Bioactivity in compound resin resistance and polibility: a clinical case report

Concern about appearance and the importance of an attractive smile is well established in modern society. A healthy aesthetic standard satisfies anyone regardless of sex, age, or social class. The growing interest of patients for a better aesthetic appearance, associated with the significant development of new restorative materials and wide dissemination in the media of this concept of beauty, led to changes in the concepts of dental treatment. This work aimed to demonstrate through a clinical case how biotechnology can help in treatments in a minimally invasive way. For this, a total of 34 articles were analyzed in full, however, 17 were included and discussed in this study. The literature reviews used and the observation of random studies was from the Bireme, PubMed, SciElo, and LILACS databases. It can be concluded in this clinical case that the success of aesthetic treatment is closely linked to the correct indication and knowledge of the dental surgeon in different products on the market, in addition to using it correctly, taking into account the patient's desire

Bowel symptoms associated with coronavirus disease 19 in hospitalized patients with moderate to severe illness

Bowel symptoms, such as diarrhea, have higher prevalence during coronavirus disease 2019 (COVID-19). The correlation between the severity of these symptoms and their prognosis has not been defined yet. Furthermore, higher prevalence of gastrointestinal symptoms after recovery from COVID-19 has been reported. This study aimed to analyze the correlation of potential factors with the severity of diarrhea during COVID-19 and to assess the progression of post-COVID-19 bowel symptoms. This prospective longitudinal cohort included 109 patients with moderate to severe COVID-19 symptoms who were hospitalized from May to July 2021. Patients were interviewed to assess the presence and intensity of bowel symptoms during COVID-19 and 3–6 months after hospital discharge using the Gastrointestinal Symptom Rating Scale questionnaire. Demographic and clinical data were obtained and their correlations with the intensity of bowel symptoms were examined. The presence of severe diarrhea was correlated with the need for ventilatory support and the use of anticoagulants but not with the use of antibiotics. In addition, bowel symptoms, such as loose stools and incomplete evacuation but not diarrhea, constipation, or abdominal pain, persisted for at least 3–6 months after hospital discharge. These results suggest that the severity of diarrhea during COVID-19 may be associated with worsening of the disease and that only loose stools and incomplete evacuation are present after COVID-19. The chronicity of these bowel symptoms should be evaluated to improve the treatment of patients with COVID-19

Tuberculose pulmonar oportunista em paciente com HIV: sistematização da assistência de enfermagem/Opportunist pulmonary tuberculosis in a patient with HIV: systematization of nursing care

Causada pelo Mycobacterium tuberculosis, a tuberculose é uma doença infecciosa e transmissível que afeta prioritariamente os pulmões, embora possa acometer outros órgãos. O tratamento da TB em pessoas vivendo com HIV (PVHIV) segue as mesmas recomendações para os não infectados. Objetivou-se explanar o conhecimento vivenciado a partir da utilização da SAE a um paciente com TB-HIV. Trata-se de um estudo descritivo do tipo relato de experiência desenvolvido em um hospital universitário da capital do Pará. O sujeito do estudo foi selecionado ao acaso, os dados coletados, analisados e posteriormente elencados os diagnósticos de enfermagem, implementadas as intervenções necessárias e verificado os resultados esperados, utilizando a taxonomia NANDA, NIC e NOC. Após identificação dos problemas, foram priorizados 4 diagnósticos de enfermagem e elaborou-se o plano de cuidados para cada um deles, evidenciando os resultados a serem alcançados por meio das intervenções. Sistematizar a assistência de enfermagem é, antes de tudo, oferecer ao paciente/cliente uma assistência de enfermagem determinada em lei, que possa garantir a biossegurança e a continuidade do cuidado

Vivenciando o cuidado de enfermagem por meio da SAE diante da coinfecção HIV/ herpes simples: um relato de experiência/ Experiencing nursing care through health before HIV/ herpes simple coinfection: an experience report

O Herpes Simplex Vírus (HSV-2) associado ao vírus da imunodeficiência adquirida (HIV), representa o aumento do HSV-2 em indivíduos HIV-positivos. Visou-se referir a prática da utilização da SAE a um paciente imunocomprometido e com Herpes genital (simples). O local do estudo foi um hospital referência, em Belém do Pará. Para subsidiar tal relato, empregou-se o processo de enfermagem, por meio da taxonomia da NANDA, NIC e NOC. Alvo por seleção acidental, foi realizada anamnese e exame físico, em seguida, verificou-se o prontuário para averiguar seu histórico e evolução do quadro clínico. Diante dos problemas de enfermagem, foram evidenciados 3 Diagnósticos de Enfermagem, estabelecido as metas e implantadas as condutas de Enfermagem. O estudo foi satisfatório, o paciente se revelou colaborativo e, com isso, foi possível identificar suas necessidades e obter resultados significativos ao final do estudo. A SAE compreende a organização do trabalho e atuação do Enfermeiro, levando em consideração a técnica, o método científico e referencial teórico

Multidimensional assessment of institutionalized elderly: the reality of a brazilian institution

