EL USO DE LAS TIC EN LA INCLUSIÓN SOCIOLABORAL DE LA PERSONA CON TRASTORNO DEL ESPECTRO AUTISTA Y/U OTRAS DISCAPACIDADES

O estudo investigou o tema da inclusão sócio laborativa da pessoa com Transtorno do Espectro Autista e/ou outras deficiências junto a 10 indivíduos com idades entre 16 a 36 anos que, além de matriculados também frequentavam a instituição Casa da Esperança. Os objetivos foram: a) identificar o uso das TIC no ambiente educacional como contribuição para o processo de aprendizagem; b) como o uso das TIC pode contribuir para a inclusão sócio laborativa. Para tal, foi realizada uma pesquisa de base qualitativa de cunho etnográfico.  Os dados foram colhidos em um recorte de tempo entre os meses de agosto e outubro de 2014. A organização educacional foi escolhida pelo seu trabalho com crianças, adolescentes e jovens com TEA e/ou outras deficiências. O critério para que os alunos participassem da pesquisa é que os mesmos frequentassem a sala de informática. Participaram também 03 indivíduos que além de frequentarem a organização, são sujeitos que trabalham na instituição, fazendo uso das TIC e as utilizam no desenvolvimento de suas ações laborativas. A ferramenta utilizada para coleta de informações foi o uso de questionário semiestruturado, contendo dezesseis questões, no qual se buscou conhecer o perfil do discente, seu nível educacional, idade e tipo de deficiência, acesso às TIC, utilização da sala de informática, uso de jogos educativos, se sofreu algum tipo de preconceito e/ou estigma, atuação ou não no mercado de trabalho. Como conclusão, a pesquisa oferece elementos que ainda é necessário trabalhar para que o processo de inclusão sócio laborativa seja uma realidade maior para as pessoas com deficiência. Palavras-chave: Aprendizagem; Etnografia; TIC.The study investigated the topic of socio-labor inclusion of the person with Autism Spectrum Disorder and/or other disabilities with 10 individuals aged between 16 and 36 years who, in addition to being enrolled in the institution, were also attending the institution Casa da Esperança. The objectives were: a) to identify the use of ICT in the educational environment as a contribution to the learning process; b) how the use of ICT can contribute to social and labor inclusion. To this end, a qualitative research of an ethnographic nature was carried out. The data were collected over a period of time between August and October 2014. The educational organization was chosen for its work with children, adolescents and young people with ASD and/or other disabilities. The criterion for students to participate in the research is that they attend the computer room. There were also 03 individuals who, in addition to attending the organization, are subjects who work at the institution, making use of ICT and those who use it in the development of their work activities. The tool used to collect information was the use of a semi-structured questionnaire, containing sixteen questions, in which it was sought to know the student's profile, their educational level, age and type of disability, access to ICT, use of the computer room, use of educational games, if you have suffered some kind of prejudice and / or stigma, whether you work in the job market or not. In conclusion, the research offers elements that still need to be worked on so that the process of social and labor inclusion is a greater reality for people with disabilities.  El estudio investigó el tema de la inclusión sociolaboral de la persona con Trastorno del Espectro Autista y / u otras discapacidades con 10 individuos de entre 16 y 36 años que, además de estar inscritos en la institución, también asistían a la institución Casa da Esperança. Los objetivos fueron: a) identificar el uso de las TIC en el ámbito educativo como una contribución al proceso de aprendizaje; b) cómo el uso de las TIC puede contribuir a la inclusión social y laboral. Para ello, se realizó una investigación cualitativa de carácter etnográfico. Los datos fueron recolectados durante un período de tiempo entre agosto y octubre de 2014. La organización educativa fue elegida por su trabajo con niños, adolescentes y jóvenes con TEA y / u otras discapacidades. El criterio para que los estudiantes participen en la investigación es que asistan al aula de informática. También participaron 03 personas que, además de asistir a la organización, son sujetos que laboran en la institución, haciendo uso de las TIC y quienes las utilizan en el desarrollo de sus actividades laborales. La herramienta utilizada para la recolección de información fue el uso de un cuestionario semiestructurado, conteniendo dieciséis preguntas, en el que se buscó conocer el perfil del estudiante, su nivel educativo, edad y tipo de discapacidad, acceso a las TIC, uso del aula de informática, uso de juegos educativos, si ha sufrido algún tipo de prejuicio y/o estigma, tanto si trabaja en el mercado laboral como si no. En conclusión, la investigación ofrece elementos en los que aún hay que trabajar para que el proceso de inclusión social y laboral sea una realidad mayor para las personas con discapacidad

