Association of PET-measured myocardial flow reserve with echocardiography-estimated pulmonary artery systolic pressure in patients with hypertrophic cardiomyopathy

BackgroundPulmonary hypertension (PH) is a known complication of HCM and is a strong predictor of mortality. We aim to investigate the relationship between microvascular dysfunction measured by quantitative PET and PH in HCM patients.MethodsEighty-nine symptomatic HCM patients were included in the study. Each patient underwent two 20-min 13N-NH3 dynamic PET scans for rest and stress conditions, respectively. A 2-tissue irreversible compartmental model was used to fit the segments time activity curves for estimating segmental and global myocardial blood flow (MBF) and myocardial flow reserve (MFR). Echocardiographic derived PASP was utilized to estimate PH.ResultsPatients were categorized into two groups across PASP: PH (PASP > 36 mmHg) and no-PH (PASP ≤ 36 mmHg). patients with PH had larger left atrium, ratio of higher inflow early diastole (E) and atrial contraction (A) waves, E/A, and ratio of inflow and peak early diastolic waves, E/e', significantly reduced global stress MBF (1.85 ± 0.52 vs. 2.13 ± 0.56 ml/min/g; p = 0.024) and MFR (2.21 ± 0.57 vs. 2.62 ± 0.75; p = 0.005), while the MBFs at rest between the two groups were similar. There were significant negative correlations between global stress MBF/MFR and PASP (stress MBF: r = -0.23, p = 0.03; MFR: r = -0.32, p = 0.002); for regional MBF and MFR measurements, the highest linear correlation coefficients were observed in the septal wall (stress MBF: r = -0.27, p = 0.01; MFR: r = -0.31, p = 0.003). Global MFR was identified to be independent predictor for PH in multivariate regression analysis.ConclusionEchocardiography-derived PASP is negatively correlated with global MFR measured by 13N-NH3 dynamic PET. Global MFR is suggested to be an index of PH in HCM patients.</div

Experimental phase functions of mm-sized cosmic dust grains

We present experimental phase functions of three types of millimeter-sized dust grains consisting of enstatite, quartz and volcanic material from Mount Etna, respectively. The three grains present similar sizes but different absorbing properties. The measurements are performed at 527 nm covering the scattering angle range from 3 to 170 degrees. The measured phase functions show two well defined regions i) soft forward peaks and ii) a continuous increase with the scattering angle at side- and back-scattering regions. This behavior at side- and back-scattering regions are in agreement with the observed phase functions for the Fomalhaut and HR 4796A dust rings. Further computations and measurements (including polarization) for millimeter sized-grains are needed to draw some conclusions about the fluffy or compact structure of the dust grains

SUSY Dark Matter In Light Of CDMS/XENON Limits

In this talk we briefly review the current CDMS/XENON constraints on the neutralino dark matter in three popular supersymmetric models: the minimal (MSSM), the next-to-minimal (NMSSM) and the nearly minimal (nMSSM). The constraints from the dark matter relic density and various collider experiments are also taken into account. The conclusion is that for each model the current CDMS/XENON limits can readily exclude a large part of the parameter space allowed by other constraints and the future SuperCDMS or XENON100 can cover most of the allowed parameter space. The implication for the Higgs search at the LHC is also discussed. It is found that in the currently allowed parameter space the MSSM charged Higgs boson is quite unlikely to be discovered at the LHC while the neutral Higgs bosons $H$ and $A$ may be accessible at the LHC in the parameter space with a large $\mu$ parameter.Comment: talk given at 2nd International Workshop on Dark Matter, Dark Energy and Matter-Antimatter Asymmetry, Nov 5-6, 2010, Hsinchu, Taiwan (to appear in Int. J. Mod. Phys. D

The composition and size distribution of the dust in the coma of comet Hale-Bopp

We discuss the composition and size distribution of the dust in the coma of comet Hale-Bopp. We do this by fitting simultaneously the infrared emission spectrum measured by the infrared space observatory (ISO) and the measured degree of linear polarization of scattered light at various phase angles and 12 different wavelengths. The effects of particle shape on the modeled optical properties of the dust grains are taken into account. We constrain our fit by forcing the abundances of the major rock forming chemical elements to be solar. The infrared spectrum at long wavelengths reveals that large grains are needed in order to fit the spectral slope. The size and shape distribution we employ allows us to estimate the sizes of the crystalline silicates. The ratios of the strength of various forsterite features show that the crystalline silicate grains in Hale-Bopp must be submicron sized. We exclude the presence of large crystalline silicate grains in the coma. Because of this lack of large crystalline grains combined with the fact that we do need large amorphous grains to fit the emission spectrum at long wavelengths, we need only approximately 4% of crystalline silicates by mass. After correcting for possible hidden crystalline material included in large amorphous grains, our best estimate of the total mass fraction of crystalline material is approximately 7.5%, significantly lower than deduced in previous studies in which the typical derived crystallinity is 20-30%. The implications of this on the possible origin and evolution of the comet are discussed. The crystallinity we observe in Hale-Bopp is consistent with the production of crystalline silicates in the inner solar system by thermal annealing and subsequent radial mixing to the comet forming region.Comment: Accepted for publication in Icaru

