Supplementary data for article: Novakovic, M.; Bukvicki, D.; Andjelkovic, B.; Ilic-Tomic, T.; Veljic, M.; Tesevic, V.; Asakawa, Y. Cytotoxic Activity of Riccardin and Perrottetin Derivatives from the Liverwort Lunularia Cruciata. Journal of Natural Products 2019, 82 (4), 694–701. https://doi.org/10.1021/acs.jnatprod.8b00390

Supporting information for: [https://doi.org/10.1021/acs.jnatprod.8b00390]Related to published version: [http://cherry.chem.bg.ac.rs/handle/123456789/3096

Supplementary data for article: Ilic-Tomic, T.; Sokovic, M.; Vojnovic, S.; Ciric, A.; Veljic, M.; Nikodinovic-Runic, J.; Novakovic, M. Diarylheptanoids from Alnus Viridis Ssp Viridis and Alnus Glutinosa: Modulation of Quorum Sensing Activity in Pseudomonas Aeruginosa. Planta Medica 2017, 83 (1–2), 117–125. https://doi.org/10.1055/s-0042-107674

Supplementary material for: [https://doi.org/10.1055/s-0042-107674]Related to published version: [http://cherry.chem.bg.ac.rs/handle/123456789/2395

Diarylheptanoids from Alnus viridis ssp viridis and Alnus glutinosa: Modulation of Quorum Sensing Activity in Pseudomonas aeruginosa

Diarylheptanoids from the barks of Alnus viridis ssp. viridis (green alder) and Alnus glutinosa (black alder) were explored for anti-quorum sensing activity. Chemicals with anti-quorum sensing activity have recently been examined for antimicrobial applications. The anti-quorum sensing activity of the selected diarylheptanoids was determined using two biosensors, namely Pseudomonas aeruginosa PAO1 and Chromobacterium violaceum CV026. Although all of the investigated compounds negatively influenced the motility of P. aeruginosa PAO1, four were able to inhibit biofilm formation of this human opportunistic pathogen for 40-70%. Three of the diarylheptanoids (3, 4, and 5) negatively influenced the biosynthesis of pyocyanin, which is under the control of quorum sensing. Platyphyllenone (7) and hirsutenone (5) were able to inhibit the biosynthesis of violacein in C. violaceum CV026, with 5 being able to inhibit the synthesis of both biopigments. Only one of the tested diarylheptanoids (1) was shown to significantly decrease the production of acyl homoserine lactones (AHL) in P. aeruginosa PAO1, more specifically, production of the long chain N-(3-oxododecanoyl)- l-HSL. On the other side, four diarylheptanoids (2-5) significantly reduced the synthesis of 2-alkyl-4-quinolones, part of the P. aeruginosa quinolone-mediated signaling system. To properly assess therapeutic potential of these compounds, their in vitro antiproliferative effect on normal human lung fibroblasts was determined, with doses affecting cell proliferation between 10 and 100 mu g/mL. This study confirms that the barks of green and black alders are rich source of phytochemicals with a wide range of biological activities that could further be exploited as natural agents against bacterial contaminations and infections.Supplementary material: [http://cherry.chem.bg.ac.rs/handle/123456789/3034

Supporting information for: "Cytotoxic Activity of Riccardin and Perrottetin Derivatives from the Liverwort Lunularia cruciata"

NMR spectra of the isolated compounds and additional figures and tables. Table S1. Elution Program for the Silica Gel Column Separation; Figure S1. Aromatic part of the 1H NMR spectrum of compound 1;This is the Supporting information for the article: Novaković, M., Bukvicki, D., Anđelković, B. D., Ilić-Tomić, T., Veljić, M., Tešević, V.,& Asakawa, Y. (2019). Cytotoxic Activity of Riccardin and Perrottetin Derivatives from the Liverwort Lunularia cruciata. Journal of Natural Products, American Chemical Society (ACS), 82(4), 694-701. [https://doi.org/10.1021/acs.jnatprod.8b00390]Published version of the article: [https://cer.ihtm.bg.ac.rs/handle/123456789/2838

Cytotoxic Activity of Riccardin and Perrottetin Derivatives from the Liverwort Lunularia cruciata

Seven new bisbibenzyls (1−7) were isolated from the methanol extract of the liverwort Lunularia cruciata along with one previously known bibenzyl and five known bisbibenzyls. The structures of compounds 1−7 were elucidated on the basis of the spectroscopic data. These newly isolated bisbibenzyls may be divided into two groups, the acyclic bisbibenzyls, perrottetins (1− 3), and the cyclic analogues, riccardins (4−7). Besides standard perrottetin and riccardin structures (1 and 4, respectively), they contain phenanthrene (3 and 5), dihydrophenanthrene (2), and quinone moieties (6 and 7), rarely found in natural products. The new compounds 3 and 5, as well as the known riccardin G, exhibited cytotoxic activity against the A549 lung cancer cell line with IC50 values of 5.0, 5.0, and 2.5 μM, respectively.Supporting information: [https://cer.ihtm.bg.ac.rs/handle/123456789/4449

