Instability of a gravity current within a soap film

One of the simplest geometries in which to study fluid flow between two soap films connected by a Plateau border is provided by a catenoid with a secondary film at its narrowest point. Dynamic variations in the spacing between the two rings supporting the catenoid lead to fluid flow between the primary and secondary films. When the rings are moved apart, while keeping their spacing within the overall stability regime of the films, after a rapid thickening of the secondary film the excess fluid in it starts to drain into the sloped primary film through the Plateau border at which they meet. This influx of fluid is accommodated by a local thickening of the primary film. Experiments described here show that after this drainage begins the leading edge of the gravity current becomes linearly unstable to a finite-wavelength fingering instability. A theoretical model based on lubrication theory is used to explain the mechanism of this instability. The predicted characteristic wavelength of the instability is shown to be in good agreement with experimental results. Since the gravity current advances into a film of finite, albeit microscopic, thickness this situation is one in which the regularization often invoked to address singularities at the nose of a thin film is physically justified

Convection-driven kinematic dynamos at low Rossby and magnetic Prandtl numbers: Single mode solutions

The onset of dynamo action is investigated within the context of a newly developed low Rossby, low magnetic Prandtl number, convection-driven dynamo model. This multiscale model represents an asymptotically exact form of an α2 mean field dynamo model in which the small-scale convection is represented explicitly by finite amplitude, single mode solutions. Both steady and oscillatory convection are considered for a variety of horizontal planforms. The kinetic helicity is observed to be a monotonically increasing function of the Rayleigh number. As a result, very small magnetic Prandtl number dynamos can be found for sufficiently large Rayleigh numbers. All dynamos are found to be oscillatory with an oscillation frequency that increases as the strength of the convection is increased and the magnetic Prandtl number is reduced. Kinematic dynamo action is strongly controlled by the profile of the helicity; single mode solutions which exhibit boundary layer behavior in the helicity show a decrease in the efficiency of dynamo action due to the enhancement of magnetic diffusion in the boundary layer regions. For a given value of the Rayleigh number, lower magnetic Prandtl number dynamos are excited for the case of oscillatory convection in comparison to steady convection. With regard to planetary dynamos, these results suggest that the low magnetic Prandtl number dynamos typical of liquid metals are more easily driven by thermal convection than by compositional convection

Genome-wide imputation study identifies novel HLA locus for pulmonary fibrosis and potential role for auto-immunity in fibrotic idiopathic interstitial pneumonia.

To access publisher's full text version of this article, please click on the hyperlink in Additional Links field or click on the hyperlink at the top of the page marked Files. This article is open access.Fibrotic idiopathic interstitial pneumonias (fIIP) are a group of fatal lung diseases with largely unknown etiology and without definitive treatment other than lung transplant to prolong life. There is strong evidence for the importance of both rare and common genetic risk alleles in familial and sporadic disease. We have previously used genome-wide single nucleotide polymorphism data to identify 10 risk loci for fIIP. Here we extend that work to imputed genome-wide genotypes and conduct new RNA sequencing studies of lung tissue to identify and characterize new fIIP risk loci.We performed genome-wide genotype imputation association analyses in 1616 non-Hispanic white (NHW) cases and 4683 NHW controls followed by validation and replication (878 cases, 2017 controls) genotyping and targeted gene expression in lung tissue. Following meta-analysis of the discovery and replication populations, we identified a novel fIIP locus in the HLA region of chromosome 6 (rs7887 P meta  = 3.7 × 10(-09)). Imputation of classic HLA alleles identified two in high linkage disequilibrium that are associated with fIIP (DRB1*15:01 P = 1.3 × 10(-7) and DQB1*06:02 P = 6.1 × 10(-8)). Targeted RNA-sequencing of the HLA locus identified 21 genes differentially expressed between fibrotic and control lung tissue (Q < 0.001), many of which are involved in immune and inflammatory response regulation. In addition, the putative risk alleles, DRB1*15:01 and DQB1*06:02, are associated with expression of the DQB1 gene among fIIP cases (Q < 1 × 10(-16)).We have identified a genome-wide significant association between the HLA region and fIIP. Two HLA alleles are associated with fIIP and affect expression of HLA genes in lung tissue, indicating that the potential genetic risk due to HLA alleles may involve gene regulation in addition to altered protein structure. These studies reveal the importance of the HLA region for risk of fIIP and a basis for the potential etiologic role of auto-immunity in fIIP.National Heart, Lung and Blood Institute R01-HL095393 R01-HL097163 P01-HL092870 RC2-HL101715 U01-HL089897 U01-HL089856 U01-HL108642 P50-HL089493

