Cytokine regulation of lung Th17 response to airway immunization using LPS adjuvant

Infections caused by bacteria in the airway preferentially induce a Th17 response. However, the mechanisms involved in the regulation of CD4 T-cell responses in the lungs are incompletely understood. Here, we have investigated the mechanisms involved in the regulation of Th17 differentiation in the lungs in response to immunization with lipopolysaccharide (LPS) as an adjuvant. Our data show that both Myd88 and TRIF are necessary for Th17 induction. This distinctive fate determination can be accounted for by the pattern of inflammatory cytokines induced by airway administration of LPS. We identified the production of interleukin (IL)-1β and IL-6 by small macrophages and IL-23 by alveolar dendritic cells (DCs), favoring Th17 responses, and IL-10 repressing interferon (IFN)-γ production. Furthermore, we show that exogenous IL-1β can drastically alter Th1 responses driven by influenza and lymphocytic choriomeningitis virus infection models and induce IL-17 production. Thus, the precision of the lung immune responses to potential threats is orchestrated by the cytokine microenvironment, can be repolarized and targeted therapeutically by altering the cytokine milieu. These results indicate that how the development of Th17 responses in the lung is regulated by the cytokines produced by lung DCs and macrophages in response to intranasal immunization with LPS adjuvant

Single Spin Asymmetry ANA_N in Polarized Proton-Proton Elastic Scattering at s=200\sqrt{s}=200 GeV

We report a high precision measurement of the transverse single spin asymmetry $A_N$ at the center of mass energy $\sqrt{s}=200$ GeV in elastic proton-proton scattering by the STAR experiment at RHIC. The $A_N$ was measured in the four-momentum transfer squared $t$ range $0.003 \leqslant |t| \leqslant 0.035$ \GeVcSq, the region of a significant interference between the electromagnetic and hadronic scattering amplitudes. The measured values of $A_N$ and its $t$-dependence are consistent with a vanishing hadronic spin-flip amplitude, thus providing strong constraints on the ratio of the single spin-flip to the non-flip amplitudes. Since the hadronic amplitude is dominated by the Pomeron amplitude at this $\sqrt{s}$, we conclude that this measurement addresses the question about the presence of a hadronic spin flip due to the Pomeron exchange in polarized proton-proton elastic scattering.Comment: 12 pages, 6 figure

High pTp_{T} non-photonic electron production in pp+pp collisions at s\sqrt{s} = 200 GeV

We present the measurement of non-photonic electron production at high transverse momentum ($p_T >$ 2.5 GeV/$c$) in $p$ + $p$ collisions at $\sqrt{s}$ = 200 GeV using data recorded during 2005 and 2008 by the STAR experiment at the Relativistic Heavy Ion Collider (RHIC). The measured cross-sections from the two runs are consistent with each other despite a large difference in photonic background levels due to different detector configurations. We compare the measured non-photonic electron cross-sections with previously published RHIC data and pQCD calculations. Using the relative contributions of B and D mesons to non-photonic electrons, we determine the integrated cross sections of electrons ($\frac{e^++e^-}{2}$) at 3 GeV/$c < p_T <~$10 GeV/$c$ from bottom and charm meson decays to be ${d\sigma_{(B\to e)+(B\to D \to e)} \over dy_e}|_{y_e=0}$ = 4.0$\pm0.5$({\rm stat.})$\pm1.1$({\rm syst.}) nb and ${d\sigma_{D\to e} \over dy_e}|_{y_e=0}$ = 6.2$\pm0.7$({\rm stat.})$\pm1.5$({\rm syst.}) nb, respectively.Comment: 17 pages, 17 figure

Evolution of the differential transverse momentum correlation function with centrality in Au+Au collisions at sNN=200\sqrt{s_{NN}} = 200 GeV

We present first measurements of the evolution of the differential transverse momentum correlation function, {\it C}, with collision centrality in Au+Au interactions at $\sqrt{s_{NN}} = 200$ GeV. {\it C} exhibits a strong dependence on collision centrality that is qualitatively similar to that of number correlations previously reported. We use the observed longitudinal broadening of the near-side peak of {\it C} with increasing centrality to estimate the ratio of the shear viscosity to entropy density, $\eta/s$, of the matter formed in central Au+Au interactions. We obtain an upper limit estimate of $\eta/s$ that suggests that the produced medium has a small viscosity per unit entropy.Comment: 7 pages, 4 figures, STAR paper published in Phys. Lett.

