Development of the mathematical model for surface topography quality determination at the end milling process

As a metal machining process, end milling is the most widely used processes in industry. One of the most important indicators of success in finishing operation is the estetic quality of the surface that is directly connected to the maximal height of uneven surfaces, namely rougness. In process of milling the quality of the machined surface depends of many factors, for example, tool geometry, cutter parallel axis offset and cutter axis tilt, tool deflection due to cutting forces, tool and work piece vibrations etc. This paper presents the development of mathematical model for the determination of the quality of the machined surface topography. The model starts from an ideal trochoid point trajectory on the cutting edge tooth end mill, and then inserts the deviations due to cutter parallel axis offset and cutter axis tilt and gives instructions for the input of other factors that influence on the machined surface quality. Also it compares the values of maximal roughness height with different mill axis positions, and on different mill cross section heights, as well as the differences at up and down milling

Extension of two minimax theorems of S. Park

In this paper we prove two general minimax theorems which gen- eralize famous classical saddle point theorems of M. Sion [6] and J. von Neu- mann. Our theorems also include some results of S. Park [3]-[5]. Results of this type have many applications in the Game theory, because they gives existence of solution of zero sums games

On entropy of probability integral transformed time series

Abstract The goal of this paper is to investigate the changes of entropy estimates when the amplitude distribution of the time series is equalized using the probability integral transformation. The data we analyzed were with known properties—pseudo-random signals with known distributions, mutually coupled using statistical or deterministic methods that include generators of statistically dependent distributions, linear and non-linear transforms, and deterministic chaos. The signal pairs were coupled using a correlation coefficient ranging from zero to one. The dependence of the signal samples is achieved by moving average filter and non-linear equations. The applied coupling methods are checked using statistical tests for correlation. The changes in signal regularity are checked by a multifractal spectrum. The probability integral transformation is then applied to cardiovascular time series—systolic blood pressure and pulse interval—acquired from the laboratory animals and represented the results of entropy estimations. We derived an expression for the reference value of entropy in the probability integral transformed signals. We also experimentally evaluated the reliability of entropy estimates concerning the matching probabilities

Novi izazovi u oplemenjivanju voćaka

The exciting challenge for all breeders is to release cultivars which the market wants and which can produce a profit for the growers. They have done it in the past and they will continue to do it in the future. Today's fruit breeding program are interrelated with other research disciplines. The complex, dynamic and interdisciplinary interactions require innovative approaches, including modern tools and techniques. The most important areas of collaboration are: database management, genetics, phytopathology entomology, ecology, physiology, molecular biology, fruit quality and sensory perception. Breeders also need to be aware of modern fruit marketing and consumer requirements. The complexity of tasks in modern fruit breeding sometimes leads to the specialization of particular breeding program and a dynamic interaction between complementary programs. Responses from fruit breeders about genetic transformation ranged from strongly negative to actively positive. Fruit breeders are constantly challenged to consider new tools and technology to increase the efficiency of their programs.Generalni, najvažniji izazov oplemenjivačkog rada je stvaranje novih sorti koje će prihvatiti tržište i koje donose profit proizvođačima. Selekcioneri su uspešno ispunjavali ove najviše ciljeve do sada i nema sumnje da će nastaviti da to rade i ubuduće. Današnji oplemenjivački programi su interdisciplinarni. Kompleksnost, dinamičan razvoj i interdisciplinarna interakcija zahtevaju nove prilaze, inventivne i dobro obučene kadrove savremene metode i opremljenost laboratorija. Najvažnije oblasti saradnje predstavljaju baze podataka, genetika, fitopatologija, entomologija fiziologija, ekologija, molekularna biologija, mehanizacija proizvodnje kvalitet ploda i senzorsko ocenjivanje. Oplemenjivači moraju biti svesni modernih zahteva tržišta i potrošača. Kompleksnost ciljeva vrlo često vodi ka specijalizaciji pojedinih oplemenjivačkih programa i dinamičkoj interakciji komplementarnih programa. Odnos oplemenjivača prema genetički modifikovanim organizmima ide od negativnog do pozitivnog. Stalan izazov pred naučnim radnicima je spoznaja novih metoda i tehnologija kako bi unapredili efikasnost svojih oplemenjivačkih programa

Komparativna analiza tumora sjemenika pasa upotrebom histopatološke pretrage i metodom protočne citometrije

Tumori sjemenika pasa najčešći su tumori spolnog sustava te među najčešćim tumorima pasa uopće. Većinom se dijagnosticiraju u kasnijoj fazi, kada dođe do povećanja sjemenika, te se u svrhu liječenja obavlja kastracija nakon koje se postavlja dijagnoza na temelju histopatološke pretrage. U ovom je istraživanju provedena histopatološka analiza i klasifikacija arhiviranih uzoraka najčešćih tumora sjemenika pasa (9 uzoraka) i jednog uzorka nepromijenjenog sjemenika, te je provedena analiza DNK metodom protočne citometrije. Provedenom komparativnom analizom nastojala se utvrditi korelacija između tipova tumora i rezultata protočne citometrije, tj. jesu li promjene u genetičkim ili fizikalnim svojstvima tumorskih stanica povezane s histološkim tipom tumora. Utvrđeno je da je histopatološka pretraga objektivna dijagnostička metoda za razlikovanje pojedinih tipova tumora sjemenika u pasa. Dobiveni rezultati protočne citometrije, iako nisu bili dostatni i dovoljno precizni za donošenje definitivnog zaključka o karakteristikama istraživanih neoplastičnih promjena, pokazuju da je primjenom protočne citometrije na uzorcima sjemenika pasa moguće dobiti nove informacije o svojstvima stanica. Kako bi se protočna citometrija i njezini rezultati mogli objektivnije analizirati te koristiti u dijagnostici neoplazija testisa u pasa, potrebno je optimizirati i standardizirati metodu te postaviti detaljne dijagnostičke kriterije, za što je potrebno provesti istraživanje na znatno većem broju uzoraka tumorozno promijenjenih i patološki nepromijenjenih sjemenika. Metoda protočne citometrije može pomoći u dijagnostici tumora sjemenika pasa, osobito ako je kombinirana s do sada uhodanim metodama pretrage kao što je histopatološka analiza tumora sjemenika