Bloqueio atrioventricular avançando no hiperparatireoidismo: uma complicaçao rara e irreversível

Hiperparatireoidismo associado a hipercalcemia causando bradicardia significativa é uma combinaçao rara. Relatamos o caso de uma paciente de 62 anos de idade em pré-operatório de paratireoidectomia total decorrente de hiperparatireoidismo primário sintomático, que evoluiu com bloqueio atrioventricular avançado percebido durante a internaçao. A paciente necessitou de implante de marcapasso definitivo, pois permaneceu com bloqueio cardíaco avançado mesmo após correçao da hipercalcemia

Morphometric Alteration of Intestinal Epithelium of Rats (Rattus norvegicus) Submitted to the Technique of Enteropexy

Background: Due to the numerous complications that enteropexy may cause in domestic animals and humans, this study aimed at investigating the microscopic level, the damage generated by this technique in mice, in order to investigate the morphometric changes caused by enteropexy technique in rats.Materials, Methods & Results: Eighteen Wistar rats were submitted to surgical technique of enteropexy. To evaluate intestinal disorders they were euthanized at 30 (Group I), 60 (group II) and 90 (group III) days after the procedure. The animals were perfused with 2.5% glutaraldehyde and 4% paraformaldehyde for the removal of intestinal fragments for analysis in conventional microscopy and scanning electron microscopy. In classical histopathology, group I presented mild lesions with necrosis of the epithelium and infiltration of mononuclear cells. After 60 days, extensive ischemic necrosis area was observed, characterized by the denudation of epithelium cells and cellular debris in the lumen surface and loss of intestinal crypts. After 90 days (group III) lesions were evident and were characterized by strong coagulative necrosis of epithelial cells and intestinal crypts. Under electron microscopy, group I showed early fusion of the adjacent intestinal walls. After 60 days there was adherence of luminal stenosis and intestinal walls. In group III loss of epithelium and substitution of necrotic tissue were identified.Discussion: In the current study it was noticed microscopically that the groups had inflammatory reactions to foreign bodies. It is known that the sutures, independent of manufacture, behave as foreign bodies that induce tissue inflammation of the recipient organism and could harm the scar repair. Among the surgical threads, the nylon type (which was chosen for the current experiment) is indicated in the approach tissues in general and bandages, including cardiovascular, ophthalmic and neurological procedures. This category wire induces minimal inflammation of the receptor tissue. In studies of the histopathological analysis of the tissue reactions produced by the wire implant or nylon thread clamp in rats, it was observed that when the local action of two implants were compared, inflammation showed qualitatively similar responses, although they had different characteristics regarding their course. Inflammation is proportional to the proliferation of fibroblasts and the presence of fibrous tissue around the suture. This quote confirms the analyzed samples, in which, in all postoperative times showed inflammatory process, although at different magnitudes. Surgical research in laboratory animals has expanded in recent decades, mainly due to better anesthetic support, the sophistication of infrastructure, material for perioperative continuous monitoring and an incessant search for species that reproduce human morbid conditions. The main focus of these studies have been improving the knowledge about the pathophysiological mechanisms of disease, undertake therapeutic trials with new drugs, studying biomarkers and evaluate new techniques to be applied prospects in man. The most common sites of occurrence of intestinal are ileocolic intussusception junction and jejunojejunal segment. The enteroplication has been used to reduce the occurrence of intussusception, promoting the adhesion of the adjacent serosa layers of intestinal segments and thereby decreasing intestinal motility, their applicability is reported in humans, dogs and cats. The enteropexy technique causes morphological changes in intestinal epithelium of rats, evidenced in conventional and electron microscopy, progress with the passing of time the procedure

