150 research outputs found
First results from the Very Small Array -- IV. Cosmological parameter estimation
We investigate the constraints on basic cosmological parameters set by the
first compact-configuration observations of the Very Small Array (VSA), and
other cosmological data sets, in the standard inflationary LambdaCDM model.
Using a weak prior 40 < H_0 < 90 km/s/Mpc and 0 < tau < 0.5 we find that the
VSA and COBE_DMR data alone produce the constraints Omega_tot =
1.03^{+0.12}_{-0.12}, Omega_bh^2 = 0.029^{+0.009}_{-0.009}, Omega_cdm h^2 =
0.13^{+0.08}_{-0.05} and n_s = 1.04^{+0.11}_{-0.08} at the 68 per cent
confidence level. Adding in the type Ia supernovae constraints, we additionally
find Omega_m = 0.32^{+0.09}_{-0.06} and Omega_Lambda = 0.71^{+0.07}_{-0.07}.
These constraints are consistent with those found by the BOOMERanG, DASI and
MAXIMA experiments. We also find that, by combining all the recent CMB
experiments and assuming the HST key project limits for H_0 (for which the
X-ray plus Sunyaev--Zel'dovich route gives a similar result), we obtain the
tight constraints Omega_m=0.28^{+0.14}_{-0.07} and Omega_Lambda=
0.72^{+0.07}_{-0.13}, which are consistent with, but independent of, those
obtained using the supernovae data.Comment: 10 pages, 6 figures, MNRAS in pres
Observations of the Cosmic Microwave Background and Galactic Foregrounds at 12-17 GHz with the COSMOSOMAS Experiment
(Abridged) We present the analysis of the first 18 months of data obtained
with the COSMOSOMAS experiment at the Teide Observatory (Tenerife). Three maps
have been obtained at 12.7, 14.7 and 16.3 GHz covering 9000 square degrees each
with a resolution of ~1 degree and with sensitivities 49, 59 and 115 muK per
beam respectively. These data in conjuction with the WMAP first year maps have
revealed that the Cosmic Microwave Background (CMB) is the dominant
astronomical signal at high galatic latitude in the three COSMOSOMAS channels
with an average amplitude of 29.7+/- 1.0 \muK (68% c.l. not including
calibration errors). This value is in agreement with the predicted CMB signal
in the COSMOSOMAS maps using the best fit Lambda-CDM model to the WMAP power
spectrum. Cross-correlation of COSMOSOMAS data with the DIRBE map at 100 \mu m
shows the existence of a common signal with amplitude 7.4+/- 1.1, 7.5+/- 1.1,
and 6.5+/-2.3 muK in the 12.7, 14.7 and 16.3 GHz COSMOSOMAS maps at
|b|>30^\deg. Using the WMAP data we find this DIRBE correlated signal rises
from high to low frequencies flattening below ~20 GHz. At higher galactic
latitudes the average amplitude of the correlated signal with the DIRBE maps
decreases slightly. The frequency behaviour of the COSMOSOMAS/WMAP correlated
signal with DIRBE is not compatible with the expected tendency for thermal
dust. A study of the H-alpha emission maps do not support free-free as a major
contributor to that signal. Our results provide evidence of a new galactic
foreground with properties compatible with those predicted by the spinning dust
models.Comment: 11 pages, 21 figures. Submitted to MNRAS. For paper with figures at
full resolution, see http://www.iac.es/project/cmb/cosmosomas
A multicenter, randomized study of argatroban versus heparin as adjunct to tissue plasminogen activator (TPA) in acute myocardial infarction: myocardial infarction with Novastan and TPA (MINT) study
AbstractOBJECTIVESThis study examined the effect of a small-molecule, direct thrombin inhibitor, argatroban, on reperfusion induced by tissue plasminogen activator (TPA) in patients with acute myocardial infarction (AMI).BACKGROUNDThrombin plays a crucial role in thrombosis and thrombolysis. In vitro and in vivo studies have shown that argatroban has advantages over heparin for the inhibition of clot-bound thrombin and for the enhancement of thrombolysis with TPA.METHODSOne hundred and twenty-five patients with AMI within 6 h were randomized to heparin, low-dose argatroban or high-dose argatroban in addition to TPA. The primary end point was the rate of thrombolysis in myocardial infarction (TIMI) grade 3 flow at 90 min.RESULTSTIMI grade 3 flow was achieved in 42.1% of heparin, 56.8% of low-dose argatroban (p = 0.20 vs. heparin) and 58.7% of high-dose argatroban patients (p = 0.13 vs. heparin). In patients presenting after 3 h, TIMI grade 3 flow was significantly more frequent in high-dose argatroban versus heparin patients: 57.1% versus 20.0% (p = 0.03 vs. heparin). Major bleeding was observed in 10.0% of heparin, and in 2.6% and 4.3% of low-dose and high-dose argatroban patients, respectively. The composite of death, recurrent myocardial infarction, cardiogenic shock or congestive heart failure, revascularization and recurrent ischemia at 30 days occurred in 37.5% of heparin, 32.0% of low-dose argatroban and 25.5% of high-dose argatroban patients (p = 0.23).CONCLUSIONSArgatroban, as compared with heparin, appears to enhance reperfusion with TPA in patients with AMI, particularly in those patients with delayed presentation. The incidences of major bleeding and adverse clinical outcome were lower in the patients receiving argatroban
