399 research outputs found
Context dependent memory and stress: a preliminary investigation using multi-task induced stress
The psychological wellbeing outcomes of nonpharmacological interventions for older persons with insomnia symptoms: a systematic review and meta-analysis
Nonpharmacological treatment of insomnia in older persons has been associated with reduced insomnia symptoms and increased psychological wellbeing. This systematic review and meta-analysis examined whether nonpharmacological interventions can promote wellbeing indicators in older persons who experience insomnia symptoms and investigated the components of these interventions. Twenty studies met inclusion criteria. Psychological wellbeing outcomes included symptoms of depression, anxiety, mental health-related quality of life, and fatigue. Interventions significantly reduced depression and fatigue symptoms in most of the studies that included these outcomes. Findings of our qualitative analysis suggest that mindfulness-based interventions in particularcan potentially reduce depression symptoms in older persons with insomnia symptoms. Meta-analyses of studies that included psychological wellbeing outcomes showed small-medium weighted mean effects indicating reductions in symptoms of depression, anxiety, and fatigue. The results suggest that nonpharmacological interventions for older persons with insomnia symptoms can potentially reduce depression and fatigue symptoms and highlight interventions that may be particularly valuable for this purpose
The role of apoptosis in the development of AGM hematopoietic stem cells revealed by Bcl-2 overexpression
Apoptosis is an essential process in embryonic tissue remodeling and adult
tissue homeostasis. Within the adult hematopoietic system, it allows for
tight regulation of hematopoietic cell subsets. Previously, it was shown
that B-cell leukemia 2 (Bcl-2) overexpression in the adult increases the
viability and activity of hematopoietic cells under normal and/or
stressful conditions. However, a role for apoptosis in the embryonic
hematopoietic system has not yet been established. Since the first
hematopoietic stem cells (HSCs) are generated within the
aortagonad-mesonephros (AGM; an actively remodeling tissue) region
beginning at embryonic day 10.5, we examined this tissue for expression of
apoptosis-related genes and ongoing apoptosis. Here, we show expression of
several proapoptotic and antiapoptotic genes in the AGM. We also generated
transgenic mice overexpressing Bcl-2 under the control of the
transcriptional regulatory elements of the HSC marker stem cell antigen-1
(Sca-1), to test for the role of cell survival in the regulation of AGM
HSCs. We provide evidence for increased numbers and viability of Sca-1(+)
cells in the AGM and subdissected midgestation aortas, the site where HSCs
are localized. Most important, our in vivo transplantation data show that
Bcl-2 overexpression increases AGM and fetal liver HSC activity, strongly
suggesting that apoptosis plays a role in HSC development
An Anglo-Saxon execution cemetery at Walkington Wold, Yorkshire
This paper presents a re-evaluation of a cemetery excavated over
30 years ago at Walkington Wold in east Yorkshire. The cemetery is
characterized by careless burial on diverse alignments, and by the fact that
most of the skeletons did not have associated crania. The cemetery has been
variously described as being the result of an early post-Roman massacre, as
providing evidence for a ‘Celtic’ head cult or as an Anglo-Saxon execution
cemetery. In order to resolve the matter, radiocarbon dates were acquired and
a re-examination of the skeletal remains was undertaken. It was confirmed that
the cemetery was an Anglo-Saxon execution cemetery, the only known example
from northern England, and the site is set into its wider context in the paper
Anthropogenic Space Weather
Anthropogenic effects on the space environment started in the late 19th
century and reached their peak in the 1960s when high-altitude nuclear
explosions were carried out by the USA and the Soviet Union. These explosions
created artificial radiation belts near Earth that resulted in major damages to
several satellites. Another, unexpected impact of the high-altitude nuclear
tests was the electromagnetic pulse (EMP) that can have devastating effects
over a large geographic area (as large as the continental United States). Other
anthropogenic impacts on the space environment include chemical release ex-
periments, high-frequency wave heating of the ionosphere and the interaction of
VLF waves with the radiation belts. This paper reviews the fundamental physical
process behind these phenomena and discusses the observations of their impacts.Comment: 71 pages, 35 figure
Meiotic behavior of interspecific hybrids between artificially tetraploidized sexual Brachiaria ruziziensis and tetraploid apomictic B. brizantha (Poaceae)
Parental stressors in professional youth football academies: a qualitative investigation of specialising stage parents
Control of Rayleigh-Taylor instability by vertical vibration in large aspect ratio containers
We consider a horizontal heavy fluid layer supported by a light, immiscible one in a wide (as compared to depth) container, which is vertically vibrated intending to counterbalance the Rayleigh-Taylor instability of the flat, rigid-body vibrating state. In the simplest case when the density and viscosity of the lighter fluid are small compared to their counterparts in the heavier fluid, we apply a long wave, weakly nonlinear analysis that yields a generalized Cahn-Hilliard equation for the evolution of the fluid interface. This equation shows that the stabilizing effect of vibration is like that of surface tension, and is used to analyze the linear stability of the flat state, the local bifurcation at the instability threshold and some global existence and stability properties concerning the steady states without dry spots. The analysis is extended to two cases of practical interest. Namely, (a) the viscosity of one of the fluids is much smaller than that of the other one, and (b) the densities and viscosities of both fluids are quite close to each other
A recepção da família na hospitalização de crianças
Fundamentando-se em estudos que discutem a participação de familiares na hospitalização de seus filhos, este trabalho pretende estudar como os familiares de crianças hospitalizadas vivenciam o momento da recepção, que profissional da equipe os acompanha durante os procedimentos iniciais, que informações recebem e quem encarrega-se de informá-los, logo que a criança é admitida no hospital em razão de uma doença que necessita de cuidados hospitalares. Os participantes foram 40 pais e se utilizou entrevistas semi-estruturadas para a coleta de dados. Estes foram analisados segundo métodos de análise de conteúdo. Os resultados mostraram que os pais vivenciam um estado de ansiedade generalizado, não sabem nomear que profissional os acompanhou, além de lembrarem-se de informações esporádicas que dizem respeito, exclusivamente, às suas necessidades imediatas
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