Design Performance Measurement in the Construction Sector: A Pilot Study

This paper examines the role and deployment of design performance measurements (DPMs) in the construction industry, focusing on the consulting engineering sector, the design 'heart' of construction. Compared with manufacturing, there has been very little research on the use of DPMs in construction, and firms often struggle to find appropriate performance indicators. Using results from structured questionnaires, the paper shows that the few DPMs which do exist focus mainly on cost. Other measures are needed to address quality, innovative performance and client satisfaction. In contrast to manufacturing, DPMs in construction also need to address the project-based, multi-firm and non-routine nature of construction design, as well as the separation of design from manufacturing, build and operation. Interviews and workshops with industrialists were used to identify recent DPM practices in construction and combine these with lessons from other sectors. The resulting DPM tools provide guidance on how to: (a) integrate design into wider business processes in construction; (b) identify key design indicators, at both project and firm level; and (c) use DPMs to provide a balanced scorecard for design performance.performance indicators, design integration, design indicators, construction industry

Modelling Temporal Uncertainty in Palaeoclimate Reconstructions

Abstract We present a method for reconstructing an aspect of climate over 13,000 years at Sluggan Moss, Northern Ireland. We extend the work of [1] to include calibrated radiocarbon ages. The required chronologies are obtained via a new monotone stochastic process. We also discuss the t 8 long-tailed random walk model and produce predictive climate estimates

E-tracers:development of a low cost wireless technique for exploring sub-surface hydrological systems

This briefing describes the first deployment of a new electronic tracer (E-tracer) for obtaining along-flowpath measurements in subsurface hydrological systems. These low-cost, wireless sensor platforms were deployed into moulins on the Greenland Ice Sheet. After descending into the moulin, the tracers travelled through the subglacial drainage system before emerging at the glacier portal. They are capable of collecting along-flowpath data from the point of injection until detection. The E-tracers emit a radio frequency signal, which enables sensor identification, location and recovery from the proglacial plain. The second generation of prototype E-tracers recorded water pressure, but the robust sensor design provides a versatile platform for measuring a range of parameters, including temperature and electrical conductivity, in hydrological environments that are challenging to monitor using tethered sensors

Cold Atom Space Payload Atmospheric Drag Mission (CASPA-ADM)

To gain better understanding of the upper atmospheric dynamics requires more accurate determination of the mass density distribution in the thermosphere. Improved measurements of drag, by means of satellite accelerometery, can be used to more precisely determine this distribution. In addition, atmospheric drag in Low Earth Orbit (LEO) is particularly of interest for climate modelling, weather forecasting and satellite orbit prediction. RAL Space, Teledyne-e2v and the University of Birmingham are developing a Cold Atom Space Payload Atmospheric Drag Mission (CASPA-ADM). The aim of the project, supported by the UK Centre for Earth Observation Instrumentation (CEOI), is to develop a technology demonstrator based on Cold Atom Interferometry (CAI) to take sensitive measurements of atmospheric drag. The underlying CAI technology has been previously flown on the Chinese Space Station, the International Space Station, and in sounding rockets. However, it has not yet been used as the fundamental sensor technology in a free flight space mission. The team is producing a space-suitable accelerometer that can be embedded in small satellites such as 16U CubeSats and are addressing the engineering challenges associated with space qualification and miniaturisation, while keeping the performance level of systems with larger Size, Weight and Power (SWaP)

Effectiveness of prolonged use of continuous passive motion (CPM), as an adjunct to physiotherapy, after total knee arthroplasty

<p>Abstract</p> <p>Background</p> <p>Adequate and intensive rehabilitation is an important requirement for successful total knee arthroplasty.</p> <p>Although research suggests that Continuous Passive Motion (CPM) should be implemented in the first rehabilitation phase after surgery, there is substantial debate about the duration of each session and the total period of CPM application. A Cochrane review on this topic concluded that short-term use of CPM leads to greater short-term range of motion. It also suggested, however, that future research should concentrate on the treatment period during which CPM should be administered.</p> <p>Methods</p> <p>In a randomised controlled trial we investigated the effectiveness of prolonged CPM use in the home situation as an adjunct to standardised PT. Efficacy was assessed in terms of faster improvements in range of motion (RoM) and functional recovery, measured at the end of the active treatment period, 17 days after surgery.</p> <p>Sixty patients with knee osteoarthritis undergoing TKA and experiencing early postoperative flexion impairment were randomised over two treatment groups. The experimental group received CPM + PT for 17 consecutive days after surgery, whereas the usual care group received the same treatment during the in-hospital phase (i.e. about four days), followed by PT alone (usual care) in the first two weeks after hospital discharge.</p> <p>From 18 days to three months after surgery, both groups received standardised PT. The primary focus of rehabilitation was functional recovery (e.g. ambulation) and regaining RoM in the knee.</p> <p>Results</p> <p>Prolonged use of CPM slightly improved short-term RoM in patients with limited RoM at the time of discharge after total knee arthroplasty when added to a semi-standard PT programme. Assessment at 6 weeks and three months after surgery found no long-term effects of this intervention Neither did we detect functional benefits of the improved RoM at any of the outcome assessments.</p> <p>Conclusion</p> <p>Although results indicate that prolonged CPM use might have a small short-term effect on RoM, routine use of prolonged CPM in patients with limited RoM at hospital discharge should be reconsidered, since neither long-term effects nor transfer to better functional performance was detected.</p> <p>Trial Registration</p> <p>ISRCTN85759656</p

HCO3(-)-independent pH regulation in astrocytes in situ is dominated by V-ATPase.