Structural assessment, toxicity, and increased antimicrobial activity

Scorpion venom is a rich source of biologically active components and various peptides with high-potential therapeutic use that have been characterized for their antimicrobial and antiproliferative activities. Stigmurin is a peptide identified from the Tityus stigmurus venom gland with high antibacterial and antiproliferative activities and low toxicity. Amino acid substitutions in peptides without a disulfide bridge sequence have been made with the aim of reducing their toxicity and increasing their biological activities. The purpose of this study was to evaluate the structural conformation and structural stability, as well as antimicrobial, antiproliferative, and hemolytic activities of two peptide analogs to Stigmurin, denominated StigA6 and StigA16. In silico analysis revealed the α-helix structure for both analog peptides, which was confirmed by circular dichroism. Data showed that the net charge and hydrophobic moment of the analog peptides were higher than those for Stigmurin, which can explain the increase in antimicrobial activity presented by them. Both analog peptides exhibited activity on cancerous cells similar to the native peptide; however, they were less toxic when tested on the normal cell line. These results reveal a potential biotechnological application of the analog peptides StigA6 and StigA16 as prototypes to new therapeutic agents.publishersversionpublishe

Malformações Arteriovenosa Cerebrais: uma revisão bibliográfica / Cerebral Arteriovenous Malformations: a bibliographic review

Esse estudo foi realizado com o intuito de realizar uma revisão sistemática dentro da literatura cientifica para poder melhor organizar o raciocínio clínicos quanto ao diagnóstico, tratamento e consequências de pacientes portadores de Malformações Arteriovenosa Cerebrais (MAV), uma vez que seu diagnóstico não é fácil de se realizar e a abordagem terapêutica varia de individuo em indivíduo. Contudo, entende-se que o MAV pode ser um dos diagnósticos diferenciais para tratamento de outras patologias através da apresentação da sintomatologia apresentadas pelo paciente admitidos em pronto atendimentos e que procuram clínicas de neurologia e/ou neurocirurgia para tratamento das sintomatologias mais brandas

Pervasive gaps in Amazonian ecological research

Biodiversity loss is one of the main challenges of our time,1,2 and attempts to address it require a clear un derstanding of how ecological communities respond to environmental change across time and space.3,4 While the increasing availability of global databases on ecological communities has advanced our knowledge of biodiversity sensitivity to environmental changes,5–7 vast areas of the tropics remain understudied.8–11 In the American tropics, Amazonia stands out as the world’s most diverse rainforest and the primary source of Neotropical biodiversity,12 but it remains among the least known forests in America and is often underrepre sented in biodiversity databases.13–15 To worsen this situation, human-induced modifications16,17 may elim inate pieces of the Amazon’s biodiversity puzzle before we can use them to understand how ecological com munities are responding. To increase generalization and applicability of biodiversity knowledge,18,19 it is thus crucial to reduce biases in ecological research, particularly in regions projected to face the most pronounced environmental changes. We integrate ecological community metadata of 7,694 sampling sites for multiple or ganism groups in a machine learning model framework to map the research probability across the Brazilian Amazonia, while identifying the region’s vulnerability to environmental change. 15%–18% of the most ne glected areas in ecological research are expected to experience severe climate or land use changes by 2050. This means that unless we take immediate action, we will not be able to establish their current status, much less monitor how it is changing and what is being lostinfo:eu-repo/semantics/publishedVersio