Rocket- and aircraft-borne trace gas measurements in the winter polar stratosphere

In January and February 1987 stratospheric rocket- and aircraft-borne trace gas measurements were done in the North Polar region using ACIMS (Active Chemical Ionization Mass Spectrometry) and PACIMS (PAssive Chemical Ionization Mass Spectrometry) instruments. The rocket was launched at ESRANGE (European Sounding Rocket Launching Range) (68 N, 21 E, Northern Sweden) and the twin-jet research aircraft operated by the DFVLR (Deutsche Forschungs- und Versuchs-anstalt fuer Luft- und Raumfahrt), and equipped with a mass spectrometer laboratory was stationed at Kiruna airport. Various stratospheric trace gases were measured including nitric acid, sulfuric acid, non-methane hydrocarbons (acetone, hydrogen cyanide, acetonitrile, methanol etc.), and ambient cluster ions. The experimental data is presented and possible implications for polar stratospheric ozone discussed

Making FORS2 fit for exoplanet observations (again)

For about three years, it was known that precision spectrophotometry with FORS2 suffered from systematic errors that made quantitative observations of planetary transits impossible. We identified the Longitudinal Atmospheric Dispersion Compensator (LADC) as the most likely culprit, and therefore engaged in a project to exchange the LADC prisms with the uncoated ones from FORS1. This led to a significant improvement in the depth of FORS2 zero points, a reduction in the systematic noise, and should make FORS2 again competitive for transmission spectroscopy of exoplanets.Comment: To appear in the March issue of the ESO Messenge

Simultaneous time-series spectroscopy and multi-band photometry of the sdBV PG 1605+072

We present time-series spectroscopy and multi-band photometry of the sdBV PG 1605+072 carried out simultaneously at the Calar Alto 2.2m and 3.5m telescopes. The periodogram analysis of the radial velocity curves reveals three frequencies at 2.078, 2.756, and 1.985 mHz for Hbeta and at 2.076, 2.753, and 1.978 mHz for Hgamma. The corresponding radial velocity amplitudes are 12.7, 8.0, and 7.9 km/s for Hbeta and 14.3, 6.5, and 7.2 km/s for Hgamma. Furthermore, we found five frequencies that are present in all wavelength bands of the BUSCA photometer. The frequencies detected in the radial velocity curves are recovered by the photometric measurements. Moreover, additional frequencies were present in the periodograms which could not be identified in all four bands simultaneously. The comparison of the amplitudes presented here with previous results from radial velocity and photometric observations of PG 1605+072 shows a significant change or even switch in the power of the modes within short time scales, i. e. about one year. No changes in frequency were registered and the phases of the modes show no wavelength dependency within our multi-band photometry.Comment: 8 pages, 12 figures, accepted by A&

The White Dwarf Distance to the Globular Cluster 47 Tucanae and its Age

We present a new determination of the distance (and age) of the Galactic globular cluster 47 Tucanae (NGC 104) based on the fit of its white dwarf (WD) cooling sequence with the empirical fiducial sequence of local WD with known trigonometric parallax, following the method described in Renzini et al. (1996). Both the cluster and the local WDs were imaged with HST+WFPC2 using the same instrument setup. We obtained an apparent distance modulus of $(m-M)_V=13.27\pm0.14$ consistent with previous ground-based determinations and shorter than that found using HIPPARCOS subdwarfs. Coupling our distance determination with a new measure of the apparent magnitude of the main sequence turnoff, based on our HST data, we derive an age of $13\pm2.5$ Gyr.Comment: Accepted for publication on the Astrophysical Journa

Horizontal Branch evolution, metallicity and sdB stars

Context. Abundance anomalies have been observed in field sdB stars and in nearly all Horizontal Branch (HB) stars of globular clusters with Teff > 11 000K whatever be the cluster metallicity. Aims. The aim is to determine the abundance variations to be expected in sdB stars and in HB stars of metallicities Z \geq 0.0001 and what observed abundances teach us about hydrodynamical processes competing with atomic diffusion. Methods. Complete stellar evolution models, including the effects of atomic diffusion and radiative acceleration, have been computed from the zero age main-sequence for metallicities of Z0 = 0.0001, 0.001, 0.004 and 0.02. On the HB the masses were selected to cover the Teff interval from 7000 to 37000K. Some 60 evolutionary HB models were calculated. The calculations of surface abundance anomalies during the horizontal branch depend on one parameter, the surface mixed mass. Results. For sdB stars with Teff 11 000K in all observed clusters, independent of metallicity, it was found that most observed abundance anomalies (even up to ~ x 200) were compatible, within error bars, with expected abundances. A mixed mass of ~1.E-7 M\odot was determined by comparison with observations. Conclusions. Observations of globular cluster HB stars with Teff > 11 000K and of sdB stars with Teff < 37 000K suggest that most observed abundance anomalies can be explained by element separation driven by radiative acceleration occuring at a mass fraction of ~1.E-7 M\odot. Mass loss or turbulence appear to limit the separation between 1.E-7 M\odot and the surface.Comment: Accepted for publication by A&