Long-range Angular Correlations On The Near And Away Side In P-pb Collisions At √snn=5.02 Tev

7191/Mar294

New insights into the genetic etiology of Alzheimer's disease and related dementias

Characterization of the genetic landscape of Alzheimer's disease (AD) and related dementias (ADD) provides a unique opportunity for a better understanding of the associated pathophysiological processes. We performed a two-stage genome-wide association study totaling 111,326 clinically diagnosed/'proxy' AD cases and 677,663 controls. We found 75 risk loci, of which 42 were new at the time of analysis. Pathway enrichment analyses confirmed the involvement of amyloid/tau pathways and highlighted microglia implication. Gene prioritization in the new loci identified 31 genes that were suggestive of new genetically associated processes, including the tumor necrosis factor alpha pathway through the linear ubiquitin chain assembly complex. We also built a new genetic risk score associated with the risk of future AD/dementia or progression from mild cognitive impairment to AD/dementia. The improvement in prediction led to a 1.6- to 1.9-fold increase in AD risk from the lowest to the highest decile, in addition to effects of age and the APOE ε4 allele

Measurement Of Charge Multiplicity Asymmetry Correlations In High-energy Nucleus-nucleus Collisions At Snn =200 Gev

A study is reported of the same- and opposite-sign charge-dependent azimuthal correlations with respect to the event plane in Au+Au collisions at sNN=200 GeV. The charge multiplicity asymmetries between the up/down and left/right hemispheres relative to the event plane are utilized. The contributions from statistical fluctuations and detector effects were subtracted from the (co-)variance of the observed charge multiplicity asymmetries. In the mid- to most-central collisions, the same- (opposite-) sign pairs are preferentially emitted in back-to-back (aligned on the same-side) directions. The charge separation across the event plane, measured by the difference, Δ, between the like- and unlike-sign up/down-left/right correlations, is largest near the event plane. The difference is found to be proportional to the event-by-event final-state particle ellipticity (via the observed second-order harmonic v2obs), where Δ=[1.3±1.4(stat)-1.0+4.0(syst)]×10- 5+[3.2±0.2(stat)-0.3+0.4(syst)]×10-3v2obs for 20-40% Au+Au collisions. The implications for the proposed chiral magnetic effect are discussed. © 2014 American Physical Society.894NRF-2012004024; National Research FoundationArsene, I., (2005) Nucl. Phys. A, 757, p. 1. , (BRAHMS Collaboration),. NUPABL 0375-9474 10.1016/j.nuclphysa.2005.02.130Back, B.B., (2005) Nucl. Phys. A, 757, p. 28. , (PHOBOS Collaboration),. NUPABL 0375-9474 10.1016/j.nuclphysa.2005.03.084Adams, J., (2005) Nucl. Phys. A, 757, p. 102. , (STAR Collaboration),. NUPABL 0375-9474 10.1016/j.nuclphysa.2005.03.085Adcox, K., (2005) Nucl. Phys. A, 757, p. 184. , (PHENIX Collaboration),. NUPABL 0375-9474 10.1016/j.nuclphysa.2005.03.086Lee, T.D., (1973) Phys. Rev. D, 8, p. 1226. , 0556-2821 10.1103/PhysRevD.8.1226Lee, T.D., Wick, G.C., (1974) Phys. Rev. D, 9, p. 2291. , 0556-2821 10.1103/PhysRevD.9.2291Morley, P.D., Schmidt, I.A., (1985) Z. Phys. C, 26, p. 627. , ZPCFD2 0170-9739 10.1007/BF01551807Kharzeev, D., Pisarski, R.D., Tytgat, M.H.G., (1998) Phys. Rev. Lett., 81, p. 512. , PRLTAO 0031-9007 10.1103/PhysRevLett.81.512Kharzeev, D., (2006) Phys. Lett. B, 633, p. 260. , PYLBAJ 0370-2693 10.1016/j.physletb.2005.11.075Kharzeev, D., Zhitnitsky, A., (2007) Nucl. Phys. A, 797, p. 67. , NUPABL 0375-9474 