What objects do 6th grade pupils decide to draw in an old museum?

Peer reviewe

Mielenterveyshankkeiden implementoinnin edistäminen työpaikalla – sisäisen markkinoinnin näkökulma

Promoting the implementation of mental health projects in the workplace – an internal marketing approach Mental health problems are a growing challenge for organizations. However, people do not take advantage of wellbeing services being offered. We examine how internal marketing can be utilized and what factors promote introducing wellbeing projects in organizations. The research was carried out as a qualitative case study. The findings show that internal marketing effectively supports the implementation of wellbeing services and help remove barriers to these services, for example by focusing on the importance of strategy, training as well as communication and marketing

Cross-sectional and longitudinal associations of circulating omega-3 and omega-6 fatty acids with lipoprotein particle concentrations and sizes: population-based cohort study with 6-year follow-up

Peer reviewe

Terveydenhuollon palveluvalikoiman priorisointi

Selvityksen tavoitteena on terveydenhuollon priorisoinnin kansallinen kehittäminen. Priorisoinnilla tarkoitetaan tässä yhteydessä kaikkia niitä toimintoja, jotka pyrkivät terveydenhuollon resurssien kohdentamiseen. Selvityksessä on kuvattu terveydenhuollon priorisoinnin oikeudellisia reunaehtoja sekä haettu tietoa eri maiden priorisoinnin kehittämisestä ja niiden vaikutuksista. Hankkeessa tehtiin myös kyselyjä ja työpajoja eri sidosryhmille. Suomessa toivotaan kansallisia avoimia ja läpinäkyviä periaatteita priorisoinnin tueksi. Tällä hetkellä kansalaiset ja ammattilaiset eivät hahmota terveyspalvelujen kokonaisuutta ja todellisia kustannuksia. Jotta priorisoinnista tulisi hyväksyttyä, on 1) alettava toteuttaa systemaattista viestintästrategiaa osallistamisen mahdollistamiseksi ja 2) osallistettava eri sidosryhmiä priorisoinnin periaatteiden kehittämiseen. Tämä vaatii myös 3) kansallisten rakenteiden ja prosessien luomista periaatteiden muodostamiseen sekä niiden jalostamiseksi kriteereiksi ja menetelmiksi sekä 4) lainsäädännön kehittämistä. Perustuslain tulkinnassa on painotettu yksilön oikeuksia. Perustuslaki jättää kuitenkin liikkumavaraa kehittää priorisoinnin oikeudellista ohjausta myös väestöterveyden ja yhteiskunnan taloudelliset voimavarat nykyistä selvemmin huomioon ottavaan suuntaan.Sivua 18 on päivitetty 29.8.2022 ja aineisto korvaa aikaisemmin, 24.8.2022 julkaistun version. Tämä julkaisu on toteutettu osana valtioneuvoston selvitys- ja tutkimussuunnitelman toimeenpanoa (tietokayttoon.fi). Julkaisun sisällöstä vastaavat tiedon tuottajat, eikä tekstisisältö välttämättä edusta valtioneuvoston näkemystä

