Fatigue Characterization of 3D Printed Elastomer Material

The Objet PolyJet 3D Printing process provides the ability to print graded materials featuring both stiff and elastomeric polymers. This capability allows for a variety of new design possibilities for additive manufacturing such as living hinges, shock absorbing casings, and integrated gaskets. Such design features typically rely upon the ability of traditional elastomers to experience large and repeated strains without permanent deformation or damage. However, voids and other flaws inherent to many Additive Manufacturing (AM) processes can have a significant negative impact on the fatigue life of elastomeric AM materials. In this paper, the authors seek to fill a gap in the literature by characterizing the fatigue life of a direct 3D printed elastomer, and the multi-material interface. Based on the results, the authors offer advice for improving fatigue life of printed elastomeric components.Mechanical Engineerin

The effectiveness of faecal removal methods of pasture management to control the cyathostomin burden of donkeys

Background: The level of anthelmintic resistance within some cyathostomin parasite populations has increased to the level where sole reliance on anthelmintic-based control protocols is not possible. Management-based nematode control methods, including removal of faeces from pasture, are widely recommended for use in association with a reduction in anthelmintic use to reduce selection pressure for drug resistance; however, very little work has been performed to quantitatively assess the effectiveness of such methods.<p></p> Methods: We analysed data obtained from 345 donkeys at The Donkey Sanctuary (Devon, UK), managed under three different pasture management techniques, to investigate the effectiveness of faeces removal in strongyle control in equids. The management groups were as follows: no removal of faeces from pasture, manual, twice-weekly removal of faeces from pasture and automatic, twice-weekly removal of faeces from pasture (using a mechanical pasture sweeper). From turn-out onto pasture in May, monthly faecal egg counts were obtained for each donkey and the dataset subjected to an auto regressive moving average model.<p></p> Results: There was little to no difference in faecal egg counts between the two methods of faecal removal; both resulted in significantly improved cyathostomin control compared to the results obtained from the donkeys that grazed pasture from which there was no faecal removal.<p></p> Conclusions: This study represents a valuable and unique assessment of the effectiveness of the removal of equine faeces from pasture, and provides an evidence base from which to advocate twice-weekly removal of faeces from pasture as an adjunct for equid nematode control. Widespread adoption of this practice could substantially reduce anthelmintic usage, and hence reduce selection pressure for nematode resistance to the currently effective anthelmintic products.<p></p&gt

The Mismatch in Distributions of Vertebrates and the Plants that they Disperse

© 2018 The Authors Little is known about how mutualistic interactions affect the distribution of species richness on broad geographic scales. Because mutualism positively affects the fitness of all species involved in the interaction, one hypothesis is that the richness of species involved should be positively correlated across their range, especially for obligate relationships. Alternatively, if mutualisms involve multiple mutualistic partners, the distribution of mutualists should not necessarily be related, and patterns in species distributions might be more strongly correlated with environmental factors. In this study, we compared the distributions of plants and vertebrate animals involved in seed-dispersal mutualisms across the United States and Canada. We compiled geographic distributions of plants dispersed by frugivores and scatter-hoarding animals, and compared their distribution of richness to the distribution in disperser richness. We found that the distribution of animal dispersers shows a negative relationship to the distribution of the plants that they disperse, and this is true whether the plants dispersed by frugivores or scatter-hoarders are considered separately or combined. In fact, the mismatch in species richness between plants and the animals that disperse their seeds is dramatic, with plants species richness greatest in the in the eastern United States and the animal species richness greatest in the southwest United States. Environmental factors were corelated with the difference in the distribution of plants and their animal mutualists and likely are more important in the distribution of both plants and animals. This study is the first to describe the broad-scale distribution of seed-dispersing vertebrates and compare the distributions to the plants they disperse. With these data, we can now identify locations that warrant further study to understand the factors that influence the distribution of the plants and animals involved in these mutualisms

