155 research outputs found
Generalized Forward-Backward Splitting
This paper introduces the generalized forward-backward splitting algorithm
for minimizing convex functions of the form , where
has a Lipschitz-continuous gradient and the 's are simple in the sense
that their Moreau proximity operators are easy to compute. While the
forward-backward algorithm cannot deal with more than non-smooth
function, our method generalizes it to the case of arbitrary . Our method
makes an explicit use of the regularity of in the forward step, and the
proximity operators of the 's are applied in parallel in the backward
step. This allows the generalized forward backward to efficiently address an
important class of convex problems. We prove its convergence in infinite
dimension, and its robustness to errors on the computation of the proximity
operators and of the gradient of . Examples on inverse problems in imaging
demonstrate the advantage of the proposed methods in comparison to other
splitting algorithms.Comment: 24 pages, 4 figure
Spin Squeezing by Rydberg Dressing in an Array of Atomic Ensembles
We report on the creation of an array of spin-squeezed ensembles of cesium
atoms via Rydberg dressing, a technique that offers optical control over local
interactions between neutral atoms. We optimize the coherence of the
interactions by a stroboscopic dressing sequence that suppresses
super-Poissonian loss. We thereby prepare squeezed states of atoms with
a metrological squeezing parameter quantifying the reduction
in phase variance below the standard quantum limit. We realize metrological
gain across three spatially separated ensembles in parallel, with the strength
of squeezing controlled by the local intensity of the dressing light. Our
method can be applied to enhance the precision of tests of fundamental physics
based on arrays of atomic clocks and to enable quantum-enhanced imaging of
electromagnetic fields.Comment: 18 pages, 11 figures, typos corrected, edits for clarit
Pion and proton showers in the CALICE scintillator-steel analogue hadron calorimeter
Showers produced by positive hadrons in the highly granular CALICE
scintillator-steel analogue hadron calorimeter were studied. The experimental
data were collected at CERN and FNAL for single particles with initial momenta
from 10 to 80 GeV/c. The calorimeter response and resolution and spatial
characteristics of shower development for proton- and pion-induced showers for
test beam data and simulations using Geant4 version 9.6 are compared.Comment: 26 pages, 16 figures, JINST style, changes in the author list, typos
corrected, new section added, figures regrouped. Accepted for publication in
JINS
Hadron shower decomposition in the highly granular CALICE analogue hadron calorimeter
The spatial development of hadronic showers in the CALICE scintillator-steel
analogue hadron calorimeter is studied using test beam data collected at CERN
and FNAL for single positive pions and protons with initial momenta in the
range from 10 to 80 GeV/c. Both longitudinal and radial development of hadron
showers are parametrised with two-component functions. The parametrisation is
fit to test beam data and simulations using the QGSP_BERT and FTFP_BERT physics
lists from Geant4 version 9.6. The parameters extracted from data and simulated
samples are compared for the two types of hadrons. The response to pions and
the ratio of the non-electromagnetic to the electromagnetic calorimeter
response, h/e, are estimated using the extrapolation and decomposition of the
longitudinal profiles.Comment: 38 pages, 19 figures, 5 tables; author list changed; submitted to
JINS
Shower development of particles with momenta from 15 GeV to 150 GeV in the CALICE scintillator-tungsten hadronic calorimeter
We present a study of showers initiated by electrons, pions, kaons, and
protons with momenta from 15 GeV to 150 GeV in the highly granular CALICE
scintillator-tungsten analogue hadronic calorimeter. The data were recorded at
the CERN Super Proton Synchrotron in 2011. The analysis includes measurements
of the calorimeter response to each particle type as well as measurements of
the energy resolution and studies of the longitudinal and radial shower
development for selected particles. The results are compared to Geant4
simulations (version 9.6.p02). In the study of the energy resolution we include
previously published data with beam momenta from 1 GeV to 10 GeV recorded at
the CERN Proton Synchrotron in 2010.Comment: 35 pages, 21 figures, 8 table
The Time Structure of Hadronic Showers in highly granular Calorimeters with Tungsten and Steel Absorbers
The intrinsic time structure of hadronic showers influences the timing
capability and the required integration time of hadronic calorimeters in
particle physics experiments, and depends on the active medium and on the
absorber of the calorimeter. With the CALICE T3B experiment, a setup of 15
small plastic scintillator tiles read out with Silicon Photomultipliers, the
time structure of showers is measured on a statistical basis with high spatial
and temporal resolution in sampling calorimeters with tungsten and steel
absorbers. The results are compared to GEANT4 (version 9.4 patch 03)
simulations with different hadronic physics models. These comparisons
demonstrate the importance of using high precision treatment of low-energy
neutrons for tungsten absorbers, while an overall good agreement between data
and simulations for all considered models is observed for steel.Comment: 24 pages including author list, 9 figures, published in JINS
Molecular Composition of Staufen2-Containing Ribonucleoproteins in Embryonic Rat Brain
Messenger ribonucleoprotein particles (mRNPs) are used to transport mRNAs along neuronal dendrites to their site of translation. Numerous mRNA-binding and regulatory proteins within mRNPs finely regulate the fate of bound-mRNAs. Their specific combination defines different types of mRNPs that in turn are related to specific synaptic functions. One of these mRNA-binding proteins, Staufen2 (Stau2), was shown to transport dendritic mRNAs along microtubules. Its knockdown expression in neurons was shown to change spine morphology and synaptic functions. To further understand the molecular mechanisms by which Stau2 modulates synaptic function in neurons, it is important to identify and characterize protein co-factors that regulate the fate of Stau2-containing mRNPs. To this end, a proteomic approach was used to identify co-immunoprecipitated proteins in Staufen2-containing mRNPs isolated from embryonic rat brains. The proteomic approach identified mRNA-binding proteins (PABPC1, hnRNP H1, YB1 and hsc70), proteins of the cytoskeleton (α- and ÎČ-tubulin) and RUFY3 a poorly characterized protein. While PABPC1 and YB1 associate with Stau2-containing mRNPs through RNAs, hsc70 is directly bound to Stau2 and this interaction is regulated by ATP. PABPC1 and YB1 proteins formed puncta in dendrites of embryonic rat hippocampal neurons. However, they poorly co-localized with Stau2 in the large dendritic complexes suggesting that they are rather components of Stau2-containing mRNA particles. All together, these results represent a further step in the characterization of Stau2-containing mRNPs in neurons and provide new tools to study and understand how Stau2-containing mRNPs are transported, translationally silenced during transport and/or locally expressed according to cell needs
Reconstructing Native American Population History
The peopling of the Americas has been the subject of extensive genetic, archaeological and linguistic research; however, central questions remain unresolved1â5. One contentious issue is whether the settlement occurred via a single6â8 or multiple streams of migration from Siberia9â15. The pattern of dispersals within the Americas is also poorly understood. To address these questions at higher resolution than was previously possible, we assembled data from 52 Native American and 17 Siberian groups genotyped at 364,470 single nucleotide polymorphisms. We show that Native Americans descend from at least three streams of Asian gene flow. Most descend entirely from a single ancestral population that we call âFirst Americanâ. However, speakers of Eskimo-Aleut languages from the Arctic inherit almost half their ancestry from a second stream of Asian gene flow, and the Na-Dene-speaking Chipewyan from Canada inherit roughly one-tenth of their ancestry from a third stream. We show that the initial peopling followed a southward expansion facilitated by the coast, with sequential population splits and little gene flow after divergence, especially in South America. A major exception is in Chibchan-speakers on both sides of the Panama Isthmus, who have ancestry from both North and South America
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