10.1016/j.nuclphysa.2007.10.001Fukushima, K., Kharzeev, D.E., Warringa, H.J., (2008) Phys. Rev. D, 78, p. 074033. , PRVDAQ 1550-7998 10.1103/PhysRevD.78.074033Kharzeev, D.E., McLerran, L.D., Warringa, H.J., (2008) Nucl. Phys. A, 803, p. 227. , NUPABL 0375-9474 10.1016/j.nuclphysa.2008.02.298Voloshin, S.A., (2004) Phys. Rev. C, 70, p. 057901. , PRVCAN 0556-2813 10.1103/PhysRevC.70.057901Abelev, B.I., (2009) Phys. Rev. Lett., 103, p. 251601. , (STAR Collaboration),. PRLTAO 0031-9007 10.1103/PhysRevLett.103.251601Abelev, B.I., (2010) Phys. Rev. C, 81, p. 054908. , (STAR Collaboration),. PRVCAN 0556-2813 10.1103/PhysRevC.81.054908Abelev, B., (2013) Phys. Rev. Lett., 110, p. 012301. , (ALICE Collaboration),. PRLTAO 0031-9007 10.1103/PhysRevLett.110.012301Wang, Q., (2012), http://drupal.star.bnl.gov/STAR/theses/phd/quanwang, Ph.D. thesis, Purdue University, arXiv:1205.4638Ackermann, K.H., (2003) Nucl. Instrum. Methods A, 499, p. 624. , (STAR Collaboration),. NIMAER 0168-9002 10.1016/S0168-9002(02)01960-5Bieser, F.S., (2003) Nucl. Instrum. Methods A, 499, p. 766. , (STAR Collaboration),. NIMAER 0168-9002 10.1016/S0168-9002(02)01974-5Adler, C., (2003) Nucl. Instrum. Methods A, 499, p. 433. , NIMAER 0168-9002 10.1016/j.nima.2003.08.112Adams, J., (2004) Phys. Rev. Lett., 92, p. 112301. , (STAR Collaboration),. PRLTAO 0031-9007 10.1103/PhysRevLett.92.112301Abelev, B.I., (2009) Phys. Rev. C, 79, p. 034909. , (STAR Collaboration),. PRVCAN 0556-2813 10.1103/PhysRevC.79.034909Ackermann, K.H., (1999) Nucl. Phys. A, 661, p. 681. , (STAR Collaboration),. NUPABL 0375-9474 10.1016/S0375-9474(99)85117-3Anderson, M., (2003) Nucl. Instrum. Methods A, 499, p. 659. , NIMAER 0168-9002 10.1016/S0168-9002(02)01964-2Poskanzer, A.M., Voloshin, S.A., (1998) Phys. Rev. C, 58, p. 1671. , PRVCAN 0556-2813 10.1103/PhysRevC.58.1671Wang, G., (2005), http://drupal.star.bnl.gov/STAR/theses/ph-d/gang-wang, Ph.D. thesis, UCLAAdamczyk, L., (2012) Phys. Rev. Lett., 108, p. 202301. , (STAR Collaboration),. PRLTAO 0031-9007 10.1103/PhysRevLett.108.202301Wang, F., (2010) Phys. Rev. C, 81, p. 064902. , PRVCAN 0556-2813 10.1103/PhysRevC.81.064902Pratt, S., Schlichting, S., Gavin, S., (2011) Phys. Rev. C, 84, p. 024909. , PRVCAN 0556-2813 10.1103/PhysRevC.84.024909Adams, J., (2005) Phys. Rev. Lett., 95, p. 152301. , (STAR Collaboration),. PRLTAO 0031-9007 10.1103/PhysRevLett.95.152301Aggarwal, M.M., (2010) Phys. Rev. C, 82, p. 024912. , (STAR collaboration),. PRVCAN 0556-2813 10.1103/PhysRevC.82.024912Abelev, B.I., (2009) Phys. Rev. Lett., 102, p. 052302. , (STAR Collaboration),. PRLTAO 0031-9007 10.1103/PhysRevLett.102.052302Abelev, B.I., (2009) Phys. Rev. C, 80, p. 064912. , (STAR Collaboration),. PRVCAN 0556-2813 10.1103/PhysRevC.80.064912Abelev, B.I., (2010) Phys. Rev. Lett., 105, p. 022301. , (STAR Collaboration),. PRLTAO 0031-9007 10.1103/PhysRevLett.105.022301Agakishiev, H., (STAR Collaboration), arXiv:1010.0690Petersen, H., Renk, T., Bass, S.A., (2011) Phys. Rev. C, 83, p. 014916. , PRVCAN 0556-2813 10.1103/PhysRevC.83.014916Adamczyk, L., (2013) Phys. Rev. C, 88, p. 064911. , (STAR Collaboration),. 10.1103/PhysRevC.88.064911Asakawa, M., Majumder, A., Müller, B., (2010) Phys. Rev. C, 81, p. 064912. , PRVCAN 0556-2813 10.1103/PhysRevC.81.064912Bzdak, A., Koch, V., Liao, J., (2010) Phys. Rev. C, 81, pp. 031901R. , PRVCAN 0556-2813 10.1103/PhysRevC.81.031901Liao, J., Koch, V., Bzdak, A., (2010) Phys. Rev. C, 82, p. 054902. , PRVCAN 0556-2813 10.1103/PhysRevC.82.054902Ma, G.-L., Zhang, B., (2011) Phys. Lett. B, 700, p. 39. , PYLBAJ 0370-2693 10.1016/j.physletb.2011.04.057Voloshin, S.A., (2010) Phys. Rev. Lett., 105, p. 172301. , PRLTAO 0031-9007 10.1103/PhysRevLett.105.17230

