Godsdiens en die pasiënt - hoe sien die algemene praktisyn dit? 'n Studie in Bellville

Godsdiens is een van die faktore wat die biopsigososiale model van moderne geneeskunde beinvloed. 'n Studie is onderneem om die invloed van godsdiens vanuit die algemene praktisyn se oogpunt te ondersoek. Vraelyste oor persoonlike godsdienstige oortuigings en hoe godsdienstige faktore die geneesheer-pasiëntverhouding beinvloed is aan 49 geneeshere in Bellville gestuur. Die responssyfer was 80%. Die meeste praktisyns in hierdie studie lewer waardevolle insette in die geestelike sake van hul pasiente. Hoewel feitlik almal reeds pasiënt na geestelike leiers verwys het, doen 17% van praktisyns nooit navraag in verband met geestelike sake nie. Die meerderheid beskik ook net soms oor genoeg kennis en insig vir die aanspreek van geestelike sake. 'n Gebrek aan opleiding in die verband en 'n gebrek aan lidmaatskap aan godsdienstig-mediese verenigings is as leemtes uitgewys. Verwysing van pasiënt na geestelike leiers word negatief beinvloed deur beperkte professionele kontak en toenemende pasiëntgetalle. WerkHke navraag in verband met geestelike sake word negatief beinvloed deur jonger ouderdom van die praktisyn, mnder tyd bestee aan persoonlike godsdienstige aktiwiteite deur die praktisyn self en toenemende pasiëntgetalle. Daar bestaan 'n wanverhouding tussen die siening van die waarde van geestelike leiers en die werkllke verwysings na hulle. Die minderheid van praktisyns verwys pasiente na alternatiewe geneeskundige rigtings

E-Theory for C*-algebras over topological spaces

We define E-theory for separable C*-algebras over second countable topological spaces and establish its basic properties. This includes an approximation theorem that relates the E-theory over a general space to the E-theories over finite approximations to this space. We obtain effective criteria for determining the invertibility of E-theory elements over possibly infinite-dimensional spaces. Furthermore, we prove a Universal Multicoefficient Theorem for C*-algebras over totally disconnected metrisable compact spaces.Comment: 33 page

The impact of globalisation on higher education : achieving a balance between local and global needs and realities.

The business world has changed dramatically over the last decade to address the reality of globalisation in the sphere of business. However, most universities have remained intact as local universities servicing local needs of citizens studying at their closest universities. For instance, a small number of universities have managed to attract students from other provinces, countries and regions. The question arises: to what extent have universities in South Africa embraced to the reality of globalisation? Are higher education institutions preparing students to work globally, or do they still function as institutions operating with a local mindset for a local market? Although South African universities have been widely criticised for not producing graduates meeting the needs of the local economy, these institutions are now challenged to prepare students for global markets. Only one local university achieved a ranking in the top hundred universities in the world according to the latest international ranking of universities. This reality poses several challenges for universities, for example, globalising curriculum to meet global needs and realities, as well as sourcing more academics from different parts of the world to infuse a global focus in the development and delivery of a global curriculum. Similarly, local universities are expected to play a key role in the socio-economic transformation of South Africa, while being challenged to meet international standards. This dichotomy places severe strain on the resources of universities, of which many may not be ready to compete globally, especially in the light of the rapid growth of private higher education, and big business, resorting to corporate universities to meet their needs. This paper seeks to determine the impact of globalisation on higher education with specific recommendations for achieving a balance between global and local higher education needs and realities

Antibacterial activity of rationally designed antimicrobial peptides.

Many infectious diseases are still prevalent in the world’s populations since no effective treatments are available to eradicate them. e reasons may either be the antibiotic resistance towards the available therapeutic molecules or the slow rate of producing adequate therapeutic regimens to tackle the rapid growth of new infectious diseases, as well as the toxicity of current treatment regimens. Due to these reasons, there is a need to seek and develop novel therapeutic regimens to reduce the rapid scale of bacterial infections. Antimicrobial Peptides (AMPs) are components of the first line of defense for prokaryotes and eukaryotes and have a wide range of activities against Gram-negative and Gram-positive bacteria, fungi, cancer cells, and protozoa, as well as viruses. In this study, peptides which were initially identified for their HIV inhibitory activity were further screened for antibacterial activity through determination of their kinetics as well as their cytotoxicity. From the results obtained, the MICs of two AMPs (Molecule 3 and Molecule 7) were 12.5 μg/ml for K. pneumoniae (ATCC 700603) and 6.25 μg/ml for P. aeruginosa (ATCC 22108). e two AMPs killed these bacteria rapidly in vitro, preventing bacterial growth within few hours of treatment. Furthermore, the cytotoxic activity of these two peptides was significantly low, even at an AMP concentration of 100 μg/ml. ese results revealed that Molecule 3 and 7 have great potential as antibacterial drugs or could serve as lead compounds in the design of therapeutic regimens for the treatment of antibiotic-resistant bacteria

