8,736 research outputs found
Effective Holographic Theories for low-temperature condensed matter systems
The IR dynamics of effective holographic theories capturing the interplay
between charge density and the leading relevant scalar operator at strong
coupling are analyzed. Such theories are parameterized by two real exponents
that control the IR dynamics. By studying the thermodynamics,
spectra and conductivities of several classes of charged dilatonic black hole
solutions that include the charge density back reaction fully, the landscape of
such theories in view of condensed matter applications is characterized.
Several regions of the plane can be excluded as the extremal
solutions have unacceptable singularities. The classical solutions have
generically zero entropy at zero temperature, except when where
the entropy at extremality is finite. The general scaling of DC resistivity
with temperature at low temperature, and AC conductivity at low frequency and
temperature across the whole plane, is found. There is a
codimension-one region where the DC resistivity is linear in the temperature.
For massive carriers, it is shown that when the scalar operator is not the
dilaton, the DC resistivity scales as the heat capacity (and entropy) for
planar (3d) systems. Regions are identified where the theory at finite density
is a Mott-like insulator at T=0. We also find that at low enough temperatures
the entropy due to the charge carriers is generically larger than at zero
charge density.Comment: (v3): Added discussion on the UV completion of the solutions, and on
extremal spectra in the charged case. Expanded discusion on insulating
extremal solutions. Many other refinements and corrections. 126 pages. 48
figure
Production of mesons in proton-proton collisions
The cross section for the production of mesons in proton-proton
collisions has been measured in a previously unexplored region of incident
energies. Cross sections were extracted at 92 MeV and 173 MeV excess energy,
respectively. The angular distribution of the at =173 MeV is
strongly anisotropic, demonstrating the importance of partial waves beyond pure
s-wave production at this energy.Comment: 12 pages, 4 figures submitted to Physics Letters B v2: figure 1
added, discussion detailing the data analysis, figure 3 (fig. 2 in v1)
modified in line styles and systematic errors displayed on dat
Measurement of the Eta Production in Proton Proton Collisions with the COSY Time of Flight Spectrometer
The reaction pp -> pp eta was measured at excess energies of 15 and 41 MeV at
an external target of the Juelich Cooler Synchrotron COSY with the Time of
Flight Spectrometer. About 25000 events were measured for the excess energy of
15 MeV and about 8000 for 41 MeV. Both protons of the process pp eta were
detected with an acceptance of nearly 100% and the eta was reconstructed by the
missing mass technique. For both excess energies the angular distributions are
found to be nearly isotropic. In the invariant mass distributions strong
deviations from the pure phase space distributions are seen.Comment: 15 pages, 14 figures, 4 table
Glulisine Versus Human Regular Insulin in Combination With Glargine in Noncritically Ill Hospitalized Patients With Type 2 Diabetes: A randomized double-blind study
Single \pi^- production in np collisions for excess energies up to 90 MeV
The quasifree reaction np\to pp\pim was studied in a kinematically complete
experiment by bombarding a liquid hydrogen target with a deuteron beam of
momentum 1.85 GeV/c and analyzing the data along the lines of the spectator
model. In addition to the three charged ejectiles the spectator proton was also
detected in the large-acceptance time-of-flight spectrometer COSY-TOF. It was
identified by its momentum and flight direction thus yielding access to the
Fermi motion of the bound neutron and to the effective neutron 4-momentum
vector which differed from event to event. A range of almost 90
MeV excess energy above threshold was covered. Energy dependent angular
distributions, invariant mass spectra as well as fully covered Dalitz plots
were deduced. Sizeable FSI effects were found as were contributions of
and partial waves. The behavior of the elementary cross section
close to threshold is discussed in view of new cross section
data. In comparison with existing literature data the results provide a
sensitive test of the spectator model.Comment: 21 pages, 9 figures, 4 tables, submitted to EPJ
Reduction of Paraoxonase Expression Followed by Inactivation across Independent Semiaquatic Mammals Suggests Stepwise Path to Pseudogenization.