The mechanisms of HCO3(-)-independent intracellular pH (pHi) regulation were examined in fibrous astrocytes within isolated neonatal rat optic nerve (RON) and in cultured cortical astrocytes. In agreement with previous studies, resting pHi in cultured astrocytes was 6.82 ± 0.06 and inhibition of the V-ATPase H(+) pump by Cl(-) removal or via the selective inhibitor bafilomycin had only a small effect upon resting pHi and recovery following an acid load. In contrast, resting pHi in RON astrocytes was 7.10 ± 0.04, significantly less acidic than that in cultured cells (p < 0.001), and responded to inhibition of V-ATPase with profound acidification to the 6.3-6.5 range. Fluorescent immuno-staining and immuno-gold labeling confirmed the presence V-ATPase in the cell membrane of RON astrocyte processes and somata. Using ammonia pulse recovery, pHi recovery in RON astrocyte was achieved largely via V-ATPase with sodium-proton exchange (NHE) playing a minor role. The findings indicate that astrocytes in a whole-mount preparation such as the optic nerve rely to a greater degree upon V-ATPase for HCO3(-)-independent pHi regulation than do cultured astrocytes, with important functional consequences for the regulation of pH in the CNS

What causes the inverse relationship between primary production and export efficiency in the Southern Ocean?

The ocean contributes to regulating atmospheric CO2 levels, partly via variability in the fraction of primary production (PP) which is exported out of the surface layer (i.e. the e-ratio). Southern Ocean studies have found that, contrary to global scale analyses, an inverse relationship exists between e-ratio and PP. This relationship remains unexplained, with potential hypotheses being i) large export of dissolved organic carbon (DOC) in high PP areas, ii) strong surface microbial recycling in high PP regions and/ or iii) grazing mediated export varies inversely with PP. We find that the export of DOC has a limited influence in setting the negative e-ratio/PP relationship. However, we observed that at sites with low PP and high e-ratios, zooplankton mediated export is large and surface microbial abundance low suggesting that both are important drivers of the magnitude of the e-ratio in the Southern Ocean

Mutations in HYAL2, Encoding Hyaluronidase 2, Cause a Syndrome of Orofacial Clefting and Cor Triatriatum Sinister in Humans and Mice.

Orofacial clefting is amongst the most common of birth defects, with both genetic and environmental components. Although numerous studies have been undertaken to investigate the complexities of the genetic etiology of this heterogeneous condition, this factor remains incompletely understood. Here, we describe mutations in the HYAL2 gene as a cause of syndromic orofacial clefting. HYAL2, encoding hyaluronidase 2, degrades extracellular hyaluronan, a critical component of the developing heart and palatal shelf matrix. Transfection assays demonstrated that the gene mutations destabilize the molecule, dramatically reducing HYAL2 protein levels. Consistent with the clinical presentation in affected individuals, investigations of Hyal2-/- mice revealed craniofacial abnormalities, including submucosal cleft palate. In addition, cor triatriatum sinister and hearing loss, identified in a proportion of Hyal2-/- mice, were also found as incompletely penetrant features in affected humans. Taken together our findings identify a new genetic cause of orofacial clefting in humans and mice, and define the first molecular cause of human cor triatriatum sinister, illustrating the fundamental importance of HYAL2 and hyaluronan turnover for normal human and mouse development

Finishing the euchromatic sequence of the human genome

The sequence of the human genome encodes the genetic instructions for human physiology, as well as rich information about human evolution. In 2001, the International Human Genome Sequencing Consortium reported a draft sequence of the euchromatic portion of the human genome. Since then, the international collaboration has worked to convert this draft into a genome sequence with high accuracy and nearly complete coverage. Here, we report the result of this finishing process. The current genome sequence (Build 35) contains 2.85 billion nucleotides interrupted by only 341 gaps. It covers ∼99% of the euchromatic genome and is accurate to an error rate of ∼1 event per 100,000 bases. Many of the remaining euchromatic gaps are associated with segmental duplications and will require focused work with new methods. The near-complete sequence, the first for a vertebrate, greatly improves the precision of biological analyses of the human genome including studies of gene number, birth and death. Notably, the human enome seems to encode only 20,000-25,000 protein-coding genes. The genome sequence reported here should serve as a firm foundation for biomedical research in the decades ahead