Rationale, design and methods for a community-based study of clustering and cumulative effects on chronic disease process and their effects on ageing: the Busselton healthy ageing study

Background: The global trend of increased life expectancy and increased prevalence of chronic and degenerative diseases will impact on health systems. To identify effective intervention and prevention strategies, greater understanding of the risk factors for and cumulative effects of chronic disease processes and their effects on function and quality of life is needed. The Busselton Healthy Ageing Study aims to enhance understanding of ageing by relating the clustering and interactions of common chronic conditions in adults to function. Longitudinal (3–5 yearly) follow-up is planned. Methods/design: Phase I (recruitment) is a cross-sectional community-based prospective cohort study involving up to 4,000 ‘Baby Boomers’ (born from 1946 to 1964) living in the Busselton Shire, Western Australia. The study protocol involves a detailed, self-administered health and risk factor questionnaire and a range of physical assessments including body composition and bone density measurements, cardiovascular profiling (blood pressure, ECG and brachial pulse wave velocity), retinal photography, tonometry, auto-refraction, spirometry and bronchodilator responsiveness, skin allergy prick tests, sleep apnoea screening, tympanometry and audiometry, grip strength, mobility, balance and leg extensor strength. Cognitive function and reserve, semantic memory, and pre-morbid intelligence are assessed. Participants provide a fasting blood sample for assessment of lipids, blood glucose, C-reactive protein and renal and liver function, and RNA, DNA and serum are stored. Clinically relevant results are provided to all participants. The prevalence of risk factors, symptoms and diagnosed illness will be calculated and the burden of illness will be estimated based on the observed relationships and clustering of symptoms and illness within individuals. Risk factors for combinations of illness will be compared with those for single illnesses and the relation of combinations of illness and symptoms to cognitive and physical function will be estimated. Discussion: This study will enable a thorough characterization of multiple disease processes and their risk factors within a community-based sample of individuals to determine their singular, interactive and cumulative effects on ageing. The project will provide novel cross-sectional data and establish a cohort that will be used for longitudinal analyses of the genetic, lifestyle and environmental factors that determine whether an individual ages well or with impairment

FOREWORD: Turbulence Colloquium Marseille 2011

International audienc

Instability of a gravity current within a soap film

One of the simplest geometries in which to study fluid flow between two soap films connected by a Plateau border is provided by a catenoid with a secondary film at its narrowest point. Dynamic variations in the spacing between the two rings supporting the catenoid lead to fluid flow between the primary and secondary films. When the rings are moved apart, while keeping their spacing within the overall stability regime of the films, after a rapid thickening of the secondary film the excess fluid in it starts to drain into the sloped primary film through the Plateau border at which they meet. This influx of fluid is accommodated by a local thickening of the primary film. Experiments described here show that after this drainage begins the leading edge of the gravity current becomes linearly unstable to a finite-wavelength fingering instability. A theoretical model based on lubrication theory is used to explain the mechanism of this instability. The predicted characteristic wavelength of the instability is shown to be in good agreement with experimental results. Since the gravity current advances into a film of finite, albeit microscopic, thickness this situation is one in which the regularization often invoked to address singularities at the nose of a thin film is physically justified