First results from the Very Small Array -- I. Observational methods
The Very Small Array (VSA) is a synthesis telescope designed to image faint
structures in the cosmic microwave background on degree and sub-degree angular
scales. The VSA has key differences from other CMB interferometers with the
result that different systematic errors are expected. We have tested the
operation of the VSA with a variety of blank-field and calibrator observations
and cross-checked its calibration scale against independent measurements. We
find that systematic effects can be suppressed below the thermal noise level in
long observations; the overall calibration accuracy of the flux density scale
is 3.5 percent and is limited by the external absolute calibration scale.Comment: 9 pages, 10 figures, MNRAS in press (Minor revisions
Fatal Human Infection with Rickettsia rickettsii, Yucatán, Mexico
The first fatal Rickettsia rickettsii infection was diagnosed in the southwest of Mexico. The patient had fever, erythematous rash, abdominal pain, and severe central nervous system involvement with convulsive crisis. The diagnosis of R. rickettsii infection was established by immunohistochemistry and specific polymerase chain reaction
Efficacy and safety assessment of different dosage of benznidazol for the treatment of Chagas disease in chronic phase in adults (MULTIBENZ study): Study protocol for a multicenter randomized Phase II non-inferiority clinical trial
Background: Chagas disease (CD) continues to be a neglected infectious disease with one of the largest burdens globally. Despite the modest cure rates in adult chronic patients and its safety profile, benznidazole (BNZ) is still the drug of choice. Its current recommended dose is based on nonrandomized studies, and efficacy and safety of the optimal dose of BNZ have been scarcely analyzed in clinical trials.Methods/design: MULTIBENZ is a phase II, randomized, noninferiority, double-blind, multicenter international clinical trial. A total of 240 patients with Trypanosoma CD in the chronic phase will be recruited in four different countries (Argentina, Brazil, Colombia, and Spain). Patients will be randomized to receive BNZ 150 mg/day for 60 days, 400 mg/day for 15 days, or 300 mg/day for 60 days (comparator arm). The primary outcome is the efficacy of three different BNZ therapeutic schemes in terms of dose and duration. Efficacy will be assessed according to the proportion of patients with sustained parasitic load suppression in peripheral blood measured by polymerase chain reaction. The secondary outcomes are related to pharmacokinetics and drug tolerability. The follow-up will be 12 months from randomization to end of study participation. Recruitment was started in April 2018.Conclusion: This is a clinical trial conducted for the assessment of different dose schemes of BNZ compared with the standard treatment regimen for the treatment of CD in the chronic phase. MULTIBENZ may help to clarify which is the most adequate BNZ regimen in terms of efficacy and safety, predicated on sustained parasitic load suppression in peripheral blood.Fil: Molina Morant, D.. Universidad Autónoma de Barcelona. Hospital Vall D' Hebron; EspañaFil: Fernández, M. L.. Dirección Nacional de Instituto de Investigación. Administración Nacional de Laboratorio e Instituto de Salud “Dr. C. G. Malbrán”. Instituto Nacional de Parasitología "Dr. Mario Fatala Chaben”; ArgentinaFil: Bosch Nicolau, P.. Universidad Autónoma de Barcelona. Hospital Vall D' Hebron; EspañaFil: Sulleiro, E.. Universidad Autónoma de Barcelona. Hospital Vall D' Hebron; EspañaFil: Bangher, M.. Instituto de Cardiologia de Corrientes Juana Francisca Cabral.; ArgentinaFil: Salvador, F.. Universidad Autónoma de Barcelona. Hospital Vall D' Hebron; EspañaFil: Sanchez Montalva, A.. Universidad Autónoma de Barcelona. Hospital Vall D' Hebron; EspañaFil: Ribeiro, A.L.P.. Universidade Federal de Minas Gerais; BrasilFil: De Paula, A.M.B.. Universidad Federal de Montes Claros; BrasilFil: Eloi, S.. Universidade Federal de Minas Gerais; BrasilFil: Oliveira Correa, Ronaldo. Fundación Oswaldo Cruz; BrasilFil: Villar, J. C.. Instituto de Cardiología; ColombiaFil: Sosa-Estani, Sergio Alejandro. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. Centro de Investigaciones en Epidemiología y Salud Pública. Instituto de Efectividad Clínica y Sanitaria. Centro de Investigaciones en Epidemiología y Salud Pública; ArgentinaFil: Molina, I.. Universidad Autónoma de Barcelona. Hospital Vall D' Hebron; Españ
