カテコールエストロゲンの基礎的・臨床的研究

金沢大学医学部研究課題/領域番号:X00080----448380, 研究期間(年度):1979 – 1981出典：「カテコールエストロゲンの基礎的・臨床的研究」研究成果報告書　課題番号X00080----448380（KAKEN：科学研究費助成事業データベース（国立情報学研究所）） （https://kaken.nii.ac.jp/ja/grant/KAKENHI-PROJECT-X00080----448380/）を加工して作

高血圧自然発症ラットの時間生物学的研究-サーカディアンリズムを中心として-

福井医科大学医学部研究課題/領域番号58480210, 研究期間(年度):1983 – 1985出典：研究課題「高血圧自然発症ラットの時間生物学的研究-サーカディアンリズムを中心として-」課題番号58480210（KAKEN：科学研究費助成事業データベース（国立情報学研究所）） （https://kaken.nii.ac.jp/ja/grant/KAKENHI-PROJECT-58480210/）を加工して作

合成副腎皮質ステロイドのヒトにおける代謝

金沢大学医学部研究課題/領域番号:X00080----948269, 研究期間(年度):1974出典：「合成副腎皮質ステロイドのヒトにおける代謝」研究成果報告書　課題番号：X00080----948269（KAKEN：科学研究費助成事業データベース（国立情報学研究所）） （https://kaken.nii.ac.jp/ja/grant/KAKENHI-PROJECT-X00080----948269/）を加工して作

Systemic hormonal and physiological abnormalities in anxiety disorders

Among the studies of systemic hormonal and physiological abnormalities associated with anxiety disorders, the most consistent and extensive findings suggest (a) peripheral adrenergic hyperactivity (including increases in norepinephrine but not epinephrine) and functional dysregulation, (b) increased incidence of mitral valve prolapse in panic patients, and (c) normal suppressibility of the hypothalamic-pituitary-adrenal cortical endocrine system with dexamethasone in panic patients. Other less-certain findings include (a) increased circulating concentrations of plasma ACTH and/or cortisol, and prolactin, in panic patients, (b) increased platelet monoamine oxidase activity in generalized anxiety and/or panic patients, (c) decreased gonadal axis activity in some anxious individuals, (d) decreased nighttime melatonin plasma concentrations in panic patients, and (e) peripheral [alpha]2 and [beta]-adrenoreceptor down-regulation, with normal serotonin binding parameters. These findings, taken together, provide tentative support for dysfunction in adrenergic and GABAergic central nervous system mechanisms in people with anxiety disorders. Abnormal anxiety and normal stress both show evidence of adrenergic hyperactivity; however, there appear to be differences in hormonal profiles, especially the apparent lack of increase of epinephrine during panic attacks, as well as differences in the reactivity of the system, and in the "trigger" mechanisms which determine when the response occurs.Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/27526/1/0000570.pd

Interference of Immunoglobulins in the Radioimmunoassay of Human β-Endorphin

Peer Reviewe