Fluctuations Of Charge Separation Perpendicular To The Event Plane And Local Parity Violation In S Nn = 200 Gev Au + Au Collisions At The Bnl Relativistic Heavy Ion Collider

Previous experimental results based on data (∼15×106 events) collected by the STAR detector at the BNL Relativistic Heavy Ion Collider suggest event-by-event charge-separation fluctuations perpendicular to the event plane in noncentral heavy-ion collisions. Here we present the correlator previously used split into its two component parts to reveal correlations parallel and perpendicular to the event plane. The results are from a high-statistics 200-GeV Au + Au collisions data set (57×106 events) collected by the STAR experiment. We explicitly count units of charge separation from which we find clear evidence for more charge-separation fluctuations perpendicular than parallel to the event plane. We also employ a modified correlator to study the possible P-even background in same- and opposite-charge correlations, and find that the P-even background may largely be explained by momentum conservation and collective motion. © 2013 American Physical Society.886NRF-2012004024; National Research FoundationLee, T.D., Yang, C.N., (1956) Phys. Rev., 104. , 1, 254. 0031-899X PHRVAO 10.1103/PhysRev.104.254Vafa, C., Witten, E., (1984) Phys. Rev. Lett., 53. , 2, 535. 0031-9007 PRLTAO 10.1103/PhysRevLett.53.535Lee, T.D., (1973) Phys. Rev. D, 8. , 3, 1226. 0556-2821 10.1103/PhysRevD.8.1226Lee, T.D., Wick, G.C., (1974) Phys. Rev. D, 9. , 4, 2291. 0556-2821 10.1103/PhysRevD.9.2291Kharzeev, D., Parity violation in hot QCD: Why it can happen, and how to look for it (2006) Physics Letters, Section B: Nuclear, Elementary Particle and High-Energy Physics, 633 (2-3), pp. 260-264. , DOI 10.1016/j.physletb.2005.11.075, PII S0370269305017430Kharzeev, D., Zhitnitsky, A., (2007) Nucl. Phys. A, 797. , 6, 67. 0375-9474 NUPABL 10.1016/j.nuclphysa.2007.10.001Kharzeev, D., McLerran, L.D., Warringa, H.J., (2008) Nucl. Phys. A, 803. , 7, 227. 0375-9474 NUPABL 10.1016/j.nuclphysa.2008.02.298Fukushima, K., Kharzeev, D.E., Warringa, H.J., (2008) Phys. Rev. D, 78. , 8, 074033. 1550-7998 PRVDAQ 10.1103/PhysRevD.78.074033Abelev, B.I., (2009) Phys. Rev. Lett., 103. , 9 (STAR Collaboration), 251601. 0031-9007 PRLTAO 10.1103/PhysRevLett.103. 251601Abelev, B.I., (2010) Phys. Rev. C, 81. , 10 (STAR Collaboration), 054908. 0556-2813 PRVCAN 10.1103/PhysRevC.81. 054908Abelev, B.I., (2013) Phys. Rev. Lett., 110. , 11 (ALICE Collaboration), 012301. 0031-9007 PRLTAO 10.1103/PhysRevLett. 110.012301Ackermann, K.H., Adams, N., Adler, C., Ahammed, Z., Ahmad, S., Allgower, C., Amonett, J., Harris, J.W., STAR detector overview (2003) Nuclear Instruments and Methods in Physics Research, Section A: Accelerators, Spectrometers, Detectors and Associated Equipment, 499 (2-3), pp. 624-632. , DOI 10.1016/S0168-9002(02)01960-5Adams, J., Aggarwal, M.M., Ahammed, Z., Amonett, J., Anderson, B.D., Arkhipkin, D., Averichev, G.S., Bai, Y., Directed flow in Au+Au collisions at sNN=62.4 GeV (2006) Physical Review C - Nuclear Physics, 73 (3), pp. 1-7. , http://oai.aps.org/oai?verb=GetRecord&Identifier=oai:aps.org: PhysRevC.73.034903&metadataPrefix=oai_apsmeta_2, DOI 10.1103/PhysRevC.73.034903, 034903Adamczyk, L., (2012) Phys. Rev. Lett., 108. , 14 (STAR Collaboration), 202301. 0031-9007 PRLTAO 10.1103/PhysRevLett. 108.202301Voloshin, S.A., Parity violation in hot QCD: How to detect it (2004) Physical Review C - Nuclear Physics, 70 (5), pp. 0579011-0579012. , DOI 10.1103/PhysRevC.70.057901, 057901Poskanzer, A.M., Voloshin, S.A., Methods for analyzing anisotropic flow in relativistic nuclear collisions (1998) Physical Review C - Nuclear Physics, 58 (3), pp. 1671-1678. , DOI 10.1103/PhysRevC.58.1671Ollitrault, J.-Y., Poskanzer, A.M., Voloshin, S.A., (2009) Phys. Rev. C, 80. , 17, 014904. 0556-2813 PRVCAN 10.1103/PhysRevC.80.014904Pratt, S., Schlichting, S., Gavin, S., (2011) Phys. Rev. C, 84. , 18, 024909. 0556-2813 PRVCAN 10.1103/PhysRevC.84.024909Schlichting, S., Pratt, S., (2011) Phys. Rev. C, 83. , 19, 014913. 0556-2813 PRVCAN 10.1103/PhysRevC.83.014913Selyuzhenkov, I., Voloshin, S., (2008) Phys. Rev. C, 77. , 20, 034904. 0556-2813 PRVCAN 10.1103/PhysRevC.77.034904Kisiel, A., (2006) Comput. Phys. Commun., 174. , 21, 669. 0010-4655 CPHCBZ 10.1016/j.cpc.2005.11.010Bzdak, A., Koch, V., Liao, J., (2011) Phys. Rev. C, 83. , 22, 014905. 0556-2813 PRVCAN 10.1103/PhysRevC.83.014905Adams, J., Aggarwal, M.M., Ahammed, Z., Amonett, J., Anderson, B.D., Arkhipkin, D., Averichev, G.S., Grebenyuk, O., Azimuthal anisotropy in Au+Au collisions at sNN=200GeV (2005) Physical Review C - Nuclear Physics, 72 (1), pp. 1-23. , http://oai.aps.org/oai/?verb=ListRecords&metadataPrefix= oai_apsmeta_2&set=journal:PRC:72, DOI 10.1103/PhysRevC.72.014904, 014904Ray, R.L., Longacre, R.S., 24, arXiv:nucl-ex/0008009 and private communicationKopylov, G.I., Podgoretsky, M.I., Kopylov, G.I., Podgoretsky, M.I., (1972) Sov. J. Nucl. Phys., 15. , 25a, 219 ()25b, Phys. Lett. B. 50, 472 (1974) 0370-2693 PYLBAJ 10.1016/0370-2693(74)90263-925c, Sov. J. Part. Nucl. 20, 266 (1989)Goldhaber, G., Goldhaber, S., Lee, W., Pais, A., (1960) Phys. Rev., 120. , 26, 325. 0031-899X PHRVAO 10.1103/PhysRev.120.32