Distribution, magnitudes, reactivities, ratios and diurnal patterns of volatile organic compounds in the Valley of Mexico during the MCMA 2002 & 2003 field campaigns
A wide array of volatile organic compound (VOC) measurements was conducted in the Valley of Mexico during the MCMA-2002 and 2003 field campaigns. Study sites included locations in the urban core, in a heavily industrial area and at boundary sites in rural landscapes. In addition, a novel mobile-laboratory-based conditional sampling method was used to collect samples dominated by fresh on-road vehicle exhaust to identify those VOCs whose ambient concentrations were primarily due to vehicle emissions. Four distinct analytical techniques were used: whole air canister samples with Gas Chromatography/Flame Ionization Detection (GC-FID), on-line chemical ionization using a Proton Transfer Reaction Mass Spectrometer (PTR-MS), continuous real-time detection of olefins using a Fast Olefin Sensor (FOS), and long path measurements using UV Differential Optical Absorption Spectrometers (DOAS). The simultaneous use of these techniques provided a wide range of individual VOC measurements with different spatial and temporal scales. The VOC data were analyzed to understand concentration and spatial distributions, diurnal patterns, origin and reactivity in the atmosphere of Mexico City. The VOC burden (in ppbC) was dominated by alkanes (60%), followed by aromatics (15%) and olefins (5%). The remaining 20% was a mix of alkynes, halogenated hydrocarbons, oxygenated species (esters, ethers, etc.) and other unidentified VOCs. However, in terms of ozone production, olefins were the most relevant hydrocarbons. Elevated levels of toxic hydrocarbons, such as 1,3-butadiene, benzene, toluene and xylenes, were also observed. Results from these various analytical techniques showed that vehicle exhaust is the main source of VOCs in Mexico City and that diurnal patterns depend on vehicular traffic in addition to meteorological processes. Finally, examination of the VOC data in terms of lumped modeling VOC classes and its comparison to the VOC lumped emissions reported in other photochemical air quality modeling studies suggests that some alkanes are underestimated in the emissions inventory, while some olefins and aromatics are overestimated
Distribution, magnitudes, reactivities, ratios and diurnal patterns of volatile organic compounds in the Valley of Mexico during the MCMA 2002 and 2003 field campaigns
International audienceA wide array of volatile organic compound (VOC) measurements was conducted in the Valley of Mexico during the MCMA-2002 and 2003 field campaigns. Study sites included locations in the urban core, in a heavily industrial area and at boundary sites in rural landscapes. In addition, a novel mobile-laboratory-based conditional sampling method was used to collect samples dominated by fresh on-road vehicle exhaust to identify those VOCs whose ambient concentrations were primarily due to vehicle emissions. Five distinct analytical techniques were used: whole air canister samples with Gas Chromatography/Flame Ionization Detection (GC-FID), on-line chemical ionization using a Proton Transfer Reaction Mass Spectrometer (PTR-MS), continuous real-time detection of olefins using a Fast Olefin Sensor (FOS), and long path measurements using UV Differential Optical Absorption Spectrometers (DOAS). The simultaneous use of these techniques provided a wide range of individual VOC measurements with different spatial and temporal scales. The VOC data were analyzed to understand concentration and spatial distributions, diurnal patterns, origin and reactivity in the atmosphere of Mexico City. The VOC burden (in ppbC) was dominated by alkanes (60%), followed by aromatics (15%) and olefins (5%). The remaining 20% was a mix of alkynes, halogenated hydrocarbons, oxygenated species (esters, ethers, etc.) and other unidentified VOCs. However, in terms of ozone production, olefins were the most relevant hydrocarbons. Elevated levels of toxic hydrocarbons, such as 1,3-butadiene, benzene, toluene and xylenes were also observed. Results from these various analytical techniques showed that vehicle exhaust is the main source of VOCs in Mexico City and that diurnal patterns depend on vehicular traffic. Finally, examination of the VOC data in terms of lumped modeling VOC classes and its comparison to the VOC lumped emissions reported in other photochemical air quality modeling studies suggests that some, but not all, VOC classes are underestimated in the emissions inventory by factors of 1.1 to 3
