Global Alfven Eigenmodes in the H-1 heliac

Recent upgrades in H-1 power supplies have enabled the operation of the H-1 experiment at higher heating powers than previously attainable. A heating power scan in mixed hydrogen/helium plasmas reveals a change in mode activity with increasing heating power. At low power (<50 kW) modes with beta-induced Alfven eigenmode (BAE) frequency scaling are observed. At higher power modes consistent with an analysis of nonconventional Global Alfven Eigenmodes (GAEs) are observed, the subject of this work. We have computed the mode continuum, and identified GAE structures using the ideal MHD solver CKA and the gyrokinetic code EUTERPE. An analytic model for ICRH-heated minority ions is used to estimate the fast ion temperature from the hydrogen species. Linear growth rate scans using a local flux surface stability calculation, LGRO, are performed. These studies demonstrate growth from circulating particles whose speed is significantly less than the Alfven speed, and are resonant with the mode through harmonics of the Fourier decomposition of the strongly-shaped heliac magnetic field. They reveal drive is possible with a small, hot energetic tail of the hydrogen species. Local linear growth rate scans are also complemented with global calculations from CKA and EUTERPE. These qualitatively confirm the findings from the LGRO study, and show that the inclusion of finite Larmor radius effects can reduce the growth rate by a factor of three, but do not affect marginal stability. Finally, a study of damping of the global mode with the thermal plasma is conducted, computing continuum, and the damping arising from parallel electric fields. We find that continuum damping is of order 0.1% for the configuration studied. The inclusion of resistivity lifts the damping to 19%. Such large damping is consistent with experimental observations that in absence of drive the mode decays rapidly (~0.1 ms).Comment: 18 pages, 15 figures, submitted 07/04/2017 to Plasma Physics and Controlled Fusio

Enhancing task fMRI preprocessing via individualized model-based filtering of intrinsic activity dynamics

Brain responses recorded during fMRI are thought to reflect both rapid, stimulus-evoked activity and the propagation of spontaneous activity through brain networks. In the current work, we describe a method to improve the estimation of task-evoked brain activity by first filtering-out the intrinsic propagation of pre-event activity from the BOLD signal. We do so using Mesoscale Individualized NeuroDynamic (MINDy; Singh et al. 2020b) models built from individualized resting-state data to subtract the propagation of spontaneous activity from the task-fMRI signal (MINDy-based Filtering). After filtering, time-series are analyzed using conventional techniques. Results demonstrate that this simple operation significantly improves the statistical power and temporal precision of estimated group-level effects. Moreover, use of MINDy-based filtering increased the similarity of neural activation profiles and prediction accuracy of individual differences in behavior across tasks measuring the same construct (cognitive control). Thus, by subtracting the propagation of previous activity, we obtain better estimates of task-related neural effects

Using Cluster Abundances and Peculiar Velocities to Test the Gaussianity of the Cosmological Density Field

(Abridged) By comparing the frequency of typical events with that of unusual events, one can test whether the cosmological density distribution function is consistent with the normally made assumption of Gaussianity. To this end, we compare the consistency of the tail-inferred (from clusters) and measured values (from large-scale flows) of the rms level of mass fluctuations for two distribution functions: a Gaussian, and a texture (positively-skewed) PDF. Averaging the recent large-scale flow measurements, we find that observations of the rms and the tail at the 10 h^-1 Mpc scale disfavor a texture PDF at ~1.5 sigma in all cases. However, taking only the most recent measurement of the rms, that from Willick et al. (1997b), the comparison disfavors textures for low Omega_0=0.3, and disfavors Gaussian models if Omega_0=1 (again at ~1.5 sigma). Predictions for evolution of high temperature clusters can also be made for the models considered, and strongly disfavor Omega_0=1 in Gaussian models and marginally disfavor Omega_0=1 in texture models. Only Omega_0=0.3 Gaussian models are consistent with all the data considered.Comment: 34 pg incl. 8 embedded figures, LaTeX, aaspp4.sty, submitted to Ap

Investigation of the neural control of cough and cough suppression in humans using functional brain imaging

Excessive coughing is one of the mostcommonreasons for seeking medical advice, yet the available therapies for treating cough disorders are inadequate. Humans can voluntarily cough, choose to suppress their cough, and are acutely aware of an irritation that is present in their airways. This indicates a significant level of behavioral and conscious control over the basic cough reflex pathway. However, very little is known about the neural basis for higher brain regulation of coughing. The aim of the present study was to use functional brain imaging in healthy humans to describe the supramedullary control of cough and cough suppression. Our data show that the brain circuitry activated during coughing in response to capsaicin-evoked airways irritation is not simply a function of voluntarily initiated coughing and the perception of airways irritation. Rather, activations in several brain regions, including the posterior insula and posterior cingulate cortex, define the unique attributes of an evoked cough. Furthermore, the active suppression of irritant-evoked coughing is also associated with a unique pattern of brain activity, including an involvement of the anterior insula, anterior mid-cingulate cortex, and inferior frontal gyrus. These data demonstrate for the first time that evoked cough is not solely a brainstem-mediated reflex response to irritation of the airways, but rather requires active facilitation by cortical regions, and is further regulated by distinct higher order inhibitory processes. Copyright © 2011 the authors

The Effect of Medicaid Expansion on Utilization in Maryland Emergency Departments

