424 research outputs found
Isotopic ratios of H, C, N, O, and S in comets C/2012 F6 (Lemmon) and C/2014 Q2 (Lovejoy)
The apparition of bright comets C/2012 F6 (Lemmon) and C/2014 Q2 (Lovejoy) in
March-April 2013 and January 2015, combined with the improved observational
capabilities of submillimeter facilities, offered an opportunity to carry out
sensitive compositional and isotopic studies of the volatiles in their coma. We
observed comet Lovejoy with the IRAM 30m telescope between 13 and 26 January
2015, and with the Odin submillimeter space observatory on 29 January - 3
February 2015. We detected 22 molecules and several isotopologues. The
HO and HO production rates measured with Odin follow a
periodic pattern with a period of 0.94 days and an amplitude of ~25%. The
inferred isotope ratios in comet Lovejoy are O/O = 499 24
and D/H = 1.4 0.4 in water, S/S = 24.7
3.5 in CS, all compatible with terrestrial values. The ratio
C/C = 109 14 in HCN is marginally higher than terrestrial
and N/N = 145 12 in HCN is half the Earth ratio. Several
upper limits for D/H or 12C/13C in other molecules are reported. From our
observation of HDO in comet C/2014 Q2 (Lovejoy), we report the first D/H ratio
in an Oort Cloud comet that is not larger than the terrestrial value. On the
other hand, the observation of the same HDO line in the other Oort-cloud comet,
C/2012 F6 (Lemmon), suggests a D/H value four times higher. Given the previous
measurements of D/H in cometary water, this illustrates that a diversity in the
D/H ratio and in the chemical composition, is present even within the same
dynamical group of comets, suggesting that current dynamical groups contain
comets formed at very different places or times in the early solar system.Comment: Accepted for publication in Astronomy and Astrophysic
Comparison of the Organic Composition of Cometary Samples with Residues Formed from the UV Irradiation of Astrophysical Ice Analogs
The NASA Stardust mission successfully collected material from Comet 81P/Wild 2 [1], including authentic cometary grains [2]. X-ray absorption near-edge structure (XANES) spectroscopy analysis of these samples indicates the presence of oxygen-rich and nitrogen-rich organic materials, which contain a broad variety of functional groups (carbonyls, C=C bonds, aliphatic chains, amines, arnides, etc.) [3]. One component of these organics appears to contain very little aromatic carbon and bears some similarity to the organic residues produced by the irradiation of ices of interstellar/cometary composition, Stardust samples were also recently shown to contain glycine, the smallest biological amino acid [4]. Organic residues produced froth the UV irradiation of astrophysical ice analogs are already known to contain a large suite of organic molecules including amino acids [5-7], amphiphilic compounds (fatty acids) [8], and other complex species. This work presents a comparison between XANES spectra measured from organic residues formed in the laboratory with similar data of cometary samples collected by the Stardust missio
Searches for HCl and HF in comets 103P/Hartley 2 and C/2009 P1 (Garradd) with the Herschel space observatory
HCl and HF are expected to be the main reservoirs of fluorine and chlorine
wherever hydrogen is predominantly molecular. They are found to be strongly
depleted in dense molecular clouds, suggesting freeze-out onto grains in such
cold environments. We can then expect that HCl and HF were also the major
carriers of Cl and F in the gas and icy phases of the outer solar nebula, and
were incorporated into comets. We aimed to measure the HCl and HF abundances in
cometary ices as they can provide insights on the halogen chemistry in the
early solar nebula. We searched for the J(1-0) lines of HCl and HF at 626 and
1232 GHz, respectively, using the HIFI instrument on board the Herschel Space
Observatory. HCl was searched for in comets 103P/Hartley 2 and C/2009 P1
(Garradd), whereas observations of HF were conducted in comet C/2009 P1. In
addition, observations of HO and HO lines were performed in C/2009
P1 to measure the HO production rate. Three lines of CHOH were
serendipitously observed in the HCl receiver setting. HCl is not detected,
whereas a marginal (3.6-) detection of HF is obtained. The upper limits