The SBF Survey of Galaxy Distances. IV. SBF Magnitudes, Colors, and Distances

We report data for $I$ band Surface Brightness Fluctuation (SBF) magnitudes, V-I colors, and distance moduli for 300 galaxies. The Survey contains E, S0 and early-type spiral galaxies in the proportions of 49:42:9, and is essentially complete for E galaxies to Hubble velocities of 2000 km/s, with a substantial sampling of E galaxies out to 4000 km/s. The median error in distance modulus is 0.22 mag. We also present two new results from the Survey. (1) We compare the mean peculiar flow velocity (bulk flow) implied by our distances with predictions of typical cold dark matter transfer functions as a function of scale, and find very good agreement with cold, dark matter cosmologies if the transfer function scale parameter $\Gamma$, and the power spectrum normalization $\sigma_8$ are related by $\sigma_8 \Gamma^{-0.5} \approx 2\pm0.5$. Derived directly from velocities, this result is independent of the distribution of galaxies or models for biasing. The modest bulk flow contradicts reports of large-scale, large-amplitude flows in the $\sim200$ Mpc diameter volume surrounding our Survey volume. (2) We present a distance-independent measure of absolute galaxy luminosity, \Nbar, and show how it correlates with galaxy properties such as color and velocity dispersion, demonstrating its utility for measuring galaxy distances through large and unknown extinction.Comment: Accepted for publication in ApJ (10 January 2001); 23 page

Independent evaluation of a simple clinical prediction rule to identify right ventricular dysfunction in patients with shortness of breath

BACKGROUND: Many patients have unexplained persistent dyspnea after negative computed tomographic pulmonary angiography (CTPA). We hypothesized that many of these patients have isolated right ventricular (RV) dysfunction from treatable causes. We previously derived a clinical decision rule (CDR) for predicting RV dysfunction consisting of persistent dyspnea and normal CTPA, finding that 53% of CDR-positive patients had isolated RV dysfunction. Our goal is to validate this previously derived CDR by measuring the prevalence of RV dysfunction and outcomes in dyspneic emergency department patients. METHODS: A secondary analysis of a prospective observational multicenter study that enrolled patients presenting with suspected PE was performed. We included patients with persistent dyspnea, a nonsignificant CTPA, and formal echo performed. Right ventricular dysfunction was defined as RV hypokinesis and/or dilation with or without moderate to severe tricuspid regurgitation. RESULTS: A total of 7940 patients were enrolled. Two thousand six hundred sixteen patients were analyzed after excluding patients without persistent dyspnea and those with a significant finding on CTPA. One hundred ninety eight patients had echocardiography performed as standard care. Of those, 19% (95% confidence interval [CI], 14%-25%) and 33% (95% CI, 25%-42%) exhibited RV dysfunction and isolated RV dysfunction, respectively. Patients with isolated RV dysfunction or overload were more likely than those without RV dysfunction to have a return visit to the emergency department within 45 days for the same complaint (39% vs 18%; 95% CI of the difference, 4%-38%). CONCLUSION: This simple clinical prediction rule predicted a 33% prevalence of isolated RV dysfunction or overload. Patients with isolated RV dysfunction had higher recidivism rates and a trend toward worse outcomes

A Comparison of Arctic Ocean Sea Ice Export Between Nares Strait and the Canadian Arctic Archipelago

