Geological setting and genesis of stratabound barite deposits at Múzquiz, Coahuila in northeastern Mexico

Peer ReviewedPreprin

La paleodieta de cinco especies de mamíferos herbívoros rancholabreanos de valsequillo (Puebla, México)

Through the use of the 13C/12C and 18O/16O isotopic relationships found at enamel and osteodentine, here it is inferred the diet and preferred habitat in which five extinct herbivore species from the Late Pleistocene of Valsequillo, Puebla, México. The horses, mammoths, and sloths showed a diet mainly based in C4, meanwhile the capybaraand gomphotheres were mixed C3/C4 feeders. The vegetation in which those animals lived was open with some trees, similar to the one proposed in other studies based in some macromammals species found in the locality.Usando las relaciones isotópicas de 13C/12C y 18O/16O presentes en el esmalte y la osteodentina, se infirió la dieta y el ambiente en el cual vivieron cinco especies extintas de herbívoros procedentes del Pleistoceno Tardío de Valsequillo, Puebla, México. Los caballos, los mamutes y el perezoso mostraban una dieta basada exclusivamente en plantas C4, mientras que el carpincho y los gonfoterios exhibían una dieta mixta C3/C4. El tipo de vegetación en el cual estos animales habitaron fue abierto con poca cobertura arbórea, misma que ha sido propuesta en otros estudios usando la presencia de algunas especies de micromamíferos encontradosen la zona

Modelo de formación de los yacimientos estratoligados de Cu en lechos rojos de Las Vigas (Chihuahua, México)

Peer ReviewedPostprint (published version

Análisis comparativo de factores que inciden en el desarrollo tenístico en España, USA y México.

La presente investigación tiene como finalidad evidenciar mediante el método analítico algunos de los factores que impactan en el éxito profesional de un jugador de tenis en base a las características de su lugar de procedencia tales como: cantidad de torneos calendarizados por parte de la federación al año, jugadores afiliados activos, economía en base al salario mínimo y al producto interno bruto (PIB) y a la población total del país; además de la metodología de entrenamiento tomando como referencia los programas de capacitación, artículos, manuales y recursos libres de cada federación. Se toma como objeto de estudio a dos de los países que han tenido mayor éxito en este deporte a nivel mundial: Estados Unidos y España tomando como referencia la investigación de Crespo, Reid, Miley, & Atienza, (2003). De igual forma, se analizan los factores presentes en México para contrastar resultados y así poder determinar los aspectos que se deben desarrollar con el fin de lograr un mayor éxito deportivo por parte de los tenistas del país. La información es consultada y recopilada de diferentes artículos relacionados a la captación de talentos y a la formación deportiva, además de los registros estadísticos de los jugadores y torneos de cada país presentes en la base de datos de su respectiva federación. El resultado es un panorama más preciso sobre las necesidades que el deporte blanco requiere dentro del contexto mexicano para el desarrollo de talentos y la optimización de resultados deportivos

Feeding habits and habitat of herbivorous mammals from the Early–Late Hemphillian (Miocene) of Costa Rica

Carbon and oxygen stable isotope values in the dental enamel of fossils were used to infer the diet and habitat of the extinct equids Calippus hondurensis, Dinohippus mexicanus, and Protohippus gidleyi, the gomphothere Gomphotherium hondurensis, and the llama Hemiauchenia vera of the Early–Late Hemphillian (Hh2) from San Gerardo de Limoncito, Puntarenas province, Costa Rica. The results suggest that these mammals fed mainly on C3 plants and lived in clearings of rainforests. This contrasts with previous studies from North America that indicated that the same species lived in forest savannas and fed mainly on C4 plants, but it is similar to the results obtained from the palynological record of the area, as well as with several vegetation models suggesting the presence of humid tropical forest during the Miocene in Central America

Exhaled volatilome analysis as a useful tool to discriminate asthma with other coexisting atopic diseases in women of childbearing age

©2021. The authors. This document is made available under the CC-BY 4.0 license http://creativecommons.org/licenses/by /4.0/ This document is published version of a Published Work that appeared in final form in Scientifc Reports. To access the final edited and published work see https://doi.org/10.1038/s41598-021-92933-2The prevalence of asthma is considerably high among women of childbearing age. Most asthmatic women also often have other atopic disorders. Therefore, the diferentiation between patients with atopic diseases without asthma and asthmatics with coexisting diseases is essential to avoid underdiagnosis of asthma and to design strategies to reduce symptom severity and improve quality of life of patients. Hence, we aimed for the frst time to conduct an analysis of volatile organic compounds in exhaled breath of women of childbearing age as a new approach to discriminate between asthmatics with other coexisting atopic diseases and non-asthmatics (with or without atopic diseases), which could be a helpful tool for more accurate asthma detection and monitoring using a noninvasive technique in the near future. In this study, exhaled air samples of 336 women (training set (n= 211) and validation set (n= 125)) were collected and analyzed by thermal desorption coupled with gas chromatography-mass spectrometry. ASCA (ANOVA (analysis of variance) simultaneous component analysis) and LASSO+LS (least absolute shrinkage and selection operator+ logistic regression) were employed for data analysis. Fifteen statistically signifcant models (p-value< 0.05 in permutation tests) that discriminated asthma with other coexisting atopic diseases in women of childbearing age were generated. Acetone, 2-ethyl-1-hexanol and a tetrahydroisoquinoline derivative were selected as discriminants of asthma with other coexisting atopic diseases. In addition, carbon disulfde, a tetrahydroisoquinoline derivative, 2-ethyl-1-hexanol and decane discriminated asthma disease among patients with other atopic disorders. Results of this study indicate that refned metabolomic analysis of exhaled breath allows asthma with other coexisting atopic diseases discrimination in women of reproductive ag