Metabolomic Profiling of Statin Use and Genetic Inhibition of HMG-CoA Reductase

BACKGROUND Statins are first-line therapy for cardiovascular disease prevention, but their systemic effects across lipoprotein subclasses, fatty acids, and circulating metabolites remain incompletely characterized. OBJECTIVES This study sought to determine the molecular effects of statin therapy on multiple metabolic pathways. METHODS Metabolic profiles based on serum nuclear magnetic resonance metabolomics were quantified at 2 time points in 4 population-based cohorts from the United Kingdom and Finland (N = 5,590; 2.5 to 23.0 years of follow-up). Concentration changes in 80 lipid and metabolite measures during follow-up were compared between 716 individuals who started statin therapy and 4,874 persistent nonusers. To further understand the pharmacological effects of statins, we used Mendelian randomization to assess associations of a genetic variant known to mimic inhibition of HMG-CoA reductase (the intended drug target) with the same lipids and metabolites for 27,914 individuals from 8 population-based cohorts. RESULTS Starting statin therapy was associated with numerous lipoprotein and fatty acid changes, including substantial lowering of remnant cholesterol (80% relative to low-density lipoprotein cholesterol [LDL-C]), but only modest lowering of triglycerides (25% relative to LDL-C). Among fatty acids, omega-6 levels decreased the most (68% relative to LDL-C); other fatty acids were only modestly affected. No robust changes were observed for circulating amino acids, ketones, or glycolysis-related metabolites. The intricate metabolic changes associated with statin use closely matched the association pattern with rs12916 in the HMGCR gene (R-2 = 0.94, slope 1.00 +/- 0.03). CONCLUSIONS Statin use leads to extensive lipid changes beyond LDL-C and appears efficacious for lowering remnant cholesterol. Metabolomic profiling, however, suggested minimal effects on amino acids. The results exemplify how detailed metabolic characterization of genetic proxies for drug targets can inform indications, pleiotropic effects, and pharmacological mechanisms. (C) 2016 by the American College of Cardiology Foundation.Peer reviewe

A Global Meta-Analysis of Forest Bioenergy Greenhouse Gas Emission Accounting Studies

The potential greenhouse gas benefits of displacing fossil energy with biofuels are driving policy development in the absence of complete information. The potential carbon neutrality of forest biomass is a source of considerable scientific debate because of the complexity of dynamic forest ecosystems, varied feedstock types, and multiple energy production pathways. The lack of scientific consensus leaves decision makers struggling with contradicting technical advice. Analyzing previously published studies, our goal was to identify and prioritize those attributes of bioenergy greenhouse gas (GHG) emissions analysis that are most influential on length of carbon payback period. We investigated outcomes of 59 previously published forest biomass greenhouse gas emissions research studies published between 1991 and 2014. We identified attributes for each study and classified study cases by attributes. Using classification and regression tree analysis, we identified those attributes that are strong predictors of carbon payback period (e.g. the time required by the forest to recover through sequestration the carbon dioxide from biomass combusted for energy). The inclusion of wildfire dynamics proved to be the most influential in determining carbon payback period length compared to other factors such as feedstock type, baseline choice, and the incorporation of leakage calculations. Additionally, we demonstrate that evaluation criteria consistency is required to facilitate equitable comparison between projects. For carbon payback period calculations to provide operational insights to decision makers, future research should focus on creating common accounting principles for the most influential fac

Metabolic Signatures of Adiposity in Young Adults : Mendelian Randomization Analysis and Effects of Weight Change

Peer reviewe

Team climate, intention to leave and turnover among hospital employees: Prospective cohort study

<p>Abstract</p> <p>Background</p> <p>In hospitals, the costs of employee turnover are substantial and intentions to leave among staff may manifest as lowered performance. We examined whether team climate, as indicated by clear and shared goals, participation, task orientation and support for innovation, predicts intention to leave the job and actual turnover among hospital employees.</p> <p>Methods</p> <p>Prospective study with baseline and follow-up surveys (2–4 years apart). The participants were 6,441 (785 men, 5,656 women) hospital employees under the age of 55 at the time of follow-up survey. Logistic regression with generalized estimating equations was used as an analysis method to include both individual and work unit level predictors in the models.</p> <p>Results</p> <p>Among stayers with no intention to leave at baseline, lower self-reported team climate predicted higher likelihood of having intentions to leave at follow-up (odds ratio per 1 standard deviation decrease in team climate was 1.6, 95% confidence interval 1.4–1.8). Lower co-worker assessed team climate at follow-up was also association with such intentions (odds ratio 1.8, 95% confidence interval 1.4–2.4). Among all participants, the likelihood of actually quitting the job was higher for those with poor self-reported team climate at baseline. This association disappeared after adjustment for intention to leave at baseline suggesting that such intentions may explain the greater turnover rate among employees with low team climate.</p> <p>Conclusion</p> <p>Improving team climate may reduce intentions to leave and turnover among hospital employees.</p