The hippocampal longitudinal axis – relevance for underlying tau and TDP-43 pathology?

Recent studies suggest that hippocampus has different cortical connectivity and functionality along its longitudinal axis. We sought to elucidate the possible different pattern of atrophy in longitudinal axis of hippocampus between Amyloid/Tau pathology and TDP-43-pathies. Seventy-three presenile subjects were included: Amyloid/Tau group (33 Alzheimer’s disease (AD) with confirmed CSF biomarkers), probable TDP-43 group (7 semantic variant progressive primary aphasia, 5 GRN and 2 C9orf72 mutation carriers) and 26 healthy controls. We conducted a region-of-interest voxel-based morphometry analysis on the hippocampal longitudinal axis, by contrasting the groups, covarying with CSF biomarkers (Aβ42, total tau, p-tau) and covarying with episodic memory scores. Amyloid/Tau pathology affected mainly posterior hippocampus while anterior left hippocampus was more atrophied in probable TDP-43pathies. We also observed a significant correlation of posterior hippocampal atrophy with AD CSF biomarkers and visual memory scores. Taken together, these data suggest that there is a potential differentiation along the hippocampal longitudinal axis based on the underlying pathology, which could be used as a potential biomarker to identify the underlying pathology in different neurodegenerative diseases

It's time for a minimum synoptic operation template in patients undergoing laparoscopic cholecystectomy : a systematic review

Background Despite the call to enhance accuracy and value of operation records few international recommended minimal standards for operative notes documentation have been described. This study undertook a systematic review of existing operative reporting systems for laparoscopic cholecystectomy (LC) to fashion a comprehensive, synoptic operative reporting template for the future. Methods A search for all relevant articles was conducted using PubMed version of Medline, Scopus and Web of Science databases in June 2021, for publications from January 1st 2011 to October 25th 2021, using the keywords: laparoscopic cholecystectomy AND operation notes OR operative notes OR proforma OR documentation OR report OR narrative OR audio-visual OR synoptic OR digital. Two reviewers (NOC, GMC) independently assessed each published study using a MINORS score of >= 16 for comparative and >= 10 for non-comparative for inclusion. This systematic review followed PRISMA guidelines and was registered with PROSPERO. Synoptic operative templates from published data were assimilated into one "ideal" laparoscopic operative report template following international input from the World Society of Emergency Surgery board. Results A total of 3567 articles were reviewed. Following MINORS grading 25 studies were selected spanning 14 countries and 4 continents. Twenty-two studies were prospective. A holistic overview of the operative procedure documentation was reported in 6/25 studies and a further 19 papers dealt with selective surgical aspects of LC. A unique synoptic LC operative reporting template was developed and translated into Chinese/Mandarin, French and Arabic. Conclusion This systematic review identified a paucity of publications dealing with operative reporting of LC. The proposed new template may be integrated digitally with hospitals' medical systems and include additional narrative text and audio-visual data. The template may help define new OR (operating room) recording standards and impact on care for patients undergoing LC.Peer reviewe

P3‐209: Impact of Biomarkers On Diagnostic Confidence in Clinical Assessment of Patients with Suspected Alzheimer's Disease and High Diagnostic Uncertainty: An EADC Study

Background: NIA-AA and IWG diagnostic criteria for Alzheimer's Disease (AD) include core structural, functional, and CSF biomarkers. The impact of core biomarkers in clinical settings is still unclear. This study aimed at measuring the impact of core biomarkers on the diagnostic confidence of uncertain AD cases in a routine memory clinic setting. // Methods: 356 patients with mild dementia (MMSE = 20) or Mild Cognitive Impairment possibly due to AD were recruited in 17 European Alzheimer's Disease Consortium (EADC) memory clinics. The following variables were collected: age; sex; MMSE; neuropsychological evaluation including long term memory, executive functions, language and visuospatial abilities. Core biomarkers were collected following local practices: Scheltens’s visual assessment of medial temporal atrophy (MTA) on MR scan; visual assessment of hypometabolism/hypoperfusion on FDG-PET/SPECT brain scan; CSF Aß1-42, tau and phospho-tau levels. At diagnostic workup completion, an estimate of confidence that cognitive complaints were due to AD was elicited from clinicians on a structured scale ranging from 0 to 100. Only cases with uncertain diagnoses (confidence between 15% and 85%) were retained for analysis. Generalized linear models were used to describe the relationship between the collected measures and the diagnostic confidence of AD. // Results: Neuropsychological assessment was carried out in almost all cases (98% of the cases). Medial temporal atrophy ratings were done in 40% of cases, assessment of cortical hypometabolism/hypoperfusion in 34%, and CSF Aß and tau levels in 26%. The markers that better explained the variability of diagnostic confidence were CSF Aß1-42 level (R2=0.46) and hypometabolism/hypoperfusion (R2=0.45), followed by CSF tau level (R2=0.35), MTA assessment (R2=0.32) and. All figures were highly significant, at p<<0.001. The diagnostic confidence variability due to neuropsychological tests for different domains was lower: MMSE (R2=0.29); long term memory (R2=0.23); executive functions (R2=0.05); language (R2=0.02); visuospatial abilities (R2=0.04) even if significant (p<0.01). // Conclusions: The use of core biomarkers in the clinical assessment of subjects with suspected AD and high diagnostic uncertainty is still limited. However, when assessed, these biomarkers show a higher impact on diagnostic confidence of AD than the most widespread clinical measures

