-invasively collected fecal samples to understand how we can best capture different DNA types, which can be used to better inform the conservation and management of this charismatic grouse

Ongoing Development of a Series Bosch Reactor System

Future manned missions to deep space or planetary surfaces will undoubtedly incorporate highly robust, efficient, and regenerable life support systems that require minimal consumables. To meet this requirement, NASA continues to explore a Bosch-based carbon dioxide reduction system to recover oxygen from CO2. In order to improve the equivalent system mass of Bosch systems, we seek to design and test a "Series Bosch" system in which two reactors in series are optimized for the two steps of the reaction, as well as to explore the use of in situ materials as carbon deposition catalysts. Here we report recent developments in this effort including assembly and initial testing of a Reverse Water-Gas Shift reactor (RWGSr) and initial testing of two gas separation membranes. The RWGSr was sized to reduce CO2 produced by a crew of four to carbon monoxide as the first stage in a Series Bosch system. The gas separation membranes, necessary to recycle unreacted hydrogen and CO2, were similarly sized. Additionally, we report results of preliminary experiments designed to determine the catalytic properties of Martian regolith simulant for the carbon formation step

Small media and client reminders for colorectal cancer screening: Current use and gap areas in CDC\u27s colorectal cancer control program

INTRODUCTION: CDC’s Colorectal Cancer Control Program (CRCCP) funds 25 states and 4 tribal organizations to promote and increase colorectal cancer screening population-wide. The CRCCP grantees must use evidence-based strategies from the Guide to Community Preventive Services, including small media and client reminders. METHODS: To assess the existing resources and needs to promote colorectal cancer screening, we conducted 2 web-based surveys of CRCCP grantees and their community partners. Survey 1 sought to identify priority populations, the number and quality of existing colorectal cancer resources for different population subgroups, and the types of small media and client reminder they were most interested in using. Survey 2 assessed screening messages that were used in the past or might be used in the future, needs for non-English–language information, and preferences for screening-related terminology. RESULTS: In survey 1 (n = 125 from 26 CRCCPs), most respondents (83%) indicated they currently had some information resources for promoting screening but were widely dissatisfied with the quality and number of these resources. They reported the greatest need for resources targeting rural populations (62% of respondents), men (53%), and Hispanics (45%). In survey 2 (n = 57 from 25 CRCCPs), respondents indicated they were most likely to promote colorectal cancer screening using messages that emphasized family (95%), role models (85%), or busy lives (83%), and least likely to use messages based on faith (26%), embarrassment (25%), or fear (22%). Nearly all (85%) indicated a need for resources in languages other than English; 16 different languages were mentioned, most commonly Spanish. CONCLUSION: These findings provide the first picture of CRCCP information resources and interests, and point to specific gaps that must be addressed to help increase screening

Phenology of Drosophila species across a temperate growing season and implications for behavior

Data have been deposited in Dryad, https://doi.org/10.5061/dryad.1bc102k.Drosophila community composition is complex in temperate regions with different abundance of flies and species across the growing season. Monitoring Drosophila populations provides insights into the phenology of both native and invasive species. Over a single growing season, we collected Drosophila at regular intervals and determined the number of individuals of the nine species we found in Kansas, USA. Species varied in their presence and abundance through the growing season with peak diversity occurring after the highest seasonal temperatures. We developed models for the abundance of the most common species, Drosophila melanogaster, D. simulans, D. algonquin, and the recent invasive species, D. suzukii. These models revealed that temperature played the largest role in abundance of each species across the season. For the two most commonly studied species, D. melanogaster and D. simulans, the best models indicate shifted thermal optima compared to laboratory studies, implying that fluctuating temperature may play a greater role in the physiology and ecology of these insects than indicated by laboratory studies, and should be considered in global climate change studies.Kansas State Biology Graduate Student Association Research GrantKU EEB GRF 210508

Dual EGFR inhibition in combination with anti-VEGF treatment: a phase I clinical trial in non-small cell lung cancer.

BackgroundPreclinical data indicate EGFR signals through both kinase-dependent and independent pathways and that combining a small-molecule EGFR inhibitor, EGFR antibody, and/or anti-angiogenic agent is synergistic in animal models.MethodsWe conducted a dose-escalation, phase I study combining erlotinib, cetuximab, and bevacizumab. The subset of patients with non-small cell lung cancer (NSCLC) was analyzed for safety and response.ResultsThirty-four patients with NSCLC (median four prior therapies) received treatment on a range of dose levels. The most common treatment-related grade ≥2 adverse events were rash (n=14, 41%), hypomagnesemia (n=9, 27%), and fatigue (n=5, 15%). Seven patients (21%) achieved stable disease (SD) ≥6 months, two achieved a partial response (PR) (6%), and two achieved an unconfirmed partial response (uPR) (6%) (total=32%). We observed SD≥6 months/PR/uPR in patients who had received prior erlotinib and/or bevacizumab, those with brain metastases, smokers, and patients treated at lower dose levels. Five of 16 patients (31%) with wild-type EGFR experienced SD≥6 months or uPR. Correlation between grade of rash and rate of SD≥6 months/PR was observed (p less than 0.01).ConclusionThe combination of erlotinib, cetuximab, and bevacizumab was well-tolerated and demonstrated antitumor activity in heavily pretreated patients with NSCLC

Impacts of ocean warming on the settlement success and post‐settlement survival of Pacific crown‐of‐thorns starfish (Acanthaster cf. solaris)

Ocean warming and population irruptions of crown-of-thorns starfish (CoTS; Acanthaster cf. solaris) are two of the greatest threats to coral reefs. As such, there is significant interest in understanding how CoTS may be directly impacted by rising ocean temperatures. Settlement of planktonic larvae and subsequent metamorphosis is purported to be a major population bottleneck in marine invertebrates, yet it is unknown how ocean warming will impact these processes in CoTS. Herein, the effect of temperature (28 °C ambient, 30 °C, 32 °C, 34 °C) on the settlement success, metamorphic success, and post-settlement survival of this corallivore was explored. While larval settlement was robust to elevated temperature, with at least 94% of larvae settling after 48 h across all temperatures, it was observed that settlement success was lower on substrate that had been pre-treated ≥ 32 °C. Metamorphic success was also significantly constrained at temperatures ≥ 32 °C. At 32 °C and 34 °C metamorphic success was 16% and 63% lower than at ambient temperature, respectively. Significant adverse effects of warming on post-settlement survival were observed at even cooler temperatures, with 10% lower survival at 30 °C compared to at ambient temperature, and at 34 °C, survival was 34% lower. Substantial reductions in metamorphic success and early post-settlement survival at elevated temperatures, as well as negative impacts of warming on the settlement substrate and its capacity to induce settlement, may present a bottleneck for recruitment in a warmer ocean

High frequency off-target mutagenesis induced by CRISPR-Cas nucleases in human cells

CRISPR RNA-guided endonucleases (RGENs) have rapidly emerged as a facile and efficient platform for genome editing. Here, we use a human cell-based reporter assay to characterize off-target cleavage of Cas9-based RGENs. We find that single and double mismatches are tolerated to varying degrees depending on their position along the guide RNA (gRNA)-DNA interface. We readily detected off-target alterations induced by four out of six RGENs targeted to endogenous loci in human cells by examination of partially mismatched sites. The off-target sites we identified harbor up to five mismatches and many are mutagenized with frequencies comparable to (or higher than) those observed at the intended on-target site. Our work demonstrates that RGENs are highly active even with imperfectly matched RNA-DNA interfaces in human cells, a finding that might confound their use in research and therapeutic applications