Convergent adaptation to the same environment by multiple lineages frequently involves rapid evolutionary change at the same genes, implicating these genes as important for environmental adaptation. Such adaptive molecular changes may yield either change or loss of protein function; loss of function can eliminate newly deleterious proteins or reduce energy necessary for protein production. We previously found a striking case of recurrent pseudogenization of the Paraoxonase 1 (Pon1) gene among aquatic mammal lineages-Pon1 became a pseudogene with genetic lesions, such as stop codons and frameshifts, at least four times independently in aquatic and semiaquatic mammals. Here, we assess the landscape and pace of pseudogenization by studying Pon1 sequences, expression levels, and enzymatic activity across four aquatic and semiaquatic mammal lineages: pinnipeds, cetaceans, otters, and beavers. We observe in beavers and pinnipeds an unexpected reduction in expression of Pon3, a paralog with similar expression patterns but different substrate preferences. Ultimately, in all lineages with aquatic/semiaquatic members, we find that preceding any coding-level pseudogenization events in Pon1, there is a drastic decrease in expression, followed by relaxed selection, thus allowing accumulation of disrupting mutations. The recurrent loss of Pon1 function in aquatic/semiaquatic lineages is consistent with a benefit to Pon1 functional loss in aquatic environments. Accordingly, we examine diving and dietary traits across pinniped species as potential driving forces of Pon1 functional loss. We find that loss is best associated with diving activity and likely results from changes in selective pressures associated with hypoxia and hypoxia-induced inflammation
Ancient convergent losses of Paraoxonase 1 yield potential risks for modern marine mammals
Mammals diversified by colonizing drastically different environments, with each transition yielding numerous molecular changes, including losses of protein function. Though not initially deleterious, these losses could subsequently carry deleterious pleiotropic consequences. We have used phylogenetic methods to identify convergent functional losses across independent marine mammal lineages. In one extreme case, Paraoxonase 1 (PON1) accrued lesions in all marine lineages, while remaining intact in all terrestrial mammals. These lesions coincide with PON1 enzymatic activity loss in marine species’ blood plasma. This convergent loss is likely explained by parallel shifts in marine ancestors’ lipid metabolism and/or bloodstream oxidative environment affecting PON1’s role in fatty acid oxidation. PON1 loss also eliminates marine mammals’ main defense against neurotoxicity from specific man-made organophosphorus compounds, implying potential risks in modern environment
Ancient convergent losses of Paraoxonase 1 yield potential risks for modern marine mammals
Mammals diversified by colonizing drastically different environments, with each transition yielding numerous molecular changes, including losses of protein function. Though not initially deleterious, these losses could subsequently carry deleterious pleiotropic consequences. We have used phylogenetic methods to identify convergent functional losses across independent marine mammal lineages. In one extreme case, Paraoxonase 1 (PON1) accrued lesions in all marine lineages, while remaining intact in all terrestrial mammals. These lesions coincide with PON1 enzymatic activity loss in marine species’ blood plasma. This convergent loss is likely explained by parallel shifts in marine ancestors’ lipid metabolism and/or bloodstream oxidative environment affecting PON1’s role in fatty acid oxidation. PON1 loss also eliminates marine mammals’ main defense against neurotoxicity from specific man-made organophosphorus compounds, implying potential risks in modern environment
Production of Lambda and Sigma^0 hyperons in proton-proton collisions
This paper reports results on simultaneous measurements of the reaction
channels pp -> pK+\Lambda and pp -> pK+\Sigma^0 at excess energies of 204, 239,
and 284 MeV (\Lambda) and 127, 162, and 207 MeV (\Sigma^0). Total and
differential cross sections are given for both reactions. It is concluded from
the measured total cross sections that the high energy limit of the cross
section ratio is almost reached at an excess energy of only about 200 MeV. From
the differential distributions observed in the overall CMS as well as in the
Jackson and helicity frames, a significant contribution of interfering nucleon
resonances to the \Lambda production mechanism is concluded while resonant
\Sigma^0-production seems to be of lesser importance and takes place only
through specific partial waves of the entrance channel. The data also indicate
that kaon exchange plays a minor role in the case of \Lambda- but an important
role for \Sigma^0-production. Thus the peculiar energy dependence of the
\Lambda-to-\Sigma^0 cross section ratio appears in a new light as its
explanation requires more than mere differences between the p\Lambda and the
p\Sigma^0 final state interaction. The data provide a benchmark for theoretical
models already available or yet to come.Comment: 18 pages, 10 figures; accepted by The European Physical Journal A
(EPJ A
Insulin resistance causes inflammation in adipose tissue
Obesity is a major risk factor for insulin resistance and type 2 diabetes. In adipose tissue, obesity-mediated insulin resistance correlates with the accumulation of proinflammatory macrophages and inflammation. However, the causal relationship of these events is unclear. Here, we report that obesity-induced insulin resistance in mice precedes macrophage accumulation and inflammation in adipose tissue. Using a mouse model that combines genetically induced, adipose-specific insulin resistance (mTORC2-knockout) and diet-induced obesity, we found that insulin resistance causes local accumulation of proinflammatory macrophages. Mechanistically, insulin resistance in adipocytes results in production of the chemokine monocyte chemoattractant protein 1 (MCP1), which recruits monocytes and activates proinflammatory macrophages. Finally, insulin resistance (high homeostatic model assessment of insulin resistance [HOMA-IR]) correlated with reduced insulin/mTORC2 signaling and elevated MCP1 production in visceral adipose tissue from obese human subjects. Our findings suggest that insulin resistance in adipose tissue leads to inflammation rather than vice versa
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