Augusto

Primer premio del Certame

An edeine resistant mRNA-dependent protein synthesis system from a Saccharomyces cerevisiae mutant

AbstractA cell-free protein synthesizing system from a mutant of Saccharomyces cerevisiae translated exogenous mRNA in the presence of 2μM edeine, while a similar system from wild-type strain was completely inhibited by the drug. The mutant ribosomes showed an affinity for [125I]edeine comparable to the wild-type ribosomes, thereby suggesting that these macromolecules alone were not responsible for the edeine-resistant capacity of the mutant

Control Interno en la Cooperativa de Servicios Agropecuarios de Exportación de Café COOPSAEC R. L. del departamento de Jinotega, en el I semestre del año 2013

La materia abordada en esta investigación trata sobre Sistemas Contables y Control Interno en las Cooperativas de los departamentos de Matagalpa y Jinotega en el año 2013, con el propósito de evaluar los procedimientos de Control Interno en la Cooperativa de Servicios Agropecuarios de Exportación de Café, COOPSAEC R. L. la que permitió la constatación de aplicación de los procedimientos de control interno diseñados para las áreas de la Cooperativa y en general la realización de las operaciones de forma objetiva y por tanto la consecución de las metas propuestas. La importancia de este trabajo radica en la evaluación del Control Interno en la COOPSAEC, R. L. lo que contribuyó a que se detectaran dos áreas básicas que presentan debilidades, en primer lugar la del inventario y en segundo lugar la del efectivo, donde la probabilidad de riesgo alta puede incidir en que la Cooperativa no consiga alcanzar sus objetivos, si los eventos relacionados con esos riesgos se capitalizaran. Los resultados de la evaluación permitieron determinar que COOPSAEC, R. L. cuenta con un Control Interno débil en ciertas áreas como son el área de efectivo e inventario, además los riesgos altos que se mencionan obligan a tomar las medidas correctivas que permitan, por lo menos, prevenirlos. Por este motivo, se hizo una propuesta de mejoras al Manual de Control Interno de la Cooperativa como una respuesta para aminorar la probabilidad de ocurrencia de los eventos relacionados con las áreas críticas de Inventarios y Efectivo, como la falta de inventarios físicos y arqueos físicos más frecuentes, así también la falta de depósitos diarios de efectivo los que debieran realizarse a más tardar a primera hora de los días hábiles con el propósito de evitar la pérdida de activos de la Cooperativa y un debido control de los bienes en el área de Inventario y en el área de Efectivo en Caja y Banc

Wetting phenomenon in the liquid-vapor phase coexistence of a partially miscible Lennard-Jones binary mixture

We have carried out extensive equilibrium molecular dynamics (MD) simulations to study the structure and the interfacial properties in the liquid-vapor (LV) phase coexistence of partially miscible binary Lennard-Jones (LJ) mixtures. By analyzing the structural properties as a function of the miscibility parameter, $\alpha$, we found that at relatively low temperatures the system separates forming a liquid A-liquid B interface in coexistence with the vapor phase. At higher temperatures and, $0<\alpha\leq 0.5$, we found a temperature range, $T^{*}_{w}(\alpha) \leq T^{*} < T^{*}_{cons}(\alpha)$, where the liquid phases are wet by the vapor phase. Here, $T^{*}_{w}(\alpha)$ represents the wetting transition temperature (WTT) and $T^{*}_{cons}(\alpha)$ is the consolute temperature of the mixture. However, for $0.5< \alpha < 1$, no wetting phenomenon occurs. For the particular value, $\alpha=0.25$, we analyzed quantitatively the $T^{*}$ versus $\rho^{*}$, and $P^{*}$ versus $T^{*}$ phase diagrams and found, $T^{*}_{c}\simeq 1.25$, and $T^{*}_{cons}\simeq1.25$. We also studied quantitatively, as a function of temperature, the surface tension and the adsorption of molecules at the liquid-liquid interface. It was found that the adsorption shows a jump from a finite negative value up to minus infinity, when the vapor wets the liquid phases, suggesting that the wetting transition (WT) is of first order. The calculated phase diagram together with the wetting phenomenon strongly suggest the existence of a tricritical point. These results agree well with some experiments carried out in fluid binary mixtures.Comment: Enlarged version that include results of more extensive simulations. A total of 24 LaTeX pages that include 12 encapsulated poscript figures. To appear in PRE, Vol. 70, issue Sept. 1st (2004

Effectiveness of a recent topical sialogogue in the management of drug-induced xerostomia