Study objective A proposed benefit of expanding Medicaid eligibility under the Patient Protection and Affordable Care Act (ACA) was a reduction in emergency department (ED) utilization for primary care needs. Pre-ACA studies found that new Medicaid enrollees increased their ED utilization rates, but the effect on system-level ED visits was less clear. Our objective was to estimate the effect of Medicaid expansion on aggregate and individual-based ED utilization patterns within Maryland. Methods We performed a retrospective cross-sectional study of ED utilization patterns across Maryland, using data from Maryland’s Health Services Cost Review Commission. We also analyzed utilization differences between pre-ACA (July 2012 to December 2013) uninsuredpatients who returned post-ACA (July 2014 to December 2015). Results The total number of ED visits in Maryland decreased by 36,531 (–1.2%) between the 6 quarters pre-ACA and the 6 quarters post-ACA. Medicaid-covered ED visits increased from 23.3% to 28.9% (159,004 additional visits), whereas uninsured patient visits decreased from 16.3% to 10.4% (181,607 fewer visits). Coverage by other insurance types remained largely stable between periods. We found no significant relationship between Medicaid expansion and changes in ED volume by hospital. For patients uninsured pre-ACA who returned post-ACA, the adjusted visits per person during 6 quarters was 2.38 (95% confidence interval 2.35 to 2.40) for those newly enrolled in Medicaid post-ACA compared with 1.66 (95% confidence interval 1.64 to 1.68) for those remaining uninsured. Conclusion There was a substantial increase in patients covered by Medicaid in the post-ACA period, but this did not significantly affect total ED volume. Returning patients newly enrolled in Medicaid visited the ED more than their uninsured counterparts; however, this cohort accounted for only a small percentage of total ED visits in Maryland

Determination of the Baryon Density from Large Scale Galaxy Redshift Surveys

We estimate the degree to which the baryon density, $\Omega_{b}$, can be determined from the galaxy power spectrum measured from large scale galaxy redshift surveys, and in particular, the Sloan Digital Sky Survey. A high baryon density will cause wiggles to appear in the power spectrum, which should be observable at the current epoch. We assume linear theory on scales $\geq 20h^{-1}Mpc$ and do not include the effects of redshift distortions, evolution, or biasing. With an optimum estimate of $P(k)$ to $k\sim 2\pi/(20 h^{-1} Mpc)$, the $1 \sigma$ uncertainties in $\Omega_{b}$ are roughly 0.07 and 0.016 in flat and open ($\Omega_{0}=0.3$) cosmological models, respectively. This result suggests that it should be possible to test for consistency with big bang nucleosynthesis estimates of $\Omega_{b}$ if we live in an open universe.Comment: 23 Pages, 10 Postscript figure

Rheumatoid Arthritis Naive T Cells Share Hypermethylation Sites With Synoviocytes.

ObjectiveTo determine whether differentially methylated CpGs in synovium-derived fibroblast-like synoviocytes (FLS) of patients with rheumatoid arthritis (RA) were also differentially methylated in RA peripheral blood (PB) samples.MethodsFor this study, 371 genome-wide DNA methylation profiles were measured using Illumina HumanMethylation450 BeadChips in PB samples from 63 patients with RA and 31 unaffected control subjects, specifically in the cell subsets of CD14+ monocytes, CD19+ B cells, CD4+ memory T cells, and CD4+ naive T cells.ResultsOf 5,532 hypermethylated FLS candidate CpGs, 1,056 were hypermethylated in CD4+ naive T cells from RA PB compared to control PB. In analyses of a second set of CpG candidates based on single-nucleotide polymorphisms from a genome-wide association study of RA, 1 significantly hypermethylated CpG in CD4+ memory T cells and 18 significant CpGs (6 hypomethylated, 12 hypermethylated) in CD4+ naive T cells were found. A prediction score based on the hypermethylated FLS candidates had an area under the curve of 0.73 for association with RA case status, which compared favorably to the association of RA with the HLA-DRB1 shared epitope risk allele and with a validated RA genetic risk score.ConclusionFLS-representative DNA methylation signatures derived from the PB may prove to be valuable biomarkers for the risk of RA or for disease status

The ISLANDS project I: Andromeda XVI, An Extremely Low Mass Galaxy not Quenched by Reionization

Based on data aquired in 13 orbits of HST time, we present a detailed evolutionary history of the M31 dSph satellite Andromeda XVI, including its life-time star formation history, the spatial distribution of its stellar populations, and the properties of its variable stars. And XVI is characterized by prolonged star formation activity from the oldest epochs until star formation was quenched ~6 Gyr ago, and, notably, only half of the mass in stars of And XVI was in place 10 Gyr ago. And XVI appears to be a low mass galaxy for which the early quenching by either reionization or starburst feedback seems highly unlikely, and thus, is most likely due to an environmental effect (e.g., an interaction), possibly connected to a late infall in the densest regions of the Local Group. Studying the star formation history as a function of galactocentric radius, we detect a mild gradient in the star formation history: the star formation activity between 6 and 8 Gyr ago is significantly stronger in the central regions than in the external regions, although the quenching age appears to be the same, within 1 Gyr. We also report the discovery of 9 RR Lyrae stars, 8 of which belong to And XVI. The RR Lyrae stars allow a new estimate of the distance, (m-M)0= 23.72+/-0.09 mag, which is marginally larger than previous estimates based on the tip of the red giant branch.Comment: Accepted for publication on Ap

Parametric flutter studies of an arrow-wing configuration: Some early results

Some early experimental results from a combined experimental and analytical study being conducted at NASA-Langley of the transonic flutter characterisitics of a generic arrow wing configuration are presented. The planned study includes the parametric variation of a variety of structural and geometric characteristics. Presented here are flutter results of the basic arrow wing, for the basic wing with the addition of two simulated lower-surface-mounted engine nacelles, and for the basic wing with the addition of both the fin and the engine nacelles