Tumour Lysis Syndrome and Partial Remission Occurring After Administration of a Test Dose of Obinutuzumab

Chronic lymphocytic leukaemia (CLL) is one of the most common haematological malignancies worldwide, with an increasing prevalence in the elderly population. Obinutuzumab is a type II anti-CD20 monoclonal antibody which showed superiority over rituximab in combination chemotherapy with chlorambucil for the treatment of CLL in the CLL11 trial (NCT01010061) and is becoming part of standard first line treatment for CLL in the elderly based on its potent efficacy and benign safety profile. We report the case of a chemotherapy naive patient who develop tumour lysis syndrome despite appropriate prophylaxis, and had partial remission of her disease after receiving only the initial test dose of obinutuzumab

PRINCIPALS\u27 INSTRUCTIONAL LEADERSHIP PRACTICES AND THEIR RELATIONSHIP TO TEACHERS\u27 INSTRUCTIONAL PRACTICES IN SHARJAH SCHOOLS

Instructional leadership has become one of the most widely researched topics. This type of leadership has been connected to teacher growth and development, teacher job satisfaction, student achievement, and improving school climate in general. This study focuses on instructional leadership in schools of Sharjah Education Zone. Specifically, the study aims to describe the principal instructional leadership practices, to identify the most and least important teachers\u27 instructional practices, and to investigate whether there is a relationship between the principals\u27 instructional practices and teachers\u27 teaching practices. This study is quantitative in nature and therefore a questionnaire was used to collect data from teachers in 24 schools in Sharjah. The sample was 111 male and 269 female teachers with a total of 380 teachers. The study found that principals in Sharjah schools practice certain tasks of instructional leadership more than others. For example, they care more for framing the school goals, providing incentives for learning, and evaluating instruction than maintaining high visibility, protecting instructional time, and providing incentives for teachers. With regard to teachers\u27 instructional practices, it was found that teachers focus on certain practices more than others. They provide attention to students working in groups, stating the lesson goals, checking students\u27 exercise books than, for example, asking students to write essays to demonstrate their creative ideas, giving them projects that last for some time, and holding debates in the classrooms. Finally, the study found a positive relationship between principals\u27 instructional leadership practices and teachers\u27 teaching practices. In other words, when the principal attends to certain leadership practices, the teacher gives more attention to certain instructional practices. This relationship was stronger in areas of monitoring vii students\u27 progress, providing incentives for teachers and protecting teachers\u27 instructional tim

Principals’ Instructional Leadership Practices and Their Relationship to Teachers’ Instructional Practices in Sharjah Schools.

Instructional leadership has become one of the most widely researched topics. This type of leadership has been connected to teacher growth and development, teacher job satisfaction, student achievement, and improving school climate in general. This study focuses on instructional leadership in schools of Sharjah Education Zone. Specifically, the study aims to describe the principal instructional leadership practices, to identify the most and least important teachers’ instructional practices, and to investigate whether there is a relationship between the principals’ instructional practices and teachers’ teaching practices. This study is quantitative in nature and therefore a questionnaire was used to collect data from teachers in 24 schools in Sharjah. The sample was 111 male and 269 female teachers with a total of 380 teachers. The study found that principals in Sharjah schools practice certain tasks of instructional leadership more than others. For example, they care more for framing the school goals, providing incentives for learning, and evaluating instruction than maintaining high visibility, protecting instructional time, and providing incentives for teachers. With regards to teachers’ instructional practices, it was found that teachers focus on certain practices more than others. They provide attention to students working in groups, stating the lesson goals, checking students’ exercise books than, for example, asking students to write essays to demonstrate their creative ideas, giving them projects that last for some time, and holding debates in the classrooms. Finally, the study found a positive relationship between principals’ instructional leadership practices and teachers’ teaching practices. In other words, when the principal attends to certain leadership practices, the teacher gives more attention to certain instructional practices. This relationship was stronger in areas of monitoring students’ progress, providing incentives for teachers and protecting teachers’ instructional time

Moroccan cinema as a component of cultural industries: limits of a model

The objective of this contribution is to analyze the characteristics of the film industry in the Moroccan context. Based on the study of public policies and the practices of the actors within the various cinematographic functions, the emphasis is placed on the main constraints facing the film industry. This includes, in particular, limits on the production, distribution, exploitation and protection of copyright of cinematographic works. The methodology adopted combines the analysis of documents and the qualitative field survey, based on semi-directive interviews. The results of the study show an almost total dependence of the actors on public subsidies, which generates imbalances between the main components of the whole sector

