Volume I. Introduction to DUNE

The preponderance of matter over antimatter in the early universe, the dynamics of the supernovae that produced the heavy elements necessary for life, and whether protons eventually decay—these mysteries at the forefront of particle physics and astrophysics are key to understanding the early evolution of our universe, its current state, and its eventual fate. The Deep Underground Neutrino Experiment (DUNE) is an international world-class experiment dedicated to addressing these questions as it searches for leptonic charge-parity symmetry violation, stands ready to capture supernova neutrino bursts, and seeks to observe nucleon decay as a signature of a grand unified theory underlying the standard model. The DUNE far detector technical design report (TDR) describes the DUNE physics program and the technical designs of the single- and dual-phase DUNE liquid argon TPC far detector modules. This TDR is intended to justify the technical choices for the far detector that flow down from the high-level physics goals through requirements at all levels of the Project. Volume I contains an executive summary that introduces the DUNE science program, the far detector and the strategy for its modular designs, and the organization and management of the Project. The remainder of Volume I provides more detail on the science program that drives the choice of detector technologies and on the technologies themselves. It also introduces the designs for the DUNE near detector and the DUNE computing model, for which DUNE is planning design reports. Volume II of this TDR describes DUNE\u27s physics program in detail. Volume III describes the technical coordination required for the far detector design, construction, installation, and integration, and its organizational structure. Volume IV describes the single-phase far detector technology. A planned Volume V will describe the dual-phase technology

Deep Underground Neutrino Experiment (DUNE), far detector technical design report, volume III: DUNE far detector technical coordination

The preponderance of matter over antimatter in the early universe, the dynamics of the supernovae that produced the heavy elements necessary for life, and whether protons eventually decay—these mysteries at the forefront of particle physics and astrophysics are key to understanding the early evolution of our universe, its current state, and its eventual fate. The Deep Underground Neutrino Experiment (DUNE) is an international world-class experiment dedicated to addressing these questions as it searches for leptonic charge-parity symmetry violation, stands ready to capture supernova neutrino bursts, and seeks to observe nucleon decay as a signature of a grand unified theory underlying the standard model. The DUNE far detector technical design report (TDR) describes the DUNE physics program and the technical designs of the single- and dual-phase DUNE liquid argon TPC far detector modules. Volume III of this TDR describes how the activities required to design, construct, fabricate, install, and commission the DUNE far detector modules are organized and managed. This volume details the organizational structures that will carry out and/or oversee the planned far detector activities safely, successfully, on time, and on budget. It presents overviews of the facilities, supporting infrastructure, and detectors for context, and it outlines the project-related functions and methodologies used by the DUNE technical coordination organization, focusing on the areas of integration engineering, technical reviews, quality assurance and control, and safety oversight. Because of its more advanced stage of development, functional examples presented in this volume focus primarily on the single-phase (SP) detector module

Epidermal growth factor upregulates motility of Mat-LyLu rat prostate cancer cells partially via voltage-gated Na+ channel activity.

The main aim of this investigation was to determine whether a functional relationship existed between epidermal growth factor (EGF) and voltage-gated sodium channel (VGSC) upregulation, both associated with strongly metastatic prostate cancer cells. Incubation with EGF for 24 h more than doubled VGSC current density. Similar treatment with EGF significantly and dose-dependently enhanced the cells' migration through Transwell filters. Both the patch clamp recordings and the migration assay suggested that endogenous EGF played a similar role. Importantly, co-application of EGF and tetrodotoxin, a highly selective VGSC blocker, abolished 65% of the potentiating effect of EGF. It is suggested that a significant portion of the EGF-induced enhancement of migration occurred via VGSC activityPeer reviewe

Laboratory and Test Beam Results from a Large Area Silicon Drift Detector

A very large-area (6.75 78cm2) silicon drift detector with integrated high-voltage divider has been designed, produced and fully characterised in the laboratory by means of ad hoc designed MOS injection electrodes. The detector is of the ``butterfly'' type, the sensitive area being subdivided into two regions with a maximum drift length of 3.3cm. The device was also tested in a pion beam (at the CERN PS) tagged by means of a microstrip detector telescope. Bipolar VLSI front-end cells featuring a noise of 250e-rms at 0pF with a slope of 40e-/pF have been used to read out the signals. The detector showed an excellent stability and featured the expected characteristics. Some preliminary results will be presented

Energy resolution of a silicon detector with the RX64 ASIC designed for X-ray imaging

Results from a silicon microstrip detector coupled to the RX64 ASIC are presented. The system is capable of single photon counting in digital X-ray imaging, with foreseen applications to dual energy mammography and angiography. The main features of the detecting system are low noise (operation with threshold as low as E4 keV is possible), good spatial resolution (a pixel of 100 mm 300 mm when oriented edge-on) and good counting rate capability (up to one million counts per channel with a maximum rate of about 200 kHz per channel). The energy resolution of the system, as obtained with several fluorescence X-ray lines, is described

Results from beam tests of large area silicon drift detectors

Silicon drift detectors with an active area of 7.0x7.5 cm2 will equip the two middle layers ofthe Inner Tracking System of the ALICE experiment. The performance of several prototypes was studied during beam tests carried out at the CERN SPS facility. In this paper, the results obtained from the data taken during August 2000 will be presented. The spatial resolution was studied in the case of tracks perpendicular to the detector and in the case ofinclined tracks. Results on the signal analysis and ofthe double-track resolution are also shown

Characteristics of the ALICE Silicon Drift Detector

A Silicon Drift Detector (SDD) with an active area of 7:0 7:5 cm2 has been designed, produced and tested for the ALICE Inner Tracking System. The development of the SDD has been focused on the capability of the detector to work without an external support to the integrated high-voltage divider. Several features have been implemented in the design in order to increase the robustness and the long-term electrical stability of the detector. One of the prototypes has been tested in a pion beam at the CERN SPS. Preliminary results on the position resolution are given

A silicon stripdetector coupled to the RX64 ASIC for X-ray diagnostic imaging

Firstresultsfromasiliconmicrostripdetectorwith100mmpitchcoupledtotheRX64ASICarepresented. The system is capable of single photon counting in digital X-ray imaging, with possible applications to dual energy mammography and angiography. The main features of the detecting system are low noise, good spatial resolution and high counting rate capability. The energy resolution and the conversion efficiency of the system are discussed, based on results obtained with fluorescence X-ray sources and quasi-monochromatic X-ray beams in the 8–36 keV energy range, with strips being either orthogonal or parallel to the incoming X-rays. We present also preliminary imaging results obtained with a plexiglass phantom with tiny cylindrical cavities filled with iodate solution, simulating patient vessels; in this case the X-ray beam has two components, respectively below and above the iodine K- edge at 33:17 keV

X-ray imaging with a silicon microstrip detector coupled to the RX64 ASIC

A single photon counting X-ray imaging system, with possible applications to dual energy mammography and angiography, is presented. A silicon microstrip detector with 100 μm pitch strips is coupled to RX64 ASICs, each of them including 64 channels of preamplifier, shaper, discriminator and scaler. The system has low noise, good spatial resolution and high counting rate capability. Results on energy resolution have been obtained with a fluorescence source and quasi-monochromatic X-rays beams. Preliminary images obtained with an angiographic phantom are presented