On the simulation of regular waves in a numerical wave tank

The use of renewable sources for electricity generation has been accelerated because of high fuel prices of fossil fuels. In addition to this, the use of conventional fuel supplies is no longer able to cater for the ever increasing energy demands of the modern world which is experiencing an age of rapid expansion. Furthermore, use of renewable energy aims to mitigate the effects of climate change such as global warming and rising sea levels which is brought about by the use of fossil fuels. Fiji is not spared from the harsh reality of rising sea levels which poses a threat on their livelihoods as a result of climate change. It is important to find alternative energy source which is environmentally friendly and reduces dependence on fossil fuel. Generating power from waves offers a good option. As such in the present study commercial computational fluid dynamics (CFD) code ANSYS-CFX is used to model a piston type 3D numerical wave tank (NWT). An actual NWT is constructed to generate desired wave climate based on field measurement at a site in Fiji. The CFD results compared very well with analytical solutions. The difference is within 3% highlighting the validity of the CFD code

Correction to: A comprehensive review about immune responses and exhaustion during coronavirus disease (COVID-19) (Cell Communication and Signaling, (2022), 20, 1, (79), 10.1186/s12964-022-00856-w)

Following publication of the original article [1], the authors identified an error in the following affiliation: 1. Medical Laboratory Analysis Department, College of Health Sciences, Cihan University of Sulaimaniya, Kurdistan Region, Iraq Cihan University was misspelt as Cihlan University. © The Author(s) 2022