Ensemble of ultra-high intensity attosecond pulses from laser-plasma interaction

The efficient generation of intense X-rays and $\gamma$-radiation is studied. The scheme is based on the relativistic mirror concept, {\it i.e.}, a flying thin plasma slab interacts with a counterpropagating laser pulse, reflecting part of it in the form of an intense ultra-short electromagnetic pulse having an up-shifted frequency. In the proposed scheme a series of relativistic mirrors is generated in the interaction of the intense laser with a thin foil target as the pulse tears off and accelerates thin electron layers. A counterpropagating pulse is reflected by these flying layers in the form of an ensemble of ultra-short pulses resulting in a significant energy gain of the reflected radiation due to the momentum transfer from flying layers.Comment: 6 pages, 2 figures. Phys. Lett. A, in pres

Correlations between the peak flux density and the position angle of inner-jet in three blazars

We aim to investigate the relation between the long-term flux density and the position angle (PA) evolution of inner-jet in blazars. We have carried out the elliptic Gaussian model-fit to the `core' of 50 blazars from 15 GHz VLBA data, and analyzed the variability properties of three blazars from the model-fit results. Diverse correlations between the long-term peak flux density and the PA evolution of the major axis of the `core' have been found in $\sim$ 20% of the 50 sources. Of them, three typical blazars have been analyzed, which also show quasi-periodic flux variations of a few years (T). The correlation between the peak flux density and the PA of inner-jet is positive for S5~0716+714, and negative for S4~1807+698. The two sources cannot be explained with the ballistic jet models, the non-ballistic models have been analyzed to explain the two sub-luminal blazars. A correlation between the peak flux density and the PA (with a T/4 time lag) of inner-jet is found in [HB89]~1823+568, this correlation can be explained with a ballistic precession jet model. All the explanations are based mainly on the geometric beaming effect; physical flux density variations from the jet base would be considered for more complicated situations in future, which could account for the no or less significance of the correlation between the peak flux density and the PA of inner-jet in the majority blazars of our sample.Comment: 6 pages, 7 figures, accepted for publication in Astrophysics and Space Scienc

Evanescent wave transport and shot noise in graphene: ballistic regime and effect of disorder

We have investigated electrical transport and shot noise in graphene field effect devices. In large width over length ratio $W/L$ graphene strips, we have measured shot noise at low frequency ($f$ = 600--850 MHz) in the temperature range of 4.2--30 K. We observe a minimum conductivity of $\frac{4e^{2}}{\pi h}$ and a finite and gate dependent Fano factor reaching the universal value of 1/3 at the Dirac point, i.e. where the density of states vanishes. These findings are in good agreement with the theory describing that transport at the Dirac point should occur via evanescent waves in perfect graphene samples with large $W/L$. Moreover, we show and discuss how disorder and non-parallel leads affect both conductivity and shot noise.Comment: Extended version (19 pages, 10 figures) of Phys. Rev. Lett. 100, 196802 (2008). Additional data on the effect of disorder and non-parallel leads. Submitted for publication in Journal of Low Temperature Physics for the Proceedings of the International Symposium on Quantum Phenomena and Devices at Low Temperatures (ULTI 2008), Espoo, Finlan

Fine-Scale Mapping of the 4q24 Locus Identifies Two Independent Loci Associated with Breast Cancer Risk

Background: A recent association study identified a common variant (rs9790517) at 4q24 to be associated with breast cancer risk. Independent association signals and potential functional variants in this locus have not been explored. Methods: We conducted a fine-mapping analysis in 55,540 breast cancer cases and 51,168 controls from the Breast Cancer Association Consortium. Results: Conditional analyses identified two independent association signals among women of European ancestry, represented by rs9790517 [conditional P = 2.51 × 10−4; OR, 1.04; 95% confidence interval (CI), 1.02–1.07] and rs77928427 (P = 1.86 × 10−4; OR, 1.04; 95% CI, 1.02–1.07). Functional annotation using data from the Encyclopedia of DNA Elements (ENCODE) project revealed two putative functional variants, rs62331150 and rs73838678 in linkage disequilibrium (LD) with rs9790517 (r2 ≥ 0.90) residing in the active promoter or enhancer, respectively, of the nearest gene, TET2. Both variants are located in DNase I hypersensitivity and transcription factor–binding sites. Using data from both The Cancer Genome Atlas (TCGA) and Molecular Taxonomy of Breast Cancer International Consortium (METABRIC), we showed that rs62331150 was associated with level of expression of TET2 in breast normal and tumor tissue. Conclusion: Our study identified two independent association signals at 4q24 in relation to breast cancer risk and suggested that observed association in this locus may be mediated through the regulation of TET2. Impact: Fine-mapping study with large sample size warranted for identification of independent loci for breast cancer risk

