Maximal Height Scaling of Kinetically Growing Surfaces

The scaling properties of the maximal height of a growing self-affine surface with a lateral extent $L$ are considered. In the late-time regime its value measured relative to the evolving average height scales like the roughness: $h^{*}_{L} \sim L^{\alpha}$. For large values its distribution obeys $\log{P(h^{*}_{L})} \sim -A({h^{*}_{L}}/L^{\alpha})^{a}$, charaterized by the exponential-tail exponent $a$. In the early-time regime where the roughness grows as $t^{\beta}$, we find $h^{*}_{L} \sim t^{\beta}[\ln{L}-({\beta\over \alpha})\ln{t} + C]^{1/b}$ where either $b=a$ or $b$ is the corresponding exponent of the velocity distribution. These properties are derived from scaling and extreme-values arguments. They are corroborated by numerical simulations and supported by exact results for surfaces in 1D with the asymptotic behavior of a Brownian path.Comment: One reference added. Minor stylistic changes in the abstarct and the paper. 4 pages, 3 figure

Prosthesis Prescription Protocol of the Arm (PPP-Arm):The implementation of a national prosthesis prescription protocol

Background and aim: In order to create more uniformity in the prescription of upper limb prostheses by Dutch rehabilitation teams, the development and implementation of a Prosthesis Prescription Protocol of the upper limb (PPP-Arm) was initiated. The aim was to create a national digital protocol to structure, underpin, and evaluate the prescription of upper limb prostheses for clients with acquired or congenital arm defects. Technique: Prosthesis Prescription Protocol of the Arm (PPP-Arm) was developed on the basis of the International Classification of Functioning and consisted of several layers. All stakeholders (rehabilitation teams, orthopedic workshops, patients, and insurance companies) were involved in development and implementation. A national project coordinator and knowledge brokers in each team were essential for the project. Discussion: PPP-Arm was successfully developed and implemented in nine Dutch rehabilitation teams. The protocol improved team collaboration, structure, and completeness of prosthesis prescriptions and treatment uniformity and might be interesting for other countries as well

Patočka ve Deleuze Felsefesinde Asubjektif ve Kişisel Olmayan

Deleuze’ün kişisel olmayan ve asubjektif (ilk anlamıyla, göreceli olmayan) felsefesi onun anti-fenomolojik olduğu iddiasına yol açan nedenlerden biridir. Ancak, Patočka tarafından tartışıldığı gibi; fenomoloji, zaten, asubjektiftir. Bu durum Deleuze tarafından geliştirilen deneyleme (yaşantılama) felsefesinin asubjektif bir fenomenoloji olabileceği ihtimalini yeniden değerlendirmenin yolunu açar. Burada karşımıza çıkan; Patočka’nın kişisel deneylemesinden (yaşantılamasından) Deleuze’ün kişisel-olmayan deneyleme yoluyla farklılaştığıdır. Bu noktada; kişisel-olmayan, asubjektif bir fenomenolojinin Deleuze’ün çalışmalarında yer bulup bulmadığını merak etmekteyiz. Bu amaçla öncelikle Patočka’nın Husserl’e karşı geliştirdiği ve fenomenolojiyi “egosal-subjektiften uzaklaştırmanın” sebeplerini araştırmaktayız. Özet olarak; Patočka, öznelliğin verili bir fenomen olmadığını ve fenomolojinin asıl derdinin de bu olmadığını ileri sürer. Böyle bir dolaysız deneyleme (yaşantılama) araştırması aşkınsal öznellik yerine dünyamıza uyguladığımız bir “delme kuvvetini”, (Patočka’nın deyimiyle) bir thrust’ı açığa çıkarır. Benzer biçimde Deleuze’ün deneyleme (yaşantılama) felsefesi de böyle bir self-dışı hareketi, Ferlinghetti’nin “dördüncü tekil şahıs” kavramına olan atfı yoluyla gördüğümüz bu hareketi, araştırır. Hatta Deleuze’ün Peircie’çı “Sıfırıncılık” kavramı da buna delil teşkil eder. Patočka’dan farklı olarak; Deleuze’de, kişi-lik deneyimin temeline konumlandırılmaz, onun çalışmalarında kişisel-olmayan bir deneycilik, paneksperiantalizm vardır