Albiglutide and cardiovascular outcomes in patients with type 2 diabetes and cardiovascular disease (Harmony Outcomes): a double-blind, randomised placebo-controlled trial

Background: Glucagon-like peptide 1 receptor agonists differ in chemical structure, duration of action, and in their effects on clinical outcomes. The cardiovascular effects of once-weekly albiglutide in type 2 diabetes are unknown. We aimed to determine the safety and efficacy of albiglutide in preventing cardiovascular death, myocardial infarction, or stroke. Methods: We did a double-blind, randomised, placebo-controlled trial in 610 sites across 28 countries. We randomly assigned patients aged 40 years and older with type 2 diabetes and cardiovascular disease (at a 1:1 ratio) to groups that either received a subcutaneous injection of albiglutide (30–50 mg, based on glycaemic response and tolerability) or of a matched volume of placebo once a week, in addition to their standard care. Investigators used an interactive voice or web response system to obtain treatment assignment, and patients and all study investigators were masked to their treatment allocation. We hypothesised that albiglutide would be non-inferior to placebo for the primary outcome of the first occurrence of cardiovascular death, myocardial infarction, or stroke, which was assessed in the intention-to-treat population. If non-inferiority was confirmed by an upper limit of the 95% CI for a hazard ratio of less than 1·30, closed testing for superiority was prespecified. This study is registered with ClinicalTrials.gov, number NCT02465515. Findings: Patients were screened between July 1, 2015, and Nov 24, 2016. 10 793 patients were screened and 9463 participants were enrolled and randomly assigned to groups: 4731 patients were assigned to receive albiglutide and 4732 patients to receive placebo. On Nov 8, 2017, it was determined that 611 primary endpoints and a median follow-up of at least 1·5 years had accrued, and participants returned for a final visit and discontinuation from study treatment; the last patient visit was on March 12, 2018. These 9463 patients, the intention-to-treat population, were evaluated for a median duration of 1·6 years and were assessed for the primary outcome. The primary composite outcome occurred in 338 (7%) of 4731 patients at an incidence rate of 4·6 events per 100 person-years in the albiglutide group and in 428 (9%) of 4732 patients at an incidence rate of 5·9 events per 100 person-years in the placebo group (hazard ratio 0·78, 95% CI 0·68–0·90), which indicated that albiglutide was superior to placebo (p&lt;0·0001 for non-inferiority; p=0·0006 for superiority). The incidence of acute pancreatitis (ten patients in the albiglutide group and seven patients in the placebo group), pancreatic cancer (six patients in the albiglutide group and five patients in the placebo group), medullary thyroid carcinoma (zero patients in both groups), and other serious adverse events did not differ between the two groups. There were three (&lt;1%) deaths in the placebo group that were assessed by investigators, who were masked to study drug assignment, to be treatment-related and two (&lt;1%) deaths in the albiglutide group. Interpretation: In patients with type 2 diabetes and cardiovascular disease, albiglutide was superior to placebo with respect to major adverse cardiovascular events. Evidence-based glucagon-like peptide 1 receptor agonists should therefore be considered as part of a comprehensive strategy to reduce the risk of cardiovascular events in patients with type 2 diabetes. Funding: GlaxoSmithKline

INNOVA Research Journal

El presente trabajo tiene por objetivo determinar la importancia del Órgano de Solución de Diferencias de la OMC dentro de las negociaciones sobre el acceso a los mercados internacionales. El área que se está investigando es el funcionamiento de la OMC especialmente, cómo esta resuelve las diferencias entre países, especialmente teniendo en cuenta el análisis de costo-beneficio que se incurre. La investigación se lleva a cabo a través de la revisión de fuentes primarias y secundarias con un enfoque cualitativo y comparativo así como perspectiva analítica y descriptiva. El resultado que se obtuvo después de estudiar dos casos específicamente en Ecuador, nos muestra cómo el organismo proporciona buenas oportunidades de desarrollo comercial a nivel mundial con ahorro de recursos. Se recomienda que los países hagan conciencia y permitan que estos organismos les asesoren al momento de tomar decisiones y resolver conflictos en búsqueda de un comercio más eficaz y eficiente

EducaFarma 9.0

Memoria ID-020 Ayudas de la Universidad de Salamanca para la innovación docente, curso 2020-2021