for the HCl abundance relative to water are 0.011% and 0.022%, for 103P and
C/2009 P1, respectively, showing that HCl is depleted with respect to the solar
Cl/O abundance by a factor more than 6 in 103P, where the error is
related to the uncertainty in the chlorine solar abundance. The marginal HF
detection obtained in C/2009 P1 corresponds to an HF abundance relative to
water of (1.80.5) 10, which is approximately consistent
with a solar photospheric F/O abundance. The observed depletion of HCl suggests
that HCl was not the main reservoir of chlorine in the regions of the solar
nebula where these comets formed. HF was possibly the main fluorine compound in
the gas phase of the outer solar nebula.Comment: Accepted for publication in Astronomy & Astrophysic
Molecular line survey of the high-mass star-forming region NGC 6334I with Herschel/HIFI and the SMA
We aim at deriving the molecular abundances and temperatures of the hot
molecular cores in the high-mass star-forming region NGC 6334I and consequently
deriving their physical and astrochemical conditions. In the framework of the
Herschel guaranteed time key program CHESS, NGC 6334I is investigated by using
HIFI aboard the Herschel Space Observatory. A spectral line survey is carried
out in the frequency range 480-1907 GHz, and auxiliary interferometric data
from the SMA in the 230 GHz band provide spatial information for disentangling
the different physical components contributing to the HIFI spectrum. The
spectral lines are identified with the aid of former surveys and spectral line
catalogs. The observed spectrum is then compared to a simulated synthetic
spectrum with XCLASS, assuming local thermal equilibrium, and best fit
parameters are derived using the model optimization package MAGIX. A total of
46 molecules are identified, with 31 isotopologues, resulting in about 4300
emission and absorption lines. High- energy levels of the dominant emitter
methanol and vibrationally excited HCN are detected. The number of unidentified
lines remains low with 75, or less than 2 percent of the lines detected. The
modeling suggests that several spectral features need two or more components to
be fitted properly. Other components could be assigned to cold foreground
clouds or to outflows, most visible in the SiO emission. A chemical variation
between the two embedded hot cores is found, with more N-bearing molecules
identified in SMA1 and O-bearing molecules in SMA2. Spectral line surveys give
powerful insights into the study of the interstellar medium. Different
molecules trace different physical conditions like the inner hot core, the
envelope, the outflows or the cold foreground clouds. The derived molecular
abundances provide further constraints for astrochemical models.Comment: 30 pages including appendix, 49 figures, accepted for publication in
Astronomy and Astrophysic
Clinical disorders affecting mesopic vision
Vision in the mesopic range is affected by a number of inherited and acquired clinical disorders. We review these conditions and summarize the historical background, describing the clinical characteristics alongside the genetic basis and molecular biological mechanisms giving rise to rod and cone dysfunction relevant to twilight vision. The current diagnostic gold standards for each disease are discussed and curative and symptomatic treatment strategies are summarized
Health Insurance Type and Control of Hypertension Among US Women Living With and Without HIV Infection in the Women’s Interagency HIV Study
BACKGROUND: Health care access is an important determinant of health. We assessed the effect of health insurance status and type on blood pressure control among US women living with (WLWH) and without HIV.
METHODS: We used longitudinal cohort data from the Women's Interagency HIV Study (WIHS). WIHS participants were included at their first study visit since 2001 with incident uncontrolled blood pressure (BP) (i.e., BP ≥140/90 and at which BP at the prior visit was controlled (i.e., <135/85). We assessed time to regained BP control using inverse Kaplan-Meier curves and Cox proportional hazard models. Confounding and selection bias were accounted for using inverse probability-of-exposure-and-censoring weights.
