Screening of the antioxidant properties of crude extracts of six selected plant species from the Canary Islands (Spain)

The extracts of six common plants from the Canary Islands were screened for their antioxidant activities and compared with several phenolic compounds of natural origin (quercetin, catechin, rutin and gentisic acid) and synthetic (butylated hydroxyanisole (BHA) and butylated hydroxytoluene (BHT)). The in vitro antioxidant activity determined by using the 1,1-diphenyl-2-picrylhydrazyl (DPPH) method revealed that Plantago major L., Artemisia canariensis (Bess.) Lessing and Bidens aurea (Dryand.) Sherff exerted greater activity than the other plants (90.9%, 89.0% and 88.2% inhibition rate, respectively). The most active plants were Bidens aurea (Dryand.) Sherff and Plantago major L. (9.5 and 7.2 trolox μmol equivalents), when the cupric ion reducing antioxidant capacity assay (CUPRAC) was used. All the plants species exhibited higher antioxidant capacities than the synthetic antioxidants BHA and BHT. Among the natural phenolic compounds, gentisic acid was the most active. However, two of the plant extracts showed higher antioxidant activity than any other of the pure compounds studied, even than that of gentisic acid. The use of reversed phase high performance liquid chromatography (RP-HPLC) allowed the identification of the natural phenolic constituents listed above in Bidens aurea (Dryand.) Sherff and Plantago major L. extracts. Catechin and quercetin were the most prominent phenolic compounds. The presence of phenolic compounds in the plant extracts and their high antioxidant activities underline their phytomedicinal potentials. These plants may be exploited in the production of health foods and as an antioxidant carrier in the food and pharmaceutical industries

Excavaciones en la ciudad hispano romana de Labitolosa (La Puebla de Castro. Huesca). Informe preliminar de la campaña del año 2002

Se da cuenta de los trabajos arqueológicos en Labitolosa (La Puebla de Castro, Huesca) durante 2002

Marcas sobre materiales de construcción hallados en Labitolosa (La Puebla de Castro, Huesca)

El siguiente estudio aporta nuevos datos sobre la gran eclosión constructiva pública y privada de Labitolosa (Cerro del Calvario, La Puebla de Castro, Huesca) en la segunda mitad del siglo I d.C., sobre todo en época flavia a través del análisis de una pequeña serie de materiales constructivos en terracota que comparten la misma marca estampillada. El texto del sello, además de demostrar la existencia del mismo abastecedor de ladrillos y tejas para los proyectos constructivos labitolosanos, permite reflexionar sobre la sociedad y la geografía del territorio de la ciudad, en particular sobre la relación de Labitolosa con la mansio Tolous

ESTUDIO DE TIEMPOS Y MOVIMIENTOS PARA MEJORAR LA PRODUCTIVIDAD DE LA EMPRESA KURI NÉCTAR SAC, 2017

Es un hecho en la actualidad que no toda empresa cuenta con un estudio de tiempos y movimientos, ya que las empresas en lo único que se preocupan es producir más en menor tiempo y se desconoce la relación y el grado de incidencia que hay entre las condiciones de trabajo y las personas y cómo influye en la productividad. El estudio realizado en la empresa KURI NECTAR SAC en el área de producción tuvo como objetivo fundamental reducir tiempos improductivos, aplicando técnicas de Ingeniería Industrial, este estudio es importante porque de este modo la empresa verifica si los métodos o procedimientos que utilizan en los procesos son los más adecuados, pudiendo lograr con esto mejorar la productividad, eliminar tareas innecesarias y como meta facilitar el desempeño de las actividades a los trabajadores. La metodología fue de tipo descriptiva con enfoque cuantitativo y en cuanto al recojo de información utilizado es de tipo mixta (documental y de campo), en su diseño de la investigación es no experimental, transversal. Se utilizó los diagramas de operaciones y diagrama de análisis de cada proceso y los formatos de estudio de tiempos y movimientos. Como resultado se obtiene que los tiempos estándar inicial del proceso de elaboración del néctar de maracuyá y granadilla sea 279.16 minutos y una productividad de 40 cajas/operario. Con la aplicación del estudio de tiempos y movimientos se obtuvo un nuevo tiempo estándar de 230.41 minutos y una productividad de 52caja/operario. Se obtuvo un beneficio/ costo de S/. 1.63, como es mayor que 1, podemos decir que el proyecto es rentable para la empresa.Tesi