The mass of the sdB primary of the binary HS 2333+3927

Short period sdB binaries with cool companions are crucial to understand pre-CV evolution, because they will evolve into cataclysmic variables, when the sdB will have left the extended horizontal branch. Recently we discovered the sixth such system, HS 2333+3927, consisting of an sdB star and an M dwarf (period: 0.172 d) with a very strong reflection effect, but no eclipses. The reflection is stronger than in any of the other similar systems which renders a quantitative spectral analysis very difficult because the Balmer line profiles may be disturbed by the reflected light. A spectroscopic analysis results in Teff = 36500 K, log g = 5.70, and log (n_He/n_H) = -2.15. Mass-radius relations were derived from the results of the analysis of light and radial-velocity curves. Comparison with the mass-radius relation derived from the surface gravity of the sdB star favours a rather low mass of 0.38 Msun for the primary. The mass of the companion is 0.29 M_sun. HS 2333+3927 is the only known sdB+dM system with a period above the CV period gap.Comment: 6 pages, 3 Fig., to appear in 14th European Workshop on White Dwarfs, ASP Conference Series, eds. D. Koester, S. Moehle

Influence of surface morphology on the immersion mode ice nucleation efficiency of hematite particles

Hiranuma N, Hoffmann N, Kiselev A, et al. Influence of surface morphology on the immersion mode ice nucleation efficiency of hematite particles. ATMOSPHERIC CHEMISTRY AND PHYSICS. 2014;14(5):2315-2324.In this paper, the effect of the morphological modification of aerosol particles with respect to heterogeneous ice nucleation is comprehensively investigated for laboratorygenerated hematite particles as a model substrate for atmospheric dust particles. The surface-area-scaled ice nucleation efficiencies of monodisperse cubic hematite particles and milled hematite particles were measured with a series of expansion cooling experiments using the Aerosol Interaction and Dynamics in the Atmosphere (AIDA) cloud simulation chamber. Complementary offline characterization of physico-chemical properties of both hematite subsets were also carried out with scanning electron microscopy (SEM), energy dispersive X-ray (EDX) spectroscopy, dynamic light scattering (DLS), and an electro-kinetic particle charge detector to further constrain droplet-freezing measurements of hematite particles. Additionally, an empirical parameterization derived from our laboratory measurements was implemented in the single-column version of the Community Atmospheric Model version 5 (CAM5) to investigate the model sensitivity in simulated ice crystal number concentration on different ice nucleation efficiencies. From an experimental perspective, our results show that the immersion mode ice nucleation efficiency of milled hematite particles is almost an order of magnitude higher at -35.2 degrees C < T < -33.5 degrees C than that of the cubic hematite particles, indicating a substantial effect of morphological irregularities on immersion mode freezing. Our modeling results similarly show that the increased droplet- freezing rates of milled hematite particles lead to about one order magnitude higher ice crystal number in the upper troposphere than cubic hematite particles. Overall, our results suggest that the surface irregularities and associated active sites lead to greater ice activation through droplet freezing

Secondary organic aerosol formation from gasoline vehicle emissions in a new mobile environmental reaction chamber