GABA transporter function, oligomerization state, and anchoring: correlates with subcellularly resolved FRET

The mouse γ-aminobutyric acid (GABA) transporter mGAT1 was expressed in neuroblastoma 2a cells. 19 mGAT1 designs incorporating fluorescent proteins were functionally characterized by [^3H]GABA uptake in assays that responded to several experimental variables, including the mutations and pharmacological manipulation of the cytoskeleton. Oligomerization and subsequent trafficking of mGAT1 were studied in several subcellular regions of live cells using localized fluorescence, acceptor photobleach Förster resonance energy transfer (FRET), and pixel-by-pixel analysis of normalized FRET (NFRET) images. Nine constructs were functionally indistinguishable from wild-type mGAT1 and provided information about normal mGAT1 assembly and trafficking. The remainder had compromised [^3H]GABA uptake due to observable oligomerization and/or trafficking deficits; the data help to determine regions of mGAT1 sequence involved in these processes. Acceptor photobleach FRET detected mGAT1 oligomerization, but richer information was obtained from analyzing the distribution of all-pixel NFRET amplitudes. We also analyzed such distributions restricted to cellular subregions. Distributions were fit to either two or three Gaussian components. Two of the components, present for all mGAT1 constructs that oligomerized, may represent dimers and high-order oligomers (probably tetramers), respectively. Only wild-type functioning constructs displayed three components; the additional component apparently had the highest mean NFRET amplitude. Near the cell periphery, wild-type functioning constructs displayed the highest NFRET. In this subregion, the highest NFRET component represented ~30% of all pixels, similar to the percentage of mGAT1 from the acutely recycling pool resident in the plasma membrane in the basal state. Blocking the mGAT1 C terminus postsynaptic density 95/discs large/zona occludens 1 (PDZ)-interacting domain abolished the highest amplitude component from the NFRET distributions. Disrupting the actin cytoskeleton in cells expressing wild-type functioning transporters moved the highest amplitude component from the cell periphery to perinuclear regions. Thus, pixel-by-pixel NFRET analysis resolved three distinct forms of GAT1: dimers, high-order oligomers, and transporters associated via PDZ-mediated interactions with the actin cytoskeleton and/or with the exocyst

Teaching Writing in Online Distance Education: Supporting Student Success

An intervention is a counseling action an instructor may use to support a student who struggles to work productively in an online writing instruction (OWI) course. Interventions may increase retention and graduation rates at institutions as well as increase student and teacher satisfaction (Allen, Bourhis, Burrell, and Mabry, 2002; Archambault and Crippen, 2009; McCombs, Ufnar, and Shepherd, 2007; O'Dwyer, Carey, and Kleiman, 2007; Stein, Wanstreet, Calvin, Overtoom, and Wheaton, 2005; Sun, Tsai, Finger, Chen, and Yeh, 2008). In Moore's (1993) Theory of Transaction Distance, interventions are called "advice and counsel," and they are a crucial component of the program structure element in the theory. Many researchers recommend early identification and intervention for struggling students (Archambault et al., 2010; Simpson, 2004). For example, Simpson (2004) found that early interventions following Keller's (1987) ARCS model (Attention, Relevance, Confidence and Satisfaction) were effective in helping students complete a course. In addition, Simpson found that such interventions could be cost effective; however, there are many open variables when calculating cost. As researchers and online instructors, the authors recommend early intervention activities performed by email and text messaging at many opportunistic intervention points during the course of the instruction. As well, developing an intervention strategy prior to course beginning to assist in planning and preparation is advocated and recommended

A capability approach for online primary and secondary students with disabilities

A capability approach was used to identify and synthesise research studies about online students with disabilities in primary and secondary school (aged five to 18 years) in an attempt to describe the experience from an empirical perspective. A capability approach is intended to maximise agency and can be used to describe the extent to which individuals are able to use limited resources to build a satisfying and enjoyable life. In this analysis, a derived capability set was used to narrow the larger body of research about primary and secondary students in online education in order to consider only studies that described ways in which students successfully used online education to maximise agency. The derived capability set was: autonomy, judgement, practical reason, affiliation, high school graduation and a desire to help others. A method for deriving the capability set and ways in which a capability approach fails to describe this experience are discussed

