Perfil social y económico de los pacientes diagnosticados con trastornos del humor del Hospital Departamental Psiquiátrico Universitario del Valle, Cali

The aim of this article is to provide a social, economic and demographic profile of the population registered with SISBÉN at the Hospital Departamental Psiquiátrico Universitario del Valle (HDPUV) between 2009 and 2018, whose diagnosis is within the group of mood disorders, (corresponding to the spectrum of ICD- 10 codes ranging from F30 to F39, manic episode, bipolar disorder, depressive episode, recurrent depressive disorder, persistent mood disorder, other mood disorders, mood disorder without specification). We opted for a study in which we complemented the information between the Cali SISBÉN and HDPUV databases to deepen in data on poverty and vulnerability of people who are potential beneficiaries of state social programs. We identified 5,280 patients diagnosed with mood disorders, mostly women (70.4%) in conditions of economic, social and access to health services vulnerability, which represent yet another risk factor for their mental health.El objetivo de este artículo consiste en dar a conocer un perfil social, económico y demográfico de la población registrada con SISBÉN en el Hospital Departamental Psiquiátrico Universitario del Valle (HDPUV) entre el 2009 y el 2018, cuyo diagnóstico se encuentra dentro del grupo de los trastornos del humor (correspondiente al espectro de códigos del CIE-10 que va desde F30 a F39, episodio maníaco, trastorno bipolar, episodio depresivo, trastorno depresivo recurrente, trastorno del humor persistente, otros trastornos del humor,  trastorno del humor sin especificación). Se optó por un trabajo en el que se complementó la información entre las bases de datos del SISBÉN de Cali y la del HDPUV para profundizar en datos sobre pobreza y vulnerabilidad de las personas que son potenciales beneficiarios de programas sociales estatales. Se identificaron 5.280 pacientes diagnosticados con trastornos del humor, en su mayoría mujeres (70,4 %) en condiciones de vulnerabilidad económicas, sociales y de acceso a servicios de salud, que representan otro factor más de riesgo para su salud mental

Espacio y clasificación poblacional frente a la pandemia de covid-19 en Cali

This paper studies the strategy deployed by the State to defining territories, classifying people, and producing control devices during the covid-19 pandemic lived in the city of Cali in 2020. The symbolic resources that the local State used in this period as strategy of control, based on moral judgments and the rhetoric of fear, led to the labelling of socially excluded localities as disobedient, undisciplined and with scarce comprehension of risk, in order to explain contagion and death by covid-19. The analysis relates poverty, crime, space, and transmission of the coronavirus, which marginalizes localities already excluded in a fragmented city like Cali. Aggregate data from State agencies and news from El País and El Tiempo are used to identify definitions and state interventions over control spaces and populations. We also used tables and maps to represent the delimitation of the reality of the State. It is concluded that symbolic production aimed at containing contagion and mortality and restrictive interventions are legitimized with statistics disseminated by the media.El propósito del artículo es estudiar la estrategia desplegada por el Estado para definir territorios, clasificar personas y producir dispositivos de control en Cali durante la pandemia del covid-19 en el 2020. Los recursos simbólicos que el Estado utilizó, como parte de su estrategia de control, con base en juicios morales y en una retórica del miedo, suscitó el etiquetaje de poblaciones como desobedientes e indisciplinadas asociado con una comprensión espacial del riesgo en zonas excluidas de la ciudad, para explicar el contagio y la muerte por covid-19. En el texto se presenta un análisis que relaciona pobreza, delincuencia, espacio y transmisión del coronavirus, la cual marginaliza a sectores ya excluidos en una ciudad fragmentada como Cali. Se usan datos agregados de organismos estatales y noticias de El País y El Tiempo para identificar las definiciones e intervenciones estatales sobre los espacios de control y las poblaciones, y además se elaboran tablas y mapas para representar la delimitación de la realidad del Estado. Se concluye que la producción simbólica orientada a contener el contagio y la mortalidad, así como las intervenciones restrictivas, se legitiman con estadísticas difundidas por los medios

Enfermedad mental y cambios institucionales en el Hospital Psiquiátrico San Isidro de Cali (1940-1970).