WHF IASC Roadmap on Chagas Disease
Background: Chagas Disease is a neglected tropical disease caused by the protozoan Trypanosoma
cruzi, with some of the most serious manifestations affecting the cardiovascular system. It is a
chronic, stigmatizing condition, closely associated with poverty and affecting close to 6 million
people globally. Although historically the disease was limited to endemic areas of Latin America
recent years have seen an increasing global spread. In addition to the morbidity and mortality associated with the disease, the social and economic burdens on individuals and society are substantial.
Often called the ‘silent killer’, Chagas disease is characterized by a long, asymptomatic phase in
affected individuals. Approximately 30% then go on develop chronic Chagas cardiomyopathy and
other serious cardiac complications such as stroke, rhythm disturbances and severe heart failure.
Methods: In a collaboration of the World Hearth Federation (WHF) and the Inter-American
Society of Cardiology (IASC) a writing group consisting of 20 diverse experts on Chagas disease
(CD) was convened. The group provided up to date expert knowledge based on their area of
expertise. An extensive review of the literature describing obstacles to diagnosis and treatment of CD along with proposed solutions was conducted. A survey was sent to all WHF Members
and, using snowball sampling to widen the consultation, to a variety of health care professionals working in the CD global health community. The results were analyzed, open comments were
reviewed and consolidated, and the findings were incorporated into this document, thus ensuring
a consensus representation.
Results: The WHF IASC Roadmap on Chagas Disease offers a comprehensive summary of current
knowledge on prevention, diagnosis and management of the disease. In providing an analysis of
‘roadblocks’ in access to comprehensive care for Chagas disease patients, the document serves
as a framework from which strategies for implementation such as national plans can be formulated. Several dimensions are considered in the analysis: healthcare system capabilities, governance, financing, community awareness and advocacy.
Conclusion: The WHF IASC Roadmap proposes strategies and evidence-based solutions for
healthcare professionals, health authorities and governments to help overcome the barriers to
comprehensive care for Chagas disease patients. This roadmap describes an ideal patient care
pathway, and explores the roadblocks along the way, offering potential solutions based on available research and examples in practice. It represents a call to action to decision-makers and
health care professionals to step up efforts to eradicate Chagas disease
Searching for non-Gaussianity in the VSA data
We have tested Very Small Array (VSA) observations of three regions of sky
for the presence of non-Gaussianity, using high-order cumulants, Minkowski
functionals, a wavelet-based test and a Bayesian joint power
spectrum/non-Gaussianity analysis. We find the data from two regions to be
consistent with Gaussianity. In the third region, we obtain a 96.7% detection
of non-Gaussianity using the wavelet test. We perform simulations to
characterise the tests, and conclude that this is consistent with expected
residual point source contamination. There is therefore no evidence that this
detection is of cosmological origin. Our simulations show that the tests would
be sensitive to any residual point sources above the data's source subtraction
level of 20 mJy. The tests are also sensitive to cosmic string networks at an
rms fluctuation level of (i.e. equivalent to the best-fit observed
value). They are not sensitive to string-induced fluctuations if an equal rms
of Gaussian CDM fluctuations is added, thereby reducing the fluctuations due to
the strings network to rms . We especially highlight the usefulness
of non-Gaussianity testing in eliminating systematic effects from our data.Comment: Minor corrections; accepted for publication to MNRA
- …