Objectives: Use of certain drugs is the most common aetiology of xerostomia. Systemic sialogogues provide a longer effect than topic ones, but also induce relevant side effects. Topical sialogogues, as malic acid, allow a safe use as they induce no systemic side-effects or pharmacological interactions, being especially interesting in cases of mild hyposalivation and oral dryness, mainly the chronic use of xerostomizing drugs. The aim of this study was to evaluate the clinical effect of 1% malic acid in patients affected by xerostomia due to antihypertensives or antidepressants. Study Design: 10 patients with drug-induced xerostomia were prospectively evaluated before and after using malic acid spray during three weeks. Xerostomia Inventory (XI) was used to evaluate subjective improvement. Unstimulated and stimulated salivary flow rates were determinated. Results: Severity significantly decreased, from 38.22 to 31.00 points (p = 0.011) after using the product. 77.8% of subjects did not complain about xerostomia at the end and 66.6% achieved an improvement > 6 points. Unstimulated flow rate singnificantly increased, from 0.163 to 0.226 mL/min (p = 0.021) at the third week. Conclusions: 1% malic acid spray induces some improvement in the management of mild and reversible xerostomia. Carrying out of randomized controlled trials is justified according to this study

Numerical analysis of the influence of the last cycle scheme on plasticity induced crack closure

D. Camas, F.V. Antunes, B. Moreno, A. Gonzalez-Herrera, Numerical analysis of the influence of the last cycle scheme on plasticity induced crack closure, Book of Abstracts of the 3rd International Conference on Structural Integrity, pp. 185.Plasticity induced crack closure is considered the main mechanism related to the premature contact of the crack flanks when a crack grows under cyclic loadings. This phenomenon has been studied numerically since the early 70s, when some researchers approached to metal fatigue problems by means of the finite element analysis. The numerical analysis requires the development of a plastic wake. How this plastic wake is developed has influence on the crack closure results and a great impact on the computational cost. When running a finite element analysis, it is not possible to consider all the loading cycles involved in an experimental test. The numerical effort is not acceptable. Therefore, in this work, the crack growth scheme is analyzed. In particular, the influence of the number of loading cycles after releasing the last set of nodes on plasticity induced crack closure results is studied. A CT aluminum specimen has been modelled three-dimensionally and several simulations have been run to evaluate the influence of the loading cycles after releasing the last set of nodes. The numerical analysis is made in terms of crack closure and opening values.Universidad de Málaga. Campus de Excelencia Internacional Andalucía Tech

Visualization and evolution of the scientific structure of fuzzy sets research in Spain

Introduction. Presents the first bibliometric study on the evolution of the fuzzy sets theory field. It is specially focused on the research carried out by the Spanish comunity. Method. The CoPalRed software, for network analysis, and the co-word analysis technique are used. Analysis. Bibliometric maps showing the main associations among the main concepts in the field are provided for the periods 1965-1993, 1994-1998, 1999-2003 and 2004-2008. Results. The bibliometric maps obtained provide insight into the structure of the fuzzy sets theory research in the Spanish community, visualize the research subfields, and show the existing relationships between those subfields. Furthermore, we compare the Spanish community with other countries (the USA and Canada; the UK and Germany; and Japan and Peoples Republic of China). Conclusions. As a result of the analysis, a complete study of the evolution of the Spanish fuzzy sets community and an analysis of its international importance are presented.Introducción. Presenta el primer estudio bibliométrico sobre la evolución del campo de la teoría de conjuntos difusos. Se centra especialmente en la investigación llevada a cabo por la comunidad española. Método. Se utiliza el software de CoPalRed, para el análisis de red, y la técnica de anñlisis de co-palabras. Aná;lisis. Se proporcionan mapas bibliométricos mostrando las principales asociaciones entre los principales conceptos en el campo para los períodos de 1965-1993, 1994-1998, 1999-2003 y 2004-2008. Resultados. Los mapas bibliométricos obtenidos proporcionan conocimientos sobre la estructura de la investigación sobre teoría de conjuntos difusos en la comunidad española, visualizan los subcampos de investigación y muestran las relaciones existentes entre los subcampos. Ademñs, se compara la comunidad española con otros países (Estados Unidos y Canada; Reino Unido y Alemania; y Japón y República Popular China). Conclusiones. Como resultado de los análisis, se presenta un estudio completo de la evolución de la comunidad española en conjuntos difusos y un anñlisis de su importancia internacional.This work has been supported by the Spanish project FUZZY-LING, Cod. TIN2007-61079, granted by the Spanish Agency for Education and Science (Ministerio de Educación y Ciencia)