Excavaciones en la ciudad hispanorromana de Labitolosa (La puebla de Castro, Huesca). Informe preliminar de la campaña del año 2001

Se da cuenta de la campaña arqueológica del año 2001 en Labitolosa (La Puebla de Castro, Huesca

Secondary metabolites from two species of Tolpis and their biological activities

Phytochemical research of two Tolpis species, T. proustii and T. lagopoda, led to the isolation of three new compounds: 30-chloro-3β-acetoxy-22α-hydroxyl-20(21)- taraxastene (1), 3β,22α-diacetoxy-30-ethoxy-20(21)-taraxastene (2) and 3β,28-dihydroxy11α-hydroperoxy-12-ursene (3). The structures of the new compounds were elucidated by means of extensive IR, NMR, and MS data and by comparison of data reported in the literature. The in vitro antioxidant activities of the extracts were assessed by the DPPH and ABTS scavenging methods. The cytotoxicity of several known compounds and its derivatives was also assessed against human myeloid leukemia K-562 and K-562/ADR cell lines.This work was supported by a Grant from the Ministry of Science of Spain and Innovation and from the European Regional Development Fund (SAF2010-21380) to F.E, Instituto Canario de Investigación del Cáncer to F.L. and Agencia Canaria de Investigación, Innovación y Sociedad de la Información (FEDER) (C200801000174) to J.T. F.L. was supported by JAE-doctoral Program from the Ministerio de Ciencia e Innovación.Peer reviewe

The attitude towards vaccination of health sciences students at a Spanish university improved over the first 18 months of the COVID-19 pandemic

It is important to know the attitudes of students of health sciences (SHSs) towards vaccination since they will be tomorrow’s health professionals. Vaccination is a powerful tool in the fight against COVID-19. The aim of the present, cross-sectional study was to examine how the COVID-19 pandemic has influenced the attitude of SHSs towards vaccination. Data were collected in the form of a questionnaire from all students of nursing, physiotherapy and chiropody matriculated at a Madrid University for the academic year 2019/2020 (i.e., before the start of the pandemic [Q1]), and from all those matriculated for the year 2021/22 (i.e., c18 months after the pandemic was declared [Q2]). A multivariate analysis was performed to identify the influence of sex, degree being studied, course year and the time of answering (Q1 or Q2), on the dimensions Beliefs, Behaviours and General Attitude. Overall, 1894 questionnaires were returned (934 [49.3%] for Q1, and 960 [50.7%] for Q2), of which 70.5% were completed by students of nursing, 14% by students of physiotherapy and 15.4% by those studying chiropody. In Q2, the results for all three dimensions were significantly better (p < 0.05). The most important influencing factors were being a student of nurs-ing, being in the final years of training (years 3 or 4), female gender and answering at the time of Q2. The results obtained are encouraging since student nurses (who showed Q1 and Q2 General Attitude scores of 3.34 and 3.47 (maximum possible 4), respectively [p < 0.05]) are the health professionals of tomorrow most likely to be involved in vaccination programmes.info:eu-repo/semantics/publishedVersio

Vaccine coverage against influenza and SARS-CoV-2 in health sciences students during COVID-19 pandemic in Spain

Vaccination against influenza and SARS-CoV-2 is recommended in health sciences students to reduce the risk of acquiring these diseases and transmitting them to patients. The aim of the study was to evaluate how the pandemic influenced the modification of influenza vaccination coverage during the 2019/2020 and 2021/2022 campaigns and to analyze the vaccination coverage against SARS-CoV-2 in health sciences students. A cross-sectional study was conducted among students of the Faculty of Nursing, Physiotherapy and Podiatry of the Complutense University of Madrid. A questionnaire was administered in two stages, the first, Q1, before the start of the pandemic, where we analyzed influenza coverage during the 2019/2020 campaign and a second, Q2, 18 months after the start of the pandemic where we analyzed influenza coverage during the 2021/2022 campaign and coverage against SARS-CoV-2. A total of 1894 students (58.78% of the total of those enrolled) participated. Flu vaccination coverage increased from 26.7% in Q1 to 35.0% in Q2 (p < 0.05), being higher in the age group older than 21 years, who studied nursing, were in their fourth year and lived with people at risk. Vaccination coverage against SARS-CoV-2 was very high (97.8%), especially in students vaccinated against influenza. Coverage of the influenza vaccine in health sciences students increased from 2019–2020 to 2021–2022, being higher in the age group older than 21 years, who studied nursing, were in their first and fourth year and lived with people at risk. Coverage of the SARS-CoV-2 vaccine in health sciences students was very high, especially in those vaccinated against influenza.info:eu-repo/semantics/publishedVersio

