Bounded Refinement Types

We present a notion of bounded quantification for refinement types and show how it expands the expressiveness of refinement typing by using it to develop typed combinators for: (1) relational algebra and safe database access, (2) Floyd-Hoare logic within a state transformer monad equipped with combinators for branching and looping, and (3) using the above to implement a refined IO monad that tracks capabilities and resource usage. This leap in expressiveness comes via a translation to "ghost" functions, which lets us retain the automated and decidable SMT based checking and inference that makes refinement typing effective in practice.Comment: 14 pages, International Conference on Functional Programming, ICFP 201

Upper limit for sea level projections by 2100

We construct the probability density function of global sea level at 2100, estimating that sea level rises larger than 180 cm are less than 5% probable. An upper limit for global sea level rise of 190 cm is assembled by summing the highest estimates of individual sea level rise components simulated by process based models with the RCP8.5 scenario. The agreement between the methods may suggest more confidence than is warranted since large uncertainties remain due to the lack of scenario-dependent projections from ice sheet dynamical models, particularly for mass loss from marine-based fast flowing outlet glaciers in Antarctica. This leads to an intrinsically hard to quantify fat tail in the probability distribution for global mean sea level rise. Thus our low probability upper limit of sea level projections cannot be considered definitive. Nevertheless, our upper limit of 180 cm for sea level rise by 2100 is based on both expert opinion and process studies and hence indicates that other lines of evidence are needed to justify a larger sea level rise this century

Reducing smoking in adolescents: cost-effectiveness results from the cluster randomized ASSIST (A Stop Smoking In Schools Trial)

Introduction: School-based smoking prevention programmes can be effective, but evidence on cost-effectiveness is lacking. We conducted a cost-effectiveness analysis of a school-based “peer-led” intervention.<p></p> Methods: We evaluated the ASSIST (A Stop Smoking In Schools Trial) programme in a cluster randomized controlled trial. The ASSIST programme trained students to act as peer supporters during informal interactions to encourage their peers not to smoke. Fifty-nine secondary schools in England and Wales were randomized to receive the ASSIST programme or usual smoking education. Ten thousand seven hundred and thirty students aged 12–13 years attended participating schools. Previous work has demonstrated that the ASSIST programme achieved a 2.1% (95% CI = 0%–4.2%) reduction in smoking prevalence. We evaluated the public sector cost, prevalence of weekly smoking, and cost per additional student not smoking at 24 months.<p></p> Results: The ASSIST programme cost of £32 (95% CI = £29.70–£33.80) per student. The incremental cost per student not smoking at 2 years was £1,500 (95% CI = £669–£9,947). Students in intervention schools were less likely to believe that they would be a smoker at age 16 years (odds ratio [OR] = 0.80; 95% CI = 0.66–0.96).<p></p> Conclusions: A peer-led intervention reduced smoking among adolescents at a modest cost. The intervention is cost-effective under realistic assumptions regarding the extent to which reductions in adolescent smoking lead to lower smoking prevalence and/or earlier smoking cessation in adulthood. The annual cost of extending the intervention to Year 8 students in all U.K. schools would be in the region of £38 million and could result in 20,400 fewer adolescent smokers.<p></p&gt

Influence of anisotropy on velocity and age distribution at Scharffenbergbotnen blue ice area

We use a full-Stokes thermo-mechanically coupled ice-flow model to study the dynamics of the glacier inside Scharffenbergbotnen valley, Dronning Maud Land, Antarctica. The domain encompasses a high accumulation rate region and, downstream a sublimation-dominated bare ice ablation area. The ablation ice area is notable for having old ice at its surface since the vertical velocity is upwards, and horizontal velocities are almost stagnant there. We compare the model simulation with field observations of velocities and the age distribution of the surface ice. A satisfactory match with simulations using an isotropic flow law was not found because of too high horizontal velocities and too slow vertical ones. However, the existence of a pronounced ice fabric may explain the present day surface velocity distribution in the inner Scharffenbergbotnen blue ice area. Near absence of data on the temporal evolution of Scharffenbergbotnen since the Late Glacial Maximum necessitates exploration of the impact of anisotropy using prescribed ice fabrics: isotropic, single maximum, and linear variation with depth, in both two-dimensional and three dimensional flow models. The realistic velocity field simulated with a non-collinear orthotropic flow law, however produced surface ages in significant disagreement with the few reliable age measurements and suggests that the age field is not in a steady state and that the present distribution is a result of a flow reorganization at about 15 000 yr BP. In order to fully understand the surface age distribution a transient simulation starting from the Late Glacial Maximum including the correct initial conditions for geometry, age, fabric and temperature distribution would be needed. It is the first time that the importance of anisotropy has been demonstrated in the ice dynamics of a blue ice area. This is useful to understand ice flow in order to better interpret archives of ancient ice for paleoclimate research

