Concentration, Propagation and Dilution of Toxic Gases in Underground Excavations under Different Ventilation Modes

[EN] The drill-and-blast method is widely used for the excavation of hard rock tunnels. Toxic gases such as carbon monoxide and nitrogen oxides are released immediately after blasting by the detonation of explosives. To provide a safe working environment, the concentration of noxious gases must be reduced below the threshold limit value according to health and safety regulations. In this paper, one-dimensional mathematical models and three-dimensional CFD numerical simulations were conducted to analyze the concentration, propagation and dilution of the blasting fumes under different operating conditions. Forced, exhaust and mixed ventilation modes were compared to determine the safe re-entry times after blasting in a 200 m-long tunnel excavated using the top-heading-and-benching method. Based on the numerical simulations, carbon monoxide was the most critical gas, as it required a longer ventilation time to reduce its concentration below the threshold limit value. The safe re-entry time reached 480 s under the typical forced ventilation mode, but was reduced to 155 s when a mixed ventilation system was used after blasting, reducing the operating costs. The reduction of the re-entry time represents a significant improvement in the excavation cycle. In addition, the results obtained show that 1D models can be used to preliminary analyze the migration of toxic gases. However, to reliably determine the safe re-entry times, 3D numerical models should be developed. Finally, to verify the accuracy of the CFD results, field measurements were carried out in a railway tunnel using gas sensors. In general, good agreements were obtained between the 3D numerical simulations and the measured values.S

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Nuevo híbrido del género Centaurea L. (Compositae) sección Seridia (Juss.) Czerep.

[EN] A new hybrid of the Centaurea L. genus (Compositae) is described: Centaurea x subdecurrens nothosubsp. oblanceolata (C. aspera subsp. stenophylla x C. seridis. subsp. cruenta). It is only found at the contact areas between the parental species, and is therefore a very rare taxon. Key words: Centaurea, hybrid, taxonomy.[ES] Se describe un nuevo híbrido del género Centaurea L. (Compositae): Centaurea x subdecurrens nothosubsp. oblanceolata (C. aspera subsp. stenophylla x C. seridis subsp. cruenta). Su área de distribución es muy reducida y se circunscribe únicamente a las zonas de contacto entre ambos parentales. Palabras clave: Centaurea, híbrido, taxonomía.Merle Farinós, HB.; Garmendia Salvador, A.; Ferriol Molina, M. (2010). Nuevo híbrido del género Centaurea L. (Compositae) sección Seridia (Juss.) Czerep. Flora Montibérica. 44:66-71. http://hdl.handle.net/10251/89689S66714

Nonparametric Population Pharmacokinetic Analysis of Amikacin in Neonates, Infants, and Children

The therapeutic and toxic effects of amikacin are known to depend on its concentration in plasma, but the pharmacokinetics of this drug in neonates, infants, and children and the influences of clinical and biological variables have been only partially assessed. Therapeutic drug monitoring data collected from 155 patients (49 neonates, 77 infants, and 29 children) receiving amikacin were analyzed by a nonparametric population-based approach, the nonparametric maximum-likelihood method. We assessed the effects of gestational and postnatal age, weight, Apgar score, and plasma creatinine and urea concentrations on pharmacokinetic parameters. There is no specific formulation of amikacin for neonates and infants. We therefore used an error model to account for errors due to dilution during preparation of the infusion. The covariates that reduced the variance of clearance from plasma and the volume of distribution by more than 10% were postnatal age (43 and 28%, respectively) and body weight (30.4 and 17.4%, respectively). The expected reduction of clearance was about 10% for the plasma creatinine concentration. The other covariates studied (Apgar scores, plasma urea concentration, gestational age, sex) were found to have little effect. Simulations showed that a smaller percentage of patients had a maximum concentration in plasma/MIC ratio greater than 8 with a regimen of 7.5 mg/kg of body weight twice daily than with a regimen of 15 mg/kg once a day for MICs of 1 to 8 mg/liter

Concentration, Propagation and Dilution of Toxic Gases in Underground Excavations under Different Ventilation Modes

The drill-and-blast method is widely used for the excavation of hard rock tunnels. Toxic gases such as carbon monoxide and nitrogen oxides are released immediately after blasting by the detonation of explosives. To provide a safe working environment, the concentration of noxious gases must be reduced below the threshold limit value according to health and safety regulations. In this paper, one-dimensional mathematical models and three-dimensional CFD numerical simulations were conducted to analyze the concentration, propagation and dilution of the blasting fumes under different operating conditions. Forced, exhaust and mixed ventilation modes were compared to determine the safe re-entry times after blasting in a 200 m-long tunnel excavated using the top-heading-and-benching method. Based on the numerical simulations, carbon monoxide was the most critical gas, as it required a longer ventilation time to reduce its concentration below the threshold limit value. The safe re-entry time reached 480 s under the typical forced ventilation mode, but was reduced to 155 s when a mixed ventilation system was used after blasting, reducing the operating costs. The reduction of the re-entry time represents a significant improvement in the excavation cycle. In addition, the results obtained show that 1D models can be used to preliminary analyze the migration of toxic gases. However, to reliably determine the safe re-entry times, 3D numerical models should be developed. Finally, to verify the accuracy of the CFD results, field measurements were carried out in a railway tunnel using gas sensors. In general, good agreements were obtained between the 3D numerical simulations and the measured values