Alien Registration- Monaghan, Hugh (Lewiston, Androscoggin County)

https://digitalmaine.com/alien_docs/27973/thumbnail.jp

Datos del subsuelo y su conocimiento para las Ciudades del Mañana: lecciones aprendidas de Glasgow y su aplicabilidad en otros lugares

El conocimiento del subsuelo es de vital importancia en la planificación y ejecución exitosa de proyectos de construcción y regeneración urbanas. Para abordar en el área de Glasgow éste y otros temas del subsuelo urbano (por ejemplo, la planificación, las inundaciones, la contaminación), el proyecto Clyde-Urban Super-Project (CUSP) del Servicio Geológico Británico (BGS, por sus siglas en inglés) ha desarrollado modelos 3D y 4D del subsuelo. Asimismo, se han producido otros conjuntos de datos de geociencias (geoquímica, agua subterránea, geología de ingeniería). Los modelos basados en información obtenida de decenas de miles de perforaciones y otras fuentes, proporcionan nuevos conocimientos sobre: la geología compleja de Glasgow, los impactos de su legado industrial, y las oportunidades para aprovechar el calor de las explotaciones mineras abandonadas. Para que los modelos y datos del proyecto CUSP fueran más accesibles, el BGS y el Ayuntamiento de Glasgow, socio clave, han establecido una red para acceder al conocimiento del subsuelo (ASK, por sus siglas en inglés). Esta red permite el intercambio de datos y conocimientos, implicando a socios de los sectores público y privado. ASK promueve el libre flujo digital de datos del subsuelo y el conocimiento entre sus socios. Las lecciones aprendidas en Glasgow se comparten a través de la Acción Europea COST (Sub-Urban), centrada en el uso sostenible del subsuelo urbano, y en la transformación de las relaciones entre los que desarrollan el conocimiento del subsuelo urbano y los que pueden beneficiarse más de él, los planificadores y promotores de las ciudades del futuro

Tyrosine hydroxylase deficiency: a treatable disorder of brain catecholamine biosynthesis

Tyrosine hydroxylase deficiency is an autosomal recessive disorder resulting from cerebral catecholamine deficiency. Tyrosine hydroxylase deficiency has been reported in fewer than 40 patients worldwide. To recapitulate all available evidence on clinical phenotypes and rational diagnostic and therapeutic approaches for this devastating, but treatable, neurometabolic disorder, we studied 36 patients with tyrosine hydroxylase deficiency and reviewed the literature. Based on the presenting neurological features, tyrosine hydroxylase deficiency can be divided in two phenotypes: an infantile onset, progressive, hypokinetic-rigid syndrome with dystonia (type A), and a complex encephalopathy with neonatal onset (type B). Decreased cerebrospinal fluid concentrations of homovanillic acid and 3-methoxy-4-hydroxyphenylethylene glycol, with normal 5-hydroxyindoleacetic acid cerebrospinal fluid concentrations, are the biochemical hallmark of tyrosine hydroxylase deficiency. The homovanillic acid concentrations and homovanillic acid/5-hydroxyindoleacetic acid ratio in cerebrospinal fluid correlate with the severity of the phenotype. Tyrosine hydroxylase deficiency is almost exclusively caused by missense mutations in the TH gene and its promoter region, suggesting that mutations with more deleterious effects on the protein are incompatible with life. Genotype-phenotype correlations do not exist for the common c.698G>A and c.707T>C mutations. Carriership of at least one promotor mutation, however, apparently predicts type A tyrosine hydroxylase deficiency. Most patients with tyrosine hydroxylase deficiency can be successfully treated with l-dop

A Review of Computational Methods in Materials Science: Examples from Shock-Wave and Polymer Physics

This review discusses several computational methods used on different length and time scales for the simulation of material behavior. First, the importance of physical modeling and its relation to computer simulation on multiscales is discussed. Then, computational methods used on different scales are shortly reviewed, before we focus on the molecular dynamics (MD) method. Here we survey in a tutorial-like fashion some key issues including several MD optimization techniques. Thereafter, computational examples for the capabilities of numerical simulations in materials research are discussed. We focus on recent results of shock wave simulations of a solid which are based on two different modeling approaches and we discuss their respective assets and drawbacks with a view to their application on multiscales. Then, the prospects of computer simulations on the molecular length scale using coarse-grained MD methods are covered by means of examples pertaining to complex topological polymer structures including star-polymers, biomacromolecules such as polyelectrolytes and polymers with intrinsic stiffness. This review ends by highlighting new emerging interdisciplinary applications of computational methods in the field of medical engineering where the application of concepts of polymer physics and of shock waves to biological systems holds a lot of promise for improving medical applications such as extracorporeal shock wave lithotripsy or tumor treatment

Alien Registration- Monaghan, Hugh (Lewiston, Androscoggin County)

https://digitalmaine.com/alien_docs/27973/thumbnail.jp

Phylogeographic, ancient DNA, fossil and morphometric analyses reveal ancient and modern introductions of a large mammal: the complex case of red deer (Cervus elaphus) in Ireland

The problem of how and when the island of Ireland attained its contemporary fauna has remained a key question in understanding Quaternary faunal assemblages. We assessed the complex history and origins of the red deer (Cervus elaphus) in Ireland using a multi-disciplinary approach. Mitochondrial sequences of contemporary and ancient red deer (dating from c 30,000 to 1700 cal. yr BP) were compared to decipher possible source populations of red deer in Ireland, in addition to craniometric analyses of skulls from candidate regions to distinguish between different colonization scenarios. Radiocarbon dating was undertaken on all bone fragments that were previously undated. Finally, a comprehensive review of the scientific literature, unpublished reports and other sources of data were also searched for red deer remains within Irish palaeontological and archaeological contexts. Despite being present in Ireland prior to the Last Glacial Maximum (LGM), there is a notable scarcity of red deer from the Younger Dryas stadial period until the Neolithic. The presence of red deer in Irish archaeological sites then occurs more frequently relative to other species. One population in the southwest of Ireland (Co. Kerry) shared haplotypes with the ancient Irish specimens and molecular dating and craniometric analysis suggests its persistence in Ireland since the Neolithic period. The synthesis of the results from this multi-disciplinary study all indicate that red deer were introduced by humans during the Irish Neolithic period and that one of these populations persists today. In conjunction with recent results from other species, Neolithic people from Ireland's nearest landmass, Britain, played a vital role in establishing its contemporary fauna and flor