“District Future – Urban Lab”

1 An Initial Overview The sustainable development of our cities is one of the most demanding challenges of the 21st century. The Urban Transition Lab “District Future – Urban Lab”, an urban research and development project in and for Karlsruhe, provides the conceptual framework for joint experiments and research on potentially sustainable societal and technological innovations originating from the urban society and the Karlsruhe Institute of Technology (KIT) (cf. Parodi 2011; Parodi et al. 20..

A comprehensive dataset of vegetation states, fluxes of matter and energy, weather, agricultural management, and soil properties from intensively monitored crop sites in western Germany

Data description paperThe development and validation of hydroecological land-surface models to simulate agricultural areas require extensive data on weather, soil properties, agricultural management, and vegetation states and fluxes. However, these comprehensive data are rarely available since measurement, quality control, documentation, and compilation of the different data types are costly in terms of time and money. Here, we present a comprehensive dataset, which was collected at four agricultural sites within the Rur catchment in western Germany in the framework of the Transregional Collaborative Research Centre 32 (TR32) "Patterns in Soil-Vegetation-Atmosphere Systems: Monitoring, Modeling and Data Assimilation". Vegetation-related data comprise fresh and dry biomass (green and brown, predominantly per organ), plant height, green and brown leaf area index, phenological development state, nitrogen and carbon content (overall > 17 000 entries), and masses of harvest residues and regrowth of vegetation after harvest or before planting of the main crop (> 250 entries). Vegetation data including LAI were collected in frequencies of 1 to 3 weeks in the years 2015 until 2017, mostly during overflights of the Sentinel 1 and Radarsat 2 satellites. In addition, fluxes of carbon, energy, and water (> 180 000 half-hourly records) measured using the eddy covariance technique are included. Three flux time series have simultaneous data from two different heights. Data on agricultural management include sowing and harvest dates as well as information on cultivation, fertilization, and agrochemicals (27 management periods). The dataset also includes gap-filled weather data (> 200 000 hourly records) and soil parameters (particle size distributions, carbon and nitrogen content; > 800 records). These data can also be useful for development and validation of remote-sensing products. The dataset is hosted at the TR32 database (https://www.tr32db.uni-koeln.de/data.php?dataID=1889, last access: 29 September 2020) and has the DOI https://doi.org/10.5880/TR32DB.39 (Reichenau et al., 2020).Peer reviewe

Photo-enhanced magnetization in Fe-doped ZnO nanowires

An emerging branch of electronics, the optospintronics, would be highly boosted if the control of magnetic order by light is implemented in magnetic semiconductors’ nanostructures being compatible with the actual technology. Here, we show that the ferromagnetic magnetization of low Fe-doped ZnO nanowires prepared by carbothermal process is enhanced under illumination up to temperatures slightly below room temperature. This enhancement is related to the existence of an oxygen vacancy VO in the neighborhood of an antiferromagnetic superexchange Fe3+-Fe3+ pair. Under illumination, the VO is ionized to to V+O giving an electron to a closeFe3+ ion from the antiferromagnetic pair. This light excited electron transition allows the transition of Fe3+ to Fe2+ forming stable ferromagnetic double exchange pairs, increasing the total magnetization. The results presented here indicate an efficient way to influence the magnetic properties of ZnO based nanostructures by light illumination at high temperatures

Switching the Switch: Ligand Induced Disulfide Formation in HDAC8

Human histone deacetylase 8 is a well‐recognized target for T‐cell lymphoma and particularly childhood neuroblastoma. PD‐404,182 was shown to be a selective covalent inhibitor of HDAC8 that forms mixed disulfides with several cysteine residues and is also able to transform thiol groups to thiocyanates. Moreover, HDAC8 was shown to be regulated by a redox switch based on the reversible formation of a disulfide bond between cysteines Cys$_{102}$ and Cys$_{153}$. This study on the distinct effects of PD‐404,182 on HDAC8 reveals that this compound induces the dose‐dependent formation of intramolecular disulfide bridges. Therefore, the inhibition mechanism of HDAC8 by PD‐404,182 involves both, covalent modification of thiols as well as ligand mediated disulfide formation. Moreover, this study provides a deep molecular insight into the regulation mechanism of HDAC8 involving several cysteines with graduated capability to form reversible disulfide bridges