3,978 research outputs found

    Relation of Chemical Structure to Fungistatic Activity1

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    ON THE GEOMETRY OF THE X-RAY EMITTING REGION IN SEYFERT GALAXIES

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    For the first time, detailed radiative transfer calculations of Comptonized X-ray and gamma-ray radiation in a hot pair plasma above a cold accretion disk are performed using two independent codes and methods. The simulations include both energy and pair balance as well as reprocessing of the X- and gamma-rays by the cold disk. We study both plane-parallel coronae as well as active dissipation regions having shapes of hemispheres and pill boxes located on the disk surface. It is shown, contrary to earlier claims, that plane-parallel coronae in pair balance have difficulties in selfconsistently reproducing the ranges of 2-20 keV spectral slopes, high energy cutoffs, and compactnesses inferred from observations of type 1 Seyfert galaxies. Instead, the observations are consistent with the X-rays coming from a number of individual active regions located on the surface of the disk. A number of effects such as anisotropic Compton scattering, the reflection hump, feedback to the soft photon source by reprocessing, and an active region in pair equilibrium all conspire to produce the observed ranges of X-ray slopes, high energy cutoffs, and compactnesses. The spread in spectral X-ray slopes can be due to a spread in the properties of the active regions such as their compactnesses and their elevations above the disk surface. Simplified models invoking isotropic Comptonization in spherical clouds are no longer sufficient when interpreting the data.Comment: 9 pages, 3 postscript figures, figures can be obtained from the authors via e-mail: [email protected]

    The MUSE Hubble Ultra Deep Field Survey X. Lyα\alpha Equivalent Widths at 2.9<z<6.62.9 < z < 6.6

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    We present rest-frame Lyα\alpha equivalent widths (EW) of 417 Lyα\alpha emitters (LAEs) detected with Multi Unit Spectroscopic Explorer (MUSE) on the Very Large Telescope (VLT) at 2.9<z<6.62.9 < z < 6.6 in the Hubble Ultra Deep Field. Based on the deep MUSE spectroscopy and ancillary Hubble Space Telescope (HST) photometry data, we carefully measured EW values taking into account extended Lyα\alpha emission and UV continuum slopes (β\beta). Our LAEs reach unprecedented depths, both in Lyα\alpha luminosities and UV absolute magnitudes, from log(LLyαL_{\rm Ly\alpha}/erg s1^{-1}) \sim41.0 to 43.0 and from Muv \sim -16 to -21 (0.01-1.0 Lz=3L^{*}_{\rm z=3}). The EW values span the range of \sim 5 to 240 \AA\ or larger, and their distribution can be well fitted by an exponential law N=N0N = N_{\rm 0} exp(-EW/w0w_{\rm 0}). Owing to the high dynamic range in Muv, we find that the scale factor, w0w_{\rm 0}, depends on Muv in the sense that including fainter Muv objects increases w0w_{\rm 0}, i.e., the Ando effect. The results indicate that selection functions affect the EW scale factor. Taking these effects into account, we find that our w0w_{\rm 0} values are consistent with those in the literature within 1σ1\sigma uncertainties at 2.9<z<6.62.9 < z < 6.6 at a given threshold of Muv and LLyαL_{\rm Ly\alpha}. Interestingly, we find 12 objects with EW >200>200 \AA\ above 1σ1\sigma uncertainties. Two of these 12 LAEs show signatures of merger or AGN activity: the weak CIV λ1549\lambda 1549 emission line. For the remaining 10 very large EW LAEs, we find that the EW values can be reproduced by young stellar ages (<100< 100 Myr) and low metallicities (0.02\lesssim 0.02 ZZ_{\rm \odot}). Otherwise, at least part of the Lyα\alpha emission in these LAEs needs to arise from anisotropic radiative transfer effects, fluorescence by hidden AGN or quasi-stellar object activity, or gravitational cooling.Comment: 22 pages, 12 figures, 9 tables, accepted for publication in A&A (MUSE UDF Series Paper X