Converting UML Class Diagrams into Temporal Object Relational DataBase

Number of active researchers and experts, are engaged to develop and implement new mechanism and features in time varying database management system (TVDBMS), to respond to the recommendation of modern business environment..Time-varying data management has been much taken into consideration with either the attribute or tuple time stamping schema. Our main approach here is to try to offer a better solution to all mentioned limitations of existing works in order to provide the non-procedural data definitions, queries of temporal data as complete as possible technical conversion that allow to easily realize and share all conceptual details of the UML class specifications, from conception and design point of view. This paper contributes to represent a logical design schema by UML class diagrams, which are handled by stereotypes to express a temporal object relational database with attribute timestamping

Economic analysis of the traditional Beldi Chicken value chain in Morocco

Poultry meat production in Morocco has experienced a considerable growth over the past two decades. Indeed, the poultry sector has a significant economic weight in Moroccan agriculture with 23.3 million days of labor and 9.9 billion dirhams in added value in 2019. However, there is a huge gap between the traditional and industrial poultry sectors in terms of production, processing, promotion and support. This work focuses on the traditional beldi chicken value chain in the Morocco. Its general objective is to contribute to the detailed economic analysis of the “Beldi” chicken value chain. In addition, this study will analyze the main factors that determine the income from traditional chicken production. We note that the traditional Beldi chicken sector is characterized by a high degree of informality, which can make it difficult to track supply and demand and ensure fair prices for all actors of the value chain. It represents an important source of income for small farmers and the most deprived families and contributes to reducing poverty. Keywords: Poultry, Traditional Beldi Chicken, value chain, actors, income, povert

Dynamic capabilities, competitiveness and performance of small and medium-sized enterprises: a systematic literature review

Dynamic capability theory was developed as part of the Resource Based View (RBV) to explain business performance and the notion of competitive advantage. The objective of this article is to offer a systematic overview of the scientific literature around the theory of Dynamic Capacities (DCs in relation to the performance of Small and Medium Enterprises (SME), it aims to explore how the theory of DCs has been approached by different authors in an SME context, and to examine the contribution of DCs to performance and their competitive advantage. One hundred and fifty-five relevant scientific contributions from 22 journals between 1997 and 2021 were analyzed through careful classification according to discipline, method and country. This literature review offers a summary of the state of the art and shares various trends and developments regarding this emerging research area. Among other things, it demonstrates the existence of conceptual ambiguities, different definitions and a lack of qualitative articles: this contributes to a wide range of research topics. Our analysis shows that DCs have received higher corroboration in the SME context than in the large enterprise context (Pezeshkan et al., 2016), and also a higher level of empirical support than RBV (Newbert, 2007)and other approaches in strategic management research such as transaction cost theory (David & Han, 2004). Thus, a need for empirical evidence and production of an explanatory nature is also noted: many hypotheses on the contribution of DCs to the competitive advantage of SMEs remain to be demonstrated. Moreover, this work highlights the significant and generally positive contribution of DCs to the performance of SMEs. Keywords: Dynamic capabilities, Small and Medium Enterprises, Resource Based View, competitive advantage, performance. JEL Classification: M19 Paper type: theoretical ResearchDynamic capability theory was developed as part of the Resource Based View (RBV) to explain business performance and the notion of competitive advantage. The objective of this article is to offer a systematic overview of the scientific literature around the theory of Dynamic Capacities (DCs in relation to the performance of Small and Medium Enterprises (SME), it aims to explore how the theory of DCs has been approached by different authors in an SME context, and to examine the contribution of DCs to performance and their competitive advantage. One hundred and fifty-five relevant scientific contributions from 22 journals between 1997 and 2021 were analyzed through careful classification according to discipline, method and country. This literature review offers a summary of the state of the art and shares various trends and developments regarding this emerging research area. Among other things, it demonstrates the existence of conceptual ambiguities, different definitions and a lack of qualitative articles: this contributes to a wide range of research topics. Our analysis shows that DCs have received higher corroboration in the SME context than in the large enterprise context (Pezeshkan et al., 2016), and also a higher level of empirical support than RBV (Newbert, 2007)and other approaches in strategic management research such as transaction cost theory (David & Han, 2004). Thus, a need for empirical evidence and production of an explanatory nature is also noted: many hypotheses on the contribution of DCs to the competitive advantage of SMEs remain to be demonstrated. Moreover, this work highlights the significant and generally positive contribution of DCs to the performance of SMEs. Keywords: Dynamic capabilities, Small and Medium Enterprises, Resource Based View, competitive advantage, performance. JEL Classification: M19 Paper type: theoretical Researc

