A Mid-Infrared Imaging Survey of Embedded Young Stellar Objects in the Rho Ophiuchi Cloud Core

Results of a comprehensive, new, ground-based mid-infrared imaging survey of the young stellar population of the Rho Ophiuchi cloud are presented. Data were acquired at the Palomar 5-m and at the Keck 10-m telescopes with the MIRLIN and LWS instruments, at 0.25 arcsec and 0.25 arcsec resolutions, respectively. Of 172 survey objects, 85 were detected. Among the 22 multiple systems observed, 15 were resolved and their individual component fluxes determined. A plot of the frequency distribution of the detected objects with SED spectral slope shows that YSOs spend ~400,000 yr in the Flat Spectrum phase, clearing out their remnant infall envelopes. Mid-infrared variability is found among a significant fraction of the surveyed objects, and is found to occur for all SED classes with optically thick disks. Large-amplitude near-infrared variability, also found for all SED classes with optically thick disks, seems to occur with somewhat higher frequency at the earlier evolutionary stages. Although a general trend of mid-infrared excess and NIR veiling exists proceeding through SED classes, with Class I objects generally exhibiting K-veilings > 1, Flat Spectrum objects with K-veilings > 0.58, and Class III objects with K-veilings =0, Class II objects exhibit the widest range of K-band veiling values, 0-4.5. However, the highly variable value of veiling that a single source can exhibit in any of the SED classes in which active disk accretion can take place is striking, and is direct observational evidence for highly time-variable accretion activity in disks. Finally, by comparing mid-infrared vs. near-infrared excesses in a subsample with well-determined effective temperatures and extinction values, disk clearing mechanisms are explored. The results are consistent with disk clearing proceeding from the inside-out.Comment: 18 pages + 5 tables + 7 figure

Measurement of an AGN Central Mass on Centiparsec Scales: Results of Long-Term Optical Monitoring of Arp 102B

The optical spectrum of the broad-line radio galaxy Arp 102B has been monitored for more than thirteen years to investigate the nature of the source of its broad, double-peaked hydrogen Balmer emission lines. The shape of the lines varied subtly; there was an interval during which the variation in the ratio of the fluxes of the two peaks appeared to be sinusoidal, with a period of 2.16 years and an amplitude of about 16% of the average value. The variable part of the broad H-alpha line is well fit by a model in which a region of excess emission (a quiescent ``hot spot'') within an accretion disk (fitted to the non-varying portion of the double-peaked line) completes at least two circular orbits and eventually fades. Fits to spectra from epochs when the hot spot is not present allow determination of the disk inclination, while fits for epochs when it is present provide a measurement of the radius of the hot spot's orbit. From these data and the period of variation, we find that the mass within the hot spot's orbit is 2.2 +0.2/-0.7 times 10^8 solar masses, within the range of previous estimates of masses of active galactic nuclei. Because this mass is determined at a relatively small distance (~1000 AU) from the central body, it is extremely difficult to explain without assuming that a supermassive black hole lies within Arp 102B. The lack of any systematic change in the velocity of the blue peak over time yields a lower limit on the combined mass of the two bodies in a binary black hole model like that of Gaskell (1983) of 10^10 solar masses.Comment: 29 pages, including 6 figures; to appear in the Astrophysical Journal 199

Hubble Space Telescope Spectroscopy of Brown Dwarfs Discovered with the Wide-field Infrared Survey Explorer

We present a sample of brown dwarfs identified with the {\it Wide-field Infrared Survey Explorer} (WISE) for which we have obtained {\it Hubble Space Telescope} ({\it HST}) Wide Field Camera 3 (WFC3) near-infrared grism spectroscopy. The sample (twenty-two in total) was observed with the G141 grism covering 1.10$-$1.70 $\mu$m, while fifteen were also observed with the G102 grism, which covers 0.90$-$1.10 $\mu$m. The additional wavelength coverage provided by the G102 grism allows us to 1) search for spectroscopic features predicted to emerge at low effective temperatures (e.g.\ ammonia bands) and 2) construct a smooth spectral sequence across the T/Y boundary. We find no evidence of absorption due to ammonia in the G102 spectra. Six of these brown dwarfs are new discoveries, three of which are found to have spectral types of T8 or T9. The remaining three, WISE J082507.35$+$280548.5 (Y0.5), WISE J120604.38$+$840110.6 (Y0), and WISE J235402.77$+$024015.0 (Y1) are the nineteenth, twentieth, and twenty-first spectroscopically confirmed Y dwarfs to date. We also present {\it HST} grism spectroscopy and reevaluate the spectral types of five brown dwarfs for which spectral types have been determined previously using other instruments.Comment: Accepted for publication in the Astrophysical Journal. 20 pages, 18 figures, 7 table

Studies of Intestinal Lymphoid Tissue. XI – The Immunopathology of Cell-Mediated Reactions in Gluten Sensitivity and Other Enteropathies