Results of the first European Source Apportionment intercomparison for Receptor and Chemical Transport Models

In this study, the performance of the source apportionment model applications were evaluated by comparing the model results provided by 44 participants adopting a methodology based on performance indicators: z-scores and RMSEu, with pre-established acceptability criteria. Involving models based on completely different and independent input data, such as receptor models (RMs) and chemical transport models (CTMs), provided a unique opportunity to cross-validate them. In addition, comparing the modelled source chemical profiles, with those measured directly at the source contributed to corroborate the chemical profile of the tested model results. The most used RM was EPA- PMF5. RMs showed very good performance for the overall dataset (91% of z-scores accepted) and more difficulties are observed with SCE time series (72% of RMSEu accepted). Industry resulted the most problematic source for RMs due to the high variability among participants. Also the results obtained with CTMs were quite comparable to their ensemble reference using all models for the overall average (>92% of successful z-scores) while the comparability of the time series is more problematic (between 58% and 77% of the candidates’ RMSEu are accepted). In the CTM models a gap was observed between the sum of source contributions and the gravimetric PM10 mass likely due to PM underestimation in the base case. Interestingly, when only the tagged species CTM results were used in the reference, the differences between the two CTM approaches (brute force and tagged species) were evident. In this case the percentage of candidates passing the z-score and RMSEu tests were only 50% and 86%, respectively. CTMs showed good comparability with RMs for the overall dataset (83% of the z-scores accepted), more differences were observed when dealing with the time series of the single source categories. In this case the share of successful RMSEu was in the range 25% - 34%.JRC.C.5-Air and Climat

Moments of astronomy education in Bucharest

Selection from past astronomy education, activities, textbooks and curricula will be presented. Didactic aspects and comparison with physics education will be exemplified. The astronomy/science education along the time in Romania was roughly divided in four directions: very broad information texts for everybody, popular science, school textbooks, science fictions and astronomy/science literature, and exemplified using original texts. All categories were intended to extend literacy in science, but in different ways. The trends for different periods were outlined. The teaching of astronomy and astrophysics in high school and universities, with special attention to the Faculty of Physic from University of Bucharest are presented. Suggestions for future improvement of both related fields, physics and astronomy, will be one of the outcomes of our communication

TECHNOLOGICAL ISSUES IN MECHANISED FEED WIG/TIG WELDING SURFACING OF WELDING

WIG welding research is currently oriented twofold namely: increasing the performance of welding equipment, and increasing both the quality of welds and welding productivity. The research aims to achieve some deposits and make some mechanised wire feed based WIG manual welding tests in the light of using the process for welding surfacing being known that in such applications mechanised operations are recommended whenever possible given the latter strengths i.e. increased productivity and quality deposits. The research also aims at achieving a comparative a study between wire mechanised feed based WIG manual welding and the manual rod entry based manual welding in terms of geometry deposits, deposits aesthetics, operating technique, productivity, etc . In this regard deposits were made by means of two welding procedures, and subsequently welding surfacing was made with the optimum values of the welding parameters in this case

Challenges that Active and Assisted Living Programme research projects working on digital solutions for older adults need to be aware of

This study wished to describe some of the challenges that AAL projects may face when designing digital solutions aimed for the evaluation of older adults health issues. With regard to neuropsychological evaluation, special attention needs to be given when wishing to digitalise pen-and paper tests, as several drawbacks have been highlighted in the literature. Not all tests are created equal, it may be easier, and less likely to conceptually change a test when digitalising a test that is based on self-report, compared to evaluations that would normally require a clinician to rate them. Even so issues may arise if participants are required to complete this on their own, because few older adults are truly technologically savvy.The work was supported by the Ministry of Research, Innovation and Digitization, CNCS/CCCDI - UEFISCIDI (Executive Unit for the Financing of Higher Education, Research, Development and Innovation), based on funding contract no. 61/2021, within the Project "Increasing the research capacity and the national and international visibility of the Ana Aslan International Foundation (FAAI), including through a better promotion of the results obtained (SMART-BEAR)", code PN-III-P3-3.6- H2020-2020-0174

Electric Vehicle Charging Station Based on Photovoltaic Energy with or without the Support of a Fuel Cell–Electrolyzer Unit

The transport sector generates more than 35% of total CO2 emissions. Electric vehicles are the future of transportation systems, and the demand for electric vehicles has grown considerably in the last few years due to government support. Companies worldwide are investing heavily in electric car charging stations based on renewable energy. This research study presents a complete design (including an appropriate energy management strategy) for a photovoltaic energy-based electric vehicle charging station (EVCS) with or without the support of a fuel cell and electrolyzer system. The parameters considered for designing the necessary capacity of the battery pack to support the required load are relative to the location-specific solar radiation (using RETScreen® Clean Energy Management Software, Version 9.0, Government of Canada, Toronto, Canada), the efficiency of the solar panel, the used strategy, etc. The battery capacity in the EVCS design based on a power-following strategy is about 20 times smaller than that resulting in the reference design. Additionally, the cost for an EVCS design based on a power-following strategy is almost half that resulting in the reference design. An analysis of the power-following strategy was carried out according to three EVCS operating scenarios