Supra-nutritional vitamin E supplementation for 28 days before slaughter maximises muscle vitamin E concentration in finisher pigs

A 4 × 3 factorial experiment (n= 8 pigs per treatment combination) was conducted with 96 female Landrace × Large White pigs to examine the required level of dietary vitamin E and optimum feeding duration before slaughter to maximise muscle vitamin E content in the Longissimus thoracis et lumborum (LTL) muscle. The respective factors were four dietary levels of vitamin E (supplemented as dl-α-tocopheryl acetate; 35, 300, 500, and 700 IU/kg) and three feeding durations (14, 28 and 42 days before slaughter). Vitamin E concentration in the LTL was maximised at 6 mg/kg, which was achieved by feeding a 700 IU vitamin E diet for 28 days before slaughter (P < 0.001). There was no further increase in the vitamin E content of the LTL by feeding the high vitamin E diet more than 28 days before slaughter

The metabolism and de-bromination of bromotyrosine in vivo

During inflammation, leukocyte-derived eosinophil peroxidase catalyses the formation of hypobromous acid, which can brominate tyrosine residues in proteins to form bromotyrosine. Since eosinophils are involved in the pathogenesis of allergic reactions, such as asthma, urinary bromotyrosine level has been used for the assessment of children with asthma. However, little is known about the metabolism and disposition of bromotyrosine in vivo. The aim of this study was to identify the major urinary metabolites formed during bromotyrosine metabolism and to develop mass spectrometric methods for their quantitation. Deuterium-labeled bromotyrosine was synthesized by deuterium exchange. [D3]bromotyrosine (500 nmole) was injected intraperitoneally into Sprague-Dawley rats and urine was collected for 24 h in a metabolic cage. 13C-labeled derivatives of bromotyrosine and its major urinary metabolite were synthesized and used as internal standards for quantitation. Following solid phase extraction, urine samples were derivatized to the pentafluorobenzyl ester, and analyzed using isotope dilution gas chromatography and negative-ion chemical ionization mass spectrometry. A novel brominated metabolite, 3-bromo-4-hydroxyphenylacetic acid (bromo-HPA), was identified as the major brominated metabolite of bromotyrosine. Bromo-HPA only accounted for 0.43±0.04% of infused [D3]bromotyrosine and 0.12±0.02% of infused [D3]bromotyrosine was excreted in the urine unchanged. However, ~1.3% (6.66±1.33 nmole) of infused [D3]bromotyrosine was excreted in the urine as the de-brominated metabolite, [D3]4-hydroxyphenylacetic acid, which is also a urinary metabolite of tyrosine in mammals. We also tested whether or not iodotyrosine dehalogenase can catalyse de-bromination of bromotyrosine and showed that iodotyrosine dehalogenase is able to de-brominate free bromotyrosine in vitro. We identified bromo-HPA as the main brominated urinary metabolite of bromotyrosine in rats. However, de-halogenation of bromotyrosine is the major metabolic pathway to eliminate free brominated tyrosine in vivo

A within farm clinical trial to compare two treatments (parenteral antibacterials and hoof trimming) for sheep lame with footrot

From observational studies, farmers who use parenteral antibacterials to promptly treat all sheep with footrot (FR) or interdigital dermatitis (ID) have a prevalence of lameness of <2% compared with a prevalence of 9% lameness reported by farmers who treat lame sheep by trimming affected feet. We tested the hypothesis that prompt treatment of sheep lame with naturally developing FR or ID with parenteral and topical antibacterials reduces the prevalence and incidence of lameness with these conditions compared with less frequent treatment with trimming of hoof horn and applying topical antibacterials. A further hypothesis was that reduction of ID and FR would improve productivity. A lowland sheep flock with 700 ewes was used to test these hypotheses in an 18-month within farm clinical trial with four groups of ewes: two intervention and two control. The duration and severity of lameness was used to categorise sheep into three weighted scores of lameness (WLS): never lame (WLS0), mildly lame/lame for <6 days (WLS1) and severely or chronically lame (WLS2). The intervention reduced the prevalence of lameness due to FR and ID in ewes and lambs and the incidence of lameness in ewes. The WLS was also significantly lower in sheep in the intervention groups. Ewes with a higher WLS were subsequently significantly more likely to have a body condition score <2.5 and to have lame lambs. Significantly more ewes lambed and successfully reared more lambs that were ready for slaughter at a younger age in the intervention versus control groups. There was an increase in the gross margin of £630/100 ewes mated in the intervention group, including the cost of treatment of £150/100 ewes mated. We conclude that prompt parenteral and topical antibacterial treatment of sheep lame with ID and FR reduced the prevalence and incidence of these infectious conditions and led to improved health, welfare and productivity