On Nietzsche’s genealogical mode of inquiry

The subject of this thesis is Friedrich Nietzsche’s methodology, the genealogical mode of inquiry, which came to fruition in On the Genealogy of Morals. The precise nature of the genealogy, as a mode of inquiry, is a site of contest amongst scholars, with the central debates pivoting around four questions which arise upon considering the methodology: (1) what is the critical import of Nietzsche’s genealogical mode of inquiry? (2) What form of critique does it take? (3) To whom does Nietzsche address his reflections? And (4) what role, if any, does history play in Nietzsche’s genealogical narratives? Accordingly, this thesis seeks to offer and to defend answers to the central questions that are generated by the consideration of Nietzsche’s methodology.In order to get a foothold into these debates and to provide the boundary within which these disagreements occur the first chapter has as its object of inquiry an examination and evaluation of Nietzsche scholars’ responses to these issues. In chapter two I defend my interpretation against these rival views, and contend that the genealogy takes the form of an immanent critique, and that it is intended, at least, to reach all of Nietzsche’s contemporaries.The adage “genealogy is history correctly practiced” is treated in the remaining three chapters, in which I attempt to morph what appears to be at present an uninformative formulation into an informative one by arguing that for Nietzsche historiography is best seen as a form of artistry. And, this I submit, serves to shed light upon the genealogical mode of inquiry, and to shape the boundary by which the equation of genealogy as methodology with history becomes instructive

Predicting pragmatic cue integration in adults’ and children’s inferences about novel word meanings

Language is learned in complex social settings where listeners must reconstruct speakers’ intended meanings from context. To navigate this challenge, children can use pragmatic reasoning to learn the meaning of unfamiliar words. A critical challenge for pragmatic reasoning is that it requires integrating multiple information sources, which have typically been studied separately. Here we study this integration process. First, we experimentally isolate two sources of pragmatic information: expectations about informative communication and common ground. Next, we use a probabilistic model of conversational reasoning to formalize how these information sources should be combined and how this process might develop. We use this model to generate quantitative predictions, which we test against new experimental data from 3- to 5-year-old children (N = 243) and adults (N = 694). Results show close alignment between model predictions and data. Furthermore, the model provided a better explanation of the data compared with simpler alternative models assuming that participants selectively ignore one information source. This work integrates distinct sets of findings regarding information sources for early language learning and suggests that pragmatic reasoning models can provide a quantitative framework for understanding developmental changes in language learning

Development and evaluation of lessons in socialized learning for grade I: volumes I-II

Thesis (Ed.M.)--Boston Universit

G-quadruplexes in pathogens: a common route to virulence control?

DNA can form several secondary structures besides the classic double helix: one that has received much attention in recent years is the G-quadruplex (G4). This is a stable four-stranded structure formed by the stacking of quartets of guanine bases. Recent work has convincingly shown that G4s can form in vivo as well as in vitro and can affect both replication and transcription of DNA. They also play important roles at G-rich telomeres. Now, a spate of exciting reports has begun to reveal roles for G4 structures in virulence processes in several important microbial pathogens of humans. Interestingly, these come from a range of kingdoms--bacteria and protozoa as well as viruses--and all facilitate immune evasion in different ways. In particular, roles for G4s have been posited in the antigenic variation systems of bacteria and protozoa, as well as in the silencing of at least two major human viruses, human immunodeficiency virus (HIV) and Epstein-Barr virus (EBV). Although antigenic variation and the silencing of latent viruses are quite distinct from one another, both are routes to immune evasion and the maintenance of chronic infections. Thus, highly disparate pathogens can use G4 motifs to control DNA/RNA dynamics in ways that are relevant to common virulence phenotypes. This review explores the evidence for G4 biology in such processes across a range of important human pathogens

Feedback GAP : study protocol for a cluster-randomized trial of goal setting and action plans to increase the effectiveness of audit and feedback interventions in primary care

Peer reviewedPublisher PD

Simulated Bladed MMC Disk LCF Validation

The goal of this program was to evaluate the low cycle fatigue behavior of an SCS-6/Ti-6Al-4V sub-component under bi-axial loading conditions at 316 C(600 F). A simulated bladed TMC disk was designed having thirty four blades representing the number that would be used in Allied Signal's JTAGG II impeller. The outer diameter of the bladed ring was 254 mm (10.0 inch) and the inner diameter 114.3 mm (4.50 inch). The outer and inner diameter of the composite zone was 177.8 mm (7.00 inch) and 127.O mm(5.00 inch) respectively. Stress analysis showed that the fatigue life of the bladed composite ring would be about 12000 cycles for the test conditions applied. A modal analysis was conducted which showed that the blades would have sufficient life margin from dynamic excitation. The arbor design was the same as that employed in the spin-to burst test of NAS3-27027. A systematic stress analysis of each part making up the arbor was undertaken to assure the design would meet the low cycle fatigue requirements of the program. The Textron Systems grooved foil-fiber process was chosen to make the SCS-6/Ti-6Al-4V core ring based on the success they had in contract NAS3-27027. Fiber buckling, however, was observed at several locations in the first ring made which rendered it unsuitable for spin testing. The fiber buckling was attributed to cracking of the graphite tooling during the consolidation process. On this basis a second ring was made but it too contained fiber buckling defects. Analysis by Textron indicated that the fiber buckling was most likely due to poor placement of the SCS-6 fiber in the etched grooves of the Ti-6Al-4V foil. This was also a contributor to the defects in the first ring. Since there was little indication of control in the process to manufacture a quality ring a third attempt at making a ring was not undertaken

Distortional Buckling Formulae for Thin Walled Channel and Z-sections with Return Lips

Cold-formed Channel- and Z-sections subject to both flexure and torsion may undergo distortional buckling where the flange and lip rotate about the flange/web junction. This mode of failure is prevalent in purlin sections when lateral deformation of the section is prevented and when the sections are manufactured from high strength steel. In an attempt to prevent distortional buckling, some manufacturers have added additional return lips to the flange lips to produce complex edge stiffeners. The Australian/New Zealand Standard for Cold-Formed Steel Structures includes design rules for determining the distortional buckling strength of cold-formed beam and column sections. These design rules require the computation of the elastic distortional buckling stress. Appendix D of ASINZS 4600 provides design rules for computing the elastic distortional buckling stress of general channels in compression, simple lipped channels in compression and simple lipped Channel- and Z-sections in bending about an axis perpendicular to the web. The paper describes general formulations for computing the elastic distortional buckling stresses of sections with return lips including those with sloping lips and return lips. The accuracy of the formulations is compared with the results for a large range of section geometries using a finite strip buckling analysis which can be regarded as providing accurate solutions for distortional buckling stress. Explicit expressions are presented in the paper for the flange properties