    Isotopic evidence of increasing water abundance and lake hydrological change in Old Crow Flats, Yukon, Canada

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    Lake-rich northern permafrost landscapes are sensitive to changing climate conditions, but ability to track real-time and potentially multiple hydrological responses (e.g. lake expansion, drawdown, drainage) is challenging due to absence of long-term, sustainable monitoring programs in these remote locations. Old Crow Flats (OCF), Yukon, is a Ramsar Wetland of International Importance where concerns about low water levels and their consequences for wildlife habitat and traditional ways of life prompted multidisciplinary studies during the International Polar Year (2007–2008) and led to the establishment of an aquatic ecosystem monitoring program. Here, we report water isotope data from 14 representative thermokarst lakes in OCF, the foundation of the monitoring program, and time-series of derived metrics including the isotope composition of input waters and evaporation-to-inflow ratios for a 13 year period (2007–2019). Although the lakes spanned multiple hydrological categories (i.e. rainfall-, snowmelt- and evaporation-dominated) based on initial surveys, well-defined trends from application of generalized additive models and meteorological records reveal that lakes have become increasingly influenced by rainfall, and potentially waters from thawing permafrost. These sources of input have led to more positive lake water balances. Given the documented role of rainfall in causing thermokarst lake drainage events in OCF and elsewhere, we anticipate increased vulnerability of lateral water export from OCF. This study demonstrates the value of long-term isotope-based monitoring programs for identifying hydrological consequences of climate change in lake-rich permafrost landscapes.Northern Scientific Training Program of Polar Knowledge Canad

    Charged Particle Production in Proton-, Deuteron-, Oxygen- and Sulphur-Nucleus Collisions at 200 GeV per Nucleon

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    The transverse momentum and rapidity distributions of net protons and negatively charged hadrons have been measured for minimum bias proton-nucleus and deuteron-gold interactions, as well as central oxygen-gold and sulphur-nucleus collisions at 200 GeV per nucleon. The rapidity density of net protons at midrapidity in central nucleus-nucleus collisions increases both with target mass for sulphur projectiles and with the projectile mass for a gold target. The shape of the rapidity distributions of net protons forward of midrapidity for d+Au and central S+Au collisions is similar. The average rapidity loss is larger than 2 units of rapidity for reactions with the gold target. The transverse momentum spectra of net protons for all reactions can be described by a thermal distribution with `temperatures' between 145 +- 11 MeV (p+S interactions) and 244 +- 43 MeV (central S+Au collisions). The multiplicity of negatively charged hadrons increases with the mass of the colliding system. The shape of the transverse momentum spectra of negatively charged hadrons changes from minimum bias p+p and p+S interactions to p+Au and central nucleus-nucleus collisions. The mean transverse momentum is almost constant in the vicinity of midrapidity and shows little variation with the target and projectile masses. The average number of produced negatively charged hadrons per participant baryon increases slightly from p+p, p+A to central S+S,Ag collisions.Comment: 47 pages, submitted to Z. Phys.

    Proteomic analysis of the Plasmodium male gamete reveals the key role for glycolysis in flagellar motility.

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    BACKGROUND: Gametogenesis and fertilization play crucial roles in malaria transmission. While male gametes are thought to be amongst the simplest eukaryotic cells and are proven targets of transmission blocking immunity, little is known about their molecular organization. For example, the pathway of energy metabolism that power motility, a feature that facilitates gamete encounter and fertilization, is unknown. METHODS: Plasmodium berghei microgametes were purified and analysed by whole-cell proteomic analysis for the first time. Data are available via ProteomeXchange with identifier PXD001163. RESULTS: 615 proteins were recovered, they included all male gamete proteins described thus far. Amongst them were the 11 enzymes of the glycolytic pathway. The hexose transporter was localized to the gamete plasma membrane and it was shown that microgamete motility can be suppressed effectively by inhibitors of this transporter and of the glycolytic pathway. CONCLUSIONS: This study describes the first whole-cell proteomic analysis of the malaria male gamete. It identifies glycolysis as the likely exclusive source of energy for flagellar beat, and provides new insights in original features of Plasmodium flagellar organization