Los trabajos que conforman este libro tienen en común la indagación por el cambio institucional en el campo de la salud mental en el país, durante un periodo de significativas transformaciones sobre las formas de concebir y gestionar la enfermedad mental y sus prácticas médicas. Estas indagaciones, inscritas en el periodo 1940-1970, abordan el cambio institucional del entonces llamado Hospital Psiquiátrico San Isidro de la ciudad de Cali, a partir del papel que juegan los actores a nivel individual y grupal, la influencia que tienen los sistemas de creencias en dichos cambios, las condiciones históricas que los soportan y el modo en que estos cambios se manifiestan. Los diferentes aspectos que conforman la dinámica del cambio institucional aportan claves para entender la manera en que se transforman las instituciones públicas y establecen relaciones con sectores privados, para dar cuenta de un campo de intervención social tan complejo como es la salud mental.Acercamientos historiográficos al programa institucional de atención a la locura en Colombia durante las primeras décadas del siglo XX -- Cambio institucional y modernización de la práctica psiquiátrica en el Hospital Psiquiátrico Universitario Del Valle 1956-1970 -- Redes cívicas y filantrópicas: el caso de la junta pro-construcción del asilo san isidro en Cali, 1950-1961 -- El rol del Departamento de Psiquiatría de la Universidad del Valle en los cambios institucionales del Hospital San Isidr

Unraveling the effect of silent, intronic and missense mutations on VWF splicing: contribution of next generation sequencing in the study of mRNA

Large studies in von Willebrand disease patients, including Spanish and Portuguese registries, led to identification of >250 different mutations. It is a challenge to determine the pathogenic effect of potential splice site mutations on VWF mRNA. This study aimed to elucidate the true effects of 18 mutations on VWF mRNA processing, investigate the contribution of next-generation sequencing to in vivo mRNA study in von Willebrand disease, and compare the findings with in silico prediction. RNA extracted from patient platelets and leukocytes was amplified by RT-PCR and sequenced using Sanger and next generation sequencing techniques. Eight mutations affected VWF splicing: c.1533+1G>A, c.5664+2T>C and c.546G>A (p.=) prompted exon skipping; c.3223-7_3236dup and c.7082-2A>G resulted in activation of cryptic sites; c.3379+1G>A and c.7473G>A (p.=) demonstrated both molecular pathogenic mechanisms simultaneously; and the p.Cys370Tyr missense mutation generated two aberrant transcripts. Of note, the complete effect of 3 mutations was provided by next generation sequencing alone because of low expression of the aberrant transcripts. In the remaining 10 mutations, no effect was elucidated in the experiments. However, the differential findings obtained in platelets and leukocytes provided substantial evidence that 4 of these would have an effect on VWF levels. In this first report using next generation sequencing technology to unravel the effects of VWF mutations on splicing, the technique yielded valuable information. Our data bring to light the importance of studying the effect of synonymous and missense mutations on VWF splicing to improve the current knowledge of the molecular mechanisms behind von Willebrand disease.info:eu-repo/semantics/publishedVersio

Unraveling the effect of silent, intronic and missense mutations on VWF splicing: contribution of next generation sequencing in the study of mRNA

Large studies in von Willebrand disease patients, including Spanish and Portuguese registries, led to the identification of >250 different mutations. It is a challenge to determine the pathogenic effect of potential splice site mutations on VWF mRNA. This study aimed to elucidate the true effects of 18 mutations on VWF mRNA processing, investigate the contribution of next-generation sequencing to in vivo mRNA study in von Willebrand disease, and compare the findings with in silico prediction. RNA extracted from patient platelets and leukocytes was amplified by RT-PCR and sequenced using Sanger and next generation sequencing techniques. Eight mutations affected VWF splicing: c.1533+1G>A, c.5664+2T>C and c.546G>A (p.=) prompted exon skipping; c.3223-7_3236dup and c.7082-2A>G resulted in activation of cryptic sites; c.3379+1G>A and c.7437G>A) demonstrated both molecular pathogenic mechanisms simultaneously; and the p.Cys370Tyr missense mutation generated two aberrant transcripts. Of note, the complete effect of three mutations was provided by next generation sequencing alone because of low expression of the aberrant transcripts. In the remaining 10 mutations, no effect was elucidated in the experiments. However, the differential findings obtained in platelets and leukocytes provided substantial evidence that four of these would have an effect on VWF levels. In this first report using next generation sequencing technology to unravel the effects of VWF mutations on splicing, the technique yielded valuable information. Our data bring to light the importance of studying the effect of synonymous and missense mutations on VWF splicing to improve the current knowledge of the molecular mechanisms behind von Willebrand disease. clinicaltrials.gov identifier:02869074

