1,205 research outputs found
An Update of the Mayo Clinic Cohort of Patients with Adult Primary Central Nervous System Vasculitis
Primary central nervous system vasculitis (PCNSV) is an uncommon condition in which lesions are limited to vessels of the brain and spinal cord. Because the clinical manifestations are not specific, the diagnosis is often difficult, and permanent disability and death are frequent outcomes. This study is based on a cohort of 163 consecutive patients with PCNSV who were examined at the Mayo Clinic over a 29-year period from 1983 to 2011. The aim of the study was to define the characteristics of these patients, which represents the largest series in adults reported to date. A total of 105 patients were diagnosed by angiographic findings and 58 by biopsy results. The patients diagnosed by biopsy more frequently had at presentation cognitive dysfunction, greater cerebrospinal fluid total protein concentrations, less frequent cerebral infarcts, and more frequent leptomeningeal gadolinium-enhanced lesions on magnetic resonance imaging (MRI), along with less mortality and disability at last follow-up. The patients diagnosed by angiograms more frequently had at presentation hemiparesis or a persistent neurologic deficit or stroke, more frequent infarcts on MRI and an increased mortality. These differences were mainly related to the different size of the vessels involved in the 2 groups. Although most patients responded to therapy with glucocorticoids alone or in conjunction with cyclophosphamide and tended to improve during the follow-up period, an overall increased mortality rate was observed. Relapses occurred in one-quarter of the patients and were less frequent in patients treated with prednisone and cyclophosphamide compared with those treated with prednisone alone. The mortality rate and degree of disability at last follow-up were greater in those with increasing age, cerebral infarctions on MRI, angiographic large vessel involvement, and diagnosis made by angiography alone, but were lower in those with gadolinium-enhanced lesions on MRI and in those with cerebral amyloid angiopathy. The annual incidence rate of PCNSV was estimated at 2.4 cases per 1,000,000 person-years. PCNSV appears to consist of several subsets defined by the size of the vessels involved, the clinical characteristics at presentation, MRI findings, and histopathological patterns on biopsy. Early recognition and treatment may reduce poor outcomes
The 13-C(p,d) Reaction at 120 MeV
This research was sponsored by the National Science Foundation Grant NSF PHY 87-1440
Naturalness and Focus Points with Non-Universal Gaugino Masses
Relations between the gaugino masses have been shown to alleviate the degree
of fine-tuning in the MSSM. In this paper we consider specific models of
supersymmetry breaking with gravity mediation and demonstrate that within both
GUT and string constructions it is possible to generate these relations in a
natural way. We have numerically studied the degree of fine-tuning in these
models, including one-loop corrections, and have found regions of parameter
space that can satisfy all known collider constraints with fine-tunings less
than 20%. We discuss some of the phenomenological features of these models
within the regions of reduced fine-tuning.Comment: 31 pages, 21 figures. Version accepted for publication in Nuclear
Physics
Nucleon Axial Form Factor from Lattice QCD
Results for the isovector axial form factors of the proton from a lattice QCD
calculation are presented for both point-split and local currents. They are
obtained on a quenched lattice at with Wilson
fermions for a range of quark masses from strange to charm. We determine the
finite lattice renormalization for both the local and point-split currents of
heavy quarks. Results extrapolated to the chiral limit show that the
dependence of the axial form factor agrees reasonably well with experiment. The
axial coupling constant calculated for the local and the point-split
currents is about 6\% and 12\% smaller than the experimental value
respectively.Comment: 8 pages, 5 figures (included in part 2), UK/93-0
One million years of climate-driven rock uplift rate variation on the Wasatch Fault revealed by fluvial topography
Displacement along the Wasatch Fault, Utah, has created the Wasatch Range. Owing to its topographic prominence, location on the eastern boundary of the Basin and Range, presently active fault slip, and proximity to Utahâs largest cities, the range and fault have garnered much attention. On the 102â103 year timescale, the behavior, displacement and seismic history of the Wasatch Fault has been well categorized in order to assess seismic hazard. On the 107 year timescale, the rock uplift rate history of the Wasatch range has also been resolved using thermochronometric data, owing to its importance in inferring the history of extension in the western US. However, little data exists that bridges the gap between these two timescales. Here, we infer an approximately 1 Ma rock uplift rate history from analysis of three river networks located in the center of the range. Our recovered rock uplift rate histories evidence periodic changes to rock uplift on the Wasatch Fault, that coincide with climate driven filling and unfilling of lakes in the Bonnneville Basin. To ensure our rock uplift rate histories are robust, we use field data and previously published cosmogenic 10Be erosion rate data to tightly constrain the erodibility parameter, and investigate an appropriate value for the slope exponent of the stream power model, n. We use our river network inversion to reconcile estimates of erodibility from a number of methodologies and show that the contrast between bedrock and bedload strength is an important factor that determines erodibility