Background: The population aging in Brazil is characterized by the accumulation of progressive disabilities in their functional activities and daily life. To consider the elderlies in his/her multiple dimensions turns out to be a critical issue to improvetheir assistance to an institu-tionalized level, improving their health and quality of life. To perform a mini-overall evaluation of institutionalized elderly person to trace their profile in relation to the socio-demographic, functional capacity, nutritional status and cognition. Methods: Descriptive study, with a cross-sectional design and quan-titative approach performed in a long - stay institution for the elderly in Natal, RN. The research was approved by the Research Ethics Com-mittee of the Federal University of Rio Grande do Norte, under opinion number 164/2011.Results: 63.3% of the elderly were female, with ages varying from 61 to 103 years. 60.0% were single; 56.7% were literate. 66.7% had no children and 55% lived with their families before the institutio-nalization. As for the institutionalization time, 63.3% resided in the institution for four years. As what concerns the aspects of health, 73.3% of the elderly presented hearing difficulties, 90% make use of medicines predominantly to diabetes and hypertension. There is clear evidence that the institutionalization has been harmful to the elderly as with regards basic activities of daily living, nutritional status and cognitive aspects. Conclusion: The progressive disability in functional activities of daily life interferes directly in the quality of life, increasing dependency and minimizing the autonomy of these individuals. It is necessary to effec-tive implementation of public policies directed to the institutionalized elderly from the perspective of effective actions for improved attention and assistance

Action potential variability in human pluripotent stem cell-derived cardiomyocytes obtained from healthy donors

Human pluripotent stem cells (PSC) have been used for disease modelling, after differentiation into the desired cell type. Electrophysiologic properties of cardiomyocytes derived from pluripotent stem cells are extensively used to model cardiac arrhythmias, in cardiomyopathies and channelopathies. This requires strict control of the multiple variables that can influence the electrical properties of these cells. In this article, we report the action potential variability of 780 cardiomyocytes derived from pluripotent stem cells obtained from six healthy donors. We analyze the overall distribution of action potential (AP) data, the distribution of action potential data per cell line, per differentiation protocol and batch. This analysis indicates that even using the same cell line and differentiation protocol, the differentiation batch still affects the results. This variability has important implications in modeling arrhythmias and imputing pathogenicity to variants encountered in patients with arrhythmic diseases. We conclude that even when using isogenic cell lines to ascertain pathogenicity to variants associated to arrythmias one should use cardiomyocytes derived from pluripotent stem cells using the same differentiation protocol and batch and pace the cells or use only cells that have very similar spontaneous beat rates. Otherwise, one may find phenotypic variability that is not attributable to pathogenic variants

COVID-19 symptoms at hospital admission vary with age and sex: results from the ISARIC prospective multinational observational study

Background: The ISARIC prospective multinational observational study is the largest cohort of hospitalized patients with COVID-19. We present relationships of age, sex, and nationality to presenting symptoms. Methods: International, prospective observational study of 60 109 hospitalized symptomatic patients with laboratory-confirmed COVID-19 recruited from 43 countries between 30 January and 3 August 2020. Logistic regression was performed to evaluate relationships of age and sex to published COVID-19 case definitions and the most commonly reported symptoms. Results: ‘Typical’ symptoms of fever (69%), cough (68%) and shortness of breath (66%) were the most commonly reported. 92% of patients experienced at least one of these. Prevalence of typical symptoms was greatest in 30- to 60-year-olds (respectively 80, 79, 69%; at least one 95%). They were reported less frequently in children (≤ 18 years: 69, 48, 23; 85%), older adults (≥ 70 years: 61, 62, 65; 90%), and women (66, 66, 64; 90%; vs. men 71, 70, 67; 93%, each P < 0.001). The most common atypical presentations under 60 years of age were nausea and vomiting and abdominal pain, and over 60 years was confusion. Regression models showed significant differences in symptoms with sex, age and country. Interpretation: This international collaboration has allowed us to report reliable symptom data from the largest cohort of patients admitted to hospital with COVID-19. Adults over 60 and children admitted to hospital with COVID-19 are less likely to present with typical symptoms. Nausea and vomiting are common atypical presentations under 30 years. Confusion is a frequent atypical presentation of COVID-19 in adults over 60 years. Women are less likely to experience typical symptoms than men

TOCILIZUMAB: UMA NOVA CLASSE DE AGENTES BIOLÓGICOS EFICAZ NO TRATAMENTO DA ARTRITE REUMATOIDE

A artrite reumatoide é uma doença autoimune inflamatória sistêmica caracterizada pelo comprometimento da membrana sinovial das articulações periféricas. Cerca de 1% da população mundial é afetada, sendo três vezes mais prevalente em mulheres. Embora a etiologia não seja totalmente compreendida, acredita-se que seja multifatorial, resultante da interação entre fatores genéticos e ambientais. Possivelmente um evento autoimune ou infeccioso inicia a inflamação das articulações, que, em seguida, precipita uma série de respostas imunes complexas. O objetivo do trabalho foi revisar a fisiopatologia da artrite reumatoide, esclarecer o mecanismo de ação do Tocilizumab e identificar as reações adversas. O Tocilizumab é um agente biológico que teve seu uso aprovado em 2008 e atua como um antagonista do receptor de interleucina 6, bloqueando a transdução do sinal dessa citocina pró-inflamatória. Apesar das evidentes vantagens demonstradas com o uso do Tocilizumab no tratamento da artrite reumatoide, um pequeno número vem apresentando efeitos adversos graves em relação ao uso dessa droga