Unraveling the effect of silent, intronic and missense mutations on VWF splicing : contribution of next generation sequencing in the study of mRNA

Large studies in von Willebrand disease patients, including Spanish and Portuguese registries, led to the identification of >250 different mutations. It is a challenge to determine the pathogenic effect of potential splice site mutations on VWF mRNA. This study aimed to elucidate the true effects of 18 mutations on VWF mRNA processing, investigate the contribution of next-generation sequencing to in vivo mRNA study in von Willebrand disease, and compare the findings with in silico prediction. RNA extracted from patient platelets and leukocytes was amplified by RT-PCR and sequenced using Sanger and next generation sequencing techniques. Eight mutations affected VWF splicing: c.1533+1G>A, c.5664+2T>C and c.546G>A (p.=) prompted exon skipping; c.3223-7_3236dup and c.7082-2A>G resulted in activation of cryptic sites; c.3379+1G>A and c.7437G>A) demonstrated both molecular pathogenic mechanisms simultaneously; and the p.Cys370Tyr missense mutation generated two aberrant transcripts. Of note, the complete effect of three mutations was provided by next generation sequencing alone because of low expression of the aberrant transcripts. In the remaining 10 mutations, no effect was elucidated in the experiments. However, the differential findings obtained in platelets and leukocytes provided substantial evidence that four of these would have an effect on VWF levels. In this first report using next generation sequencing technology to unravel the effects of VWF mutations on splicing, the technique yielded valuable information. Our data bring to light the importance of studying the effect of synonymous and missense mutations on VWF splicing to improve the current knowledge of the molecular mechanisms behind von Willebrand disease. identifier:02869074

Spread of a SARS-CoV-2 variant through Europe in the summer of 2020.

Following its emergence in late 2019, the spread of SARS-CoV-21,2 has been tracked by phylogenetic analysis of viral genome sequences in unprecedented detail3–5. Although the virus spread globally in early 2020 before borders closed, intercontinental travel has since been greatly reduced. However, travel within Europe resumed in the summer of 2020. Here we report on a SARS-CoV-2 variant, 20E (EU1), that was identified in Spain in early summer 2020 and subsequently spread across Europe. We find no evidence that this variant has increased transmissibility, but instead demonstrate how rising incidence in Spain, resumption of travel, and lack of effective screening and containment may explain the variant’s success. Despite travel restrictions, we estimate that 20E (EU1) was introduced hundreds of times to European countries by summertime travellers, which is likely to have undermined local efforts to minimize infection with SARS-CoV-2. Our results illustrate how a variant can rapidly become dominant even in the absence of a substantial transmission advantage in favourable epidemiological settings. Genomic surveillance is critical for understanding how travel can affect transmission of SARS-CoV-2, and thus for informing future containment strategies as travel resumes. © 2021, The Author(s), under exclusive licence to Springer Nature Limited

Bienestar y familia, una mirada desde la psicología positiva

Este libro está dirigido a estudiantes y profesionales en psicología y áreas afines, como enfermería, trabajo social o educación, y a los interesados en personalidad positiva. Cada capítulo se presenta de manera sencilla y con una estructura didáctica, pero sin perder rigor científico y calidad de la revisión, con el fin de facilitar el acceso a la información sobre bienestar individual, familiar y social de una forma accesible para adentrarnos al estudio de temas de psicología positiva. Dadas las temáticas, se consideró pertinente dividir este libro en dos secciones: I. Psicología positiva y bienestar. II. Bienestar individual y familiar.Universidad Autónoma del Estado de México y Ediciones y Gráficos Eón, S.A. de C.V

