The RESEARCH project. Soil-related hazards and archaeological heritage in the challenge of climate change

Archaeological Heritage, naturally endangered by environmental processes and anthropogenic pressures, is today increasingly at risk, because of intense human activities and climate change, and their impact on atmosphere and soil. European research is increasingly dedicated to the development of good practices for monitoring archaeological sites and their preservation. One of the running projects about these topics is RESEARCH (Remote Sensing techniques for Archaeology; H2020-MSCA-RISE, grant agreement: 823987), started in 2018 and ending in 2022. RESEARCH aims at testing risk assessment methodology using an integrated system of documentation and research in the fields of archaeology and environmental studies. It will introduce a strategy and select the most efficient tools for the harmonization of different data, criteria, and indicators in order to produce an effective risk assessment. These will be used to assess and monitor the impact of soil erosion, land movement, and land-use change on tangible archaeological heritage assets. As a final product, the Project addresses the development of a multi-task thematic platform, combining advanced remote sensing technologies with GIS application. The demonstration and validation of the Platform will be conducted on six case studies located in Italy, Greece, Cyprus, and Poland, and variously affected by the threats considered by the Project. In the frame of RISE (Research and Innovation Staff Exchange), RESEARCH will coordinate the existing expertise and research efforts of seven beneficiaries into a synergetic plan of collaborations and exchanges of personnel (Ph.D. students and research staff), to offer a comprehensive transfer of knowledge and training environment for the researchers in the specific area. This paper aims at illustrating the results of the activities conducted during the first year of the Project, which consisted in developing an effective risk assessment methodology for soil-related threats affecting archaeological heritage, and defining the scientific requirements and the user requirements of the Platform. The activities have been conducted in synergy with all the Partners and were supported by the possibility of staff exchange allowed by the funding frame MSCA-RISE

Mixed and galerkin finite element approximation of flow in a linear viscoelastic porous medium

This is the post-print version of the Article. The official published version can be accessed from the link below - Copyright @ 2013 ElsevierThis article has been made available through the Brunel Open Access Publishing Fund.We propose two fully discrete mixed and Galerkin finite element approximations to a system of equations describing the slow flow of a slightly compressible single phase fluid in a viscoelastic porous medium. One of our schemes is the natural one for the backward Euler time discretization but, due to the viscoelasticity, seems to be stable only for small enough time steps. The other scheme contains a lagged term in the viscous stress and pressure evolution equations and this is enough to prove unconditional stability. For this lagged scheme we prove an optimal order a priori error estimate under ideal regularity assumptions and demonstrate the convergence rates by using a model problem with a manufactured solution. The model and numerical scheme that we present are a natural extension to ‘poroviscoelasticity’ of the poroelasticity equations and scheme studied by Philips and Wheeler in (for example) [Philip Joseph Philips, Mary F.Wheeler, Comput. Geosci. 11 (2007) 145–158] although — importantly — their algorithms and codes would need only minor modifications in order to include the viscous effects. The equations and algorithms presented here have application to oil reservoir simulations and also to the condition of hydrocephalus — ‘water on the brain’. An illustrative example is given demonstrating that even small viscoelastic effects can produce noticeable differences in long-time response. To the best of our knowledge this is the first time a mixed and Galerkin scheme has been analysed and implemented for viscoelastic porous media

The action of obestatin in skeletal muscle repair: stem cell expansion, muscle growth, and microenvironment remodeling

The development of therapeutic strategies for skeletal muscle diseases, such as physical injuries and myopathies, depends on the knowledge of regulatory signals that control the myogenic process. The obestatin/GPR39 system operates as an autocrine signal in the regulation of skeletal myogenesis. Using a mouse model of skeletal muscle regeneration after injury and several cellular strategies, we explored the potential use of obestatin as a therapeutic agent for the treatment of trauma-induced muscle injuries. Our results evidenced that the overexpression of the preproghrelin, and thus obestatin, and GPR39 in skeletal muscle increased regeneration after muscle injury. More importantly, the intramuscular injection of obestatin significantly enhanced muscle regeneration by simulating satellite stem cell expansion as well as myofiber hypertrophy through a kinase hierarchy. Added to the myogenic action, the obestatin administration resulted in an increased expression of VEGF/VEGFR2 and the consequent microvascularization, with no effect on collagen deposition in skeletal muscle. Furthermore, the potential inhibition of myostatin during obestatin treatment might contribute to its myogenic action improving muscle growth and regeneration. Taken together, our data demonstrate successful improvement of muscle regeneration, indicating obestatin is a potential therapeutic agent for skeletal muscle injury and would benefit other myopathies related to muscle regeneration

