Efficacy and safety of menopausal hormone therapy on women with Human Immunodeficiency Virus Infection: a systematic review

Abstracts: 30th Annual Meeting of The North America Menopause Society September 25 – 28, 2019, Chicago, IL. P-41 Human immunodeficiency virus (HIV) infection is a relevant worldwide public health issue. Current, due to highly active antiretroviral therapy (HAART), most infected women reach mid-age, stage were estrogen deficiency changes occurs. An important proportion of these women develop premature menopause..

Menopausal symptoms are associated with non-adherence to highly active antiretroviral therapy in human immunodeficiency virus-infected middle-aged women

Objective: This study aimed to evaluate the association between the intensity of menopausal symptoms and highly active antiretroviral therapy (HAART) adherence in middle-aged women with human immunodeficiency virus (HIV) infection. Methods: In this cross-sectional study, 313 Peruvian women with HIV infection (age 40-59 years) were surveyed and classified as adherent or non-adherent to HAART based on the Antiretroviral Treatment Adherence Evaluation Questionnaire. The intensity of menopausal symptoms was assessed with the Menopause Rating Scale, and categorized as none, mild, moderate, and/or severe. Age, sexual orientation, used HAART scheme, time since HIV diagnosis, menopausal status, risk of depression, and presence of comorbidities were also assessed. Poisson generalized linear models with robust variance were performed in order to estimate crude prevalence ratios (PRs) and adjusted PRs using statistical (a1PR) and epidemiological criteria (a2PR). Results: A total of 19.9%, 32.6%, and 15.0% of all women presented mild, moderate, and severe menopausal symptoms, respectively. Overall, 70.6% women were non-adherent to HAART. The probability of non-adherence was higher in women with mild, moderate, and severe symptoms as compared to asymptomatic women in the non-adjusted model (PR: 1.79, 95% confidence interval [CI]: 1.39–2.29; PR: 1.76, 95% CI: 1.38–2.23; and PR: 2.07, 95% CI: 1.64–2.61, respectively) and the adjusted model. Conclusion: The severity of menopausal symptoms was associated with HAART non-adherence in HIV-infected middle-aged women.Revisión por pare

Cost-effectiveness analysis of 10- and 13-valent pneumococcal conjugate vaccines in Peru

This study was made possible through the financial support of the Instituto Nacional de Salud (National Institute of Health, Lima, Peru) and the PROVAC Initiative of the Pan American Health Organization (Washington, DC, USA). This study was presented at 9th International Symposium of Pneumococci and Pneumococcal Diseases, Hyderabad, India, March 2014, and supported by the National Council of Science, Technology and Technological Innovation of Peru (CONCYTEC) and International Clinical Epidemiology Network (INCLEN Trust).Consejo Nacional de Ciencia, Tecnología e Innovación Tecnológica - Concyte

Decline in sexuality and wellbeing in older adults: a population-based study

Background: Age-related declines in sexuality and increase in mental health complications have been well documented. However, whether these two phenomena are related has not been explored. The present study therefore aimed to investigate associations between a decline in sexuality and markers of mental health and wellbeing. Method: Data were collected in 2012/13 from 2,614 men and 3,217 women participating in the English Longitudinal Study of Ageing, a population-representative panel study of older adults (≥50y). Past-year declines in sexual desire, frequency of sexual activities, and sexual function were self-reported. Three markers of wellbeing (depressive symptoms, quality of life and life satisfaction) were assessed using validated scales. Associations between declines in sexuality and wellbeing were analysed using one-way independent analyses of variance, adjusted for a range of socio-demographic and health-related covariates. Results: Men and women who reported a past-year decline in sexual desire or frequency of sexual activities had a higher number of depressive symptoms (desire p=0.001, frequency p<0.001) and lower quality of life (all p<0.001). Decline in sexual desire was also associated with lower life satisfaction in men (p=0.012) and decline in frequency of sexual activities was associated with lower life satisfaction in women (p<0.001). Declines in erectile function in men and ability to become sexually aroused in women were also significantly associated with more depressive symptoms (p<0.001), lower quality of life (p<0.001) and lower life satisfaction (p<0.001 in men, p=0.024 in women). Conclusion: Older adults who experience a decline in sexuality report poorer wellbeing than those who do not

Prevalence and risk factors of the female sexual dysfunction in a sample of infertile Iranian women

Background Infertility has a major impact on women’s quality of life and emotional well-being. The resulting interpersonal problems extend to women’s sexual relationships, with a high proportion of infertile women reporting sexual problems. Aim To determine the prevalence and identify the potential risk factors of female sexual dysfunction (FSD) among infertile Iranian women. Methods Using a cross-sectional study design including 12 infertility clinics in five Iranian cities, FSD was assessed in 604 infertile women using the culturally adapted, multidimensional Female Sexual Function Index (IV-FSFI). Depression, anxiety and health-related quality of life (HRQL) were also assessed for all infertile patients. Depression and anxiety were assessed with the Hospital Anxiety and Depression Scale (HADS) while HRQL was measured using the Short Form 36 (SF-36).Main outcome measure Prevalence of FSD in infertile women and associated factors. Results Infertile women reported significantly lower scores on the FSFI domains in comparison with healthy women. Risk factors for FSD as determined by multilevel analyses were older age and self-reported depression. Furthermore, secondary infertility, lower educational level and higher partner education put women at increased risk for FSD. Conclusions Among infertile women, sexual dysfunctions seem to be prevalent higher than previously published in Iran. This finding may have implications on the clinical assessment of sexual function and the role of demographic and psychological factors in infertile women