Subcortical volumes across the lifespan: data from 18,605 healthy individuals aged 3-90 years

Age has a major effect on brain volume. However, the normative studies available are constrained by small sample sizes, restricted age coverage and significant methodological variability. These limitations introduce inconsistencies and may obscure or distort the lifespan trajectories of brain morphometry. In response, we capitalized on the resources of the Enhancing Neuroimaging Genetics through Meta-Analysis (ENIGMA) Consortium to examine age-related trajectories inferred from cross-sectional measures of the ventricles, the basal ganglia (caudate, putamen, pallidum, and nucleus accumbens), the thalamus, hippocampus and amygdala using magnetic resonance imaging data obtained from 18,605 individuals aged 3-90 years. All subcortical structure volumes were at their maximum value early in life. The volume of the basal ganglia showed a monotonic negative association with age thereafter; there was no significant association between age and the volumes of the thalamus, amygdala and the hippocampus (with some degree of decline in thalamus) until the sixth decade of life after which they also showed a steep negative association with age. The lateral ventricles showed continuous enlargement throughout the lifespan. Age was positively associated with inter-individual variability in the hippocampus and amygdala and the lateral ventricles. These results were robust to potential confounders and could be used to examine the functional significance of deviations from typical age-related morphometric patterns.Education and Child Studie

Reducing the environmental impact of surgery on a global scale: systematic review and co-prioritization with healthcare workers in 132 countries

Background Healthcare cannot achieve net-zero carbon without addressing operating theatres. The aim of this study was to prioritize feasible interventions to reduce the environmental impact of operating theatres. Methods This study adopted a four-phase Delphi consensus co-prioritization methodology. In phase 1, a systematic review of published interventions and global consultation of perioperative healthcare professionals were used to longlist interventions. In phase 2, iterative thematic analysis consolidated comparable interventions into a shortlist. In phase 3, the shortlist was co-prioritized based on patient and clinician views on acceptability, feasibility, and safety. In phase 4, ranked lists of interventions were presented by their relevance to high-income countries and low–middle-income countries. Results In phase 1, 43 interventions were identified, which had low uptake in practice according to 3042 professionals globally. In phase 2, a shortlist of 15 intervention domains was generated. In phase 3, interventions were deemed acceptable for more than 90 per cent of patients except for reducing general anaesthesia (84 per cent) and re-sterilization of ‘single-use’ consumables (86 per cent). In phase 4, the top three shortlisted interventions for high-income countries were: introducing recycling; reducing use of anaesthetic gases; and appropriate clinical waste processing. In phase 4, the top three shortlisted interventions for low–middle-income countries were: introducing reusable surgical devices; reducing use of consumables; and reducing the use of general anaesthesia. Conclusion This is a step toward environmentally sustainable operating environments with actionable interventions applicable to both high– and low–middle–income countries

Expression of the envelope antigen F1 of Y. pestis is mediated by the product of caf1M gene having homology with chaperon protein PapD of E. coli.

AbstractThe effective synthesis of the envelope antigen F1 of Y. pestis in E. coli HB101 is mediated by the expression of the caf1M gene. This gene was sequenced, and the protein encoded was found to have a significant homology with the chaperone protein PapD of uropathogenic E. coli. The data presented allow one to suppose Caf1M and PapD proteins perform similar functions in the biogenesis of the Y. pestis capsule and E. coli P-pili, respectively