Cartografía estructural y mineral mediante imagen multiespectral en el Alto Atlas Central de Marruecos

The Central High Atlas is one of the geological structures that belong to the Moroccan Atlas massif. It presents a great geological diversity and many structural and facies features. It is controlled by main faults of N70 to E-W direction that are visible at different scales and is rich in numerous mineralized veins. This area was the subject of the present work, in which we simulated the images of Landsat 8 OLI, Sentinel 2, and Aster sensors to map the hydrothermal alteration minerals associated with a lithostructural mapping that can provide more information on the mineralization of this study area. We highlight different approaches to remote sensing, considering first the methods of extraction of lineaments from the infrared-band of the Landsat 8 OLI image and from the GDEM ASTER to highlight the geological features of the study area. To obtain a good discrimination of the lithological units, Principal Component Analysis and Optimal Index Factor were applied to create colored composites with a better visual interpretation in order to generate a good lithological mapping, and finally, many band ratios are proposed for ASTER, Landsat 8 OLI and Sentinel 2 to derive several maps corresponding to the hydrothermal alteration zones that are compared to the geological map of the studied site, presenting a favorable correlation between them. The analysis of the results of the obtained maps allowed us to identify the main structural directions encompassing the NE-SW to E-W, NNE-SWSW and ENE-WSW families and also allowed us to highlight two potential zones of mineralization; one located to the south of Demnate at the western end of the Central High Atlas and the other in the middle part of the Central High Atlas. The superposition of the alteration maps and the fracturing map shows that the zones that are favorable for mineralization deposits are affected by faults in a generally NE-SW direction.El Alto Atlas Central es una de las estructuras geológicas que pertenecen al Macizo del Atlas marroquí. Presenta una gran diversidad geológica y muchas características estructurales y de facies. Está controlada por fallas principales de dirección N70 a E-O, visibles a diferentes escalas y ricas en numerosas vetas mineralizadas. Esta zona ha sido objeto del presente trabajo, en el que hemos simulado las imágenes de los sensores Landsat 8 OLI, Sentinel 2 y Aster para cartografiar los minerales de alteración hidrotermal asociados a una cartografía litoestructural que puede aportar más información sobre la mineralización de esta zona de estudio. En este punto destacamos los diferentes enfoques de teledetección adoptados, citando en primer lugar los métodos de extracción de lineamientos a partir de la banda infrarroja de la imagen Landsat 8 OLI y del GDEM ASTER para destacar la fracción geológica del área de estudio. Para obtener una buena discriminación de las unidades litológicas se realizó un Análisis de Componentes Principales y se aplicó el Factor de Índice Óptimo para crear composiciones de color con mejor interpretación visual para tener una buena cartografía litológica, y finalmente, se proponen muchas relaciones de bandas para ASTER, Landsat 8 OLI y Sentinel 2 para derivar varios mapas correspondientes a las zonas de alteración hidrotermal que se comparan con el mapa geológico del lugar estudiado, que presenta una correlación favorable entre ellos. El análisis de los resultados de los mapas obtenidos permitió identificar las grandes direcciones estructurales materializadas por las familias NE-SW a E-W, NNE-SWSW y ENE-WSW y también permitió destacar dos zonas potenciales de mineralización: una situada al sur de Demnate en el extremo occidental del Alto Atlas Central y la otra en la parte central del Alto Atlas Central. La superposición de los mapas de alteración y del mapa de fracturación muestra que las zonas que pueden ser favorables para los depósitos de mineralización están afectadas por fallas en dirección generalmente NE-SW

A Review on In Situ Mechanical Testing of Coatings

Real-time evaluation of materials’ mechanical response is crucial to further improve the performance of surfaces and coatings because the widely used post-processing evaluation techniques (e.g., fractography analysis) cannot provide deep insight into the deformation and damage mechanisms that occur and changes in coatings’ material corresponding to the dynamic thermomechanical loading conditions. The advanced in situ examination methods offer deep insight into mechanical behavior and material failure with remarkable range and resolution of length scales, microstructure, and loading conditions. This article presents a review on the in situ mechanical testing of coatings under tensile and bending examinations, highlighting the commonly used in situ monitoring techniques in coating testing and challenges related to such techniques