We present a new mobile environmental reaction chamber for the simulation of the atmospheric aging of different emissions sources without limitation from the instruments or facilities available at any single site. Photochemistry is simulated using a set of 40 UV lights (total power 4 KW). Characterisation of the emission spectrum of these lights shows that atmospheric aging of emissions may be simulated over a range of temperatures (-7 to 25°C). A photolysis rate of NO2, JNO2, of (8.0±0.7)×10-3 s-1 was determined at 25°C. We demonstrate the utility of this new system by presenting results on the aging (OH=12×106 cm-3h) of emissions from a modern (Euro 5) gasoline car operated during a driving cycle (New European Driving Cycle, NEDC) on a chassis dynamometer in a vehicle test cell. Emissions from the entire NEDC were sampled and aged in the chamber. A thorough investigation of the composition of the gas phase emissions suggests that the observed SOA is from previously unconsidered precursors and processes. This large enhancement in PM mass from gasoline vehicle aerosol emissions due to SOA formation, if it occurs across a wider range of gasoline vehicles, would have significant implications for our understanding of the contribution of on-road gasoline vehicles to ambient aerosols.JRC.F.8-Sustainable Transpor

Irinotecan plus folinic acid/continuous 5-fluorouracil as simplified bimonthly FOLFIRI regimen for first-line therapy of metastatic colorectal cancer

BACKGROUND: Combination therapy of irinotecan, folinic acid (FA) and 5-fluorouracil (5-FU) has been proven to be highly effective for the treatment of metastatic colorectal cancer. However, in light of safety and efficacy concerns, the best combination regimen for first-line therapy still needs to be defined. The current study reports on the bimonthly FOLFIRI protocol consisting of irinotecan with continuous FA/5-FU in five German outpatient clinics, with emphasis on the safety and efficiency, quality of life, management of delayed diarrhea, and secondary resection of regressive liver metastases. METHODS: A total of 35 patients were treated for metastatic colorectal cancer. All patients received first-line treatment according to the FOLFIRI regimen, consisting of irinotecan (180 mg/m(2)), L-FA (200 mg/m(2)) and 5-FU bolus (400 mg/m(2)) on day 1, followed by a 46-h continuous infusion 5-FU (2400 mg/m(2)). One cycle contained three fortnightly administrations. Staging was performed after 2 cycles. Dosage was reduced at any time if toxicity NCI CTC grade III/IV was observed. Chemotherapy was administered only to diarrhea-free patients. RESULTS: The FOLFIRI regimen was generally well tolerated. It was postponed for one-week in 51 of 415 applications (12.3%). Dose reduction was necessary in ten patients. Grade III/IV toxicity was rare, with diarrhea (14%), nausea/vomiting (12%), leucopenia (3%), neutropenia (9%) and mucositis (3%). The overall response rate was 31% (4 CR and 7 PR), with disease control in 74%. After primary chemotherapy, resection of liver metastases was achieved in three patients. In one patient, the CR was confirmed pathologically. Median progression-free and overall survival were seven and 17 months, respectively. CONCLUSIONS: The FOLFIRI regimen proved to be safe and efficient. Outpatient treatment was well tolerated. Since downstaging was possible, combinations of irinotecan and continuous FA/5-FU should further be investigated in neoadjuvant protocols

Quality of life of palliative chemotherapy naive patients with advanced adenocarcinoma of the stomach or esophagogastric junction treated with irinotecan combined with 5-fluorouracil and folinic acid: results of a randomised phase III trial

41st Annual Meeting of the American-Society-of-Clinical-Oncology -- MAY 13-17, 2005 -- Orlando, FLWOS: 000268881000007PubMed ID: 19568958The quality of life (QL) of advanced gastric cancer patients receiving irinotecan, folinic acid and 5-fluorouracil (5-FU) (IF arm) or cisplatin with 5-FU (CF arm) is presented. Patients with measurable or evaluable advanced gastric cancer received IF weekly for 6/7 weeks or CF q4 weeks. QL was assessed using the EORTC QLQ-C30 at baseline, subsequently every 8 weeks until progression and thereafter every 3 months until death. The QL data were analysed using several statistical methods including summary measures and pattern-mixture modelling. A total of 333 patients were randomised and treated (IF 170, CF 163). The time-to-progression for IF and CF was 5.0 and 4.2 months (P = 0.088), respectively. The overall compliance rates for QL questionnaire completion were 60 and 56% in the IF and CF arms, respectively. Significant treatment differences were observed for the physical functioning scale (P = 0.024), nausea\vomiting (P = 0.001) and EQ-5D thermometer (P = 0.020) in favour of the IF treatment arm. There was a trend in favour of IF over CF in time-to-progression. The IF group also demonstrated a better safety profile than CF and a better QL on a number of multi-item scales, suggesting that IF offers an alternative first-line platinum-free treatment option for advanced gastric cancer.Amer Soc Clin Onco