Komparativna analiza tumora sjemenika pasa upotrebom histopatološke pretrage i metodom protočne citometrije

Tumori sjemenika pasa najčešći su tumori spolnog sustava te među najčešćim tumorima pasa uopće. Većinom se dijagnosticiraju u kasnijoj fazi, kada dođe do povećanja sjemenika, te se u svrhu liječenja obavlja kastracija nakon koje se postavlja dijagnoza na temelju histopatološke pretrage. U ovom je istraživanju provedena histopatološka analiza i klasifikacija arhiviranih uzoraka najčešćih tumora sjemenika pasa (9 uzoraka) i jednog uzorka nepromijenjenog sjemenika, te je provedena analiza DNK metodom protočne citometrije. Provedenom komparativnom analizom nastojala se utvrditi korelacija između tipova tumora i rezultata protočne citometrije, tj. jesu li promjene u genetičkim ili fizikalnim svojstvima tumorskih stanica povezane s histološkim tipom tumora. Utvrđeno je da je histopatološka pretraga objektivna dijagnostička metoda za razlikovanje pojedinih tipova tumora sjemenika u pasa. Dobiveni rezultati protočne citometrije, iako nisu bili dostatni i dovoljno precizni za donošenje definitivnog zaključka o karakteristikama istraživanih neoplastičnih promjena, pokazuju da je primjenom protočne citometrije na uzorcima sjemenika pasa moguće dobiti nove informacije o svojstvima stanica. Kako bi se protočna citometrija i njezini rezultati mogli objektivnije analizirati te koristiti u dijagnostici neoplazija testisa u pasa, potrebno je optimizirati i standardizirati metodu te postaviti detaljne dijagnostičke kriterije, za što je potrebno provesti istraživanje na znatno većem broju uzoraka tumorozno promijenjenih i patološki nepromijenjenih sjemenika. Metoda protočne citometrije može pomoći u dijagnostici tumora sjemenika pasa, osobito ako je kombinirana s do sada uhodanim metodama pretrage kao što je histopatološka analiza tumora sjemenika

On the convergence of Ishikawa iterates defined by nonlinear quasi-contractions

In this study, we establish the convergence of Ishikawa iterates defined by nonlinear quasicontractive mappings on TVS-cone metric space. Further, our results generalize many existing results in the literature

Chemosensory Responses to the Repellent Nepeta Essential Oil and Its Major Component Nepetalactone by Aedes aegypti (Diptera: Culicidae), a Vector of Zika Virus

Nepeta essential oil (Neo; catnip) and its major component, nepetalactone, have long been known to repel insects including mosquitoes. However, the neural mechanisms through which these repellents are detected by mosquitoes, including the yellow fever mosquito Aedes aegypti (L.), an important vector of Zika virus, were poorly understood. Here we show that Neo volatiles activate olfactory receptor neurons within the basiconic sensilla on the maxillary palps of female Ae. aegypti. A gustatory receptor neuron sensitive to the feeding deterrent quinine and housed within sensilla on the labella of females was activated by both Neo and nepetalactone. Activity of a second gustatory receptor neuron sensitive to the feeding stimulant sucrose was suppressed by both repellents. Our results provide neural pathways for the reported spatial repellency and feeding deterrence of these repell ents. A better understanding of the neural input through which female mosquitoes make decisions to feed will facilitate design of new repellents and management strategies involving their use.The final publication is now available at: [https://doi.org/10.1093/jme/tjx059

The First Report of mcr-1-Carrying Escherichia coli Originating from Animals in Serbia

The aim of this study was continuous monitoring of the presence of mcr-1 to mcr-5 genes in Enterobacterales isolated from cattle, pigs, and domestic poultry at intensive breeding facilities in Northern Vojvodina, Serbia, from 1 January 1 to 1 October 2020. Out of 2167 examined samples, mcr-1 was observed in five E. coli isolates originating from healthy turkeys. Four isolates belonged to the phylogenetic group B1, and one isolate to the phylogenetic group A. Detected E. coli serogenotypes (somatic O and flagellar H antigens) were O8:H25 and O29:H25. Core-genome multi-locus sequence typing (cgMLST) revealed three ST58 isolates clustering together in Clonal Complex (CC) 155 and two singletons of ST641-CC86 and ST410-CC23, respectively. Clonotyping revealed CH4-32 (n = 3), CH6-53 (n = 1) and CH4-24 (n = 1). In all isolates, the mcr-1 gene was located on a large IncX4 replicon type plasmid. Eight virulence-associated genes (VAGs) typical of avian pathogenic E. coli (APEC) (fyuA, fimH, hlyF, iss, ompT, sitA, traT, iroN) were detected in four isolates. These isolates were investigated for susceptibility to four biocides and revealed MIC values of 0.125% for glutardialdehyde, of 0.00003–0.00006% for chlorohexidine, of 4–6% for isopropanol and of 0.001–0.002% for benzalkonium chloride. All obtained MIC values of the tested biocides were comparable to the reference strain, with no indication of possible resistance. This is the first report of mcr-1.1-carrying E. coli from Serbia. Although only samples from turkeys were mcr-positive in this study, continuous monitoring of livestock samples is advised to prevent a spill-over from animals to humans