A radium assay technique using hydrous titanium oxide adsorbent for the Sudbury Neutrino Observatory
As photodisintegration of deuterons mimics the disintegration of deuterons by
neutrinos, the accurate measurement of the radioactivity from thorium and
uranium decay chains in the heavy water in the Sudbury Neutrino Observatory
(SNO) is essential for the determination of the total solar neutrino flux. A
radium assay technique of the required sensitivity is described that uses
hydrous titanium oxide adsorbent on a filtration membrane together with a
beta-alpha delayed coincidence counting system. For a 200 tonne assay the
detection limit for 232Th is a concentration of 3 x 10^(-16) g Th/g water and
for 238U of 3 x 10^(-16) g U/g water. Results of assays of both the heavy and
light water carried out during the first two years of data collection of SNO
are presented.Comment: 12 pages, 4 figure
Configuration-interaction calculations of positron binding to group-II elements
The configuration-interaction (CI) method is applied to the study of positronic magnesium (e+Mg), positronic calcium (e+Ca), and positronic strontium (e+Sr). The CI expansion was seen to converge slowly with respect to Lmax, the maximum angular momentum of any orbital used to construct the CI basis. Despite doing explicit calculations with Lmax=10, extrapolation corrections to the binding energies for the Lmax→∞ limit were substantial in the case of e+Ca (25%) and e+Sr (50%). The extrapolated binding energies were 0.0162 hartree for e+Mg, 0.0165 hartree for e+Ca, and 0.0101 hartree for e+Sr. The static-dipole polarizabilities for the neutral parent atoms were computed as a by-product, giving 71.7a03, 162a03, and 204a03 for Mg, Ca, and Sr, respectively
Meson exchange currents in electromagnetic one-nucleon emission
The role of meson exchange currents (MEC) in electron- and photon-induced
one-nucleon emission processes is studied in a nonrelativistic model including
correlations and final state interactions. The nuclear current is the sum of a
one-body and of a two-body part. The two-body current includes pion seagull,
pion-in-flight and the isobar current contributions. Numerical results are
presented for the exclusive 16O(e,e'p)15N and 16O(\gamma,p)15N reactions. MEC
effects are in general rather small in (e,e'p), while in (\gamma,p) they are
always large and important to obtain a consistent description of (e,e'p) and
(\gamma,p) data, with the same spectroscopic factors. The calculated (\gamma,p)
cross sections are sensitive to short-range correlations at high values of the
recoil momentum, where MEC effects are larger and overwhelm the contribution of
correlations.Comment: 9 pages, 6 figure
Proton-proton scattering above 3 GeV/c
A large set of data on proton-proton differential cross sections, analyzing
powers and the double polarization parameter A_NN is analyzed employing the
Regge formalism. We find that the data available at proton beam momenta from 3
GeV/c to 50 GeV/c exhibit features that are very well in line with the general
characteristics of Regge phenomenology and can be described with a model that
includes the rho, omega, f_2, and a_2 trajectories and single Pomeron exchange.
Additional data, specifically for spin-dependent observables at forward angles,
would be very helpful for testing and refining our Regge model.Comment: 16 pages, 19 figures; revised version accepted for publication in
EPJ
Virtual Compton Scattering and Neutral Pion Electroproduction in the Resonance Region up to the Deep Inelastic Region at Backward Angles
We have made the first measurements of the virtual Compton scattering (VCS)
process via the H exclusive reaction in the nucleon resonance
region, at backward angles. Results are presented for the -dependence at
fixed GeV, and for the -dependence at fixed near 1.5 GeV.
The VCS data show resonant structures in the first and second resonance
regions. The observed -dependence is smooth. The measured ratio of
H to H cross sections emphasizes the different
sensitivity of these two reactions to the various nucleon resonances. Finally,
when compared to Real Compton Scattering (RCS) at high energy and large angles,
our VCS data at the highest (1.8-1.9 GeV) show a striking -
independence, which may suggest a transition to a perturbative scattering
mechanism at the quark level.Comment: 20 pages, 8 figures. To appear in Phys.Rev.
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