Applications of dynamic diffuse signal processing in sound reinforcement and reproduction.

Electroacoustic systems are subject to position-dependent frequency responses due to coherent interference between multiple sources and/or early reflections. Diffuse signal processing (DiSP) provides a mechanism for signal decorrelation to potentially alleviate this well-known issue in sound reinforcement and reproduction applications. Previous testing has indicated that DiSP provides reduced low-frequency spatial variance across wide audience areas, but in closed acoustic spaces is less effective due to coherent early reflections. In this paper, dynamic implementation of DiSP is examined, whereby the decorrelation algorithm varies over time, thus allowing for decorrelation between surface reflections and direct sounds. Potential applications of dynamic DiSP are explored in the context of sound reinforcement (subwoofers, stage monitoring) and sound reproduction (small-room low-frequency control, loudspeaker crossovers), with preliminary experimental results presented.N/

Macrophage transactivation for chemokine production identified as a negative regulator of granulomatous inflammation using agent-based modeling

Cellular activation in trans by interferons, cytokines and chemokines is a commonly recognized mechanism to amplify immune effector function and limit pathogen spread. However, an optimal host response also requires that collateral damage associated with inflammation is limited. This may be particularly so in the case of granulomatous inflammation, where an excessive number and / or excessively florid granulomas can have significant pathological consequences. Here, we have combined transcriptomics, agent-based modeling and in vivo experimental approaches to study constraints on hepatic granuloma formation in a murine model of experimental leishmaniasis. We demonstrate that chemokine production by non-infected Kupffer cells in the Leishmania donovani-infected liver promotes competition with infected KCs for available iNKT cells, ultimately inhibiting the extent of granulomatous inflammation. We propose trans-activation for chemokine production as a novel broadly applicable mechanism that may operate early in infection to limit excessive focal inflammation

Champ or chump? Challenge and threat states during pressurized competition

Copyright © 2013 Human Kinetics, IncThe present research examined the immediate impact of challenge and threat states on golf performance in both real competition and a laboratory-based task. In Study 1, 199 experienced golfers reported their evaluations of competition demands and personal coping resources before a golf competition. Evaluating the competition as a challenge (i.e., sufficient resources to cope with demands) was associated with superior performance. In Study 2, 60 experienced golfers randomly received challenge or threat manipulation instructions and then performed a competitive golf-putting task. Challenge and threat states were successfully manipulated and the challenge group outperformed the threat group. Furthermore, the challenge group reported less anxiety, more facilitative interpretations of anxiety, less conscious processing, and displayed longer quiet eye durations. However, these variables failed to mediate the group-performance relationship. These studies demonstrate the importance of considering preperformance psychophysiological states when examining the influence of competitive pressure on motor performance

Quiet eye training improves small arms maritime marksmanship

Quiet eye training—teaching task-specific gaze control—has been consistently shown to optimize the acquisition of motor skills. The present study aimed to examine the potential benefits of a quiet eye training intervention in a simulated maritime marksmanship task that involved shooting fast approaching moving targets with a decommissioned general-purpose machine gun. Twenty participants were randomly assigned to a quiet eye trained (QET) or technical trained (TT) group and completed 2 baseline, 20 training, and 2 retention trials on the moving-target task. Compared to their TT counterparts, the QET group displayed more effective gaze control (longer quiet eye durations and greater target locking) and more accurate performance (smaller radial error of both the initial shot and average of all shots) at retention. These findings highlight the potential for quiet eye training to be used to support the training of marksmanship skills in military settings

Optimizing wide-area sound reproduction using a single subwoofer with dynamic signal decorrelation

A central goal in small room sound reproduction is achieving consistent sound energy distribution across a wide listening area. This is especially difficult at low-frequencies where room-modes result in highly position-dependent listening experiences. While numerous techniques for multiple-degree-of-freedom systems exist and have proven to be highly effective, this work focuses on achieving position-independent low-frequency listening experiences with a single subwoofer. The negative effects due to room-modes and comb-filtering are mitigated by applying a time-varying decorrelation method known as dynamic diffuse signal processing. Results indicate that spatial variance in magnitude response can be significantly reduced, although there is a sharp trade-off between the algorithm’s effectiveness and the resulting perceptual coloration of the audio signal.N/

Semi-field evaluation of freestanding transfluthrin passive emanators and the BG sentinel trap as a "push-pull control strategy" against Aedes aegypti mosquitoes

Spatial repellents that drive mosquitoes away from treated areas, and odour-baited traps, that attract and kill mosquitoes, can be combined and work synergistically in a push-pull system. Push-pull systems have been shown to reduce house entry and outdoor biting rates of malaria vectors and so have the potential to control other outdoor biting mosquitoes such as Aedes aegypti that transmit arboviral diseases. In this study, semi-field experiments were conducted to evaluate whether a push-pull system could be used to reduce bites from Aedes mosquitoes.; The push and pull under investigation consisted of two freestanding transfluthrin passive emanators (FTPE) and a BG sentinel trap (BGS) respectively. The FTPE contained hessian strips treated with 5.25 g of transfluthrin active ingredient. The efficacies of FTPE and BGS alone and in combination were evaluated by human landing catch in a large semi-field system in Tanzania. We also investigated the protection of FTPE over six months. The data were analyzed using generalized linear mixed models with binomial distribution.; Two FTPE had a protective efficacy (PE) of 61.2% (95% confidence interval (CI): 52.2-69.9%) against the human landing of Ae. aegypti. The BGS did not significantly reduce mosquito landings; the PE was 2.1% (95% CI: -2.9-7.2%). The push-pull provided a PE of 64.5% (95% CI: 59.1-69.9%). However, there was no significant difference in the PE between the push-pull and the two FTPE against Ae. aegypti (P = 0.30). The FTPE offered significant protection against Ae. aegypti at month three, with a PE of 46.4% (95% CI: 41.1-51.8%), but not at six months with a PE of 2.2% (95% CI: -9.0-14.0%).; The PE of the FTPE and the full push-pull are similar, indicative that bite prevention is primarily due to the activity of the FTPE. While these results are encouraging for the FTPE, further work is needed for a push-pull system to be recommended for Ae. aegypti control. The three-month protection against Ae. aegypti bites suggests that FTPE would be a useful additional control tool during dengue outbreaks, that does not require regular user compliance

Hypothalamic Vitamin D Improves Glucose Homeostasis and Reduces Weight

Despite clear associations between vitamin D deficiency and obesity and/or type 2 diabetes, a causal relationship is not established. Vitamin D receptors (VDRs) are found within multiple tissues, including the brain. Given the importance of the brain in controlling both glucose levels and body weight, we hypothesized that activation of central VDR links vitamin D to the regulation of glucose and energy homeostasis. Indeed, we found that small doses of active vitamin D, 1α,25-dihydroxyvitamin D3 (1,25D3) (calcitriol), into the third ventricle of the brain improved glucose tolerance and markedly increased hepatic insulin sensitivity, an effect that is dependent upon VDR within the paraventricular nucleus of the hypothalamus. In addition, chronic central administration of 1,25D3 dramatically decreased body weight by lowering food intake in obese rodents. Our data indicate that 1,25D3-mediated changes in food intake occur through action within the arcuate nucleus. We found that VDR colocalized with and activated key appetite-regulating neurons in the arcuate, namely proopiomelanocortin neurons. Together, these findings define a novel pathway for vitamin D regulation of metabolism with unique and divergent roles for central nervous system VDR signaling. Specifically, our data suggest that vitamin D regulates glucose homeostasis via the paraventricular nuclei and energy homeostasis via the arcuate nuclei