Detectability of dirty dust grains in brown dwarf atmospheres

Dust clouds influence the atmospheric structure of brown dwarfs, and they affect the heat transfer and change the gas-phase chemistry. However, the physics of their formation and evolution is not well understood. In this letter, we predict dust signatures and propose a potential observational test of the physics of dust formation in brown dwarf atmosphere based on the spectral features of the different solid components predicted by dust formation theory. A momentum method for the formation of dirty dust grains (nucleation, growth, evaporation, drift) is used in application to a static brown dwarf atmosphere structure to compute the dust grain properties, in particular the heterogeneous grain composition and the grain size. Effective medium and Mie theory are used to compute the extinction of these spherical grains. Dust formation results in grains whose composition differs from that of grains formed at equilibrium. Our kinetic model predicts that solid amorphous SiO2[s] (silica) is one of the most abundant solid component followed by amorphous MgSiO4[s] and MgSiO3[s], while SiO2[s] is absent in equilibrium models because it is a metastable solid. Solid amorphous SiO2[s] possesses a strong broad absorption feature centered at 8.7mum, while amorphous Mg2SiO4[s]/MgSiO3[s] absorb at 9.7mum beside other absorption features at longer wavelength. Those features at lambda < 15mum are detectable in absorption if grains are small (radius < 0.2mum) in the upper atmosphere as suggested by our model. We suggest that the detection of a feature at 8.7mum in deep infrared spectra could provide evidence for non-equilibrium dust formation that yields grains composed of metastable solids in brown dwarf atmospheres. This feature will shift towards 10mum and broaden if silicates (e.g. fosterite) are much more abundant.Comment: A&A Letter, accepte

Entangling two superconducting LC coherent modes via a superconducting flux qubit

Based on a pure solid-state device consisting of two superconducting LC circuits coupled to a superconducting flux qubit, we propose in this paper that the maximally entangled coherent states of the two LC modes can be generated for arbitrary coherent states through flux qubit controls.Comment: 5 pages, 2 figure

Electronic structure of YbB6_{6}: Is it a Topological Insulator or not?

To resolve the controversial issue of the topological nature of the electronic structure of YbB$_{6}$, we have made a combined study using density functional theory (DFT) and angle resolved photoemission spectroscopy (ARPES). Accurate determination of the low energy band topology in DFT requires the use of modified Becke-Johnson exchange potential incorporating the spin-orbit coupling and the on-site Coulomb interaction $U$ of Yb $4f$ electrons as large as 7 eV. We have double-checked the DFT result with the more precise GW band calculation. ARPES is done with the non-polar (110) surface termination to avoid band bending and quantum well confinement that have confused ARPES spectra taken on the polar (001) surface termination. Thereby we show definitively that YbB$_{6}$ has a topologically trivial B 2$p$-Yb 5$d$ semiconductor band gap, and hence is a non-Kondo non-topological insulator (TI). In agreement with theory, ARPES shows pure divalency for Yb and a $p$-$d$ band gap of 0.3 eV, which clearly rules out both of the previous scenarios of $f$-$d$ band inversion Kondo TI and $p$-$d$ band inversion non-Kondo TI. We have also examined the pressure-dependent electronic structure of YbB$_{6}$, and found that the high pressure phase is not a Kondo TI but a \emph{p}-\emph{d} overlap semimetal.Comment: The main text is 6 pages with 4 figures, and the supplementary information contains 6 figures. 11 pages, 10 figures in total To be appeared in Phys. Rev. Lett. (Online publication is around March 16 if no delays.

Anthelmintic tolerance in free-living and facultative parasitic isolates of Halicephalobus (Panagrolaimidae)

Studies on anthelmintic resistance in equine parasites do not include facultative parasites. Halicephalobus gingivalis is a free-living bacteriovorous nematode and a known facultative parasite of horses with a strong indication of some form of tolerance to common anthelmintic drugs. This research presents the results of an in vitro study on the anthelmintic tolerance of several isolates of Halicephalobus to thiabendazole and ivermectin using an adaptation of the Micro-Agar Larval Development Test hereby focusing on egg hatching and larval development. Panagrellus redivivus and Panagrolaimus superbus were included as a positive control. The results generally show that the anthelmintic tolerance of Halicephalobus to both thiabendazole and ivermectin was considerably higher than that of the closely related Panagrolaimidae and, comparing to other studies, than that of obligatory equine parasites. Our results further reveal a remarkable trend of increasing tolerance from fully free-living isolates towards horse-associated isolates. In vitro anthelmintic testing with free-living and facultative parasitic nematodes offers the advantage of observing drug effect on the complete lifecycle as opposed to obligatory parasites which can only be followed until the third larval stage. We therefore propose Halicephalobus gingivalis as an experimental tool to deepen our understanding of the biology of anthelmintic tolerance