Computerised image-analysis was used to quantitate small intestinal mucosae from celiac sprue and dermatitis herpetiformis patients, Gambian children with tropical-sprue-like malabsorption, first-degree celiac sprue relatives, and treated celiac sprue patients during challenge with a peptic-tryptic digest of gluten. A wide range of mucosal appearances was observed. Typically, \u27flat\u27 lesions (Type 2) revealed a reduced number of epithelial lymphocytes that were large and mitotically active. At the other extreme, mucosal architecture was relatively well preserved (Type 1) but surface epithelium contained an expanded population of small, non-mitotic lymphocytes, with or without crypt hyperplasia. Similar changes were observed in one-third of celiac relatives and following small dose gluten challenge. Larger dose challenges revealed a transition from Type 1 to Type 2 lesions over a 5-day period. Studies in a few patients over 2-4 years showed a similar type of progression. A major feature of this sequence was early appearance of crypt hypertrophy while villi persisted, indicating a role for factors other than increased loss of enterocytes from surface epithelium. These changes parallel the T lymphocyte-mediated events in graft-versus-host reactions in animals. It is thus concluded that the spectrum of immunopathologic changes observed in gluten sensitivity is fundamentally a cell-mediated effect, the degree of change being controlled by host genetic factors. In becoming flat, it appears obligatory for the mucosa to evolve through the earlier Type 1 lesion in which crypt hypertrophy is a prominent response

Evidence For A Precessing Accretion Disk in the Nucleus of NGC 1097

We present new spectroscopic observations of the LINER (and now Seyfert 1) nucleus of NGC 1097, and discuss the evolution of its broad, double-peaked Balmer lines. When originally discovered in 1991, the red peak of the double-peaked H-alpha line was stronger than the blue, while by 1994 the H-alpha profile had become almost symmetric and the integrated line flux had decreased to half its original value. Our new spectrum, taken in 1996, shows that the broad, double-peaked lines have returned to almost their original strengths, the profiles of H-beta and H-alpha are identical to within errors, and the broad-line emitting region is unreddened. However, the profile of the Balmer lines is now such that the blue peak is stronger than the red, opposite to the asymmetry observed in 1991. Various models are considered for the observed behavior, all assuming that the emission lines originate in an accretion disk. We present a refined version of the precessing, planar, elliptical accretion ring model proposed by Storchi-Bergmann et al. and Eracleous et al. This model provides an acceptable fit to the line profiles. We also consider the possibility that the line profile evolution results from a precessing warp in the disk, induced by irradiation from the center, and show that the range of radii and precession time scales expected in this model are consistent with the observations. The sudden appearance of the "disk-like" broad line profiles in NGC 1097 could have resulted from the formation of a new accretion disk due to, for example, the tidal disruption of a star, or the illumination of a pre-existing disk by a transient ionizing source at the center of the disk.Comment: Accepted for publication in the Astrophysical Journal. TeX file with 5 postscript figures embeded using psfig.tex, 13 page

A Study of the Diverse T Dwarf Population Revealed by WISE

We report the discovery of 87 new T dwarfs uncovered with the Wide-field Infrared Survey Explorer (WISE) and three brown dwarfs with extremely red near-infrared colors that exhibit characteristics of both L and T dwarfs. Two of the new T dwarfs are likely binaries with L7+/-1 primaries and mid-type T secondaries. In addition, our follow-up program has confirmed 10 previously identified T dwarfs and four photometrically-selected L and T dwarf candidates in the literature. This sample, along with the previous WISE discoveries, triples the number of known brown dwarfs with spectral types later than T5. Using the WISE All-Sky Source Catalog we present updated color-color and color-type diagrams for all the WISE-discovered T and Y dwarfs. Near-infrared spectra of the new discoveries are presented, along with spectral classifications. To accommodate later T dwarfs we have modified the integrated flux method of determining spectral indices to instead use the median flux. Furthermore, a newly defined J-narrow index differentiates the early-type Y dwarfs from late-type T dwarfs based on the J-band continuum slope. The K/J indices for this expanded sample show that 32% of late-type T dwarfs have suppressed K-band flux and are blue relative to the spectral standards, while only 11% are redder than the standards. Comparison of the Y/J and K/J index to models suggests diverse atmospheric conditions and supports the possible re-emergence of clouds after the L/T transition. We also discuss peculiar brown dwarfs and candidates that were found not to be substellar, including two Young Stellar Objects and two Active Galactic Nuclei. The coolest WISE-discovered brown dwarfs are the closest of their type and will remain the only sample of their kind for many years to come.Comment: Accepted to ApJS on 15 January 2013; 99 pages in preprint format, 30 figures, 12 table

The Initial Mass Function and Disk Frequency of the Rho Ophiuchi Cloud: An Extinction-Limited Sample

