Type 3 innate lymphoid cells maintain intestinal epithelial stem cells after tissue damage

Disruption of the intestinal epithelial barrier allows bacterial translocation and predisposes to destructive inflammation. To ensure proper barrier composition, crypt-residing stem cells continuously proliferate and replenish all intestinal epithelial cells within days. As a consequence of this high mitotic activity, mucosal surfaces are frequently targeted by anticancer therapies, leading to dose-limiting side effects. The cellular mechan

First World Consensus Conference on pancreas transplantation: Part II - recommendations.

Funder: Fondazione Pisa, Pisa, Italy; Id: http://dx.doi.org/10.13039/100007368Funder: Tuscany Region, Italy; Id: http://dx.doi.org/10.13039/501100009888Funder: Pisa University Hospital, Pisa, ItalyFunder: University of Pisa, Pisa, Italy; Id: http://dx.doi.org/10.13039/501100007514The First World Consensus Conference on Pancreas Transplantation provided 49 jury deliberations regarding the impact of pancreas transplantation on the treatment of diabetic patients, and 110 experts' recommendations for the practice of pancreas transplantation. The main message from this consensus conference is that both simultaneous pancreas-kidney transplantation (SPK) and pancreas transplantation alone can improve long-term patient survival, and all types of pancreas transplantation dramatically improve the quality of life of recipients. Pancreas transplantation may also improve the course of chronic complications of diabetes, depending on their severity. Therefore, the advantages of pancreas transplantation appear to clearly surpass potential disadvantages. Pancreas after kidney transplantation increases the risk of mortality only in the early period after transplantation, but is associated with improved life expectancy thereafter. Additionally, preemptive SPK, when compared to SPK performed in patients undergoing dialysis, appears to be associated with improved outcomes. Time on dialysis has negative prognostic implications in SPK recipients. Increased long-term survival, improvement in the course of diabetic complications, and amelioration of quality of life justify preferential allocation of kidney grafts to SPK recipients. Audience discussions and live voting are available online at the following URL address: http://mediaeventi.unipi.it/category/1st-world-consensus-conference-of-pancreas-transplantation/246

Mean Positive Affect Ratings by Strategy (Reappraise, Suppress, or View), Picture Valence (Neutral or Positive), and Order (Neutral or Positive Pictures first).

<p>Mean Positive Affect Ratings by Strategy (Reappraise, Suppress, or View), Picture Valence (Neutral or Positive), and Order (Neutral or Positive Pictures first).</p

Non-verbal memory scores for neutral (A) and positive (B) pictures.

<p>Legend: Non-verbal memory score according to emotion regulation strategy (reappraise, suppress, or view)and order (neutral or positive pictures first); error bars represent standard error of the mean.</p

Mean Negative Affect Ratings by Strategy (Reappraise, Suppress, or View), Picture Valence (Neutral or Positive), and Order (Neutral or Positive Pictures first).

<p>Mean Negative Affect Ratings by Strategy (Reappraise, Suppress, or View), Picture Valence (Neutral or Positive), and Order (Neutral or Positive Pictures first).</p