Supplementary data for article: Novakovic, M.; Bukvicki, D.; Andjelkovic, B.; Ilic-Tomic, T.; Veljic, M.; Tesevic, V.; Asakawa, Y. Cytotoxic Activity of Riccardin and Perrottetin Derivatives from the Liverwort Lunularia Cruciata. Journal of Natural Products 2019, 82 (4), 694–701. https://doi.org/10.1021/acs.jnatprod.8b00390

Supporting information for: [https://doi.org/10.1021/acs.jnatprod.8b00390]Related to published version: [http://cherry.chem.bg.ac.rs/handle/123456789/3096

Reducing the environmental impact of surgery on a global scale: systematic review and co-prioritization with healthcare workers in 132 countries

Abstract Background Healthcare cannot achieve net-zero carbon without addressing operating theatres. The aim of this study was to prioritize feasible interventions to reduce the environmental impact of operating theatres. Methods This study adopted a four-phase Delphi consensus co-prioritization methodology. In phase 1, a systematic review of published interventions and global consultation of perioperative healthcare professionals were used to longlist interventions. In phase 2, iterative thematic analysis consolidated comparable interventions into a shortlist. In phase 3, the shortlist was co-prioritized based on patient and clinician views on acceptability, feasibility, and safety. In phase 4, ranked lists of interventions were presented by their relevance to high-income countries and low–middle-income countries. Results In phase 1, 43 interventions were identified, which had low uptake in practice according to 3042 professionals globally. In phase 2, a shortlist of 15 intervention domains was generated. In phase 3, interventions were deemed acceptable for more than 90 per cent of patients except for reducing general anaesthesia (84 per cent) and re-sterilization of ‘single-use’ consumables (86 per cent). In phase 4, the top three shortlisted interventions for high-income countries were: introducing recycling; reducing use of anaesthetic gases; and appropriate clinical waste processing. In phase 4, the top three shortlisted interventions for low–middle-income countries were: introducing reusable surgical devices; reducing use of consumables; and reducing the use of general anaesthesia. Conclusion This is a step toward environmentally sustainable operating environments with actionable interventions applicable to both high– and low–middle–income countries

Cobalt(II) complexes with disubstituted 3-aminopyrazole derivative: Mononuclear Co(II) complex with in situ prepared formamidine ligand

In the reaction of Co(NO3)(2) center dot 6H(2)O with 4-acetyl-3-amino-5-methylpyrazole (aamp) two octahedral Co(II) complexes, [Co(aamp)2(H2O)(4)](NO3)(2), 1, and [Co(ampf)(MeOH)(2)NO3]NO3 (ampf= N,N-bis(4-acetyl-5-metliylpyrazole-3-yl)formamidine), 2, were obtained, depending on the reaction conditions. The presence of water in the reaction system leads to incorporation of water molecules into the crystal lattice and I was formed. In all anhydrous environment, due to addition of CH(OEt)3, the fusion of two aamp) was induced through their NH2-groups, incorporating the methine group of CH(OEt)(3). As a result, complex 2, containing an adenino-mimetic NNO pharmacophore ligand, was obtained. The crystal and molecular structure of both compounds was determined. The coordination of aamp in I was achieved through N2 of the pyrazole ring. On the contrary, in 2, an unusual coordination mode of pyrazole is found: one of the pyrazole moieties, due to steric hindrance, coordinates through the oxygen atom of the acetyl group instead of N2. The complexes were characterized by elemental analysis and electronic spectra. For 2 a comprehensive IR spectral analysis is given. The metalligand interactions in 2 are analyzed by quantum chemical computations. The desolvation mechanism of both compounds is discussed in detail. (c) 2007 Elsevier B.V. All rights reserved

Significance of the structural properties of CaO catalyst in the production of biodiesel: An effect on the reduction of greenhouse gases emission

The influence of the physicochemical properties of a series of CaO catalysts activated at different temperatures on the biodiesel production was investigated. These catalysts show dissimilar yields in the transesterification of triglycerides with methanol. We have found significant relationships between structural properties (the type of the pore system, the typical CaO crystal phase and the sizes of crystallites (up to 25 nm), the minimal weight percentage of CaO phase, the total surface basicity and potential existence of two types of basic active sites) of CaO prepared and activated by means of thermal treatment at highest temperature and catalytic efficiency. Benefits of this catalyst are short contact time, standard operating temperature and atmospheric conditions, relatively low molar ratios and small catalyst loading. These all together resulted in a very high biodiesel yield of high purity. The properties of different biodiesel (obtained with the use of the prepared CaO catalyst) blends with different diesel and biodiesel ratios indicate that the higher the fraction of biodiesel fuel the better the achieved fuel properties according to the EU standards. A significant reduction of CO2 and CO emissions and only a negligible NOx increase occurred when blends with an increased biodiesel portion was used. The use of biodiesel derived blends, and the eventual complete replacement of fossil fuels with biodiesel as a renewable, alternative fuel for diesel engines, would greatly contribute to the reduction of greenhouse gases emissions. [Projekat Ministarstva nauke Republike Srbije, br. ON 172061 i TR 34008