RICORS2040 : The need for collaborative research in chronic kidney disease

Chronic kidney disease (CKD) is a silent and poorly known killer. The current concept of CKD is relatively young and uptake by the public, physicians and health authorities is not widespread. Physicians still confuse CKD with chronic kidney insufficiency or failure. For the wider public and health authorities, CKD evokes kidney replacement therapy (KRT). In Spain, the prevalence of KRT is 0.13%. Thus health authorities may consider CKD a non-issue: very few persons eventually need KRT and, for those in whom kidneys fail, the problem is 'solved' by dialysis or kidney transplantation. However, KRT is the tip of the iceberg in the burden of CKD. The main burden of CKD is accelerated ageing and premature death. The cut-off points for kidney function and kidney damage indexes that define CKD also mark an increased risk for all-cause premature death. CKD is the most prevalent risk factor for lethal coronavirus disease 2019 (COVID-19) and the factor that most increases the risk of death in COVID-19, after old age. Men and women undergoing KRT still have an annual mortality that is 10- to 100-fold higher than similar-age peers, and life expectancy is shortened by ~40 years for young persons on dialysis and by 15 years for young persons with a functioning kidney graft. CKD is expected to become the fifth greatest global cause of death by 2040 and the second greatest cause of death in Spain before the end of the century, a time when one in four Spaniards will have CKD. However, by 2022, CKD will become the only top-15 global predicted cause of death that is not supported by a dedicated well-funded Centres for Biomedical Research (CIBER) network structure in Spain. Realizing the underestimation of the CKD burden of disease by health authorities, the Decade of the Kidney initiative for 2020-2030 was launched by the American Association of Kidney Patients and the European Kidney Health Alliance. Leading Spanish kidney researchers grouped in the kidney collaborative research network Red de Investigación Renal have now applied for the Redes de Investigación Cooperativa Orientadas a Resultados en Salud (RICORS) call for collaborative research in Spain with the support of the Spanish Society of Nephrology, Federación Nacional de Asociaciones para la Lucha Contra las Enfermedades del Riñón and ONT: RICORS2040 aims to prevent the dire predictions for the global 2040 burden of CKD from becoming true

Epidemiological trends of HIV/HCV coinfection in Spain, 2015-2019

Altres ajuts: Spanish AIDS Research Network; European Funding for Regional Development (FEDER).Objectives: We assessed the prevalence of anti-hepatitis C virus (HCV) antibodies and active HCV infection (HCV-RNA-positive) in people living with HIV (PLWH) in Spain in 2019 and compared the results with those of four similar studies performed during 2015-2018. Methods: The study was performed in 41 centres. Sample size was estimated for an accuracy of 1%. Patients were selected by random sampling with proportional allocation. Results: The reference population comprised 41 973 PLWH, and the sample size was 1325. HCV serostatus was known in 1316 PLWH (99.3%), of whom 376 (28.6%) were HCV antibody (Ab)-positive (78.7% were prior injection drug users); 29 were HCV-RNA-positive (2.2%). Of the 29 HCV-RNA-positive PLWH, infection was chronic in 24, it was acute/recent in one, and it was of unknown duration in four. Cirrhosis was present in 71 (5.4%) PLWH overall, three (10.3%) HCV-RNA-positive patients and 68 (23.4%) of those who cleared HCV after anti-HCV therapy (p = 0.04). The prevalence of anti-HCV antibodies decreased steadily from 37.7% in 2015 to 28.6% in 2019 (p < 0.001); the prevalence of active HCV infection decreased from 22.1% in 2015 to 2.2% in 2019 (p < 0.001). Uptake of anti-HCV treatment increased from 53.9% in 2015 to 95.0% in 2019 (p < 0.001). Conclusions: In Spain, the prevalence of active HCV infection among PLWH at the end of 2019 was 2.2%, i.e. 90.0% lower than in 2015. Increased exposure to DAAs was probably the main reason for this sharp reduction. Despite the high coverage of treatment with direct-acting antiviral agents, HCV-related cirrhosis remains significant in this population