Bifurcations in a convection problem with temperature-dependent viscosity

A convection problem with temperature-dependent viscosity in an infinite layer is presented. As described, this problem has important applications in mantle convection. The existence of a stationary bifurcation is proved together with a condition to obtain the critical parameters at which the bifurcation takes place. For a general dependence of viscosity with temperature a numerical strategy for the calculation of the critical bifurcation curves and the most unstable modes has been developed. For a exponential dependence of viscosity on temperature the numerical calculations have been done. Comparisons with the classical Rayleigh-B\'enard problem with constant viscosity indicate that the critical threshold decreases as the exponential rate parameter increases.Comment: 16 pages, 5 figure

Aerobic Exercise and Pharmacological Treatments Counteract Cachexia by Modulating Autophagy in Colon Cancer

Recent studies have correlated physical activity with a better prognosis in cachectic patients, although the underlying mechanisms are not yet understood. In order to identify the pathways involved in the physical activity-mediated rescue of skeletal muscle mass and function, we investigated the effects of voluntary exercise on cachexia in colon carcinoma (C26)-bearing mice. Voluntary exercise prevented loss of muscle mass and function, ultimately increasing survival of C26-bearing mice. We found that the autophagic flux is overloaded in skeletal muscle of both colon carcinoma murine models and patients, but not in running C26-bearing mice, thus suggesting that exercise may release the autophagic flux and ultimately rescue muscle homeostasis. Treatment of C26-bearing mice with either AICAR or rapamycin, two drugs that trigger the autophagic flux, also rescued muscle mass and prevented atrogene induction. Similar effects were reproduced on myotubes in vitro, which displayed atrophy following exposure to C26-conditioned medium, a phenomenon that was rescued by AICAR or rapamycin treatment and relies on autophagosome-lysosome fusion (inhibited by chloroquine). Since AICAR, rapamycin and exercise equally affect the autophagic system and counteract cachexia, we believe autophagy-triggering drugs may be exploited to treat cachexia in conditions in which exercise cannot be prescribed

Spreading continents kick-started plate tectonics

International audienceStresses acting on cold, thick and negatively buoyant oceanic litho- sphere are thought to be crucial to the initiation of subduction and the operation of plate tectonics, which characterizes the present- day geodynamics of the Earth. Because the Earth’s interior was hotter in the Archaean eon, the oceanic crust may have been thicker, thereby making the oceanic lithosphere more buoyant than at present, and whether subduction and plate tectonics occurred during this time is ambiguous, both in the geological record and in geodynamic models. Here we show that because the oceanic crust was thick and buoyant5, early continents may have produced intra-lithospheric gravitational stresses large enough to drive their gravitational spreading, to initiate subduction at their margins and to trigger episodes of subduction. Our model predicts the co-occurrence of deep to progressively shallower mafic volcanics and arc magmatism within continents in a self-consistent geodynamic framework, explaining the enigmatic multimodal volcanism and tectonic record of Archaean cratons. Moreover, our model predicts a petrological stratification and tectonic structure of the sub-continental lithospheric mantle, two predictions that are consistent with xenolith and seismic studies, respectively, and consistent with the existence of a mid-lithospheric seismic discontinuity. The slow gravitational collapse of early continents could have kick-started transient episodes of plate tectonics until, as the Earth’s interior cooled and oceanic lithosphere became heavier, plate tectonics became self-sustaining