We have completed an optical spectroscopic survey of an unbiased, extinction-limited sample of candidate young stars covering 1.3 square degrees of the Rho Ophiuchi star forming region. While infrared, X-ray, and optical surveys of the cloud have identified many young stellar objects (YSOs), these surveys are biased towards particular stages of stellar evolution and are not optimal for studies of the disk frequency and initial mass function.We have obtained over 300 optical spectra to help identify 135 association members based on the presence of H-alpha in emission, lithium absorption, X-ray emission, a mid-infrared excess, a common proper motion, reflection nebulosity, and/or extinction considerations. Spectral types along with R and I band photometry were used to derive effective temperatures and bolometric luminosities for association members to compare with theoretical tracks and isochrones for pre-main-sequence stars. An average age of 3.1 Myr is derived for this population which is intermediate between that of objects embedded in the cloud core of Rho Ophiuchi and low mass stars in the Upper Scorpius subgroup. Consistent with this age we find a circumstellar disk frequency of 27% plus or minus 5%. We also constructed an initial mass function for an extinction-limited sample of 123 YSOs (A_v less than or equal to 8 mag), which is consistent with the field star initial mass function for YSOs with masses > 0.2 M_sun. There may be a deficit of brown dwarfs but this result relies on completeness corrections and requires confirmation.Comment: 46 pages, 7 figures, 4 table

Detectors for the James Webb Space Telescope Near-Infrared Spectrograph I: Readout Mode, Noise Model, and Calibration Considerations

We describe how the James Webb Space Telescope (JWST) Near-Infrared Spectrograph's (NIRSpec's) detectors will be read out, and present a model of how noise scales with the number of multiple non-destructive reads sampling-up-the-ramp. We believe that this noise model, which is validated using real and simulated test data, is applicable to most astronomical near-infrared instruments. We describe some non-ideal behaviors that have been observed in engineering grade NIRSpec detectors, and demonstrate that they are unlikely to affect NIRSpec sensitivity, operations, or calibration. These include a HAWAII-2RG reset anomaly and random telegraph noise (RTN). Using real test data, we show that the reset anomaly is: (1) very nearly noiseless and (2) can be easily calibrated out. Likewise, we show that large-amplitude RTN affects only a small and fixed population of pixels. It can therefore be tracked using standard pixel operability maps.Comment: 55 pages, 10 figure

Double-Peaked Low-Ionization Emission Lines in Active Galactic Nuclei

We present a new sample of 116 double-peaked Balmer line Active Galactic Nuclei (AGN) selected from the Sloan Digital Sky Survey. Double-peaked emission lines are believed to originate in the accretion disks of AGN, a few hundred gravitational radii (Rg) from the supermassive black hole. We investigate the properties of the candidate disk emitters with respect to the full sample of AGN over the same redshifts, focusing on optical, radio and X-ray flux, broad line shapes and narrow line equivalent widths and line flux-ratios. We find that the disk-emitters have medium luminosities (~10^44erg/s) and FWHM on average six times broader than the AGN in the parent sample. The double-peaked AGN are 1.6 times more likely to be radio-sources and are predominantly (76%) radio quiet, with about 12% of the objects classified as LINERs. Statistical comparison of the observed double-peaked line profiles with those produced by axisymmetric and non-axisymmetric accretion disk models allows us to impose constraints on accretion disk parameters. The observed Halpha line profiles are consistent with accretion disks with inclinations smaller than 50 deg, surface emissivity slopes of 1.0-2.5, outer radii larger than ~2000 Rg, inner radii between 200-800Rg, and local turbulent broadening of 780-1800 km/s. The comparison suggests that 60% of accretion disks require some form of asymmetry (e.g., elliptical disks, warps, spiral shocks or hot spots).Comment: 60 pages, 19 figures, accepted for publication in AJ. For high quality figures and full tables, please see http://astro.princeton.edu/~iskra/disks.htm

IKK phosphorylates Huntingtin and targets it for degradation by the proteasome and lysosome

Expansion of the polyglutamine repeat within the protein Huntingtin (Htt) causes Huntington's disease, a neurodegenerative disease associated with aging and the accumulation of mutant Htt in diseased neurons. Understanding the mechanisms that influence Htt cellular degradation may target treatments designed to activate mutant Htt clearance pathways. We find that Htt is phosphorylated by the inflammatory kinase IKK, enhancing its normal clearance by the proteasome and lysosome. Phosphorylation of Htt regulates additional post-translational modifications, including Htt ubiquitination, SUMOylation, and acetylation, and increases Htt nuclear localization, cleavage, and clearance mediated by lysosomal-associated membrane protein 2A and Hsc70. We propose that IKK activates mutant Htt clearance until an age-related loss of proteasome/lysosome function promotes accumulation of toxic post-translationally modified mutant Htt. Thus, IKK activation may modulate mutant Htt neurotoxicity depending on the cell's ability to degrade the modified species