Intervention in Online Writing Instruction: An Action-theoretical Perspective

This analysis argues for an interwoven perspective of motivation, engagement, agency, and action in Online Writing Instruction (OWI) compiled from shared elements of empirical research in online education, writing instruction, and especially student academic engagement in traditional classrooms, where the research domain is comparatively mature. Engagement is the common element shared by these domains. In online education research, engagement is sometimes understood through intentional student actions. In writing instruction, engagement is commonly understood through human agency. In academic settings, engagement can be seen as a foundational part of Self-Determination Theory, which is comprised of cognitive, behavioral, and emotional engagement (Deci and Ryan, 1985). Educators often find measures of engagement valuable because they are reliable predictors of student outcomes, and they suggest a reasonable point of intervention for struggling students. A measure of agentic engagement, which describes the extent to which a student exerts agency to personalize a learning experience, could add value to measures of engagement, especially in OWI where actions and agency are integral to student success. In addition, a focus on engagement and intervention/remediation may offer an opportunity for students to succeed in learning online, not just in OWI, which is a valued skill in the workplace

Understanding Online Teacher Best Practices: A Thematic Analysis to Improve Learning

The purpose of this study was to examine brick-and-mortar and online teacher best practice themes using thematic analysis and a newly developed theory-based analytic process entitled Synthesized Thematic Analysis Criteria (STAC). The STAC was developed to facilitate the meaningful thematic analysis of research based best practices of K-12 education delivery options. In the study, data for the thematic analysis consisted of published research about best practices in both brick-and-mortar and online education. The use of both brick-and-mortar as well as online teacher best practices provided an opportunity to identify commonalities among these modes of delivery. Based on these commonalities, the thematic analysis detected emergent themes, which could be used as a foundation upon which online teachers might build specialized practice. As well, research-validated teacher best practice themes generated from this study may be considered a starting point for defining teacher best practices in online education and for their development. Emergent themes were discussed in the context of the data and the environment of online education. The STAC analytic process provides a foundation for analysis and may be used by researchers for other thematic analyses in the future

Autoreactive T Cells in Human Smokers is Predictive of Clinical Outcome

Cross-sectional studies have suggested a role for activation of adaptive immunity in smokers with emphysema, but the clinical application of these findings has not been explored. Here we examined the utility of detecting autoreactive T cells as a screening tool for emphysema in an at-risk population of smokers. We followed 156 former and current (ever)-smokers for 2 years to assess whether peripheral blood CD4 T cell cytokine responses to lung elastin fragments (EFs) could discriminate between those with and without emphysema, and to evaluate the relevance of autoreactive T cells to predict changes during follow-up in lung physiological parameters. Volunteers underwent baseline complete phenotypic assessment with pulmonary function tests, quantitative chest CT, yearly 6-min walk distance (6MWD) testing, and annual measurement of CD4 T cell cytokine responses to EFs. The areas under the receiver operating characteristic curve to predict emphysema for interferon gamma (IFN-γ), and interleukin 6 (IL-6) responses to EFs were 0.81 (95% CI of 0.74–0.88) and 0.79 (95% CI of 0.72–0.86) respectively. We developed a dual cytokine enzyme-linked immunocell spot assay, the γ-6 Spot, using CD4 T cell IFN-γ and IL-6 responses and found that it discriminated emphysema with 90% sensitivity. After adjusting for potential confounders, the presence of autoreactive T cells was predictive of a decrease in 6MWD over 2 years (decline in 6MWD, −19 m per fold change in IFN-γ; P = 0.026, and −26 m per fold change in IL-6; P = 0.003). In support of the human association studies, we cloned CD4 T cells with characteristic T helper (Th)1 and Th17 responses to EFs in the peripheral blood of ever-smokers with emphysema, confirming antigenicity of lung elastin in this population. These findings collectively suggest that the EF-specific autoreactive CD4 T cell assay, γ-6 Spot, could provide a non-invasive diagnostic tool with potential application to large-scale screening to discriminate emphysema in ever-smokers, and predict early relevant physiological outcomes in those at risk