Fumaric acid production by fermentation

The potential of fumaric acid as a raw material in the polymer industry and the increment of cost of petroleum-based fumaric acid raises interest in fermentation processes for production of this compound from renewable resources. Although the chemical process yields 112% w/w fumaric acid from maleic anhydride and the fermentation process yields only 85% w/w from glucose, the latter raw material is three times cheaper. Besides, the fermentation fixes CO2. Production of fumaric acid by Rhizopus species and the involved metabolic pathways are reviewed. Submerged fermentation systems coupled with product recovery techniques seem to have achieved economically attractive yields and productivities. Future prospects for improvement of fumaric acid production include metabolic engineering approaches to achieve low pH fermentations

Investigating Glioblastoma Multiforme Sub-Proteomes: A Computational Study of CUSA Fluid Proteomic Data

Based on our previous proteomic study on Cavitating Ultrasound Aspirator (CUSA) fluid pools of Newly Diagnosed (ND) and Recurrent (R) glioblastomas (GBMs) of tumor core and periphery, as defined by 5-aminolevulinc acid (5-ALA) metabolite fluorescence, this work aims to apply a bioinformatic approach to investigate specifically into three sub-proteomes, i.e., Not Detected in Brain (NB), Cancer Related (CR) and Extracellular Vesicles (EVs) proteins following selected database classification. The study of these yet unexplored specific datasets aims to understand the high infiltration capability and relapse rate that characterizes this aggressive brain cancer. Out of the 587 proteins highly confidently identified in GBM CUSA pools, 53 proteins were classified as NB. Their gene ontology (GO) analysis showed the over-representation of blood coagulation and plasminogen activating cascade pathways, possibly compatible with Blood Brain Barrier damage in tumor disease and surgery bleeding. However, the NB group also included non-blood proteins and, specifically, histones correlated with oncogenesis. Concerning CR proteins, 159 proteins were found in the characterized GBM proteome. Their GO analysis highlighted the over-representation of many pathways, primarily glycolysis. Interestingly, while CR proteins were identified in ND-GBM exclusively in the tumor zones (fluorescence positive core and periphery zones) as predictable, conversely, in R-GBM they were unexpectedly characterized prevalently in the healthy zone (fluorescence negative tumor periphery). Relative to EVs protein classification, 60 proteins were found. EVs are over-released in tumor disease and are important in the transport of biological macromolecules. Furthermore, the presence of EVs in numerous body fluids makes them a possible low-invasive source of brain tumor biomarkers to be investigated. These results give new hints on the molecular features of GBM in trying to understand its aggressive behavior and open to more in-depth investigations to disclose potential disease biomarkers

Modelling gravitational instabilities: slab break-off and Rayleigh-Taylor diapirism

A non-standard new code to solve multiphase viscous thermo–mechanical problems applied to geophysics is presented. Two numerical methodologies employed in the code are described: A level set technique to track the position of the materials and an enrichment of the solution to allow the strain rate to be discontinuous across the interface. These techniques have low computational cost and can be used in standard desktop PCs. Examples of phase tracking with level set are presented in two and three dimensions to study slab detachment in subduction processes and Rayleigh–Taylor instabilities, respectively. The modelling of slab detachment processes includes realistic rheology with viscosity depending on temperature, pressure and strain rate; shear and adiabatic heating mechanisms; density including mineral phase changes and varying thermal conductivity. Detachment models show a first prolonged period of thermal diffusion until a fast necking of the subducting slab results in the break–off. The influence of several numerical and physical parameters on the detachment process is analyzed: The shear heating exerts a major influence accelerating the detachment process, reducing the onset time to one half and lubricating the sinking of the detached slab. The adiabatic heating term acts as a thermal stabilizer. If the mantle temperature follows an adiabatic gradient, neglecting this heating term must be included, otherwise all temperature contrasts are overestimated. As expected, the phase change at 410 km depth (olivine–spinel transition) facilitates the detachment process due to the increase in negative buoyancy. Finally, simple plume simulations are used to show how the presented numerical methodologies can be extended to three dimensions.Peer ReviewedPostprint (author’s final draft