Nares Strait and the channels of the Canadian Arctic Archipelago (CAA) act as conduits for sea ice export from the Arctic Ocean but have never been directly compared. Here, we perform such a comparison for both the sea ice area and volume fluxes from October 2016 to December 2021. Nares Strait provided the largest average seasonal (October through September) ice area flux of 95 ± 8 × 103 km2 followed by the CAA regions of the Queen Elizabeth Islands (QEI) at 41 ± 7 × 103 km2 and M’Clure Strait at 2 ± 8 × 103 km2 with corresponding ice volume fluxes of 177 ± 15 km3, 59 ± 10 km3, and 8 ± 8 km3, respectively. Larger Arctic Ocean ice export at Nares Strait was associated with a shorter ice arch duration (237 days) compared to M’Clure Strait (163 days) and QEI (65 days). Seasonal Arctic Ocean ice export was dominated by Nares Strait in 2017–2019 and 2021 but was remarkably exceeded by the QEI in 2020. Large-scale atmospheric circulation patterns were found to influence the ice area flux in the absence of ice arches but no occurrence of coherent Arctic Ocean ice export events coinciding across all gates were observed. Average net seasonal Arctic Ocean ice area and volume export were 138 × 103 km2 and 245 km3, which represent ∼16% of the area and ∼25% of the volume of sea ice export from Fram Strait. Divergent Arctic Ocean export ice trajectories are apparent for Nares Strait and the QEI when compared to Fram Strait

Modelling the Seasonal Epidemics of Respiratory Syncytial Virus in Young Children

BACKGROUND Respiratory syncytial virus (RSV) is a major cause of paediatric morbidity. Mathematical models can be used to characterise annual RSV seasonal epidemics and are a valuable tool to assess the impact of future vaccines. OBJECTIVES Construct a mathematical model of seasonal epidemics of RSV and by fitting to a population-level RSV dataset, obtain a better understanding of RSV transmission dynamics. METHODS We obtained an extensive dataset of weekly RSV testing data in children aged less than 2 years, 2000-2005, for a birth cohort of 245,249 children through linkage of laboratory and birth record datasets. We constructed a seasonally forced compartmental age-structured Susceptible-Exposed-Infectious-Recovered-Susceptible (SEIRS) mathematical model to fit to the seasonal curves of positive RSV detections using the Nelder-Mead method. RESULTS From 15,830 specimens, 3,394 were positive for RSV. RSV detections exhibited a distinct biennial seasonal pattern with alternating sized peaks in winter months. Our SEIRS model accurately mimicked the observed data with alternating sized peaks using disease parameter values that remained constant across the 6 years of data. Variations in the duration of immunity and recovery periods were explored. The best fit to the data minimising the residual sum of errors was a model using estimates based on previous models in the literature for the infectious period and a slightly lower estimate for the immunity period. CONCLUSIONS Our age-structured model based on routinely collected population laboratory data accurately captures the observed seasonal epidemic curves. The compartmental SEIRS model, based on several assumptions, now provides a validated base model. Ranges for the disease parameters in the model that could replicate the patterns in the data were identified. Areas for future model developments include fitting climatic variables to the seasonal parameter, allowing parameters to vary according to age and implementing a newborn vaccination program to predict the effect on RSV incidence.HCM is funded by National Health and Medical Research Council Fellowship #1034254

Transcriptomes of parents identify parenting strategies and sexual conflict in a subsocial beetle

This work was funded by UK NERC grants to M.G.R. and A.J.M. an NERC studentship to D.J.P. the University of Georgia and a US NSF grant to A.J.M. and M.G.R.Parenting in the burying beetle Nicrophorus vespilloides is complex and, unusually, the sex and number of parents that can be present is flexible. Such flexibility is expected to involve specialized behaviour by the two sexes under biparental conditions. Here, we show that offspring fare equally well regardless of the sex or number of parents present. Comparing transcriptomes, we find a largely overlapping set of differentially expressed genes in both uniparental and biparental females and in uniparental males including vitellogenin, associated with reproduction, and takeout, influencing sex-specific mating and feeding behaviour. Gene expression in biparental males is similar to that in non-caring states. Thus, being ‘biparental’ in N. vespilloides describes the family social organization rather than the number of directly parenting individuals. There was no specialization; instead, in biparental families, direct male parental care appears to be limited with female behaviour unchanged. This should lead to strong sexual conflict.Publisher PDFPeer reviewe