The last glacial maximum Balearic Abyssal Plain megabed revisited

Megabeds are thick sedimentary layers extending over thousands square kilometres in deep sea basins and are thought to result from large slope failures triggered by major external events. Such deposits have been found in at least three areas of the Mediterranean Sea. Although their discovery dates back to the early 1980s, many questions remain, concerning their initiation, source area, extent, and the nature of their emplacement. One of the largest previously documented megabeds was emplaced during the Last Glacial Maximum across the Balearic Abyssal Plain with a thickness of 8-10 m in water depths of up to 2800 m. New 3.5 kHz sub-bottom profiles and sediment cores provide greater constraint on the lateral variability of the megabed and allow to map it beyond previous estimates, with a revised areal extent up to 90,000-100,000 km2. Megabed terminations show gradual pinch-out to the West and an abrupt eastward termination against the Sardinia steep margin. The megabed presents both in seismic profiles and in sediment cores a tripartite subdivision likely corresponding to changes in flow regimes across the basin with a central area of sandy facies and erosional base oriented NNE-SSW allowing renewed discussions about sources and trigger of the megabed

A novel thrombopoietin ( THPO ) mutation altering mRNA splicing in a case of familial thrombocytosis

International audienceNo abstract availabl

A novel thrombopoietin ( THPO

International audienceNo abstract availabl

Allogenic Stem Cell Transplantation Abrogates Negative Impact on Outcome of AML Patients with KMT2A Partial Tandem Duplication

Recently, a new subset of acute myeloid leukemia (AML) presenting a direct partial tandem duplication (PTD) of the KMT2A gene was described. The consequences of this alteration in terms of outcome and response to treatment remain unclear. We analyzed retrospectively a cohort of KMT2A-PTD-mutated patients with newly diagnosed AML. With a median follow-up of 3.6 years, the median overall survival was 12.1 months. KMT2A-PTD-mutated patients were highly enriched in mutations affecting epigenetic actors and the RTK/RAS signaling pathway. Integrating KMT2A-PTD in ELN classification abrogates its predictive value on survival suggesting that this mutation may overcome other genomic marker effects. In patients receiving intensive chemotherapy, hematopoietic stem cell transplantation (HSCT) significantly improved the outcome compared to non-transplanted patients. In the multivariate analysis, only HSCT at any time in complete remission (HR = 2.35; p = 0.034) and FLT3-ITD status (HR = 0.29; p = 0.014) were independent variables associated with overall survival, whereas age was not. In conclusion, our results emphasize that KMT2A-PTD should be considered as a potential adverse prognostic factor. However, as KMT2A-PTD-mutated patients are usually considered an intermediate risk group, upfront HSCT should be considered in first CR due to the high relapse rate observed in this subset of patients

Clinical and biological characterization of patients with low (0.1-2%) JAK2V617F allele burden at diagnosis

International audience.

Concordance of assays designed for the quantification of JAK2V617F: a multicenter study

This study shows that different techniques, particularly following calibration to a reference standard, can guarantee accurate quantification of the JAK2 (V617) mutant allele burden. See related perspective article on page 7

Heat flow in the Western Mediterranean: Thermal anomalies on the margins, the seafloor and the transfer zones

The Western Mediterranean basin has been formed by Miocene back-arc extension and is underlain by a thin and young lithosphere. This young lithosphere is warm, as testified by an overall elevated offshore heat flow. Heat flow within the Western Mediterranean is, however, highly variable and existing data are unevenly distributed and poorly studied in the central part of the Liguro-Provençal and Algero-Balearic basins. This central part is floored by a young oceanic crust, bordered by different continental margins, cut by transform faults, and filled by up to 8 km of sediments. We present a total of 148 new heat flow data collected during the MedSalt and WestMedFlux cruises in 2015 and 2016 and aligned along seven regional profiles that show an important heat flow variability on the basin-scale, but also locally on the margins. A new heat flow map for the Western Mediterranean outlines the following regional features: (1) a higher average heat flow in the Algero-Balearic basin compared to the Liguro-Provençal basin (94 ± 13 mW/m2 and 78 ± 16 mW/m2, respectively), and (2) a regional thermal asymmetry in both basins, but with opposed heat flow trends. Up to 20% of this heat flow difference can be explained by sediment blanketing, but age and heterogeneity of ocean crust due to an asymmetric and polyphased opening of the basins are believed to have given the major thermal imprint. Estimates of the age of the oceanic crust based on the new heat flow suggest a considerably younger West Algerian basin (16–23 Ma) compared to the East Algerian basin and the West Sardinia oceanic floor (31–37 Ma). On the margins and ocean-continent transitions of the Western Mediterranean the new heat flow data point out the existence of two types of local anomalies (length scale 5–30 km): (1) locally increased heat flow up to 153 mW/m2 on the Gulf of Lion margin results from thermal refraction of large salt diapirs, and (2) the co-existing of both low (110 mW/m2) heat flow areas on the South Balearic margin suggests a heat redistribution system. We suspect the lateral heat advection is resulting from a regional fluid circulation in the sediments associated to the widespread Plio-Pleistocene volcanism on the South Balearic margin

Heat flow in the Western Mediterranean: new data from the MedSalt and WestMedFlux cruises and consequences for regional predictive mapping

The Western Mediterranean basin has been formed by Miocene back-arc extension and is underlain by a thin and young lithosphere. This young lithosphere is warm, as testified by an overall elevated offshore heat flow. Heat flow within the Western Mediterranean is, however, highly variable and existing data are unevenly distributed and poorly studied in the central part of the Liguro-Provençal and Algero-Balearic basins. This central part is floored by a young oceanic crust, bordered by different continental margins, cut by transform faults, and filled by up to 8 km of sediments. We present a total of 148 new heat flow data collected during the MedSalt and WestMedFlux cruises in 2015 and 2016 and aligned along seven regional profiles that show an important heat flow variability on the basin-scale, but also locally on the margins. A new heat flow map for the Western Mediterranean outlines the following regional features: (1) a higher average heat flow in the Algero-Balearic basin compared to the Liguro-Provençal basin (94 ± 13 mW/m2 and 78 ± 16 mW/m2, respectively), and (2) a regional thermal asymmetry in both basins, but with opposed heat flow trends. Up to 20% of this heat flow difference can be explained by sediment blanketing, but age and heterogeneity of ocean crust due to an asymmetric and polyphased opening of the basins are believed to have given the major thermal imprint. Estimates of the age of the oceanic crust based on the new heat flow suggest a considerably younger West Algerian basin (16–23 Ma) compared to the East Algerian basin and the West Sardinia oceanic floor (31–37 Ma). On the margins and ocean-continent transitions of the Western Mediterranean the new heat flow data point out the existence of two types of local anomalies (length scale 5–30 km): (1) locally increased heat flow up to 153 mW/m2 on the Gulf of Lion margin results from thermal refraction of large salt diapirs, and (2) the co-existing of both low (110 mW/m2) heat flow areas on the South Balearic margin suggests a heat redistribution system. We suspect the lateral heat advection is resulting from a regional fluid circulation in the sediments associated to the widespread Plio-Pleistocene volcanism on the South Balearic margi