Effectiveness of double-layered compression therapy against crepe bandage for healing venous ulcers in primary care. Randomized clinical trial

Objetivo: Evaluar si el vendaje de 2 capas es más efectivo que el vendaje de crepé en la cicatrización de úlceras venosas tras 12 semanas de seguimiento. Diseño: Ensayo clínico aleatorizado multicéntrico. Emplazamiento: 22 Centros de Salud de Madrid. Participantes: Mayores de 18 años, con diagnóstico de úlceras venosas. Se aleatorizaron 93 pacientes, 56 en el grupo de doble capa y 37 en crepé. Retiradas: 16 en el grupo de doble capa y 7 en el de crepé. Intervenciones: Grupo control: práctica clínica habitual: tratamiento de la herida y vendaje con crepé. Grupo experimental: misma práctica habitual para tratamiento de la herida y vendaje con doble capa. Mediciones principales: Variable respuesta principal: cicatrización completa a las 12 semanas. Variables secundarias: severidad de las lesiones, calidad de vida, reacciones adversas. Evaluación ciega de la variable respuesta. Resultados: Cicatrización completa: 25 (67%) en el grupo crepé (IC al 95% 50,2-81,9) y 32 (57,1%) en doble capa (IC al 95% 43,2-70,3). Sin diferencias en ambos grupos, RR = 1,10 (IC al 95% 0,864-1,424). La severidad de las úlceras basales se asocia al tiempo de cicatrización, HR = 0,86 (IC al 95% 0,78-0,94). Se objetiva mejora significativa en la calidad de vida total y en las dimensiones cosmesis y estado emocional. No se encuentran diferencias según el vendaje utilizado. Sin reacciones adversas graves en ninguno de los grupos. Conclusiones: No encontramos diferencias significativas en la cicatrización entre los 2 tipos de vendaje. Ambos son apropiados para la cicatrización de las úlceras y para mejorar la calidad de vida.Objective: To evaluate if the two-layer bandage is more effective than the crepe bandage in the healing of venous ulcers after 12 weeks of follow-up. Design: Randomized multicentre controlled clinical trial. Location: 22 Primary Health Centers of Madrid. Participants: Over 18 years old, with diagnosis of venous ulcers. 93 patients were randomized, 56 in the double layer group and 37 in the crepe group. Withdrawals: 16 in double layer group, 7 in crepe group. Interventions: Control group: usual clinical practice: treatment of the wound and bandage with crepe. Experimental group: same usual clinical practice for wound treatment and bandage with double layer. Main measurements: Primary outcome: complete healing at 12 weeks. Secondary outcomes: severity of ulceration, health-related quality of life, adverse events. Blind evaluation of the response variable. Results: Complete healing: in crepe group, 25, 67.5% (95% CI 50.2-81.9) and in double layer group, 32, 57.1% (95% CI 43.2-70.3). No evidence of a difference in both groups, RR = 1.10 (95% CI 0.864-1.424). The basal severity of the ulcers is associated with the healing time. HR = 0.86 (95% CI 0.78-0.94). Our data showed a significant improvement in health-related quality of life, total and in the of cosmesis and emotional dimensions. No evidence of a difference in both groups. We didn’t find serious adverse events in any of the groups. Conclusions: We didn’t find significant differences in the healing between the two bandages evaluated. Both are appropriate for ulcer healing and to improve the health-related quality of life.Financiado por el Ministerio de Ciencia e Innovación, a través del Instituto de Salud Carlos III. PN de I+D+I 2008-2011 Cofinanciado con fondos FEDER (PI13/01975) y la Fundación para la Investigación e Innovación Biosanitaria de Atención Primaria de la Comunidad de Madrid (FIIBAP)