    Earliest Palaeocene purgatoriids and the initial radiation of stem primates

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    Plesiadapiform mammals, as stem primates, are key to understanding the evolutionary and ecological origins of Pan-Primates and Euarchonta. The Purgatoriidae, as the geologically oldest and most primitive known plesiadapiforms and one of the oldest known placental groups, are also central to the evolutionary radiation of placentals and the Cretaceous-Palaeogene biotic recovery on land. Here, we report new dental fossils of Purgatorius from early Palaeocene (early Puercan) age deposits in northeastern Montana that represent the earliest dated occurrences of plesiadapiforms. We constrain the age of these earliest purgatoriids to magnetochron C29R and most likely to within 105–139 thousand years post- K/Pg boundary. Given the occurrence of at least two species, Purgatorius janisae and a new species, at the locality, we provide the strongest support to date that purgatoriids and, by extension, Pan-Primates, Euarchonta and Placentalia probably originated by the Late Cretaceous. Within 1 million years of their arrival in northeastern Montana, plesiadapiforms outstripped archaic ungulates in numerical abundance and dominated the arboreal omnivore–frugivore niche in mammalian local faunas

    Energy security and shifting modes of governance

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    The concept of energy security fits uneasily into contemporary security debates. It is neither a clearly traditional nor a fully ‘non-traditional’ security issue. There are also limits to the social constructedness of the concept. This article argues that, while it is important to identify the differing securitizations of energy, these must be contextualized within the material realities and the differing historical modes of governance of the political economy of resources. This is essential for understanding the differing meanings accorded to energy security, the shifting modes through which energy is governed, and the extent to which energy security concerns drive international politics. In this context, contemporary concerns over energy security have both material and ideological dimensions: anxiety over the dual shift of power from West to East and from resource-importing to resource-exporting countries; and concern over the normative weakening of the neo-liberal mode of energy governance

    Length of carotid stenosis predicts peri-procedural stroke or death and restenosis in patients randomized to endovascular treatment or endarterectomy.

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    BACKGROUND: The anatomy of carotid stenosis may influence the outcome of endovascular treatment or carotid endarterectomy. Whether anatomy favors one treatment over the other in terms of safety or efficacy has not been investigated in randomized trials. METHODS: In 414 patients with mostly symptomatic carotid stenosis randomized to endovascular treatment (angioplasty or stenting; n = 213) or carotid endarterectomy (n = 211) in the Carotid and Vertebral Artery Transluminal Angioplasty Study (CAVATAS), the degree and length of stenosis and plaque surface irregularity were assessed on baseline intraarterial angiography. Outcome measures were stroke or death occurring between randomization and 30 days after treatment, and ipsilateral stroke and restenosis ≥50% during follow-up. RESULTS: Carotid stenosis longer than 0.65 times the common carotid artery diameter was associated with increased risk of peri-procedural stroke or death after both endovascular treatment [odds ratio 2.79 (1.17-6.65), P = 0.02] and carotid endarterectomy [2.43 (1.03-5.73), P = 0.04], and with increased long-term risk of restenosis in endovascular treatment [hazard ratio 1.68 (1.12-2.53), P = 0.01]. The excess in restenosis after endovascular treatment compared with carotid endarterectomy was significantly greater in patients with long stenosis than with short stenosis at baseline (interaction P = 0.003). Results remained significant after multivariate adjustment. No associations were found for degree of stenosis and plaque surface. CONCLUSIONS: Increasing stenosis length is an independent risk factor for peri-procedural stroke or death in endovascular treatment and carotid endarterectomy, without favoring one treatment over the other. However, the excess restenosis rate after endovascular treatment compared with carotid endarterectomy increases with longer stenosis at baseline. Stenosis length merits further investigation in carotid revascularisation trials
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