RESULTS: Most of the 1,130 WLWH and 422 HIV-uninfected WIHS participants who had an elevated systolic or diastolic measurement were insured via Medicaid, were African-American, and had a yearly income ≤$12,000. Among participants living with HIV, comparing the uninsured to those with Medicaid yielded an 18-month BP control risk difference of 0.16 (95% CI: 0.10, 0.23). This translates into a number-needed-to-treat (or insure) of 6; to reduce the caseload of WLWH with uncontrolled BP by one case, five individuals without insurance would need to be insured via Medicaid. Blood pressure control was similar among WLWH with private insurance and Medicaid. There were no differences observed by health insurance status on 18-month risk of BP control among the HIV-uninfected participants.
CONCLUSIONS: These results underscore the importance of health insurance for hypertension control-especially for people living with HIV
Impact of Health Insurance, ADAP, and Income on HIV Viral Suppression Among US Women in the Womenʼs Interagency HIV Study, 2006–2009
Implementation of the Affordable Care Act motivates assessment of health insurance and supplementary programs, such as the AIDS Drug Assistance Program (ADAP) on health outcomes of HIV-infected people in the United States. We assessed the effects of health insurance, ADAP, and income on HIV viral load suppression
PPAR? Downregulation by TGF in Fibroblast and Impaired Expression and Function in Systemic Sclerosis: A Novel Mechanism for Progressive Fibrogenesis
The nuclear orphan receptor peroxisome proliferator-activated receptor-gamma (PPAR-γ) is expressed in multiple cell types in addition to adipocytes. Upon its activation by natural ligands such as fatty acids and eicosanoids, or by synthetic agonists such as rosiglitazone, PPAR-γ regulates adipogenesis, glucose uptake and inflammatory responses. Recent studies establish a novel role for PPAR-γ signaling as an endogenous mechanism for regulating transforming growth factor-ß (TGF-ß)- dependent fibrogenesis. Here, we sought to characterize PPAR-γ function in the prototypic fibrosing disorder systemic sclerosis (SSc), and delineate the factors governing PPAR-γ expression. We report that PPAR-γ levels were markedly diminished in skin and lung biopsies from patients with SSc, and in fibroblasts explanted from the lesional skin. In normal fibroblasts, treatment with TGF-ß resulted in a time- and dose-dependent down-regulation of PPAR-γ expression. Inhibition occurred at the transcriptional level and was mediated via canonical Smad signal transduction. Genome-wide expression profiling of SSc skin biopsies revealed a marked attenuation of PPAR-γ levels and transcriptional activity in a subset of patients with diffuse cutaneous SSc, which was correlated with the presence of a ''TGF-ß responsive gene signature'' in these biopsies. Together, these results demonstrate that the expression and function of PPAR-γ are impaired in SSc, and reveal the existence of a reciprocal inhibitory cross-talk between TGF-ß activation and PPAR-γ signaling in the context of fibrogenesis. In light of the potent anti-fibrotic effects attributed to PPAR-γ, these observations lead us to propose that excessive TGF-ß activity in SSc accounts for impaired PPAR-γ function, which in turn contributes to unchecked fibroblast activation and progressive fibrosis. © 2010 Wei et al
No phosphine in the atmosphere of Venus
The detection of phosphine (PH₃) has been recently reported in the atmosphere of Venus employing mm-wave radio observations (Greaves et at. 2020). We here demonstrate that the observed PH₃ feature with JCMT can be fully explained employing plausible mesospheric SO₂ abundances (~100 ppbv as per the SO₂ profile given in their figure 9), while the identification of PH₃ in the ALMA data should be considered invalid due to severe baseline calibration issues. We demonstrate this by independently calibrating and analyzing the ALMA data using different interferometric analysis tools, in which we observe no PH₃ in all cases. Furthermore, for any PH₃ signature to be produced in either ALMA or JCMT spectra, PH₃ needs to present at altitudes above 70 km, in stark disagreement with their photochemical network. We ultimately conclude that this detection of PH₃ in the atmosphere of Venus is not supported by our analysis of the data
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